Protein Alignment Hipk and Dyrk1b

DIOPT Version :10

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_001402788.1
• Gene: Dyrk1b / 308468
• RGDID: 1307223
• Length: 689
• Species: Rattus norvegicus
• Alignment Length: 779
• Identity: 215/779 - (27%)
• Similarity: 305/779 - (39%)
• Gaps: 236/779 - (30%)

  Fly   110 HGPPVQQDSSAA-----AGAGSVGS---KAGSG----PG-------------PDGIGPISSL--K 147
            |..|..:..||:     :|.||.|:   ||..|    ||             |.|.||.|..  .
  Rat    12 HRAPAPRGPSASPDPGLSGGGSRGAGCEKAPPGRAPAPGLTPLRPSEPTMAVPPGHGPFSGFPGP 76

  Fly   148 TAHTKV-----------------ATSG-------------GHAN-----------TQPPSKRSSS 171
            ..||:|                 |||.             .|.|           .|.|.:.||:
  Rat    77 QEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSST 141

  Fly   172 ---------GADGDYQLVQHEVLYSLSAE-----YEVLEFLGRGTFGQVVKCWKRGTSEIVAIKI 222
                     |.|.|    .|:.:.. |.|     ||:...:|:|:||||||.:...|.|:|||||
  Rat   142 KKEKKVLNHGYDDD----NHDYIVR-SGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKI 201

  Fly   223 LKNHPSYARQGQIEVSILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKF 286
            :||..::..|.|||:.:|..::|.:.: ::..|.....|..:||.|||||:|..||||.|:...|
  Rat   202 IKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHF 266

  Fly   287 SPLPLKYIRPILEQVLTALLKL--KQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKT 349
            ..:.|...|.:.:|:.||||.|  .:|.:||.|||||||:|.:|.|.  .:|::||||:..:.:.
  Rat   267 RGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQR 329

  Fly   350 VCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPT 414
            :.. |:|||:||:||::||.|:..|||||||||::.|:..|.||:.||:|.||:..|.:..|:|.
  Rat   330 IYQ-YIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPP 393

  Fly   415 EHMLNSASKTSKFFYRDVDSTYP--FWRLKTTEE----HEAETNTKSKEARKYIFNCLDDIGQVN 473
            ..||..|.|..|:|.|     .|  .|.|:.|:|    ::.....:.:|.             :.
  Rat   394 APMLEQAPKARKYFER-----LPGGGWTLRRTKELRKDYQGPGTRRLQEV-------------LG 440

  Fly   474 VPTDLEGGQLLAE----KTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNV 534
            |.|...||:...|    ..|...|.||:.|||..:...|::|..||.|.|.|.|  .|
  Rat   441 VQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRT--AD------- 496

  Fly   535 KASVQMMEVCRRGDFHTVQPASTLVTNFVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEGLYQ 599
                   |....|...:....|....:..|||:...:.:.:...:....    |.|...|
  Rat   497 -------EATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSS----DNRAYRY----- 545

  Fly   600 IYNGRSVARQYPQTRTDSFQHQLVSNILC----PPSYQTMPSPTKHVVVGSATMQPPLQVPPQQ- 659
                                    ||..|    ||             :....|..| ||.|.|
  Rat   546 ------------------------SNRYCGGPGPP-------------ITDCEMNSP-QVLPSQP 572

  Fly   660 ---YVNVPVPVSMVE-PTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQAPAHSL----IVD 716
               :....||....: ||||..:|      .:|...|...|.:...|| |...|...|    :|.
  Rat   573 LRPWAGGDVPHKTHQAPTSGSTLL------GTGAQLPPQPRCLGRPPS-PTSPPPPELMDVSLVG 630

  Fly   717 STPLFNVEEIYPKHHLNLPRNDLKKESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKESSPP 780
            |.|     :..|.|....|                           :|...|.::.|:....||
  Rat   631 SPP-----DCSPPHPAPAP---------------------------QHPAASALRTRMTGGRPP 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	129/340 (38%)
		PHA03378	<1080..1327	CDD:223065
Dyrk1b	NP_001402788.1	PHA03378	<3..147	CDD:223065	30/134 (22%)
		PKc_DYRK1	157..496	CDD:271128	135/362 (37%)