DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hipk and Dyrk3

DIOPT Version :10

Sequence 1:NP_001369036.1 Gene:Hipk / 38070 FlyBaseID:FBgn0035142 Length:1409 Species:Drosophila melanogaster
Sequence 2:NP_001019938.1 Gene:Dyrk3 / 304775 RGDID:1310924 Length:586 Species:Rattus norvegicus


Alignment Length:503 Identity:155/503 - (30%)
Similarity:227/503 - (45%) Gaps:102/503 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 HILRQPATSASTSSVAAAATSK----------RKRQTDCDCGCVDSYNSSHGPPVQQDSSAAAGA 124
            :|..:|.|...|....:....|          |:..|....|..:|..||   |..|..|:.: .
  Rat    63 NITTEPFTRGHTQHFVSGGVMKVEQLFQEFGSRRTSTLQSDGVSNSEKSS---PASQGKSSDS-L 123

  Fly   125 GSVGSKAGSGPG---PDGIGPISSLK------TAHTK--------VATSGGHANTQP-----PSK 167
            |:|.....|.|.   |  :.|..:||      ||:.|        :...|.:|..:.     |:.
  Rat   124 GTVKCSLSSRPSKVLP--LTPEQALKQYKHHLTAYEKLEIISYPEIYFVGPNAKKRQGVIGGPNN 186

  Fly   168 RSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQ 232
            .....|||.|..|..:   .|:..||||:.:|:|:||||.:.:.....:.||:|:::|...:.||
  Rat   187 GGYDDADGAYIHVPRD---HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQ 248

  Fly   233 GQIEVSILSRL-SQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRP 296
            ...|:.||..| .|:.....|.:...|.|..:||.|:.||:|..:||:.:|:|||....::.:|.
  Rat   249 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRK 313

  Fly   297 ILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYR 361
            ..:.:|.:|..|.:..:||.|||||||:|....|.  ..|||||||:....:.: .||:|||:||
  Rat   314 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRS--ATKVIDFGSSCFEYQKL-YTYIQSRFYR 375

  Fly   362 APEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSK 426
            |||||||..:...||:||.||::|||..|.||:||..|.||:..:.:..|:|.:.:|.. ||.:|
  Rat   376 APEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPQKLLEQ-SKRAK 439

  Fly   427 FFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRR 491
            :|                        ..||...:|   |       :|.|..:|..:|.....||
  Rat   440 YF------------------------INSKGLPRY---C-------SVTTQTDGRVVLLGGRSRR 470

  Fly   492 E----------------------FIDLLKRMLTIDQERRLTPAEALNH 517
            .                      ||:.|||.|..|...|||||:||.|
  Rat   471 GKKRGPPGSKDWAAALKGCDDYLFIEFLKRCLQWDPSARLTPAQALRH 518

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HipkNP_001369036.1 STKc_HIPK 192..520 CDD:271113 121/349 (35%)
PHA03378 <1080..1327 CDD:223065
Dyrk3NP_001019938.1 Disordered. /evidence=ECO:0000250|UniProtKB:O43781 1..187 28/129 (22%)
PKc_DYRK2_3 142..521 CDD:271126 136/418 (33%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O43781 467..480 2/12 (17%)
Blue background indicates that the domain is not in the aligned region.

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