Protein Alignment Hipk and mnb

DIOPT Version :10

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: XP_003436034.2
• Gene: mnb / 1281364
• VectorBaseID: AGAMI1_007360
• Length: 1484
• Species: Anopheles gambiae
• Alignment Length: 1441
• Identity: 318/1441 - (22%)
• Similarity: 461/1441 - (31%)
• Gaps: 576/1441 - (39%)

  Fly    18 AGGGGSG--------------FCSGLGAGLSVRATSFYGDQTVTATTDGTRHQ---EQQQQQLQQ 65
            :|.||||              |.|.|.:  .:.....||.:::..:...::.|   :||||.|||
Mosquito   406 SGSGGSGKRILAVNRNIDDLLFGSDLDS--LINDNIIYGFKSLKVSRAQSQDQLDYQQQQQLLQQ 468

  Fly    66 QQQQHILRQP------------------------------------------------------- 75
            ||||...:||
Mosquito   469 QQQQQQQQQPFYHHYHSNPLHLQQHLQQQQQQQQHHLPNTAATLGYQPYQPQQQSHHPAHQQQQH 533

  Fly    76 --------------ATSASTSSVAAAATSKRKRQTDCDCGCV-DSYNSSHGPP------------ 113
                          ::|.|.||...|..:|:|.......|.| ||....|..|
Mosquito   534 QSHIGHWIESEIIASSSNSNSSTMLADKAKQKLAAQFASGNVPDSTRQRHHAPLYGRLVTEEHLP 598

  Fly   114 -----VQQDSSAAAGAGSVGSKAGSGP---GPDGIGPISSL-----------------KTAHTKV 153
                 :.|.|.:...:..:.:.....|   ......|:..|                 |......
Mosquito   599 AVHRDIHQRSISPTSSTDIRAMEARIPVLFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRAQ 663

  Fly   154 ATSGGHANTQPPSKRSSSGADG---DYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTS 215
            .|.|...:.:...|..:.|.|.   ||.:...|....   .||:...:|:|:||||||.:.....
Mosquito   664 QTQGEDTSHKKERKLYNDGYDDENHDYIIKNGEKFLD---RYEIDSLIGKGSFGQVVKAFDHEER 725

  Fly   216 EIVAIKILKNHPSYARQGQIEVSILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFEMLEQNLYD 279
            ..|||||:||...:..|.||||.:|..:::.:|: ::..|:....|..:||.|||||:|..||:|
Mosquito   726 CQVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLFD 790

  Fly   280 FLKQNKFSPLPLKYIRPILEQVLTALLKLK--QLGLIHADLKPENIMLVDPVRQPYRVKVIDFGS 342
            .|:...|..:.|...:...:|:.||||.|.  :|.:||.|||||||:|.:|.|.  .:|::||||
Mosquito   791 LLRNTNFRGVSLNLTKKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRS--AIKIVDFGS 853

  Fly   343 ASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYIS 407
            :..:.:.:.. |:|||:||:||::||:|:..|||||||||::.|:..|.||:.||:|.|||..|.
Mosquito   854 SCQLGQRIYQ-YIQSRFYRSPEVLLGIPYDLAIDMWSLGCILVEMHTGEPLFSGSNEADQINRIV 917

  Fly   408 QTQGLPTEHMLNSASKTSKFFYR-DVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQ 471
            :..|:|.:|:|:.|.||.|||.: ..|.:|.   |:.|:.   :...|...:||     |.||
Mosquito   918 EVLGMPPKHILDQAHKTRKFFEKLPSDGSYV---LRKTQN---QRKYKPPGSRK-----LHDI-- 969

  Fly   472 VNVPTDLEGGQLLAEK----TDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCN 532
            :.|.|...||:...|.    :|..:|.||:.|||..|.:.|:||..||.|
Mosquito   970 LGVETGGPGGRRHGEPGHSVSDYLKFKDLILRMLDYDPKTRVTPYYALQH--------------- 1019

  Fly   533 NVKASVQMMEVCRRGDFHTVQPASTLVTNFVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEGL 597
                                        ||...:::..|.|.|.
Mosquito  1020 ----------------------------NFFKRTSDESTNTANT--------------------- 1035

  Fly   598 YQIYNGRSVARQYPQTRTDSFQHQLVSNILCPPSYQTMPSPTKHVVVGSATMQPPLQVPPQQYVN 662
                                     :|::...||..|
Mosquito  1036 -------------------------ISSLSTSPSVST---------------------------- 1047

  Fly   663 VPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQAPAHSLIVDSTPLFNVEEIY 727
                                                       |..|:|.|
Mosquito  1048 -------------------------------------------QDQPSHGL-------------- 1055

  Fly   728 PKHHLNLPRNDLKKESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKESSPPHQQRYQRAAHVS 792
                                             ...|||.|        |.||.||:.|..|
Mosquito  1056 ---------------------------------SSLHQQQS--------SQPPSQQQTQPKA--- 1076

  Fly   793 PQYHA-------------------HHNCNYGNGSGYSASAGSVVASSAASSSNIVNGSSSSSHHH 838
            ||...                   ::|.|..:.|..::|.|:|..:.|.:.|:.|.|.|:
Mosquito  1077 PQQQTLVLLAQPATVGTNGTHNNNNNNTNSSSSSSSNSSGGAVAGNGAIAGSSSVTGVST----- 1136

  Fly   839 HVPVAHAQPYSSSSGHHIVSNCNANGGAGGAVVYQQPPAHAHQQHGQQPHPQSSQHPQHVKQPTI 903
                                       |.|.:|   |.::.   .|....|.:|.:|
Mosquito  1137 ---------------------------AAGVIV---PGSNV---VGSSTAPTTSSYP-------- 1160

  Fly   904 TIHDTPSPTAVITISDSEDEGGEAGGAQVPVLKQRAHAQSQTSGSLLQHAPSSS---CSRSSAHQ 965
             :.....|.|.:::.     |..|||:   ...:..:....|||:    ||:.|   .||..|.|
Mosquito  1161 -LAMDCDPPATVSLG-----GHHAGGS---AAARYGNTAVSTSGA----APAPSHYHRSRYLAQQ 1212

  Fly   966 QPHPHPQQQQQQQINYGDHDPEDARRRHHAAAAAAVGSPKHHHHQQQQQPAPPPQQQQQQYQPQP 1030
                  ||||.||...|.|....|  .|..::|..||....|                :.|.|..
Mosquito  1213 ------QQQQHQQAQQGQHLQGSA--SHLGSSALVVGGGGGH----------------KSYAPAS 1253

  Fly  1031 PPQQ------------VLPQPQPSIKYEPGQSQKKRILAMAQSECGYQPQVPS-----QPSSSAS 1078
            .|..            |:|.     .:.|.        ||:.|...:...:|.     .|.|...
Mosquito  1254 LPLDLGSHMASSLGGLVIPD-----HHAPA--------AMSGSFLAHNLSMPPGGGVVGPGSIGG 1305

  Fly  1079 LP------HIPTKQEPAEFYPEYAAAPPQQLDTKRSSWAPTSSGSGVSALPLAHPKR-------- 1129
            :|      :.|.....|......||                |||:|.|..||.....
Mosquito  1306 MPVGGAVGYAPFSVNEAMLMAAAAA----------------SSGAGGSVGPLGGGNSLGVIGGPI 1354

  Fly  1130 ---EAPSVAPISYVAPSVAPPLA--------H---------SKSSSASSSSSISAATAAAAAAAA 1174
               ...:|.|.|.|....|..::        |         |.|||:|||::.......|..|..
Mosquito  1355 GVGSVSTVGPASLVVGGSAAAVSVGVGVSSHHLIGGTGSSISNSSSSSSSTNGGGGGGGAGLAGP 1419

  Fly  1175 AAAASVGPPSWGPPQVYRQPSQPPPGSVGLPGSTQPPPSSVAPHPHHHSHGHHHHQAGTPLGGSP 1239
            ..:.:||..|         .|.....|||..||.....||        :.||.....|.|.....
Mosquito  1420 LGSGTVGAGS---------GSASGGSSVGSGGSGIVSSSS--------AKGHGRGPPGAPSDRDE 1467

  Fly  1240 SSTAAAALLQP 1250
            ||......:||
Mosquito  1468 SSPMVGVCVQP 1478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	134/335 (40%)
		PHA03378	<1080..1327	CDD:223065	46/205 (22%)
mnb	XP_003436034.2	None