Protein Alignment Hipk and dyrk1aa

DIOPT Version :10

• Sequence 1: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Sequence 2: NP_001074158.1
• Gene: dyrk1aa / 100005019
• ZFINID: ZDB-GENE-050302-29
• Length: 737
• Species: Danio rerio
• Alignment Length: 680
• Identity: 199/680 - (29%)
• Similarity: 289/680 - (42%)
• Gaps: 172/680 - (25%)

  Fly   192 YEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENAD-EFNFVR 255
            ||:...:|:|:||||||.:.|...|.|||||:||..::..|.||||.:|..:::.:.: ::..|.
Zfish   164 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVH 228

  Fly   256 AFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKL--KQLGLIHADL 318
            ....|..:||.|||||||..||||.|:...|..:.|...|...:|:.||||.|  .:|.:||.||
Zfish   229 LKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLATPELSIIHCDL 293

  Fly   319 KPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCV 383
            |||||:|.:|.|.  .:|::||||:..:.:.:.. |:|||:||:||::||:|:..|||||||||:
Zfish   294 KPENILLCNPKRS--AIKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLGMPYDLAIDMWSLGCI 355

  Fly   384 VAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHE 448
            :.|:..|.||:.|::|.||:..|.:..|:|..|:|..|.|..|||.:..||   .|..|.|::.:
Zfish   356 LVEMHTGEPLFSGANEVDQMNKIVEVLGVPPSHILEQAPKARKFFEKMPDS---MWCAKKTKDGK 417

  Fly   449 AETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEK----TDRREFIDLLKRMLTIDQERRL 509
               ..|...:||     |..|  :.|.....||:...|.    .|..:|.||:.|||..|.:.|:
Zfish   418 ---RYKPAGSRK-----LHSI--LGVEAGGPGGRRAGESGHAVADYLKFKDLILRMLDYDPKTRI 472

  Fly   510 TPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRRGDFHTVQPASTLVTNFVPSSTENMTFTI 574
            .|..||.|||.:.|  .|  ...|..:||.......       |..|:..|:...||:...:.|.
Zfish   473 QPYYALQHSFFKKT--AD--EGTNTSSSVSTSPALE-------QSQSSGTTSSTSSSSGGSSGTS 526

  Fly   575 NNQLTSQVQRLVRDGRPLAYEGLYQIYNGRSVARQYPQTRTDSFQHQ----------LVSNILCP 629
            .                          :||  ||..|   |...:|.          :..:.|||
Zfish   527 T--------------------------SGR--ARSDP---THQHRHSGGGHFSAAVAMDCHNLCP 560

  Fly   630 PSYQTMPSPTKHVVVGSATMQPPLQVPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQT 694
            .:.|..                   ||...:|.           .|.:       ||||...|..
Zfish   561 QARQAF-------------------VPALGWVG-----------DGLQ-------QASGETHPVQ 588

  Fly   695 GRQMALVPSWPQQAPAHSLIVDSTPLFNVEEIYPKHHLNLPRNDLKKESPAHHIAKGNSYRVPRH 759
            .....:.|..|:....|                 :||              ||         ..|
Zfish   589 ETTFHVPPHQPKALHPH-----------------QHH--------------HH---------HHH 613

  Fly   760 EKKEHQQLSPVKKRVKESSPPHQQRYQRAAHVSPQYHAHHNCNYGNGSGYSASAGSVVASSAASS 824
            ....|.| .|.:.|.:..||.|....|.:..|:   |.|.:.             :.::|||:||
Zfish   614 HPPPHGQ-GPARPRPRLYSPSHSASTQDSMEVT---HGHLSM-------------TSLSSSASSS 661

  Fly   825 SNIVNGSSSSSHHHHVPVAHAQPYSSSSGH 854
            |   ..|||:.:||:...:...|:....||
Zfish   662 S---TSSSSTGNHHYAYQSRPLPHGLGFGH 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	134/334 (40%)
		PHA03378	<1080..1327	CDD:223065
dyrk1aa	NP_001074158.1	PKc_DYRK1	151..488	CDD:271128	136/341 (40%)