DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1231 and ZNF385D

DIOPT Version :9

Sequence 1:	NP_612032.1	Gene:	CG1231 / 38060	FlyBaseID:	FBgn0035134	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	XP_016862680.1	Gene:	ZNF385D / 79750	HGNCID:	26191	Length:	515	Species:	Homo sapiens

Alignment Length:	428	Identity:	89/428 - (20%)
Similarity:	143/428 - (33%)	Gaps:	144/428 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PDAEISTSNRLVAP--GKRTDKKDNGSIRTNMKRKAKCMEEDSLKANGDLALFPGRDESYPEELN 96
            |....:.|.|:.:.  |:|  :|..|:.:....|...|:.:...:|.    |.|...|..||...
Human     4 PGRRAAASRRMKSSVGGRR--EKLLGAPKAQPSRDFTCVHDGESEAE----LIPDDFEEKPEREK 62

  Fly    97 RLIGPLNCQLCKVQMTSRKRARDHYESKAHD---RHISAWLAKNYTEVGLEAPPVKRLAKQGPTG 158
            :......|.:|.:|:.|..:|:.||..|:|.   :.:|....||......::|.:..|.:  |..
Human    63 KHTNFTLCNVCNIQLNSAAQAQIHYNGKSHQKRLKQLSNGTLKNDNGGTCQSPALPALVR--PPA 125

  Fly   159 P----------------------NAF------------------------------HCELCNLDL 171
            |                      |.|                              .|.:|.|..
Human   126 PPLQPSLDIKPFLPFPLDTAAAVNLFPNFNAMDPIQKAVINHTFGVPLPHRRKQIISCNICQLRF 190

  Fly   172 TSSMHARQHYLGRKH----KRVE-------------------------------------QGVAK 195
            .|...|..||.|.||    |.:|                                     :|..|
Human   191 NSDSQAAAHYKGTKHAKKLKALEAMKNKQKSVTAKDSAKTTFTSITTNTINTSSDKTGGKKGAMK 255

  Fly   196 PSG--ARHC--DTSVGRYGIGSL----FRKPESLTKD-------SPTDVLISENSVIKSDDNERT 245
            |.|  ...|  |.:.|...|.:.    .||...:|.:       |||..  :.||...|.:.|..
Human   256 PCGLFLPFCTRDGTAGTPAISTTTTVEIRKSSVMTTEITSKVEKSPTTA--TGNSSCPSTETEEE 318

  Fly   246 -------CHLCKIVVTSAAQMQAHLAGARHQKNWRTSRQDQNHS-------EAPIPETEKLDAAE 296
                   |.|||:.|.||:|::||.:|.:|    :|..:.:|.|       .|.:.....::...
Human   319 KAKRLLYCSLCKVAVNSASQLEAHNSGTKH----KTMLEARNGSGTIKAFPRAGVKGKGPVNKGN 379

  Fly   297 LALYRTPMGQYYCQPCNMMMNHESTLQQHFIGKKHLKR 334
            ..|...   .::|:.|::.:|.|:.|:||...::|..|
Human   380 TGLQNK---TFHCEICDVHVNSETQLKQHISSRRHKDR 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1231	NP_612032.1	C2H2 Zn finger	104..163	CDD:275371	18/113 (16%)
		zf-met	104..126	CDD:289631	8/21 (38%)
		zf-met	163..186	CDD:289631	8/22 (36%)
		C2H2 Zn finger	164..186	CDD:275371	8/21 (38%)
		UFD2	255..>338	CDD:227443	21/87 (24%)
		ZnF_U1	304..336	CDD:197732	9/31 (29%)
ZNF385D	XP_016862680.1	C2H2 Zn finger	70..92	CDD:275371	8/21 (38%)
		zf-met	70..92	CDD:289631	8/21 (38%)
		C2H2 Zn finger	183..205	CDD:275371	8/21 (38%)
		zf-met	183..205	CDD:289631	8/21 (38%)
		zf-met	325..348	CDD:289631	11/22 (50%)
		C2H2 Zn finger	326..348	CDD:275371	11/21 (52%)
		zf-met	388..411	CDD:289631	7/22 (32%)
		C2H2 Zn finger	389..411	CDD:275371	7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148184
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.800