DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and Frmd4b

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_038964692.1	Gene:	Frmd4b / 252858	RGDID:	620172	Length:	1066	Species:	Rattus norvegicus

Alignment Length:	746	Identity:	154/746 - (20%)
Similarity:	260/746 - (34%)	Gaps:	225/746 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 VLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLF---------------------PQ 81
            |..|||......::.:....||||.|..:..|.|::|||:.|                     |:
  Rat    63 VHLLDDRRLELLVQPKLLSRELLDLVASHFNLKEKEYFGITFIDDTGQENWLQLDHRVLEHDLPK 127

  Fly    82 KPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILL 146
            |||..|                         |.|.|:|::...|.|:::.|...|:|..|..:..
  Rat   128 KPGPAV-------------------------LHFAVRFYIESISFLKDKNTVELFFLNAKACVHK 167

  Fly   147 GKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTE-------AERKVGELHKL 204
            |::...|.|...||:..:|...||:.:.|:....|..:.:...:|.:       .|.:|.|.:..
  Rat   168 GQIEVDSETIFKLAALVLQESKGDYTSDENARKDLKTLPVFPTKTLQEHPSLAYCEDRVIEHYLK 232

  Fly   205 HRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNT-----FS 264
            .:|.....|...|::..:.|..||:..:...|..|....||:|..|  :.|:.|:...     |.
  Rat   233 IKGLTRGQAVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKG--IGQYDLQDKVKPRKLFQ 295

  Fly   265 WSKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMS---------SHKHAKALWKSCVEHHSFFRL 320
            |.::..:.|:.|.|.::: .:|.....:...||.|         :....|::|...:..|.|: |
  Rat   296 WKQLENLYFREKKFAVEV-HDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFY-L 358

  Fly   321 KRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRG--RIHK-VFVRSPSKRLLGAAGGVGTSGS 382
            .|....::.          .|.|:......:..:.|  |:.| |.:.:.|:.::.:.|.:.:|||
  Rat   359 DRKQSKAKI----------PSARSLDDIAMDLTETGTQRVSKLVTLEAKSQFIMASNGSLISSGS 413

  Fly   383 SGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRPHDNKVTSK----------EAD---SMP 434
            .....|::....:               ||.:.|..:....|:..|          ||:   .||
  Rat   414 QDSEGMEEQKREK---------------ILELKKKEKLLQEKLLKKVEELKKICLREAELTGRMP 463

  Fly   435 RKAWEQQSDEYDIQLDVGFIEQCTRR--------FESASPSPMPPAYSSGQHSPILLPTTIADA- 490
            :        ||  .|::|......||        .::..|:...||... ..|..|:...:.:|
  Rat   464 K--------EY--PLNIGEKPPQVRRRVGTTFKLDDNLLPTEEDPALQE-LESNFLIQQKLVEAA 517

  Fly   491 ------------VGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLS-----------LPVQVS 532
                        |..::.:..:|.:. |||..|.....:.::.|...|           :|.:.|
  Rat   518 KKLASEPDLCKTVKKKRKQDYTDAVK-RLQEIENSINEYRIRCGKKPSQKAAVVPPEDIIPSESS 581

  Fly   533 KV----------------------VPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRD 575
            .:                      |||:|  |..|....|.|.:......:    :||.|    |
  Rat   582 SLSDTTTYDDPNDSFTLAGQRPSSVPHSP--RILPPKSLGIERIHFRKSSI----NEQFV----D 636

  Fly   576 CRHQASGELL---------LTVRPQ--RSAPLL------------LEEEPLYQYVPE-SDEIGSH 616
            .|.  |.|:|         |..|||  ||.|..            ||.:...|:..: |..:.|.
  Rat   637 TRQ--SREMLSTHSSPYKTLERRPQGGRSMPTTPVLTRNAYSSSHLEPDSSSQHCRQRSGSLESQ 699

  Fly   617 SNLL---DGDALF--------TQSLLLLSDG 636
            |:||   |.|..|        :.|..:|.||
  Rat   700 SHLLSEMDSDKPFFTLSKSQRSSSTEILDDG 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	50/221 (23%)
		FERM_N	38..102	CDD:286467	20/84 (24%)
		FERM_M	125..232	CDD:278785	26/113 (23%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	23/107 (21%)
		FA	333..369	CDD:285894	7/38 (18%)
		PDZ_signaling	502..589	CDD:238492	25/128 (20%)
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
Frmd4b	XP_038964692.1	FERM_F1_FRMD4B	57..145	CDD:340720	24/106 (23%)
		B41	75..260	CDD:214604	46/209 (22%)
		FERM_C_FRMD4A_FRMD4B	256..366	CDD:270012	24/113 (21%)
		DUF3338	395..528	CDD:403120	27/158 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910