DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and Frmd4b

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_001333566.1	Gene:	Frmd4b / 232288	MGIID:	2141794	Length:	1035	Species:	Mus musculus

Alignment Length:	732	Identity:	156/732 - (21%)
Similarity:	263/732 - (35%)	Gaps:	197/732 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 VLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSS 102
            |..|||......::.:....||||.|..:..|.|::|||:.|....|. ..|:        |...
Mouse    63 VHLLDDRRLELLVQPKLLSRELLDLVASHFNLKEKEYFGITFIDDTGQ-ENWL--------QLDH 118

  Fly   103 VSLDNDAVP------LLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLAS 161
            ..|::| :|      ||.|.|:|::...|.|:::.|...|:|..|..:..|::...|.|...||:
Mouse   119 RVLEHD-LPKKPGPTLLHFAVRFYIESISFLKDKNTVELFFLNAKACVHKGQIEVDSETIFKLAA 182

  Fly   162 YTVQSELGDFNALEHQPGYLSGMQLLCDQTTE-------AERKVGELHKLHRGQLPADAEYNYLE 219
            ..:|...||:.:.|:....|..:.:...:|.:       .|.:|.|.:...:|.....|...|::
Mouse   183 LVLQESKGDYTSDENARKDLKTLPVFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQAVVQYMK 247

  Fly   220 HAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNT-----FSWSKMVKVSFKRKDFF 279
            ..:.|..||:..:...|..|....||:|..|  :.|:.|:...     |.|.::..:.|:.|.|.
Mouse   248 IVEALPTYGVHYYAVKDKQGLPWWLGISYKG--IGQYDLQDKVKPRKLFQWKQLENLYFREKKFA 310

  Fly   280 IQLRREPSENYDTLLGFGMS---------SHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISLG 335
            ::: .:|.....:...||.|         :....|::|...:..|.|: |.|....::.
Mouse   311 VEV-HDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFY-LDRKQSKAKI------ 367

  Fly   336 SKFYYSGRT----ELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSES 396
                .|.|:    .:...:...|||. ..|.:.:.|:.::.:.|.:.:|||.....|::....:
Mouse   368 ----PSARSLDDIAMDLTETGTQRGS-KLVTLEAKSQFIMASNGSLISSGSQDSEGMEEQKREK- 426

  Fly   397 ANSHNNGKPAGAGTILTITKTSRPHDNKVTSK----------EAD---SMPRKAWEQQSDEYDIQ 448
                          ||.:.|..:....|:..|          ||:   .||:        ||  .
Mouse   427 --------------ILELKKKEKLLQEKLLQKVEELKKICLREAELTGRMPK--------EY--P 467

  Fly   449 LDVGFIEQCTRR--------FESASPSPMPPAYSSGQHSPILLPTTIADA-------------VG 492
            |::|......||        .::..|:...||... ..|..|:...:.:|             |.
Mouse   468 LNIGEKPPQVRRRVGTTFKLDDNLLPTEEDPALQE-LESNFLIQQKLVEAAKKLASEPDLCKTVK 531

  Fly   493 HQQPESGSDLITIRLQADEQGRYGFNVKGGVDLS-----------LPVQVSKV------------ 534
            .::.:..:|.:. |||..|.....:.::.|...|           :|.:.|.:
Mouse   532 KKRKQDYTDAVK-RLQEIENSINEYRIRCGKKPSQKAAVVPPEDIIPSESSSLSDTTTYDDPNDS 595

  Fly   535 ----------VPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELL---- 585
                      |||:|  |..|....|.|       .:| .|...:.....|.||  |.|:|
Mouse   596 FTLAGQRPSSVPHSP--RILPPKSLGIE-------RIH-FRKSSINEQFMDTRH--SREMLSTHS 648

  Fly   586 -----LTVRPQ--RSAPLL------------LEEEPLYQYVPE-SDEIGSHSNLL---DGDALF- 626
                 |..|||  ||.|..            ||.:...|:..: |..:.|.|:||   |.|..|
Mouse   649 SPYKTLERRPQGGRSMPTTPVLTRNAYSSSHLEPDSSSQHCRQRSGSLESQSHLLSEMDSDKPFF 713

  Fly   627 -------TQSLLLLSDG 636
                   :.|..:|.||
Mouse   714 TLSKSQRSSSTEILDDG 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	52/206 (25%)
		FERM_N	38..102	CDD:286467	18/63 (29%)
		FERM_M	125..232	CDD:278785	26/113 (23%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	23/107 (21%)
		FA	333..369	CDD:285894	7/39 (18%)
		PDZ_signaling	502..589	CDD:238492	25/128 (20%)
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
Frmd4b	NP_001333566.1	Necessary for adherens junction and tight junction localization. /evidence=ECO:0000269\|PubMed:20080746	542..972		46/202 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..615		8/53 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..699		17/69 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	713..738		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..798
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	906..926
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..958
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	994..1035
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910