DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and F57H12.5

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_501331.1	Gene:	F57H12.5 / 177592	WormBaseID:	WBGene00019020	Length:	543	Species:	Caenorhabditis elegans

Alignment Length:	354	Identity:	74/354 - (20%)
Similarity:	117/354 - (33%)	Gaps:	114/354 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   659 TEARKPANAPKNRYRDISPYDCTRVSL-------VNSLTGDYINAN----------------YVN 700
            |||.: ||..:||......||..||.|       ||     ||||:                ||:
Worm   237 TEAFE-ANKVRNREGCPKIYDENRVQLNRPGHEDVN-----YINASVITLTDVCRRMACVPAYVH 295

  Fly   701 MEIPGGAV----NRYIATQGPL---ASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVT 758
            :.:....:    ::.|..|.|.   .|...|||.|:.||..||:                |..|.
Worm   296 LVVLYFVIFQFEHKLIVAQLPQMENESFVEDFWYMIYQEQIHLV----------------YLMVP 344

  Fly   759 GEELQLAEGFSVRCLSEKPDETGSFVF--REFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLE 821
            .::|:..      ..|...||.|.:.:  :.|:...:.:                |..||.   |
Worm   345 DDKLKNT------TTSLFNDENGGYQYTGKMFINNRRAD----------------VSGDPK---E 384

  Fly   822 FTERVRAARNR-TLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVH 885
            :|..|....|. :::.::........|..                        |....|:...:|
Worm   385 YTIEVLPEGNSDSVICQVHHHAPWKHLQQ------------------------PPKTLPIIKMIH 425

  Fly   886 QCIS---AANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYP--LDIVRTMRDQRACMVQNV 945
            |.:|   ..|..|.|....|.||....|  ....|:.:....:.|  .:|::.::.||...|::.
Worm   426 QFLSEKQVQNAGVCVVSLFGCGRACSFI--GALYAINQLNNGIEPNICEIMKNIKQQRPGGVESF 488

  Fly   946 SQYRFVCECICAAYMKISR--SSAAINDD 972
            :||..: ..|...|:...|  ..|.:|.|
Worm   489 AQYASI-YAIVFDYIARKRGGKKAPVNKD 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492
		Y_phosphatase	666..955	CDD:278528	64/326 (20%)
		PTPc	668..955	CDD:238006	63/324 (19%)
F57H12.5	NP_501331.1	PTPc	220..500	CDD:214550	69/336 (21%)
F57H12.5	NP_501331.1	PTPc	255..498	CDD:304379	61/315 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910