DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and frmd4b

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_002940561.2	Gene:	frmd4b / 100489171	XenbaseID:	XB-GENE-958639	Length:	1024	Species:	Xenopus tropicalis

Alignment Length:	879	Identity:	164/879 - (18%)
Similarity:	290/879 - (32%)	Gaps:	275/879 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 VLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQ-----FK 97
            |..|||......::.:....||||.|..:..|.|::|||:.|....|... |:...::     |.
Frog    63 VHLLDDRELELLVQPKLLSRELLDLVASHFSLKEKEYFGISFLDDTGQYA-WLQLDQRVLDHDFP 126

  Fly    98 KQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASY 162
            |:...||        |.|.|:|::...:.|::..|...|:|..|..:..|.:...|.|...||:.
Frog   127 KKSGPVS--------LYFVVRFYIESITFLKDITTVELFFLNAKACVFKGLIEVDSETIFKLAAL 183

  Fly   163 TVQSELGDFNALEHQPGYLSGMQLLCDQTTE-------AERKVGELHKLHRGQLPADAEYNYLEH 220
            .:|...||:::.|:....|..:..|..:..:       .|.:|.|..|..:|.....|...|::.
Frog   184 ILQEARGDYSSDENARKDLKILPALPTRALQEHPSLSYCEDRVIEHCKKLKGVTRGQAIVRYMKI 248

  Fly   221 AKRLELYGIDLHRATDSNGKELQLGVS--AVGLLVFQHSLRV-NTFSWSKMVKVSFKRKDFFIQL 282
            .:.|..||:..::..|..|....||:|  .:|....|..::. ..|.|.::..:.|:.|.|.:::
Frog   249 VEALPTYGVHYYKVKDKQGIPWWLGISFKGIGQYDIQDKIKPRKLFQWKQLENLYFREKKFAVEV 313

  Fly   283 RREPSENYDTLLGFGMS---------SHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNI----SL 334
             .:|.....:...||.|         |:...|::|...:..|.|: |.|....::..:.    .:
Frog   314 -HDPRRISVSRRTFGQSSLVVQTWYASNSLIKSIWVMAISQHQFY-LDRKQSKAKIPSAKSLDDI 376

  Fly   335 GSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSESANS 399
            ..:...:|.|::..:.|.|             :..::.::|.:.:|||
Frog   377 AMELTEAGTTKVARIVEGK-------------NPLIMASSGSLISSGS----------------- 411

  Fly   400 HNNGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQ-LDVGFIEQ----CTR 459
                                 .|::::.::   ...|..|.:..|..:| :.:..||:    |.|
Frog   412 ---------------------QDSEISEEQ---RMEKIQELKKKEEALQNILLKKIEELKKICLR 452

  Fly   460 RFESASPSPMPPAYSSGQHSP------------------------------ILLPTTIADA---- 490
            ..|.....|.....:.|:..|                              .|:...:.:|
Frog   453 EAELTGKLPTEYPLNPGEKPPNVRRRMGATFKLNDILHTDEDPALQELERKFLIQQQLVEATKKL 517

  Fly   491 ---------VGHQQPESGSDLITIRLQADEQGRYGFNVKGGVD----LSLPVQVSKVVPHTPADR 542
                     |..::.:..||.|. :||..|.....|.||.|..    .|:.:| ..::|...:..
Frog   518 ATEPDLSKNVKRKRKQDYSDSIK-KLQELESTINEFRVKSGKTPTKRASMILQ-DDIIPSETSSL 580

  Fly   543 CTPRVCEGDEVLMINGRDVHGLRHEQVVAMI--------RDCRHQASGELLLTVRPQR------- 592
            ......|.||..:..|:.:|...:..:...|        :...::...|:.:|..|..
Frog   581 SDTTTLEDDESQLPQGQRLHNSPNVHLTKSIGGDKSLARKFSLNEQLSEMRVTREPSSTHSSPYK 645

  Fly   593 -------------SAPLL---------LEEEPLYQYVPE-SDEIGSH----SNLLDGDALF---- 626
                         |.|:|         |:.|...||..: ...:.||    |:.:||...|
Frog   646 TQERKPHGGRSMPSTPVLTRNAFSSSHLQNEGTPQYNRQRRGSLESHTPILSDAVDGTPAFSISK 710

  Fly   627 ---TQSLLLLSDGLASGALLAQYELMY---------------------------RKN-------- 653
               :.|..:|.||   .:..:|....|                           |:|
Frog   711 SQRSNSTEVLDDG---SSCTSQSSSEYYSTPPKHNPCYTTQTLDNRSRDRRRHKRQNFSAANSGS 772

  Fly   654 -PDLAITEARK-----PANAPKNRY--RDISPYDCTRVSLVNSLTGDYINANYVNMEIPGG--AV 708
             |:||..:||.     ..|.|.:.|  ...|||         ..|..|.|..|:......|  :|
Frog   773 MPNLAHRDARNSMYQTAQNQPASSYLIPGYSPY---------PETDPYYNGGYIYENDTEGQYSV 828

  Fly   709 N----------------------RYIATQGPLAS 720
            |                      :||::|.|.|:
Frog   829 NPSYRSSAHYGYDQYRDVRYDGDQYISSQNPYAT 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	51/205 (25%)
		FERM_N	38..102	CDD:286467	19/68 (28%)
		FERM_M	125..232	CDD:278785	26/113 (23%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	23/105 (22%)
		FA	333..369	CDD:285894	4/35 (11%)
		PDZ_signaling	502..589	CDD:238492	19/98 (19%)
		Y_phosphatase	666..955	CDD:278528	18/81 (22%)
		PTPc	668..955	CDD:238006	17/79 (22%)
frmd4b	XP_002940561.2	Ubiquitin_like_fold	57..145	CDD:391949	25/90 (28%)
		B41	60..260	CDD:214604	51/205 (25%)
		FERM_C_FRMD4A_FRMD4B	256..366	CDD:270012	24/111 (22%)
		DUF3338	393..525	CDD:371743	21/185 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910