Protein Alignment gol and rnf130

DIOPT Version :10

• Sequence 1: NP_001163300.1
• Gene: gol / 38006
• FlyBaseID: FBgn0004919
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_001018301.2
• Gene: rnf130 / 553950
• ZFINID: ZDB-GENE-050522-525
• Length: 428
• Species: Danio rerio
• Alignment Length: 504
• Identity: 165/504 - (32%)
• Similarity: 238/504 - (47%)
• Gaps: 83/504 - (16%)

  Fly    19 LPPLTFPATTTTLVAAMSIANQDLERYFRPGNGTHSFSGMEDRIAVDVYNY--AFLNWSYVEH-G 80
            |..|..||:.::.:.|:.:|      :..|   ..|.|...|:..|:..:|  |.:|.:.::| |
Zfish     2 LKRLAAPASCSSCLLALLLA------FVSP---RCSLSIGADKTMVNKEDYYSAIVNATVLDHKG 57

  Fly    81 NMLCNMEFAQEQARYGEGK-VLNVTGRLIHITATDNFSDDYACTPYIRGTLGAPIPDKGETWIAL 144
            |.  .....:...|||:.. .....|.::...|.:...|...|.|:.|..    :|.|...|:|:
Zfish    58 NP--QQMVTKNDGRYGQNSPKTEAKGIVVAPAAVNGAVDLQGCCPHTRFI----VPPKTTHWVAI 116

  Fly   145 VRRGRCTFEEKVKHVYQQNAAGVIIYNDKQVMQLEKMQIKGKTRNIAAVITYQNIGQDLSLTLDK 209
            ::||:|||:||:......||:.|||||:........|..:| |.:|.||:..::.|:::...|:|
Zfish   117 MQRGKCTFKEKILKAAAFNASAVIIYNNNTKEDTVTMAHEG-TGDIVAVMITESFGKEILGFLEK 180

  Fly   210 GYNVTISIIEGRRGVRTISSLNRTSVLFVSISFIVLMIISLVWLIFYYIQRFRYMQAKDQQSRNL 274
            ...|.:|:|.|.||:.  .::||.|::|||||||||||||..|||||:||:.|...|:|:..|.|
Zfish   181 NQTVLVSVIVGSRGMP--KNINRGSLVFVSISFIVLMIISSAWLIFYFIQKIRDTSARDRSQRRL 243

  Fly   275 CSVTKKAIMKIPTKTGKFSD-EKDLDSDCCAICIEAYKPTDTIRILPCKHEFHKNCIDPWLIEHR 338
            ....||||.|:.|:|.|..| |.:.|.:.||:|||.|:..|.:|||||||.|||.|:||||.||.
Zfish   244 GDAAKKAISKLTTRTVKRGDKETEPDFNHCAVCIEGYQLNDVVRILPCKHVFHKMCVDPWLNEHC 308

  Fly   339 TCPMCKLDVLKFYGYVFLGSEESILEYQPDPPQGLALVEARDESADLNRSRDFVVDFPRVFVLDS 403
            |||||||::||..|.:            |:.|
Zfish   309 TCPMCKLNILKALGVM------------PNLP--------------------------------- 328

  Fly   404 GCVVGAREMLFPCRIPERSQSSLSLRQARDWVSLMSNKLEEQQGLRSMRNDEMQQQLLSARESAR 468
             ||   ..|.|......|||:| |.|.|     |:....|....|..:|:.. ..||.|..|..
Zfish   329 -CV---DNMAFDMDRMSRSQTS-SQRTA-----LVDLSSETSISLEPLRHSS-SSQLPSDEELI- 381

  Fly   469 HRRSRSADGRYSTGCFGGRQR-QPSVLVSSLGQPQLHSEVAQMQRSNSS 516
             .||...:...:||.|..|.. .|..:|..:..|.:.:.: .|...|.|
Zfish   382 -PRSGEINIAVTTGHFFNRNSVSPRSVVCEMELPDIQASL-DMYDDNKS 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gol	NP_001163300.1	PA_GRAIL_like	73..217	CDD:239037	41/145 (28%)
		HRD1	<237..>347	CDD:227568	67/110 (61%)
		RING-H2_RNF130-like	302..347	CDD:438330	31/44 (70%)
rnf130	NP_001018301.2	PA_GRAIL_like	49..188	CDD:239037	41/145 (28%)
		HRD1	<206..>315	CDD:227568	65/108 (60%)
		RING-H2_RNF130	271..319	CDD:319717	31/47 (66%)