Protein Alignment gol and RNF133

DIOPT Version :10

• Sequence 1: NP_001163300.1
• Gene: gol / 38006
• FlyBaseID: FBgn0004919
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_631914.1
• Gene: RNF133 / 168433
• HGNCID: 21154
• Length: 376
• Species: Homo sapiens
• Alignment Length: 289
• Identity: 87/289 - (30%)
• Similarity: 141/289 - (48%)
• Gaps: 59/289 - (20%)

  Fly    97 EGKVLNVTGRLIHITATDNFSDDYACTP---YIRGTLGAPIPDKGETWIALVRRGRCTFEEKVKH 158
            |||:.|                  ||.|   :.|...       .|||:||:.||.|||.:|:|.
Human    79 EGKIQN------------------ACNPNTIFSRSKY-------SETWLALIERGGCTFTQKIKV 118

  Fly   159 VYQQNAAGVIIYN----DKQVMQLEKMQIKGKTRNIAAVITYQNI-GQDLSLTLDKGYNVTISII 218
            ..::.|:||||||    ..||..:.....:.     ..|:...|: |.::...:.||..:|..:.
Human   119 ATEKGASGVIIYNVPGTGNQVFPMFHQAFED-----VVVVMIGNLKGTEIFHLIKKGVLITAVVE 178

  Fly   219 EGRRGVRTISSLNRTSVLFVS---ISFIVLMIISLVWLIFYYIQRFRYMQAKDQQSRNLCSVTKK 280
            .||:           .:::::   :||:::...:|.:.|||:|.|....:.::::.:.|.:..:.
Human   179 VGRK-----------HIIWMNHYLVSFVIVTTATLAYFIFYHIHRLCLARIQNRRWQRLTTDLQN 232

  Fly   281 AIMKIPTKTGKFSDEK-DLDSDCCAICIEAYKPTDTIRILPCKHEFHKNCIDPWLIEHRTCPMCK 344
            ...::..:..|..||: :.:.|.|.||.|.|||.|.:|||.|||.|||||||||::.|.|||:||
Human   233 TFGQLQLRVVKEGDEEINPNGDSCVICFERYKPNDIVRILTCKHFFHKNCIDPWILPHGTCPICK 297

  Fly   345 LDVLKFYGYVFLGSEESILEYQPDPPQGL 373
            .|:||..|.      :.::|...:|.|.|
Human   298 CDILKVLGI------QVVVENGTEPLQVL 320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gol	NP_001163300.1	PA_GRAIL_like	73..217	CDD:239037	35/127 (28%)
		HRD1	<237..>347	CDD:227568	42/113 (37%)
		RING-H2_RNF130-like	302..347	CDD:438330	29/44 (66%)
RNF133	NP_631914.1	PA_GRAIL_like	43..177	CDD:239037	35/127 (28%)
		RING-H2_RNF128-like	254..302	CDD:438454	31/47 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..376