Protein Alignment gol and TRAIP

DIOPT Version :10

• Sequence 1: NP_001163300.1
• Gene: gol / 38006
• FlyBaseID: FBgn0004919
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_005870.2
• Gene: TRAIP / 10293
• HGNCID: 30764
• Length: 469
• Species: Homo sapiens
• Alignment Length: 323
• Identity: 66/323 - (20%)
• Similarity: 117/323 - (36%)
• Gaps: 98/323 - (30%)

  Fly   303 CAICIEAYKPTDTIRILPCKHEFHKNCIDPWL--IEHRTCPMCKLDVLK-------FYGYVFLGS 358
            |.||.:.:..:..:..:.|.|.||..|:..|.  ...||||.|::.|.|       |:.  ....
Human     7 CTICSDFFDHSRDVAAIHCGHTFHLQCLIQWFETAPSRTCPQCRIQVGKRTIINKLFFD--LAQE 69

  Fly   359 EESILE---------------YQPDPPQGLALVEARDESADLNRSRDFVVDFPRVFVLDSGCVVG 408
            ||::|:               .|.|.       |.||....::..||
Human    70 EENVLDAEFLKNELDNVRAQLSQKDK-------EKRDSQVIIDTLRD------------------ 109

  Fly   409 AREMLFPCRIPERSQSSLSLRQARDWVSLMSNKLEEQQGLRSMRNDEMQQQLLSARESARHRRSR 473
                    .:.||:.:.:||:||.....::.:.|::|......:.||.:|    |:|.||..||:
Human   110 --------TLEERNATVVSLQQALGKAEMLCSTLKKQMKYLEQQQDETKQ----AQEEARRLRSK 162

  Fly   474 SADGRYSTGCFGGRQRQPSVLVSSLGQPQLHSEVAQMQRSNSSQALKHLTDAAHAQSRQRQRESF 538
            ..           ...|..:|:.| .:|::...:..|....|  |::.|  |.:..|.:::.|:.
Human   163 MK-----------TMEQIELLLQS-QRPEVEEMIRDMGVGQS--AVEQL--AVYCVSLKKEYENL 211

  Fly   539 DFARTRRRFMRRESDEISLRSLPRRGATSAAHRQLHREREPDDSVHT--DQITIQVNGKGVDL 599
            ..|       |:.|.|::          ....:.|...|....:|::  ||..:::.....||
Human   212 KEA-------RKASGEVA----------DKLRKDLFSSRSKLQTVYSELDQAKLELKSAQKDL 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gol	NP_001163300.1	PA_GRAIL_like	73..217	CDD:239037
		HRD1	<237..>347	CDD:227568	14/45 (31%)
		RING-H2_RNF130-like	302..347	CDD:438330	14/45 (31%)
TRAIP	NP_005870.2	RING-H2_TRAIP	6..50	CDD:438143	13/42 (31%)
		EnvC	65..>278	CDD:443969	49/265 (18%)
		Interaction with CYLD. /evidence=ECO:0000269|PubMed:14676304	211..469		11/64 (17%)
		PIP-box. /evidence=ECO:0000269|PubMed:26711499	460..469