DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and MYA2

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_001190465.1	Gene:	MYA2 / 834412	AraportID:	AT5G43900	Length:	1565	Species:	Arabidopsis thaliana

Alignment Length:	1222	Identity:	386/1222 - (31%)
Similarity:	627/1222 - (51%)	Gaps:	183/1222 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 VWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDK----VEDMAELTCL 142
            |||...::.::...:.:.:|||::| |..:||.|:   ..|....|...:.    |:||..|..|
plant    73 VWVEDPDEAWIDGEVVQVNGDEIKV-LCTSGKHVV---TKISNAYPKDVEAPASGVDDMTRLAYL 133

  Fly   143 NEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLP-IYTEKIMERYKGIKRHEVPPHVFAITDS 206
            :|..||.|:..||....||||:|...:.|||:::|| :|:..:|.:|||....|:.||.||:.|:
plant   134 HEPGVLQNLHSRYDINEIYTYTGSILIAVNPFRRLPHLYSSHMMAQYKGASLGELSPHPFAVADA 198

  Fly   207 AYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKY 271
            |||.|:.|...||||.:|||||||||:||.::::|||:.     |..|.
plant   199 AYRQMINDGVSQSILVSGESGAGKTESTKLLMRYLAYMG-----GRAAA---------------- 242

  Fly   272 IKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEG-ELEQQLLQANPILEAFGNAKTVKNDNSSRFGK 335
                                          || .:||::|::||:||||||||||:|:|||||||
plant   243 ------------------------------EGRSVEQKVLESNPVLEAFGNAKTVRNNNSSRFGK 277

  Fly   336 FIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDDVKSYAF 400
            |:.|.||..|.||||.|.|||||:||..:.:..||.:|.||.|.| |..|..:||.|::.|.|.:
plant   278 FVEIQFDEKGRISGAAIRTYLLERSRVCQVSDPERNYHCFYMLCA-APQEDVKKFKLEEPKKYHY 341

  Fly   401 LSNGS-LPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLP 464
            |:... |.:..::|..|:.||.::|:::|:::|:.::||.:|:|:|..|:::|.:....|.:...
plant   342 LNQSKCLELDSINDAEEYHATRRAMDVVGISTEEQDAIFSVVAAILHIGNIEFAKGEEIDSSIPK 406

  Fly   465 DNTV---AQKIAHLLGLSVTDMTRAFLTPRIKVGRD-FVTKAQTKEQVEFAVEAIAKACYERMFK 525
            |:..   .:..|.||......:..: |..||.|.|| .:||....|....:.:|:||..|.|:|.
plant   407 DDKSLFHLKTAAELLSCDEKALEDS-LCKRIMVTRDETITKTLDPEAATLSRDALAKVMYSRLFD 470

  Fly   526 WLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEY 590
            |||::||.|:.: .......||:||:.|||.|:.|||||.|||.|||||||.||..:|.:|||||
plant   471 WLVDKINSSIGQ-DHDSKYLIGVLDIYGFESFKTNSFEQFCINLTNEKLQQHFNQHVFKMEQEEY 534

  Fly   591 QREGIEWKFIDFGLDLQPTIDLID-KPGGIMALLDEECWFPKATDKTFVDKLVSAHSMHPKFMKT 654
            ::|.|.|.:|:| :|.|..:|||: |||||:|||||.|.||::|.:||..||......|.:|.|.
plant   535 KKEEINWSYIEF-VDNQDILDLIEKKPGGIIALLDEACMFPRSTHETFAQKLYQTFKTHKRFTKP 598

  Fly   655 DFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQAL 719
            .. ..:||.|.||||.|.|....:|.||.|.:.....:||..|...||.:::          ..:
plant   599 KL-ARSDFTICHYAGDVTYQTELFLDKNKDYVIAEHQALLNSSSCSFVASLF----------PPM 652

  Fly   720 TDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRC 784
            :|.     :::..|.::...:|:||..|::.|..|.|:::|||.||:..:.|..:...:|.||||
plant   653 SDD-----SKQSKFSSIGTRFKQQLVSLLEILNTTEPHYIRCIKPNNLLKPGIFENENILQQLRC 712

  Fly   785 NGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKGFMDGKKACEKMIQALELDSNLYRVGQS 849
            .||:|.|||...|:|.|..|.||..|:.:|.|.|:.|. .|...||:|::..:.|:.  |::|::
plant   713 GGVMEAIRISCAGYPTRKHFDEFLARFGILAPEVLVKN-SDDPAACKKLLDKVGLEG--YQIGKT 774

  Fly   850 KIFFRAGVLAHLEEERD------------------FKISDLIV-----NFQAFCRGFLARRNYQK 891
            |:|.|||.:|.|:..|.                  .|.|.:::     ..|:.|||:|||..|:.
plant   775 KVFLRAGQMADLDTRRTEVLGRSASIIQRKVRSYLAKKSFIVLRNSAKQIQSVCRGYLARSVYEG 839

  Fly   892 RLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKV-KPLLEVTKQEEKLVQKEDELKQVREKLDTLA 955
            ..::..|:: |||:      ||.:...:.||:: ...:.|......:|.:::...:.:.|...:.
plant   840 MRREAAALK-IQRD------LRRFLARKAYTELYSAAVSVQAGMRGMVARKELCFRRQTKAAIII 897

  Fly   956 KN------TQEYERKYQQALVEKTT----LAEQLQAEIELCAEAEESRSRLMARKQELEDMMQEL 1010
            :.      .:.:.||.::|.:  ||    .::..:.|:.....|......|.|.|.:||..::||
plant   898 QTWCRGYLARLHYRKLKKAAI--TTQCAWRSKVARGELRKLKMAARETGALQAAKNKLEKQVEEL 960

  Fly  1011 ETRIEEEEERVLALGGEKKKLELNIQ-DLEEQLEEEEAARQKLQLEKVQLDAK------IKKYEE 1068
            ..|::               ||..|: |||| .:::|:|:.:..||::||..|      ||  |.
plant   961 TWRLQ---------------LEKRIRTDLEE-AKKQESAKAQSSLEELQLKCKETEALLIK--ER 1007

  Fly  1069 DLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQR 1133
            :.|....:...::||..::::   :|...:..|.||.|.:          :|.||.::.:.:::.
plant  1008 EAAKKIAETAPIIKEIPVVDQ---ELMDKITNENEKLKSM----------VSSLEMKIGETEKKL 1059

  Fly  1134 QES-----DRSKRKIETE--VADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRID----EESA 1187
            ||:     ||..:.:|.|  :..||..:.....::.:|:|:.....::...|.:|.:    ..:.
plant  1060 QETTKISQDRLNQALEAESKLVKLKTAMQRLEEKILDMEAEKKIMHQQTISTPVRTNLGHPPTAP 1124

  Fly  1188 TKATAQKAQRELESQLAEIQEDLEAE-KAARAKAEKVRRDLSEELEALKNEL 1238
            .|......|..||.:..|.:.....: ||.::.||:...::...::.:|:.:
plant  1125 VKNLENGHQTNLEKEFNEAEFTTPVDGKAGKSAAERQIMNVDALIDCVKDNI 1176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	11/34 (32%)
		Myosin_head	133..854	CDD:278492	281/728 (39%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	275/716 (38%)
		Myosin_tail_1	931..2011	CDD:279860	67/337 (20%)
		Prefoldin	1431..1515	CDD:298833
		FAM76	<1847..1926	CDD:292665
MYA2	NP_001190465.1	Myosin_N	73..108	CDD:280832	11/38 (29%)
		MYSc	117..790	CDD:214580	286/746 (38%)
		MYSc_Myo11	136..779	CDD:276835	275/716 (38%)
		IQ	889..911	CDD:197470	1/21 (5%)
		RILP-like	964..1083	CDD:304877	34/149 (23%)
		MyosinXI_CBD	1159..1535	CDD:271259	2/18 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		mtm946
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910