DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and MYH9

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_002464.1	Gene:	MYH9 / 4627	HGNCID:	7579	Length:	1960	Species:	Homo sapiens

Alignment Length:	2003	Identity:	1199/2003 - (59%)
Similarity:	1541/2003 - (76%)	Gaps:	68/2003 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 KYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDI 122
            |||.|::|..|:|..||:|..|:|||||.:..||..||:|.|.|:|..|||.|.||:|.:.:|||
Human     8 KYLYVDKNFINNPLAQADWAAKKLVWVPSDKSGFEPASLKEEVGEEAIVELVENGKKVKVNKDDI 72

  Fly   123 QKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMER 187
            ||||||||.|||||||||||||||||||:|:|||||||||||||||||:||||.||||:|:|:|.
Human    73 QKMNPPKFSKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEM 137

  Fly   188 YKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGS 252
            |||.||||:|||::||||:|||:|:.||||||||||||||||||||||||||:|||||:|.
Human   138 YKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSH---- 198

  Fly   253 GAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILE 317
                                                        .|...:||||:||||||||||
Human   199 --------------------------------------------KSKKDQGELERQLLQANPILE 219

  Fly   318 AFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGA 382
            |||||||||||||||||||||||||.:|:|.|||||||||||||||||||:||||||||.||:||
Human   220 AFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGA 284

  Fly   383 TPEQREKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLF 447
            ....:...:|:....|.|||||.:.:||..|...||.|:::|.|||:..|:...:.|::|.||..
Human   285 GEHLKTDLLLEPYNKYRFLSNGHVTIPGQQDKDMFQETMEAMRIMGIPEEEQMGLLRVISGVLQL 349

  Fly   448 GSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAV 512
            |::.|::|||.|||::||||.|||::||||::|||.||..||||||||||:|.|||||||.:||:
Human   350 GNIVFKKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTKEQADFAI 414

  Fly   513 EAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQL 577
            ||:|||.|||||:|||.|||::||:|||||||||||||:||||||:|||||||||||||||||||
Human   415 EALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQL 479

  Fly   578 FNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPG---GIMALLDEECWFPKATDKTFVD 639
            ||||||||||||||||||||.||||||||||.||||:||.   ||:|||||||||||||||:||:
Human   480 FNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPKATDKSFVE 544

  Fly   640 KLVSAHSMHPKFMK-TDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVV 703
            |::.....||||.| ...:..|||.|:||||:|||.|.:||||||||||:||.:||..|.|.||.
Human   545 KVMQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVS 609

  Fly   704 NIWKDAE-IVGMAQQA-LTDTQF-GA-RTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIP 764
            .:|||.: |:|:.|.| :::|.. || :|||||||||..||||||||||.|||||||||||||||
Human   610 ELWKDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTNPNFVRCIIP 674

  Fly   765 NHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKGFMDGKKA 829
            ||||:|||:|..|||||||||||||||||||||||||:.|||||||||:||||.|||||||||:|
Human   675 NHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIPKGFMDGKQA 739

  Fly   830 CEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQ 894
            |..||:||||||||||:||||:|||||||||||||||.||:|:|:.|||.|||:|||:.:.||.|
Human   740 CVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLARKAFAKRQQ 804

  Fly   895 QLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQ 959
            ||.|::::||||||||||||||||||:|||||||:|::|||:::.||:||.:||||.........
Human   805 QLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLT 869

  Fly   960 EYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLAL 1024
            |.|....|.:.||..|.||||||.||||||||.|:||.|:|||||::..:||.|:||||||...|
Human   870 EMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHL 934

  Fly  1025 GGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEE 1089
            ..||||::.|||:|||||||||:||||||||||..:||:||.||:..:.:|||.||.|||||||:
Human   935 QAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLED 999

  Fly  1090 RANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQL 1154
            |..:.:..|.|||||:|.|||||.||||.|::|||||.::::||||.::::||:|.:..||.:|:
Human  1000 RIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQI 1064

  Fly  1155 NERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAK 1219
            .|.:.|:.|::.||||:||||...|.|::||:|.|..|.|..||||||::|:|||||:|:|:|.|
Human  1065 AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNK 1129

  Fly  1220 AEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKH 1284
            |||.:|||.|||||||.||.|:||:||||||||||||||:..|||:||||...||..:.:||.||
Human  1130 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH 1194

  Fly  1285 SQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQV 1349
            ||.:..:.:|||..::.|..|||||.|||.|..:||.|::.:...:.:::.:||:.|:|:.||||
Human  1195 SQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQV 1259

  Fly  1350 KLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQK 1414
            |..|.||.|:||.:|.||||.|.:|:|..|.:::.|:|...|..|.:||||.:.|:||:||.|||
Human  1260 KFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324

  Fly  1415 LGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKR 1479
            |.||:||:|:|.||.:.:|||||::|||.|.|:::|.:..|:.::|||.|:.....:..||.|::
Human  1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRK 1389

  Fly  1480 LNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEK 1544
            |.||:|.|.::.:|.:|..|:|:|:|.::|.||:|..::|:.||.....||||||.||::|||||
Human  1390 LQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEK 1454

  Fly  1545 AISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKN 1609
            .||.:.|:|||.||.||||||||.||::|.|:||.::..:||...|..:.|::||.:::....|:
Human  1455 TISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKS 1519

  Fly  1610 VHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKR 1674
            ||||||:|||||.|:.|:|.|.|||||:||.|||||||||||:||:::||||||..::|.:|||:
Human  1520 VHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKK 1584

  Fly  1675 RGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKD 1739
            :.||:|:|::|.||::|||||:.|||::||||.|||::|..::..||.:::|:|..:|||||:||
Human  1585 KQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1649

  Fly  1740 ALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNA 1804
            .:|:.::.:|::||:.|.:||.|:|:|::|||::||.|:||::|||:|.|:.||||||:||||::
Human  1650 CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSS 1714

  Fly  1805 NKGSLMIDEKRRLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENG 1869
            .||:|.::||||||||||.|||||||||.|:|::.||.:||.|||:|:.|:|..|:|::|||||.
Human  1715 GKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENA 1779

  Fly  1870 RALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKI 1934
            |..|||||||||.||.|:|...::|.||:|..||||||.|||||:||.|||....|..|:.:||:
Human  1780 RQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKL 1844

  Fly  1935 KELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEA 1999
            |::.:.::||||:.:|:|:|.||.::|:|.|||.|:|.|||.|:....:||.|||.||..|:.:|
Human  1845 KDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADA 1909

  Fly  2000 MNREINSLKTKLRRTGGIGLSSSRLTGTPSSKRAGGGGGGDDSSVQDESLDGE 2052
            ||||::|||.|||| |.:.....|        |....|.||.|   ||.:||:
Human  1910 MNREVSSLKNKLRR-GDLPFVVPR--------RMARKGAGDGS---DEEVDGK 1950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	20/36 (56%)
		Myosin_head	133..854	CDD:278492	501/728 (69%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	489/716 (68%)
		Myosin_tail_1	931..2011	CDD:279860	581/1079 (54%)
		Prefoldin	1431..1515	CDD:298833	33/83 (40%)
		FAM76	<1847..1926	CDD:292665	47/78 (60%)
MYH9	NP_002464.1	Mediates interaction with LIMCH1. /evidence=ECO:0000269\|PubMed:28228547	2..838		600/877 (68%)
		Myosin_N	29..68	CDD:367160	21/38 (55%)
		Motor_domain	95..764	CDD:354959	489/716 (68%)
		Actin-binding	654..676		20/21 (95%)
		Myosin_tail_1	841..1921	CDD:366712	581/1079 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1035..1057		9/21 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1118..1137		12/18 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1877..1960		38/86 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1156	1.000	Domainoid score	I16
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2373	1.000	Inparanoid score	I35
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40305at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm42309
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	LDO	PTHR45615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R786
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860