DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and Myo7b

DIOPT Version :10

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0287873 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_115770.2 Gene:Myo7b / 17922 MGIID:107709 Length:2113 Species:Mus musculus


Alignment Length:2242 Identity:541/2242 - (24%)
Similarity:887/2242 - (39%) Gaps:527/2242 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 VWV--PHENQGFVAASIKREHGDEVEVELAET------GKRVMILRDD---IQKMNPPKFDKVED 135
            ||:  |..::..||..     |...|.:|.:|      ||...:..:|   ::.|:|.....|:|
Mouse    10 VWLDPPSSSKTGVAIG-----GIVKETKLGKTLIEDDEGKEHWVHAEDLSTLRPMHPNSAQGVDD 69

  Fly   136 MAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHV 200
            |..|..||||.|:||:..||....||||:|...|.|||::.||:||.:.::.|......|:|||:
Mouse    70 MIRLGDLNEAGVVHNLLIRYQQHKIYTYTGSILVAVNPFQMLPLYTLEQVQIYYSRHMGELPPHI 134

  Fly   201 FAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFS 265
            |||.:|.|.||..::.||..:.:|||||||||.||.::||||.|:.                   
Mouse   135 FAIANSCYFNMKKNKRDQCCIISGESGAGKTETTKLILQFLATVSG------------------- 180

  Fly   266 VNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNS 330
                                               |...:|||:|:|||||||||||||::||||
Mouse   181 -----------------------------------QHSWIEQQVLEANPILEAFGNAKTIRNDNS 210

  Fly   331 SRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDDV 395
            |||||:|.|:|::||.|.||:||.:||||||..|||.:||.:||||.:|.|.:||:::...|...
Mouse   211 SRFGKYIDIHFNSSGVIEGASIEHFLLEKSRVCRQAPEERNYHIFYCMLMGMSPEEKQMLSLGMP 275

  Fly   396 KSYAFLSNGS-LPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSM-----KFRQ 454
            ..|.:|:.|| ....|:.|..::.....:|.|:..:..:...|.::::|:|..|::     .|..
Mouse   276 SEYHYLTMGSCTSSEGLSDAKDYAHVRSAMKILQFSDSENWDISKLLAAILHLGNVGFMAAVFEN 340

  Fly   455 ERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKAC 519
            ..::|....|...:|.|:..:...::.|   ..:...|.|..:||::.....|.....:|..|..
Mouse   341 LDSSDVMETPAFPLAMKLLEVQHQALRD---CLIKHTIPVLGEFVSRPVNIAQATDRRDAFVKGI 402

  Fly   520 YERMFKWLVNRINRSLDRTKRQGAS----FIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNH 580
            |.|:|:|:|.:||.::...:.|...    .||:||:.|||.|:.|||||||||:.||.|||.|..
Mouse   403 YGRLFQWIVKKINAAIFTPQAQDPQNVRRAIGLLDIFGFENFQNNSFEQLCINFANEHLQQFFVK 467

  Fly   581 TMFILEQEEYQREGIEWKFIDFGLDLQPTIDLID-KPGGIMALLDEECWFPKATDKTFVDKLVSA 644
            .:|.:|||||..|.|.|.:|.: .|.||.:|::. ||..|::|||||..||:.||.|.:.||.|.
Mouse   468 HVFTMEQEEYLSENITWNYIHY-TDNQPILDMLALKPMSIISLLDEESRFPQGTDVTMLQKLNSI 531

  Fly   645 HSMHPKFMKTDFRGVAD--FAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWK 707
            |:.:..|:..  |.:.|  |.|.|:||.|.|.|..:|.||.|.|:.:|:.|:..|::.|:..|:.
Mouse   532 HANNKSFLSP--RSIHDTRFGIAHFAGDVYYQAEGFLEKNRDVLSTDILILIHSSKNKFLKEIFN 594

  Fly   708 -DAEIVGMAQQALTDTQFGARTRKGMFR---------TVSHLYKEQLAKLMDTLRNTNPNFVRCI 762
             |:....:....:...:.|::    :|:         |::..:|:.|.:||..|.|..|.|||||
Mouse   595 VDSSQTKLGHGTICQVKAGSQ----LFKSSDSIKRPVTLASQFKQSLDQLMRILTNCQPYFVRCI 655

  Fly   763 IPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKGFMDGK 827
            .||..|:....|..|.:.|||.:|::|.:.|.:.|||.|..|.||.||:.:|.|:.....|.:..
Mouse   656 KPNEYKKPLLFDRELCIQQLRYSGMMETVHIRKSGFPIRYTFDEFSQRFRVLLPSPERMQFQNKP 720

  Fly   828 KACEKMIQALELDSNL-YRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQK 891
            :.....|..|.|.::. ::||::|||.:......||..|...:....:..|...||...|:.:  
Mouse   721 RQMTLHIADLCLGTDKDWKVGKTKIFLKDHQDTVLEIRRSQALDGAAIRIQRVLRGHKYRKEF-- 783

  Fly   892 RLQQLNAIRIIQRNCAAYLKLRNWQ-----WWRLYTKVKPLL---EVTKQEEKLVQKEDELKQVR 948
             |:|..|...:|.....|.:.:|::     :.||....:..|   :.....:::||.:...:...
Mouse   784 -LRQRRAAVTLQAGWRGYSQRKNFKLILVGFERLQAIARSHLLMRQFQAMRQRIVQLQARCRGYL 847

  Fly   949 EKLDTLAKN-----TQEYER------KYQQALVEKTT-----LAEQLQAEIELCAEAEESRSRLM 997
            .:....||.     .|.:.|      .|.|   :|:|     ||::.:|::     |...|.|  
Mouse   848 VRQQVQAKRRAVVIIQAHARGMVVRKSYWQ---QKSTGPQVILAKEPKAQV-----AVHERKR-- 902

  Fly   998 ARKQELEDMMQELETRIEEEEERVL--ALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLD 1060
               :.:.|.:  .:|.:.|:....|  .:||::.......:|||.:.:         :|.:|.||
Mouse   903 ---KSIYDTV--TDTAMVEKVFGFLPAMIGGQEGPAPTRFEDLEVKTQ---------KLHEVDLD 953

  Fly  1061 A--KIKKYEEDL-----------ALTDDQN-------QKLLKEKKLLEERANDLSQTL------- 1098
            .  .:...||::           |:|..|.       ||.|:...|..|...|.|..|       
Mouse   954 TVPMMAMPEEEVDSLAEYTFPKFAVTYFQKSASHTHIQKPLRYPLLYHENDTDHSAALDVWIIIL 1018

  Fly  1099 ---AEEEEKAKHLAKLKAKHEATISELEERLHKD---QQQRQESDRSKRKIETEVADLKEQLNER 1157
               .:..|...: .:......:.:.::.::|.||   |..|.....|:.....|.......:::|
Mouse  1019 RFMGDLPEPVVY-GRNSLTGSSVMRQIHDKLGKDSVTQHNRSSQVASQLNFGEEAFKFDGPISDR 1082

  Fly  1158 RVQVDEMQAQLAK--------------REEELTQTLLRIDEESATKATAQ-------------KA 1195
            .:      :.|.|              |:|...|...::.|...|.:.|:             .:
Mouse  1083 PM------SNLEKVHFIVGYAIMRPGLRDEIYCQICKQLSENYKTSSRARGWILLSLCLGCFPPS 1141

  Fly  1196 QRELESQLAEIQE------DLEAEKAARAKAEKVRRDLSE--ELEALKNELLDSLDTTAAQQELR 1252
            :|.::..|..|.:      ...||:..|..|..||.:...  ||:|:|     |......|..|.
Mouse  1142 ERFMKYLLNFISQGPPSYGPFCAERLQRTFANGVRAEPPTWLELQAVK-----SKKHIPIQVILA 1201

  Fly  1253 SKREQELATLKKSLEEETVNHEGVLADMRHKHSQELN--------SINDQLENLRKAKTVLE--- 1306
            :.|...::....|...|...|......:|......|.        |:....::|..|....|   
Mouse  1202 TGRSLTISVDSASTSREICQHVAQKQGLRDNLGFSLQVAVYDKFWSLGSGCDHLMDAVAQCEQLA 1266

  Fly  1307 KAKGTL-------------------EAENADLATE------LRSVNSSRQENDRRRKQAESQIAE 1346
            :.:|..                   :::...::||      ||.|.|.....::..:..|.....
Mouse  1267 RERGESQRQAPWRIYFRKEFFTPWHDSQEDPVSTELIYHQVLRGVWSGEYNFEKEEELVELLARH 1331

  Fly  1347 LQVKLAEIERARS--ELQEKC--TKL------QQEAENITNQLEEAELKASAAVKSASNMESQLT 1401
            ..|:|....::.:  ||...|  :||      ::.|..:|....:|:...|.|...|  :..|..
Mouse  1332 CYVQLGATVKSNAVQELLPSCVPSKLYRTKSPEKWASLVTAAHAKAQYTQSKATPLA--VREQTV 1394

  Fly  1402 EAQQL------------------------------------LEEETRQKLGLS-------SKLRQ 1423
            ||.:|                                    |:::.|..||||       ...|.
Mouse  1395 EAARLLWPLLFSRLFEVTTLSGPRLPKTQLVLAINWKGMYFLDQKERTLLGLSFAEVMGLVANRD 1459

  Fly  1424 IESEKEALQEQLEEDDEAKRNYERKLAE-VTTQMQEIKKKAEEDADLAKELEEGKKRLNKDIEAL 1487
            ....|:.|...|:|:.|........:|| |...:..:|:::.    .|..|::  :|...||..|
Mouse  1460 APGGKKLLLATLQEEYEFVSPSSVAIAEMVALFLGGLKERSV----FAMALQD--RRATDDITLL 1518

  Fly  1488 ERQVKEL----------------IAQNDRLDKS-------KKKIQSELEDATIELEAQRTKVLEL 1529
            ..:..:|                :.||||..|:       ...|.|..:.:|     |...:|.:
Mouse  1519 PFKKGDLLILTKKQGLLASENWALGQNDRTGKTGLVPTACLYTIPSVTKPST-----QLLSLLAM 1578

  Fly  1530 --EKKQKNFDKILAEEKAISEQIAQERDTAER------EAREKET---KVLSVSRELDE--AFDK 1581
              ||::....::.|.|..:.:|:.:...|.|.      .|.||||   ..:.::|....  |:..
Mouse  1579 SPEKRKLAAQEVRALEPPLEDQLTESPYTLEEFSYQFFRAPEKETISRAAMPMARSRGHLWAYSP 1643

  Fly  1582 IEDLENKRKTLQNELDD------------LANTQGTAD----KNVHELEKAKRALESQLAELKAQ 1630
                |..|:.|...:.|            ||..:.|.|    ::.|.||     |..|:..|..|
Mouse  1644 ----EPLRQPLLKSVHDKAKLRDAACQIFLAILKYTGDYPSRQSWHSLE-----LTDQMFSLALQ 1699

  Fly  1631 NEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQR 1695
            :..|:|:|...                                   ::|||........|||..:
Mouse  1700 DPALQDELYCQ-----------------------------------ILKQLTHNSIRFSEERAWQ 1729

  Fly  1696 TAAVAS------KKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEEL 1754
            ...:.:      |..|....|.|::     .|.|..||..:::|...::...|     |....::
Mouse  1730 LLWLCTGLFPPGKTLLPHAQKFIDS-----RKKKPLALDCSRRLHRVLRVGPR-----KQPPHDV 1784

  Fly  1755 QALSKEAERKVKALEAEV-----LQLTEDLASSERARRAAETERDELAEEIANNANKG-----SL 1809
            :.  |.||:.|..|..||     ...:.::.||.|.|        :|.|.|.......     ||
Mouse  1785 EV--KAAEQNVSKLHHEVYLPNDTSKSMEVGSSSRVR--------DLCEGIGTRLQLASWDGCSL 1839

  Fly  1810 MIDEKRRLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLE 1874
            .|    ::..::.:|:|        .:...|..|:....:          |.|..:.|.....|.
Mouse  1840 FI----KITDKVISLKE--------GDFFFDSLRQVSDWV----------KKNRPQKEGASVTLP 1882

  Fly  1875 RQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTM 1939
            .|...::              |..:.....|..|.:..|.           .::::.|.::....
Mouse  1883 YQVFFMR--------------KLWLNVTPGKDVNADTILH-----------YHQELPKYLRGFHK 1922

  Fly  1940 NIEDERRHVD------QHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQE 1998
            ...::..|:.      |......:|.|..|:||..:.:....|...:..|:....|| |..:.:.
Mouse  1923 CSREDAIHLGGLICKIQFGSDSSQLASVSKVLKELVPQNLTRLMSSEEWKKSLLLEC-DKNKRKT 1986

  Fly  1999 AMNREINSLKTKLR-RTGGIGLSSSRLTGTPS 2029
            ....::..||...| .|.|......:.|..||
Mouse  1987 VAEAKVEFLKYMYRWPTFGSAFFEVKQTSEPS 2018

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 79..122 CDD:460670 12/50 (24%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 261/732 (36%)
Myosin_tail_1 931..2011 CDD:460256 237/1329 (18%)
Myo7bNP_115770.2 MYSc_Myo7 79..748 CDD:276832 261/732 (36%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 637..659 12/21 (57%)
IQ 785..807 CDD:197470 5/21 (24%)
Mediates interaction with ANKS4B. /evidence=ECO:0000269|PubMed:26812017 962..1578 114/640 (18%)
MyTH4 989..1189 CDD:214535 37/206 (18%)
FERM1_F1_Myosin-VII 1193..1291 CDD:340612 13/97 (13%)
B41 1196..1409 CDD:214604 37/214 (17%)
FERM_C1_MyoVII 1403..1499 CDD:270019 16/95 (17%)
Mediates interaction with CDHR2, CDHR5 and USH1C. /evidence=ECO:0000250|UniProtKB:Q6PIF6 1497..2113 118/645 (18%)
SH3 1500..1560 CDD:473055 12/65 (18%)
MyTH4 1641..1788 CDD:214535 35/202 (17%)
FERM2_F1_Myosin-VII 1795..1892 CDD:340613 23/140 (16%)
B41 1797..2009 CDD:214604 43/267 (16%)
FERM_C2_MyoVII 2005..2100 CDD:270020 4/14 (29%)

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