Protein Alignment NaCP60E and CCH1

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_011733.3
• Gene: CCH1 / 853131
• SGDID: S000003449
• Length: 2039
• Species: Saccharomyces cerevisiae
• Alignment Length: 2641
• Identity: 424/2641 - (16%)
• Similarity: 747/2641 - (28%)
• Gaps: 1220/2641 - (46%)

  Fly    53 DGDVLPRKFEPFPEHMYG---------KPLE-EIDTFIYEETFCVVSKRFRKNYIHRFTGTKSLF 107
            |.:.|.||.|..|..:||         .||. :|..|:       :.:|:...|....|....|.
Yeast   304 DFETLQRKLESRPFVLYGHSLGVFSPTNPLRIKIARFL-------LHRRYSLLYNTLLTFYAILL 361

  Fly   108 LFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMTETVEEAEYIFLAIYSIEMVIKIIAKG 172
            ....::|...|.:|..:| :.||.:                     :|..|.::...:.||||.|
Yeast   362 AIRTYNPHNVVFLYRFSN-WTDYFI---------------------FILSACFTGNDIAKIIAFG 404

  Fly   173 F----------------------LLNKYTYL---------------------------------- 181
            |                      ::..|.||
Yeast   405 FWDDSEMFKAYGREYKSILQRSGIMKLYIYLREKYGRKLIDFIIPFRIISPGEETKYQRSSLSTS 469

  Fly   182 ---------------------RNPWNWLDFVVITSGYATIGMEVGNL---AGLRTFR---VLRAL 219
                                 |:.||.:|.|...|.:..:.:.:.:.   .|:|.|:   :||.|
Yeast   470 LTKPYGAKENQRPFGTPRAFARSSWNRIDLVSSVSFWLGMFLSIKSYDTKTGIRIFKPLAILRIL 534

  Fly   220 KTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVS 284
            :.|::..|:.:|:..|.:...||..|.::.::..:.|.:..:|::.|..|.:||...|.|.|:..
Yeast   535 RLVNVDTGMPSILRGLKYGIPQLVNVSSMLVYFWIFFGILGVQIFQGSFRRQCVWFNPEDPTDTY 599

  Fly   285 HTDWQIWVNDTD-------NWLYDEDELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFM 342
            ..|.|......|       |::|::...    |:::....|| :|.......||.:|..:|||.:
Yeast   600 QYDMQFCGGYLDPVTKRKQNYIYEDGSE----GSVSKGFLCP-QYSKCVSNANPYNGRISFDNIV 659

  Fly   343 WSMLTTFQLITLDYWENV--YNM---VLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEE 402
            .||...|.:::.:.:.::  |.|   .:|.|     .||.|.:|..:.:|:||::||:..|:
Yeast   660 NSMELVFVIMSANTFTDLMYYTMDSDEMAAC-----LFFIVCIFVLTIWLLNLLIAVLVSSF--- 716

  Fly   403 AEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGG 467
             ||.|||.||                           ||.|          |..:||
Yeast   717 -EIANEEYKK---------------------------KKFI----------YGSRKT-------- 735

  Fly   468 KEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGG 532
                                                                             
Yeast   736 ----------------------------------------------------------------- 735

  Fly   533 SNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDD 597
                                                                             
Yeast   736 ----------------------------------------------------------------- 735

  Fly   598 HEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHN-----VYALHQEFSSEVVVIDDLP 657
                      |:|:.:....    .:..|...|..:..|.:     :|: |.||...:::|.|:.
Yeast   736 ----------GYVARIVTGY----WKYFKLKANQTKFPNWSQKGLAIYS-HVEFIFVILIICDIG 785

  Fly   658 DR---------NCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMS 713
            .|         ||:                |.|.|..|.        :.|||....||
Yeast   786 MRASVKVSTSANCN----------------NILLKTDRG--------ISIVLFIESLA------- 819

  Fly   714 ESFRNALDVGN--KVFTS-IFTFECIVKLMALSKDFFLCGWNIFDLLIVTASLLDIIFELVDGLS 775
               |..|.:.|  |..|. .:.::.|:              :|..|:|...::..::..:...||
Yeast   820 ---RLVLYLPNMWKFLTKPSYVYDFII--------------SIITLVISCLAVEGVLGHMYAWLS 867

  Fly   776 VLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKF 840
            :....|..||:   .|:...|.|...|:|....:.||:.......::.|:|....|.....||:.
Yeast   868 IFHISRFYRVI---ISFNLTKKLWKQILSNGVMIWNLSSFYFFFTFLVAIIMAVYFEGVIPPEEM 929

  Fly   841 DPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGAST--CFAIFLPTLVMGNFMV 902
            ...|...::..   :||:.:|.|...| |.:.|: .::......:||  |...|:...::.|.::
Yeast   930 ADQPFGMYSLP---NSFLSLFIIGSTENWTDILY-ALQKHSPNISSTFFCSVFFIIWFLLSNSVI 990

  Fly   903 LNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVL 967
            ||:|:||:     ||.::.|:||                   |:.|:.|
Yeast   991 LNIFIALI-----SESMEVKEEE-------------------KRPQQIK---------------- 1015

  Fly   968 DAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVD 1032
                                            |.|.:.
Yeast  1016 --------------------------------HYLKFV--------------------------- 1021

  Fly  1033 GLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERR 1097
                     .|::||...|
Yeast  1022 ---------YPQKIQEYTH---------------------------------------------- 1031

  Fly  1098 LQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRY 1162
                                                                             
Yeast  1032 ----------------------------------------------------------------- 1031

  Fly  1163 GSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQ 1227
                         .||:.|                             :|:...|...|.
Yeast  1032 -------------ASLVAR-----------------------------IRKKFFGGHRNE----- 1049

  Fly  1228 DELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEH 1292
                             |.::..||      |.:||.:..|:..|...  :.:..:|.:|.:
Yeast  1050 -----------------DTRDFKQF------LMRGTAIMNIAQNMGEL--ADEFKEPPSENL--- 1086

  Fly  1293 SEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVV 1357
                     |:|.|.::.....||:|
Yeast  1087 ---------FKKGLSKLTIGVPSLKR--------------------------------------- 1103

  Fly  1358 LPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFV 1422
                                                                :|...:
Yeast  1104 ----------------------------------------------------LRMFAN------- 1109

  Fly  1423 AMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEK 1487
                               :||.:.....||...|...|..::|
Yeast  1110 -------------------NPFYKNSDVVFTETNDINGRTYILE--------------------- 1134

  Fly  1488 MPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISS 1552
                                 .|.||:                                 .::..
Yeast  1135 ---------------------LNEYED---------------------------------EKLDY 1145

  Fly  1553 LKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSA 1617
            ||..|    |..:..:|.        :|.|              :.||.
Yeast  1146 LKKYP----LFNYSYYFF--------SPQH--------------RFRRF---------------- 1168

  Fly  1618 RTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRR 1682
                                      .|...|.:|.|.:..:|           :.:|.|
Yeast  1169 --------------------------CQRLVPPSTGKRTDGSR-----------FFEDST----- 1191

  Fly  1683 NSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTV 1747
                                     |.:.::.|.|.
Yeast  1192 -------------------------DLYNKRSYFHH----------------------------- 1202

  Fly  1748 VDTPAFEWFVLVLIFASSITL-----CFEDINLDKNKTLKRVLY------W---INFSFCLIFVV 1798
                 .|..|.|.|||.:..|     |:.       ..|.|:.:      |   ::.:|...|.:
Yeast  1203 -----IERDVFVFIFALATILLIVCSCYV-------TPLYRMHHKMGTWNWSSALDCAFIGAFSI 1255

  Fly  1799 EMILKWLALGF----SKYFTSFWTILDFIIVFVSVFSLL--IEENENLKVLRSLRTLRALRPLRA 1857
            |.|:|.:|.||    :.|..:.|..:||.::.....:|:  ::.|.||.  |..:.|.|||.||.
Yeast  1256 EFIVKTVADGFIYSPNAYLRNPWNFIDFCVLISMWINLIAYLKNNGNLS--RIFKGLTALRALRC 1318

  Fly  1858 ISRWQGMRIVVNALMY-AIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN-EMGELLPITEV 1920
            ::.....|...|.:|: .:..||...|:.|.....|::.|:..|.|:...|.: .:|......|.
Yeast  1319 LTISNTARQTFNLVMFDGLNKIFEAGLISLSLLFPFTVWGLSIFKGRLGTCNDGSLGRADCYNEY 1383

  Fly  1921 ND---KWDCI-----EQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQ 1977
            ::   :||.:     :|.|      :..|.....:.:|.|:.:.|||::::.:.:::.|:.....
Yeast  1384 SNSVFQWDIMSPRVYQQPY------LHLDSFASAFSSLYQIISLEGWVDLLENMMNSSGIGTPAT 1442

  Fly  1978 REANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLG 2042
            ...:....::.|:|......|.||||:..|::|    :.:..|..   :.|..:|.:..:.|.|.
Yeast  1443 VMGSAGNALFLVLFNFLSMVFILNLFVSFIVNN----QARTTGSA---YFTIEEKAWLESQKLLS 1500

  Fly  2043 RKKPQKVIKRP----INHFLAMFYDLS-NSRRFEIAIF--VLIFLNMLTMGIEHYDQPH-----A 2095
            :.||:.:   |    ::.....||.|: ..:.|..|.|  |:::|:::.:....|:..:     .
Yeast  1501 QAKPKAI---PNLIELSRVRQFFYQLAVEKKNFYYASFLQVVLYLHIIMLLSRSYNPGNLIGYQG 1562

  Fly  2096 VFFILEVSNAFFTTVFGLEAIVKIVGLRYH-YFTVPWNVFDFLLVLASIFGILMEDIMIDLPISP 2159
            |:|:      |.|:||.::..:.:.|.... ||...||.....::   |...:|..:...:|.|.
Yeast  1563 VYFM------FSTSVFLIQEALHMCGEGPRLYFRQKWNSIRLSII---IIAFIMNAVAFHVPASH 1618

  Fly  2160 TLLRVVR-VFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVK 2223
            .....:: .|.:...|.:|.....:.:||...:.|||.:.::....|::..:|||....:||..:
Yeast  1619 YWFHNIKGFFLLVIFLFIIPQNDTLTELLETAMASLPPILSLTYTWGVLFLVYAIALNQIFGLTR 1683

  Fly  2224 LQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAITY 2288
            |.....|.:||:|..:||.:|||.....|||.::..|.:..|.|.. ....|..:||....|...
Yeast  1684 LGSNTTDNINFRTVIKSMIVLFRCSFGEGWNYIMADLTVSEPYCSS-DDNSTYTDCGSETYAYLL 1747

  Fly  2289 FTSFIIISYMIVINMYIAIILENFNQAHQE--EEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQL 2351
            ..|:.|||..|.:||::::|:.||:..::.  ...||...:::.:...|||:|...|..:..|.|
Yeast  1748 LMSWNIISMYIFVNMFVSLIIGNFSYVYRSGGSRSGINRSEIKKYIEAWSKFDTDGTGELELSYL 1812

  Fly  2352 SDFIASLDPPLGIS------------------KPNN-----VALVSFNLPISKGNK--------- 2384
            ...:.|.|.||...                  .|::     :.|:..|..::..:|
Yeast  1813 PRIMHSFDGPLSFKIWEGRLTIKSLVENYMEVNPDDPYDVKIDLIGLNKELNTIDKAKIIQRKLQ 1877

  Fly  2385 -------IH----------------------------CLDI---LHALVKHVLGHVEETDNFKQL 2411
                   ||                            ||.|   :|.|  ::||.|   |.:.:.
Yeast  1878 YRRFVQSIHYTNAYNGCIRFSDLLLQIPLYTAYSARECLGIDQYVHHL--YILGKV---DKYLEN 1937

  Fly  2412 QEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGW 2452
            |...||           ||:| .|| ||...:..:||:..|
Yeast  1938 QRNFDV-----------LEMV-VTR-WKFHCRMKRTIEPEW 1965

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	64/340 (19%)
		Ion_trans	687..902	CDD:459842	44/220 (20%)
		Ion_trans	1751..2019	CDD:459842	68/297 (23%)
		Na_channel_gate	2009..2063	CDD:240441	10/57 (18%)
		Ion_trans	2067..2320	CDD:459842	65/263 (25%)
		GPHH	2332..2378	CDD:465306	14/68 (21%)
CCH1	NP_011733.3	Ion_trans	<483..722	CDD:459842	63/252 (25%)
		Ion_trans	769..1010	CDD:459842	67/320 (21%)
		Ion_trans	1210..1480	CDD:459842	65/288 (23%)
		Ion_trans	1529..1776	CDD:459842	65/256 (25%)