Protein Alignment NaCP60E and TPC1

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_567258.1
• Gene: TPC1 / 825655
• AraportID: AT4G03560
• Length: 733
• Species: Arabidopsis thaliana
• Alignment Length: 672
• Identity: 136/672 - (20%)
• Similarity: 242/672 - (36%)
• Gaps: 209/672 - (31%)

  Fly  1810 SKYFTSF------WTILDFIIVFVSVFS--LLIEENEN--------------------LKVLRSL 1846
            ::|:..|      |::..|.::|::.|.  |..|:|..                    ..::..:
plant    61 ARYYFIFTRLDLIWSLNYFALLFLNFFEQPLWCEKNPKPSCKDRDYYYLGELPYLTNAESIIYEV 125

  Fly  1847 RTLRALR-----PLRAISRWQGMRIVVNALMYAIPSIFNVLLV--CLVFWLIFSIMGVQFFGGKF 1904
            .||..|.     |:    .::|.||...:.:..:.....|:|.  .||.:|..|.:...|...:.
plant   126 ITLAILLVHTFFPI----SYEGSRIFWTSRLNLVKVACVVILFVDVLVDFLYLSPLAFDFLPFRI 186

  Fly  1905 FKCVNEMGELLPITEVNDKWDCIEQNY-TWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVD 1968
            ...|..:..:|.|.|:.|....:.... |::|.      :.:..|.||    |..|:..:.....
plant   187 APYVRVIIFILSIRELRDTLVLLSGMLGTYLNI------LALWMLFLL----FASWIAFVMFEDT 241

  Fly  1969 ARGVDLQPQREANLY-----------------AY-------IYFVIFIVCGSFFTLNLFIGVIID 2009
            .:|:.:.....|.||                 ||       ::||::::.|.:|..||.:.|:.|
plant   242 QQGLTVFTSYGATLYQMFILFTTSNNPDVWIPAYKSSRWSSVFFVLYVLIGVYFVTNLILAVVYD 306

  Fly  2010 NFNMLKKKYEGGVLEM---------FLTESQKH----------------YYTAMKKLGRKKPQKV 2049
            :|.....|...|:.:|         .|.:|.|:                .|..:.|:.:::
plant   307 SFKEQLAKQVSGMDQMKRRMLEKAFGLIDSDKNGEIDKNQCIKLFEQLTNYRTLPKISKEE---- 367

  Fly  2050 IKRPINHFLAMFYDLSNSRRFEI----------AIFVLIFLNMLTMGIEHYDQ------------ 2092
                   |..:|.:|.::|.|:|          ||.:......:....||:.|
plant   368 -------FGLIFDELDDTRDFKINKDEFADLCQAIALRFQKEEVPSLFEHFPQIYHSALSQQLRA 425

  Fly  2093 -------PHAVFFIL------------------------EVSNAFFTTVFGLEAIVKIVGLRYHY 2126
                   .:|:.|||                        :|:...|..::.||..:||    |.|
plant   426 FVRSPNFGYAISFILIINFIAVVVETTLDIEESSAQKPWQVAEFVFGWIYVLEMALKI----YTY 486

  Fly  2127 -FTVPW----NVFDFLLVLASIFGILMEDIMIDLPISPTL------LRVVRVFRIGRILRLIKAA 2180
             |...|    |.||||:....:.|   |......|...|.      :|.:.:.|:.|::||:...
plant   487 GFENYWREGANRFDFLVTWVIVIG---ETATFITPDENTFFSNGEWIRYLLLARMLRLIRLLMNV 548

  Fly  2181 KGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLF------GNVKL---QGALDD--MVNF 2234
            :..|..:...:..:|:|......:..:..||..:|:.:|      ||.||   :.|.||  :.||
plant   549 QRYRAFIATFITLIPSLMPYLGTIFCVLCIYCSIGVQVFGGLVNAGNKKLFETELAEDDYLLFNF 613

  Fly  2235 QTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMI 2299
            ..:...|..||.|:....|...:||            :....|.    ..:||||.||.:|:.::
plant   614 NDYPNGMVTLFNLLVMGNWQVWMES------------YKDLTGT----WWSITYFVSFYVITILL 662

  Fly  2300 VINMYIAIILEN-FNQAHQEEE 2320
            ::|:.:|.:||. |.:...|||
plant   663 LLNLVVAFVLEAFFTELDLEEE 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842
		Ion_trans	687..902	CDD:459842
		Ion_trans	1751..2019	CDD:459842	51/268 (19%)
		Na_channel_gate	2009..2063	CDD:240441	12/78 (15%)
		Ion_trans	2067..2320	CDD:459842	73/328 (22%)
		GPHH	2332..2378	CDD:465306
TPC1	NP_567258.1	Ion_trans	124..315	CDD:459842	41/204 (20%)
		FRQ1	<307..393	CDD:444056	15/96 (16%)
		Ion_trans	429..675	CDD:459842	63/268 (24%)