DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and Scn9a

DIOPT Version :10

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_579823.1 Gene:Scn9a / 78956 RGDID:69368 Length:1984 Species:Rattus norvegicus


Alignment Length:2633 Identity:824/2633 - (31%)
Similarity:1180/2633 - (44%) Gaps:869/2633 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 FNDEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKP 72
            |..:......|.::..:..:.|.|.:..:   |.|  |:..:.:|.|..||..:...|..|..:|
  Rat    15 FTKQSLALIEQRISEEKAKEHKDEKKDDE---EEG--PKPSSDLEAGKQLPFIYGDIPPGMVSEP 74

  Fly    73 LEEIDTFIYE-ETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATI 136
            ||::|.:..: :||.|::|   ...|.||..|.:|::..|:||.||:.:.|..:..|...:|.||
  Rat    75 LEDLDPYYADKKTFIVLNK---GKAIFRFNATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTI 136

  Fly   137 LFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYA 198
            |.||||:.::   |..:..||.|..||:.|.:|||:|:||.:.::|:||:||||||||||...|.
  Rat   137 LTNCIFMTLSNPPEWTKNVEYTFTGIYTFESLIKILARGFCVGEFTFLRDPWNWLDFVVIVFAYL 201

  Fly   199 TIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQV 263
            |..:.:||::.||||||||||||:|::||||||:.||:.|.::|::||.||:|||.||||..||:
  Rat   202 TEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQL 266

  Fly   264 YMGELRNKCVRQVPTDWTNVSHTDWQIWVNDT----DNWLYDEDEL------------PVLCGNL 312
            :||.|::||.|:             ::..|:|    .|....|:||            .:|||..
  Rat   267 FMGNLKHKCFRK-------------ELEENETLESIMNTAESEEELKKYFYYLEGSKDALLCGFS 318

  Fly   313 TGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFT 377
            |.:..||..|:|:..|.||::|||:||.|.|:.|..|:|:|.|||||:|...|...|...:.||.
  Rat   319 TDSGQCPEGYICVKAGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFV 383

  Fly   378 VVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKK 442
            ||:|.||||||||:|||||::|||:.:...||.|:               ..|..:::....||:
  Rat   384 VVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQ---------------KELEFQQMLDRLKKE 433

  Fly   443 IDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSA 507
            .:..:.:..|:.......|.:..|..|         |:.:.::..|          .||.||.:.
  Rat   434 QEEAEAIAAAAAEFTSIGRSRIMGLSE---------SSSETSRLSS----------KSAKERRNR 479

  Fly   508 LTMQAQKQYQQMEQ--QHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVK-----------NPNM 559
            ...:.||.....|:  ..||:||||..|           |..:...:||:           .||.
  Rat   480 RKKKKQKMSSGEEKGDDEKLSKSGSEES-----------IRKKSFHLGVEGHHRTREKRLSTPNQ 533

  Fly   560 LYPSDYKGQLIANSGQPSSNSS-----------GVNRESSQDDSGVVDDHEEQDTTNDMGHVSTV 613
             .|...:|.|.  |.:.||.:|           |...|.:.|:..:..|:|.:..:..:.|    
  Rat   534 -SPLSIRGSLF--SARRSSRTSLFSFKGRGRDLGSETEFADDEHSIFGDNESRRGSLFVPH---- 591

  Fly   614 ELALSPREVR----------------------LIKCNGNIARIKNHNVYAL-HQEFSSEVVV--- 652
                .|||.|                      .:.|||.::.:...:...| :.:...||::   
  Rat   592 ----RPRERRSSNISQASRSPPVLPVNGKMHSAVDCNGVVSLVDGPSALMLPNGQLLPEVIIDKA 652

  Fly   653 ----------------------------------------------IDDLPDRNCDRCVHW---- 667
                                                          :::| :.:..:|..|    
  Rat   653 TSDDSGTTNQMRKKRLSSSYFLSEDMLNDPHLRQRAMSRASILTNTVEEL-EESRQKCPPWWYRF 716

  Fly   668 --------CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGN 724
                    |:.|  |::|:..:|.:|.||..:||||:||||||.|:|||||.|:|.|:|.|.|||
  Rat   717 AHTFLIWNCSPY--WIKFKKLIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAVGN 779

  Fly   725 KVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKL 788
            .:||.||..|.::||:|:.. ::|..||||||.||||.||:::....|:||||||..|||||.||
  Rat   780 LIFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLIELFLADVEGLSVLRSFRLLRVFKL 844

  Fly   789 AQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPRWNF 850
            |:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|..  .|.:.| .:|||:.
  Rat   845 AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINVDCKLPRWHM 909

  Fly   851 NDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFN 915
            |||||||:::||:|||||||.:||||   |..|.:.|..:::..:|:||.:||||||||||:||:
  Rat   910 NDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQTMCLIVYMMVMVIGNLVVLNLFLALLLSSFS 971

  Fly   916 SEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQ 980
            |:.|.:.:|                                                        
  Rat   972 SDNLTAIEE-------------------------------------------------------- 980

  Fly   981 AAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQ 1045
                                                                             
  Rat   981 ----------------------------------------------------------------- 980

  Fly  1046 IQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQ 1110
                                                                             
  Rat   981 ----------------------------------------------------------------- 980

  Fly  1111 YDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQ 1175
                                  |||  ||:.:.......||                    :.|.
  Rat   981 ----------------------DTD--ANNLQIAVARIKRG--------------------INYV 1001

  Fly  1176 KSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREE 1240
            |.                                                          .|||.
  Rat  1002 KQ----------------------------------------------------------TLREF 1008

  Fly  1241 LLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQM-GQPENETMVEHSEFDNIIQSFEK 1304
            :|....|:           .||:|     :..|:..|:::. ....|.|:.|.|:..|    |.|
  Rat  1009 ILKSFSKK-----------PKGSK-----DTKRTADPNNKKENYISNRTLAEMSKDHN----FLK 1053

  Fly  1305 ELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLS 1369
            |.:.|....:||                                ::|..||     |.|.|    
  Rat  1054 EKDRISGYGSSL--------------------------------DKSFMDE-----NDYQS---- 1077

  Fly  1370 SVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSA 1434
                                                                             
  Rat  1078 ----------------------------------------------------------------- 1077

  Fly  1435 SQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQL 1499
                                                                     |:|.|   
  Rat  1078 ---------------------------------------------------------FIHNP--- 1082

  Fly  1500 RLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTE 1564
                                                                ||..|.|:|    
  Rat  1083 ----------------------------------------------------SLTVTVPIA---- 1091

  Fly  1565 HQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADA 1629
                                          .|:              :..:...||..||   |:
  Rat  1092 ------------------------------PGE--------------SDLEIMNTEELSS---DS 1109

  Fly  1630 SSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTF 1694
            .|..:     |.::::|::.:.                   |.||:...|    .:.|..:|:. 
  Rat  1110 DSDYS-----KEKRNRSSSSEC-------------------STVDNPLPG----EEEAEAEPVN- 1145

  Fly  1695 PSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLV 1759
                    |..|:.||...|...|    |.....:|:...|.|..:|.....:|:...||.|:::
  Rat  1146 --------ADEPEACFTDGCVRRF----PCCQVNVDSGKGKVWWTIRKTCYRIVEHSWFESFIVL 1198

  Fly  1760 LIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFII 1824
            :|..||..|.||||.::|.||:|.:|.:.:..|..||::||:|||:|.|:..|||:.|..|||:|
  Rat  1199 MILLSSGALAFEDIYIEKKKTIKIILEYADKIFTYIFILEMLLKWVAYGYKTYFTNAWCWLDFLI 1263

  Fly  1825 VFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLV 1887
            |.||:.:|:...  ..:|..::|||||||||||||:||::|||:|||||:.|||||.|||||||:
  Rat  1264 VDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLI 1328

  Fly  1888 FWLIFSIMGVQFFGGKFFKCVNEM-GELLPITEVNDKWDC-----IEQNYTWINSKITFDHVGMG 1946
            ||||||||||..|.|||::|||.. |...|.::|.::.:|     :..|..|.|.|:.||:||:|
  Rat  1329 FWLIFSIMGVNLFAGKFYECVNTTDGSRFPTSQVANRSECFALMNVSGNVRWKNLKVNFDNVGLG 1393

  Fly  1947 YLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNF 2011
            ||:|||||||:|||::|..|||:..|:.||:.|.:||.||||||||:.|||||||||||||||||
  Rat  1394 YLSLLQVATFKGWMDIMYAAVDSVNVNEQPKYEYSLYMYIYFVIFIIFGSFFTLNLFIGVIIDNF 1458

  Fly  2012 NMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFV 2076
            |..|||..|  .::|:||.||.||.||||||.|||||.|.||.|.|....:||..::.|:|.|.|
  Rat  1459 NQQKKKLGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGCIFDLVTNQAFDITIMV 1521

  Fly  2077 LIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLA 2141
            ||.|||:||.:|...|...:.::|...|..|..:|..|.::|::.||::||||.||:|||::|:.
  Rat  1522 LICLNMVTMMVEKEGQTEYMDYVLHWINMVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIL 1586

  Fly  2142 SIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGL 2206
            ||.|:.:.:::....:||||.||:|:.||||||||||.|||||.|||||::|||||||||.||.|
  Rat  1587 SIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFL 1651

  Fly  2207 ITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLM-IQPPDCDP- 2269
            :.|||||.|||.|..||.:..::||.||:|||.||..||::.|||||:.:|..:: ..|||||| 
  Rat  1652 VMFIYAIFGMSNFAYVKKEAGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPK 1716

  Fly  2270 FIH--GHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFY 2332
            .:|  ....|:||:|.:.|.||.|:||||:::|:|||||:|||||:.|.:|....:.|||.||||
  Rat  1717 KVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFY 1781

  Fly  2333 IRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKH 2397
            ..|.|:||.|||||.|.:||||.|:|||||.|:|||.|.|::.:||:..|::|||||||.|..|.
  Rat  1782 EVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKR 1846

  Fly  2398 VLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREK 2462
            |||...|.|:   |:.||:.:|....|::...|.:::|...|::|.:|..||..::.|..|:..|
  Rat  1847 VLGEGGEMDS---LRSQMEERFMSANPSKVSYEPITTTLKRKQEEVSATIIQRAYRRYRLRQHVK 1908

  Fly  2463 ERSN----SG--------------DSATQTSSP 2477
            ..|:    .|              |:..:.|||
  Rat  1909 NISSIYIKDGDRDDDLPNKEDTVFDNVNENSSP 1941

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 125..371 CDD:459842 117/264 (44%)
Ion_trans 687..902 CDD:459842 120/218 (55%)
Ion_trans 1751..2019 CDD:459842 155/275 (56%)
Na_channel_gate 2009..2063 CDD:240441 31/53 (58%)
Ion_trans 2067..2320 CDD:459842 133/256 (52%)
GPHH 2332..2378 CDD:465306 27/45 (60%)
Scn9aNP_579823.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..55 5/33 (15%)
I. /evidence=ECO:0000305 112..410 143/310 (46%)
Ion_trans 125..410 CDD:459842 138/297 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 461..542 23/102 (23%)
Na_trans_cytopl 534..693 CDD:463401 23/168 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 576..609 7/40 (18%)
II. /evidence=ECO:0000305 725..988 146/477 (31%)
Ion_trans 742..955 CDD:459842 118/215 (55%)
Na_trans_assoc 981..1185 CDD:461936 70/613 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1040 6/40 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1103..1145 13/72 (18%)
III. /evidence=ECO:0000305 1178..1486 168/309 (54%)
Ion_trans 1189..1464 CDD:459842 153/274 (56%)
Na_channel_gate 1456..1508 CDD:240441 31/53 (58%)
IV. /evidence=ECO:0000305 1495..1793 152/297 (51%)
Ion_trans 1512..1768 CDD:459842 132/255 (52%)
IQ 1886..1908 CDD:197470 6/21 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1916..1984 5/26 (19%)

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