Protein Alignment NaCP60E and CACNA1B

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_000709.1
• Gene: CACNA1B / 774
• HGNCID: 1389
• Length: 2339
• Species: Homo sapiens
• Alignment Length: 3013
• Identity: 644/3013 - (21%)
• Similarity: 1084/3013 - (35%)
• Gaps: 964/3013 - (31%)

  Fly    80 IYEETFCVVSKRFRKNYIHR--------FTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATI 136
            :|:::   :::|.|...::.        ||..:|||:|...:..|:....|.....|:|.::|||
Human    44 LYKQS---IAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATI 105

  Fly   137 LFNCIFLA------------MTETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLD 189
            :.|||.||            |:|.:::.|..|:.|:..|..|||||.||:.:|.:||||.||.:|
Human   106 IANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMD 170

  Fly   190 FVVITSG-YATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCL 253
            |||:.:| .||.|.:. :|..||..||||.||.||.:|.|:.::.:::.:...|.::..|..|.:
Human   171 FVVVLTGILATAGTDF-DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAI 234

  Fly   254 MVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHC 318
            ::||:..|:.|||:....|                  :.|.||  .....:.|  ||....||.|
Human   235 LMFAIIGLEFYMGKFHKAC------------------FPNSTD--AEPVGDFP--CGKEAPARLC 277

  Fly   319 PFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFF 382
            ..:..|......||.|.|||||.::::||.||.||::.|.:: ||...|.....:..:|..::..
Human   278 EGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIII 342

  Fly   383 GSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRK 447
            |||:::||:|.|::..:.:|.|  ..|.::..|..|......        ::|| ...:.|...:
Human   343 GSFFMLNLVLGVLSGEFAKERE--RVENRRAFLKLRRQQQIE--------RELN-GYLEWIFKAE 396

  Fly   448 GVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQA 512
            .|:||...:                       |.::.       ||....:.:||::
Human   397 EVMLAEEDR-----------------------NAEEK-------SPLDVLKRAATKK-------- 423

  Fly   513 QKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQP- 576
                                |.|.:....:|...|.|                    :...|.|
Human   424 --------------------SRNDLIHAEEGEDRFAD--------------------LCAVGSPF 448

  Fly   577 --SSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNV 639
              :|..||....||
Human   449 ARASLKSGKTESSS--------------------------------------------------- 462

  Fly   640 YALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAF 704
            |...:|                             ..|:..:.::|:...|...:...:.|||..
Human   463 YFRRKE-----------------------------KMFRFFIRRMVKAQSFYWVVLCVVALNTLC 498

  Fly   705 LAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIF 768
            :||.|:.........|.....||..:|..|..:|:..|. :.:|...:|.||..::..|:.::::
Human   499 VAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVW 563

  Fly   769 ELVD-----GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGM 828
            ..:.     |:||||.|||||:.|:.:.|::::.|:..:::::.::.:|..:|.:.|.:||::||
Human   564 AAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGM 628

  Fly   829 QLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAE--EEQGASTCFAI 890
            |||...:..:    |..|..||:.|..:.:.:|:||.|| |...::..:.::  ..:|..:.|..
Human   629 QLFGGQFNFQ----DETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYF 689

  Fly   891 FLPTLVMGNFMVLNLFLALLL-NSFNSEELKSKKEEVGEESKLARSIERVRDLIR---------- 944
            .:.|| .||:.:||:|||:.: |..|::||...:||:.|.:....::::.:::..
Human   690 IVLTL-FGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANIS 753

  Fly   945 -KKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVL--AETKFHRLSYQE 1006
             ..||:...:....:.::..|:.|...:|..:.|..:.       |....|  |.|:..|...:.
Human   754 IAARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEM-------DPEERLRFATTRHLRPDMKT 811

  Fly  1007 SMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMAT 1071
            .::||:. .:.|     .||....|.|....:..:.||.:.             ||
Human   812 HLDRPLV-VELG-----RDGARGPVGGKARPEAAEAPEGVD-------------PP--------- 848

  Fly  1072 TGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDP 1136
                                     |..|                           ::...|..|
Human   849 -------------------------RRHH---------------------------RHRDKDKTP 861

  Fly  1137 YANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQR 1201
            .|.||       :|.::.:..|......||...             |....|.:.......:|:|
Human   862 AAGDQ-------DRAEAPKAESGEPGAREERPR-------------PHRSHSKEAAGPPEARSER 906

  Fly  1202 SLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLR 1266
            ......|...|.|..|                                    ..||..::..:..
Human   907 GRGPGPEGGRRHHRRG------------------------------------SPEEAAEREPRRH 935

  Fly  1267 RISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAAD 1331
            |   ..|.:.||.:....:.|....|                 :....:..|:..:..||:....
Human   936 R---AHRHQDPSKECAGAKGERRARH-----------------RGGPRAGPREAESGEEPARRHR 980

  Fly  1332 EATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEK 1396
            ...||...|.|:....:|:.|.                                         ||
Human   981 ARHKAQPAHEAVEKETTEKEAT-----------------------------------------EK 1004

  Fly  1397 QRKI---DEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDR 1458
            :.:|   |::..:.|.      |...|...:|.............|:
Human  1005 EAEIVEADKEKELRNH------QPREPHCDLETSGTVTVGPMHTLPS------------------ 1045

  Fly  1459 FKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLG 1523
                :.:::|||.||:                                  .::..|:    .::|
Human  1046 ----TCLQKVEEQPED----------------------------------ADNQRNV----TRMG 1068

  Fly  1524 MATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQ 1588
                    :.||       :|.|:..|..:.|.|    |.|      ||.:
Human  1069 --------SQPP-------DPNTIVHIPVMLTGP----LGE------ATVV-------------- 1094

  Fly  1589 AHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQ 1653
                           |...:|         .||.:.|..:..:
Human  1095 ---------------PSGNVD---------LESQAEGKKEVEA---------------------- 1113

  Fly  1654 KPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHF 1718
                                ||:...|          |.....|.:
Human  1114 --------------------DDVMRSG----------PRPIVPYSS------------------- 1129

  Fly  1719 YFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFED-INLD--KNKT 1780
                   |.|:...:.     :|.....:|....||..:||:|..|||.|..|| :..|  :|..
Human  1130 -------MFCLSPTNL-----LRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNA 1182

  Fly  1781 LKRVLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIV--FVSVFSLLIEENEN 1839
            ||    ::::.|..:|..||::|.:.||.    ..||...|.|||||:|  .:..|:....:.::
Human  1183 LK----YLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKD 1243

  Fly  1840 LKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKF 1904
            :..::|||.||.||||:.|.|...::.|.:.::.::.::.|:|:|.::|..||:::.||.|.|||
Human  1244 INTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKF 1308

  Fly  1905 FKCVNEMGELLPITEVNDKWDC-----------IE-QNYTWINSKITFDHVGMGYLALLQVATFE 1957
            |.|.:|..||        :.||           :| |...|......:|:|....|.|..|:|.|
Human  1309 FYCTDESKEL--------ERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGE 1365

  Fly  1958 GWMEVMADAVDARGVDLQP----QREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKY 2018
            ||..|:..:|||...:..|    :.|.:::..:|||:|    .||.:|:|:.:||..|   :::.
Human  1366 GWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVF----PFFFVNIFVALIIITF---QEQG 1423

  Fly  2019 EGGVLEMFLTESQK---HYYTAMKKLGRKKPQK-----------VIKRPINHFLAMFYDLSNSRR 2069
            :..:.|..|.::::   .:..:.|.|.|..||.           |:..|
Human  1424 DKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPP---------------- 1472

  Fly  2070 FEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLR-YHYFTVPWNV 2133
            ||..|..:|.||.:.:.::.||.|:....:|:..|..||::|.:|.::||:... .:||...|||
Human  1473 FEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNV 1537

  Fly  2134 FDFLLVLASIFGILMEDI-----MIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVS 2193
            |||:.||.||..||:.:|     .|:|..       :|:||..|:::|::....||.||:..|.|
Human  1538 FDFVTVLGSITDILVTEIAETNNFINLSF-------LRLFRAARLIKLLRQGYTIRILLWTFVQS 1595

  Fly  2194 LPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMV------NFQTFGRSMQLLFRLMTSAG 2252
            ..||..:..|:.::.|||||:||.:|||:    ||||..      ||:||.:::.||||..|...
Human  1596 FKALPYVCLLIAMLFFIYAIIGMQVFGNI----ALDDDTSINRHNNFRTFLQALMLLFRSATGEA 1656

  Fly  2253 WNDVLESLMIQPPDCDPFIHGHTNG-NCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAH 2316
            |::::.|.:.... ||.    ..|. .||.. .|..||.|||.:...:::|:::|:|::||....
Human  1657 WHEIMLSCLSNQA-CDE----QANATECGSD-FAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLT 1715

  Fly  2317 QEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFN 2376
            ::..| :....|:.|...|::|||.|...|.::.:.:.:..:.||||:.|  |..||   ||..|
Human  1716 RDSSI-LGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMN 1779

  Fly  2377 LPISKGN-KIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKR 2440
            :|||..: .:|....|.||::..|.........|  |.|.|.:.      |||:.:|     |..
Human  1780 MPISNEDMTVHFTSTLMALIRTALEIKLAPAGTK--QHQCDAEL------RKEISVV-----WAN 1831

  Fly  2441 QEKAAKTI-----------QTGWKEY---LRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFH 2491
            ..:  ||:           .|..|.|   :.....|:...:.|...|  :||| .|::..::.||
Human  1832 LPQ--KTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQ--APGG-LSQMGPVSLFH 1891

  Fly  2492 -LQVSRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDE----- 2550
             |:.:...|..:....:|...|...::.||. .|...|..    ||..|.|....|:..:
Human  1892 PLKATLEQTQPAVLRGARVFLRQKSSTSLSN-GGAIQNQE----SGIKESVSWGTQRTQDAPHEA 1951

  Fly  2551 -------------LGKRGSIFVEAPRASRRRSFYNFFLRHQD-----AVDDSLTSPSVHRKTA-- 2595
                         :|:.|::.|:....|..|       |..|     .::....:.|:.|..|
Human  1952 RPPLERGHSTEIPVGRSGALAVDVQMQSITR-------RGPDGEPQPGLESQGRAASMPRLAAET 2009

  Fly  2596 --------MNNTTNTTSNSASTSGTASSTATAPATG----------C-------------GPAAT 2629
                    |..:.:|.:.....:...|:|...|...          |             ||:.:
Human  2010 QPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLS 2074

  Fly  2630 SASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQ----SALRVNKNAFVS----EASAPE 2686
            :..|.....|||.|..|..........::...|||.|.:    |:....|..|.|    ....|
Human  2075 ADMDGAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREP- 2138

  Fly  2687 VIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRESEEYKEEDESSPSVSGN-----------GNG 2740
               .:|.|...:||.|.:               ..:|.....:.|.||:|:           |.|
Human  2139 ---PKPKPSLSSHPTSPT---------------AGQEPGPHPQGSGSVNGSPLLSTSGASTPGRG 2185

  Fly  2741 FGVGLDMLSKQP-PPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPPRG----------DFSSAP 2794
               |...|.:.| .|:..||..:..||....|.....:...||....||          |..|.|
Human  2186 ---GRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPLSQP 2247

  Fly  2795 IDDVGAPIDVNVQGDTSQVFYDYNPEKATDDQGNGQ--DETAQFESLPDRQRXPPVNTPLRDSEK 2857
            :    ||                 ..:...|...||  |..|...:||:        ..|...|.
Human  2248 L----AP-----------------GSRIGSDPYLGQRLDSEASVHALPE--------DTLTFEEA 2283

  Fly  2858 RSSRGSRSSSSSTSSIRSCSSSS 2880
            .::...|  ||.||.:.|.:|.|
Human  2284 VATNSGR--SSRTSYVSSLTSQS 2304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	89/259 (34%)
		Ion_trans	687..902	CDD:459842	59/223 (26%)
		Ion_trans	1751..2019	CDD:459842	92/292 (32%)
		Na_channel_gate	2009..2063	CDD:240441	10/67 (15%)
		Ion_trans	2067..2320	CDD:459842	89/265 (34%)
		GPHH	2332..2378	CDD:465306	17/50 (34%)
CACNA1B	NP_000709.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37
		I	82..359		99/299 (33%)
		Ion_trans	94..367	CDD:459842	99/297 (33%)
		Binding to the beta subunit. /evidence=ECO:0000250	379..396		3/25 (12%)
		II	468..712		67/277 (24%)
		Ion_trans	481..720	CDD:459842	68/243 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	816..1038		54/424 (13%)
		PRK12678	831..>988	CDD:237171	37/306 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1054..1076		7/74 (9%)
		III	1137..1419		93/302 (31%)
		Ion_trans	1150..1380	CDD:459842	79/241 (33%)
		IV	1456..1711		89/287 (31%)
		Ion_trans	1470..1719	CDD:459842	90/281 (32%)
		GPHH	1728..1781	CDD:465306	18/52 (35%)
		Ca_chan_IQ	1792..1869	CDD:462591	19/91 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1916..1968		10/56 (18%)
		PHA03307	1942..>2338	CDD:223039	81/423 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1981..2206		47/253 (19%)