Protein Alignment NaCP60E and CACNA1A

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_075461.2
• Gene: CACNA1A / 773
• HGNCID: 1388
• Length: 2512
• Species: Homo sapiens
• Alignment Length: 2942
• Identity: 664/2942 - (22%)
• Similarity: 1103/2942 - (37%)
• Gaps: 864/2942 - (29%)

  Fly    93 RKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLA------------M 145
            |:|.:   |..:|||||...:..|:....|.....|:|.::|||:.|||.||            |
Human    68 RQNCL---TVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPM 129

  Fly   146 TETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSG-YATIGMEVGNLAG 209
            :|.:::.|..|:.|:..|..|||||.||..:|.:||||.||.:||||:.:| .||:|.|. :|..
Human   130 SERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEF-DLRT 193

  Fly   210 LRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVR 274
            ||..||||.||.||.:|.|:.::.:::.:...|.::..|..|.:::||:..|:.|||:....|..
Human   194 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 258

  Fly   275 QVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFD 339
            :                  .||:   .:.|.|..||....||.||....|....|.||:|.|.||
Human   259 E------------------GTDD---IQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFD 302

  Fly   340 NFMWSMLTTFQLITLDYWEN-VYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEA 403
            |.::::||.||.||::.|.: :||...|:....:..:|..::..|||:::||:|.|::..:.:|.
Human   303 NILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKER 367

  Fly   404 EITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGK 468
            |  ..|.::..|..|......        ::|| ...:.|...:.|:||
Human   368 E--RVENRRAFLKLRRQQQIE--------RELN-GYMEWISKAEEVILA---------------- 405

  Fly   469 EGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGS 533
            |..|:|                                             ||:|..    .|..
Human   406 EDETDG---------------------------------------------EQRHPF----DGAL 421

  Fly   534 NNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQL--IANSGQPSSNSSGVNRESSQDDSGVVD 596
            .         |.:.:.|     ..::|.|.:.:.||  ||:.|.|.:.:|
Human   422 R---------RTTIKKS-----KTDLLNPEEAEDQLADIASVGSPFARAS--------------- 457

  Fly   597 DHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNC 661
                                        ||.    |:::|...:  |::
Human   458 ----------------------------IKS----AKLENSTFF--HKK---------------- 472

  Fly   662 DRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKV 726
                      |..::|.  :.::|:...|...:...:.|||..:|:.|:...|...:.|.....:
Human   473 ----------ERRMRFY--IRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFI 525

  Fly   727 FTSIFTFECIVKLMAL-SKDFFLCGWNIFDLLIVTASLLDIIFELVD-----GLSVLRGLRLLRV 785
            |..:|..|..:|:..| ::.:|...:|.||..::..|:.::|:.::.     |:||||.|||||:
Human   526 FLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 590

  Fly   786 LKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNF 850
            .|:.:.|.:::.|:..:::::.::.:|..:|.:.|.:||::|||||...:   .|| :..|..||
Human   591 FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF---NFD-EGTPPTNF 651

  Fly   851 NDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVM-GNFMVLNLFLALLL-N 912
            :.|..:.|.:|:||.|| |.|.::|.::::........|:|:...|.: ||:.:||:|||:.: |
Human   652 DTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDN 716

  Fly   913 SFNSEEL-----KSKKEEVGEESKL----ARSIERVRDL--------IRKKRQERKDRK---ERK 957
            ..|::||     ..::||.....||    |:.:..|..|        ::::::.:|..|   |::
Human   717 LANAQELTKVEADEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQR 781

  Fly   958 FAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIP 1022
            .:|..:|.:|.:::|....:.         .|:....|.|:..|...:..::||:
Human   782 TSEMRKQNLLASREALYNEMD---------PDERWKAAYTRHLRPDMKTHLDRPL---------- 827

  Fly  1023 LHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQN 1087
                   :||          |:
Human   828 -------VVD----------PQ------------------------------------------- 832

  Fly  1088 LTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGD 1152
                   |.|..:...|..:....|.|           |||..:.|              |.|
Human   833 -------ENRNNNTNKSRAAEPTVDQR-----------LGQQRAED--------------FLR-- 863

  Fly  1153 SLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSS- 1216
                 ...||    ||.|          |.||....||        ::|....|:|||:.|...
Human   864 -----KQARY----HDRA----------RDPSGSAGLD--------ARRPWAGSQEAELSREGPY 901

  Fly  1217 GQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQK-GTKLRRISNVMRSRRPSSQ 1280
            |:       |.|. .:::|:|.:.          .|.:.|.|..| |...||..:.....| .|:
Human   902 GR-------ESDH-HAREGSLEQP----------GFWEGEAERGKAGDPHRRHVHRQGGSR-ESR 947

  Fly  1281 MGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIIT 1345
            .|.|......||.......:..|:..|:      ..||:..:.....||..
Human   948 SGSPRTGADGEHRRHRAHRRPGEEGPED------KAERRARHREGSRPARG-------------- 992

  Fly  1346 GASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAA-----QRQSVKLKRRSLEKQRKIDEDFS 1405
            |..|....|              ....||.....|.|     .|:..|.:|   .::||.::.
Human   993 GEGEGEGPD--------------GGERRRRHRHGAPATYEGDARREDKERR---HRRRKENQG-- 1038

  Fly  1406 ISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEE 1470
                               ..:.|:..:.|..:|.|.. |.|:..|.....|..|...|......
Human  1039 -------------------SGVPVSGPNLSTTRPIQQD-LGRQDPPLAEDIDNMKNNKLATAESA 1083

  Fly  1471 VPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPP 1535
            .|                     ||                         .||.|..|..||
Human  1084 AP---------------------HG-------------------------SLGHAGLPQSPA--- 1099

  Fly  1536 TSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRR 1600
             .:.:|.:|..:..|.::.|.|..||......:   ....:.|.|..|..:|..
Human  1100 -KMGNSTDPGPMLAIPAMATNPQNAASRRTPNN---PGNPSNPGPPKTPENSLI----------- 1149

  Fly  1601 MEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTA-PDATQKPSAFTRLTEK 1664
            :.:|..|...:|  ::||...|::  .|...|....:.....|....| ||...|.....:..|:
Human  1150 VTNPSGTQTNSA--KTARKPDHTT--VDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEEEE 1210

  Fly  1665 PWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCM 1729
                     ||      |...|    |...|.|.:.......:   |.:...|:.....:|..|
Human  1211 ---------DD------RGEDG----PKPMPPYSSMFILSTTN---PLRRLCHYILNLRYFEMC- 1252

  Fly  1730 DTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCL 1794
                                       :|::|..|||.|..|| .:..|.....||.:.::.|..
Human  1253 ---------------------------ILMVIAMSSIALAAED-PVQPNAPRNNVLRYFDYVFTG 1289

  Fly  1795 IFVVEMILKWLALGF----SKYFTSFWTILDFIIVFVSVFSLLIEEN---ENLKVLRSLRTLRAL 1852
            :|..||::|.:.||.    ..||...|.|||||:|..::.:.....|   :::..::|||.||.|
Human  1290 VFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVL 1354

  Fly  1853 RPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPI 1917
            |||:.|.|...::.|.:.::.::.::||:|:|.::|..||:::.||.|.||||.|.:|..|.  .
Human  1355 RPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEF--E 1417

  Fly  1918 TEVNDKWDCIEQNYT------WINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQP 1976
            .:...|:...|:|..      |...:..:|:|....|.|..|:|.|||.:|:..:|||...:..|
Human  1418 KDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGP 1482

  Fly  1977 ----QREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKH---- 2033
                :.|.:::..:|||:|    .||.:|:|:.:||..|.....|    ::|.:..|..:.
Human  1483 SPGYRMEMSIFYVVYFVVF----PFFFVNIFVALIIITFQEQGDK----MMEEYSLEKNERACID 1539

  Fly  2034 YYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFF 2098
            :..:.|.|.|..||.  |:...:.:..|.   .|..||..|..:|.||.:.:.::.|....|...
Human  1540 FAISAKPLTRHMPQN--KQSFQYRMWQFV---VSPPFEYTIMAMIALNTIVLMMKFYGASVAYEN 1599

  Fly  2099 ILEVSNAFFTTVFGLEAIVKIVGLR-YHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLL 2162
            .|.|.|..||::|.||.::|::... .:||...||:|||:.||.||..||:.:  ...|.:...|
Human  1600 ALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTE--FGNPNNFINL 1662

  Fly  2163 RVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKL--- 2224
            ..:|:||..|:::|::....||.||:..|.|..||..:..|:.::.|||||:||.:|||:.:
Human  1663 SFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVE 1727

  Fly  2225 -------QGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHP 2282
                   :..:.:..||:||.:::.||||..|...|::::.|.:...| ||. ..|.....||:.
Human  1728 DEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP-CDK-NSGILTRECGNE 1790

  Fly  2283 LLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIH 2347
             .|..||.|||.:...:::|:::|:|::||....::..| :....|:.:...|::|||.|...:.
Human  1791 -FAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSI-LGPHHLDEYVRVWAEYDPAAWGRMP 1853

  Fly  2348 FSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVL------GH 2401
            :..:...:..:.||||:.|  |..||   |:..:||::..|.:|....|.||::..|      |.
Human  1854 YLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGG 1918

  Fly  2402 VEETDNFKQLQEQMDVKFKKQ----FP--TRKELEIV----SSTRI-------------WKRQEK 2443
            .:        ::|||.:.:|:    :|  ::|.|:::    .||.:             :.||.|
Human  1919 AD--------KQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSK 1975

  Fly  2444 AAKTIQTGWKEYLRRKREKE-------RSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTAC 2501
            |.|         |:..||::       :.....|.||...||  |:.|.:...      ..|.|.
Human  1976 AKK---------LQAMREEQDRTPLMFQRMEPPSPTQEGGPG--QNALPSTQL------DPGGAL 2023

  Fly  2502 SSRASSRKSSRA---SDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKRGSIFVEAPR 2563
            .:..|..|.|.:   ..|.::.:..|.|                     :.|.|
Human  2024 MAHESGLKESPSWVTQRAQEMFQKTGTW---------------------SPEQG----------- 2056

  Fly  2564 ASRRRSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASSTATAPATGCGPAA 2628
                                    |......:..|:.:.........|.:.|....|..|.|.||
Human  2057 ------------------------PPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEGQGRAA 2097

  Fly  2629 TSASDSDRHQAVGGGSAPSRKRAS--SFIRKKPPLERGLS--AQSALRVNKNAFVSEASAPEVIV 2689
            :.......:|...|     |.|.:  |.|....|::|..|  ...|.|::           :..:
Human  2098 SMPRLPAENQRRRG-----RPRGNNLSTISDTSPMKRSASVLGPKARRLD-----------DYSL 2146

  Fly  2690 TRPSPEQQTHPHSLSLRPDNATLVHVLVHRESE----EYKEEDESSPSVSGNGNGFGVGLDMLSK 2750
            .|..||:....|  ..|.|.:       ||.||    .|.:.|          .|.|..|.|
Human  2147 ERVPPEENQRHH--QRRRDRS-------HRASERSLGRYTDVD----------TGLGTDLSM--- 2189

  Fly  2751 QPPPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPPRGDFSSAPID-DVGAPIDVNVQGDTSQVF 2814
                    ||.|                         ||..|...| :.|.|.|...:.......
Human  2190 --------TTQS-------------------------GDLPSKERDQERGRPKDRKHRQHHHHHH 2221

  Fly  2815 YDYNPEKATDDQGNGQDETAQFESLPDRQRXPPVNTPLRDSEKRSSRGSRSSSSSTSSIRSCSSS 2879
            :.::|..        .|:....:..||..|          :..|..|.|||.|.....:  ....
Human  2222 HHHHPPP--------PDKDRYAQERPDHGR----------ARARDQRWSRSPSEGREHM--AHRQ 2266

  Fly  2880 SSSSAASAAAPSARRTS 2896
            .|||.:.:.|||...||
Human  2267 GSSSVSGSPAPSTSGTS 2283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	91/259 (35%)
		Ion_trans	687..902	CDD:459842	62/222 (28%)
		Ion_trans	1751..2019	CDD:459842	88/284 (31%)
		Na_channel_gate	2009..2063	CDD:240441	11/57 (19%)
		Ion_trans	2067..2320	CDD:459842	85/263 (32%)
		GPHH	2332..2378	CDD:465306	14/50 (28%)
CACNA1A	NP_075461.2	I	85..363		101/299 (34%)
		Ion_trans	97..371	CDD:459842	101/297 (34%)
		Binding to the beta subunit. /evidence=ECO:0000250|UniProtKB:P27884	383..400		3/25 (12%)
		II	473..717		70/249 (28%)
		Ion_trans	487..725	CDD:459842	71/241 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..1224		118/697 (17%)
		III	1234..1517		90/320 (28%)
		Ion_trans	1247..1478	CDD:459842	76/261 (29%)
		Ion_trans	1568..1827	CDD:459842	85/263 (32%)
		GPHH	1836..1889	CDD:465306	14/52 (27%)
		Ca_chan_IQ	1899..1976	CDD:462591	16/84 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1994..2037		12/50 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2049..2512		69/382 (18%)
		PHA03307	2239..>2509	CDD:223039	17/57 (30%)
		polyglutamine repeat	2319..2331