|
Fly 104 KSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNC----IFLAMTET--------VEEAEYIF 156
::||.....:|.|:.|:.:...:.|:..::.||..|| ::|.|.|. :|:.||.|
Rat 29 RALFCLTLQNPLRKACISVVEWKPFETIILLTIFANCVALAVYLPMPEDDNNTLNLGLEKLEYFF 93
Fly 157 LAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNL------------AG 209
|.::|||..:||||.|||.::..|||:.||.|||:::..|..|..:|..|: ||
Rat 94 LIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTAILEQVNIIQTNTAPMSSKGAG 158
Fly 210 -----LRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELR 269
||.|||||.|:.||.:|.|:.::|::..:...|..:..|.:|.::::|:..|:::.|::.
Rat 159 LDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMH 223
Fly 270 NKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFE-YVCLCVGENPNH 333
..| :...||.....|:|.|..|......|.|... ..|......|||
Rat 224 KTC------------------YFIGTDIVATVENEKPSPCARTGSGRPCTINGSECRGGWPGPNH 270
Fly 334 GYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCG---PMSVSFFTVVVFFGSFYLINLMLAVV 395
|.|:||||.:||||.:|.|:::.|.:|...|....| |. .:|..::..|||:::||:|
Rat 271 GITHFDNFGFSMLTVYQCISMEGWTDVLYWVNDAIGNEWPW--IYFVTLILLGSFFILNLVL--- 330
Fly 396 ALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTR 460
|||...::|::.:
Rat 331 ----------------------------------------------------GVLSGEFTKEREK 343
Fly 461 RKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKL 525
.| |.| |.|..::.||:|:
Rat 344 AK----------------SRG---------------------------TFQKLREKQQLEE---- 361
Fly 526 AKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQD 590
|.:|.: |.:.:....|
Rat 362 --------------------------------------DLRGYM-----------SWITQGEVMD 377
Fly 591 DSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDD 655
|||..|...:.|.|...|..| :.:..|:: :|..
Rat 378 ----VDDLREGKLSLDEGGSDTESL---------------------YEIEGLNK-------IIQF 410
Fly 656 LPD-RNCDRCVHW-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRN 718
:.. |..:|...| |.| :|:..:|...:.|.:.|||..:|.|||.......:
Rat 411 IRHWRQWNRVFRWKCHD-------------LVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTH 462
Fly 719 ALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-------GLS 775
..||.|:|..::||.|.::|:..|. :.:|:..:|.||..:|.:.:|:|: ||: |:|
Rat 463 LQDVANRVLLALFTIEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEIL--LVESGAMTPLGIS 525
Fly 776 VLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKF 840
|||.:||||:.|:.:.||::..|::.::::|.::.:|.|:|.:.:.|||::|||||...| .|
Rat 526 VLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFMIIFALLGMQLFGGRY---DF 587
Fly 841 DPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRA---EEEQGASTCFAIFLPTLVMGNFM 901
:...|.|.||::|..:.:.:|::|.|| |...:::.:.| ....|...|. .|:...|.||::
Rat 588 EDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCI-YFIILFVCGNYI 651
Fly 902 VLNLFLALLL-NSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQI 965
:||:|||:.: |...:|.|.|.: :.|.:|||.||
Rat 652 LLNVFLAIAVDNLAEAESLTSAQ--------------------KAKAEERKRRK----------- 685
Fly 966 VLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTI 1030
:.||
Rat 686 -------------------MSRG------------------------------------------ 689
Fly 1031 VDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAE 1095
||::
Rat 690 -----------LPDK-------------------------------------------------- 693
Fly 1096 RRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSR 1160
Rat 694 ----------------------------------------------------------------- 693
Fly 1161 RYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSI 1225
||| ::|.:| |.|::..:..|....:.||.:|
Rat 694 ---SEE--------ERSTMT------KKLEQKPKGEGIPTTAKLKIDE----------------- 724
Fly 1226 EQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMV 1290
Rat 725 ----------------------------------------------------------------- 724
Fly 1291 EHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADE 1355
||..:.|:| :|.|:||
Rat 725 -----------FESNVNEVK--------------DPYPSAD------------------------ 740
Fly 1356 VVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAP 1420
.|.| ||
Rat 741 -----FPGD------------------------------------DE------------------ 746
Fly 1421 FVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIES 1485
|:|
Rat 747 ----------------------------------------------------EDE---------- 749
Fly 1486 EKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQI 1550
|.:||:| .|..||::
Rat 750 ------------------------------------------PEIPASP--------RPRPLAEL 764
Fly 1551 SSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQ 1615
. |.| :|.|.|
Rat 765 Q----------LKE----------KAVPIP----------------------------------- 774
Fly 1616 SARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGG 1680
:|||
Rat 775 ------------EASS------------------------------------------------- 778
Fly 1681 RRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVL 1745
|:...| ..::|....
Rat 779 -------------------------------------FFIFSP-------------TNKIRVLCH 793
Fly 1746 TVVDTPAFEWFVLVLIFASSITLCFED-INLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF 1809
.:|:...|..|:|:.|..||..|..|| |..|..: .::|.:.::.|..:|.||::||....|.
Rat 794 RIVNATWFTNFILLFILLSSAALAAEDPIRADSMR--NQILEYFDYVFTAVFTVEIVLKMTTYGA 856
Fly 1810 ----SKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNA 1870
..:..:::.|||.::|.||:.|:.:|.:. :.|::.||.||.|||||||:|.:|::.||..
Rat 857 FLHKGSFCRNYFNILDLLVVAVSLISMGLESSA-ISVVKILRVLRVLRPLRAINRAKGLKHVVQC 920
Fly 1871 LMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQNY---- 1931
:..||.:|.|::||..:...:|:.:|||.|.|||:.| .:|..:||. :|....|
Rat 921 VFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFYSC----NDLSKMTEE----ECRGYYYIYKD 977
Fly 1932 -----------TWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAY 1985
.||::...||:|....::|..|:|||||.:::..|:|:...|..|.....:...
Rat 978 GDPTQIELRPRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNEEDTGPVYNNRVEMA 1042
Fly 1986 IYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQK-- 2048
|:|:|:|:..:||.:|:|:|.:|..|. |.|..|....|..|:....::...:.:|.:
Rat 1043 IFFIIYIILIAFFMMNIFVGFVIVTFQ------EQGETEYKNCELDKNQRQCVQYALKARPLRCY 1101
Fly 2049 VIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGL 2113
:.|.|..: .::|.:::| .||..:|.||.||.:.:|::||:|...:..|.::.|..||.:|.|
Rat 1102 IPKNPYQY--QVWYVVTSS-YFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTL 1163
Fly 2114 EAIVKIVGLRYH-YFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTL---------------L 2162
|.|:|::..:.. ||..||||||||:|:.||..:::.:|...|..|..| .
Rat 1164 EMILKLIAFKPRGYFGDPWNVFDFLIVIGSIIDVILSEIDTLLASSGGLYCLGGGCGNVDPDESA 1228
Fly 2163 RV----VRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVK 2223
|: .|:||:.|:::|:..|:|:|.||:..:.|..||..:..|:.::.||||::||.:||.:.
Rat 1229 RISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIA 1293
Fly 2224 LQGA--LDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDP---FIHGHTNGNCGHPL 2283
:... ::...|||||.:::.||||..|...|.::|.:.. ....||| :..|.... || ..
Rat 1294 MVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACS-YGKRCDPESDYAPGEEYA-CG-TN 1355
Fly 2284 LAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHF 2348
.|..||.||.::...::||:::|:|::||:...::..| :....|:.|...|::|||.|...|..
Rat 1356 FAYYYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSI-LGPHHLDEFKAIWAEYDPEAKGRIKH 1419
Fly 2349 SQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNF 2408
..:...:..:.||||..| |:.|| ||..|:|::....:.....|.|||:..| .::...||
Rat 1420 LDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTAL-KIKTEGNF 1483
Fly 2409 KQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEK---------------------AAKTIQTGW 2452
:|..|::....|| ||||... |...||..:
Rat 1484 EQANEELRAIIKK---------------IWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHF 1533
Fly 2453 KEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDAS 2517
:::::|:.|.. |::.|...: .:|...|
Rat 1534 RKFMKRQEEYY---------------GYRPKKDTV---QIQAGLR-------------------- 1560
Fly 2518 DLSELAGPWLNLPLMLVSG----ADEVVKDIKQQNDELG---KRGSIFVEA-----------PRA 2564
.:.|.|.|.:: ..:|| .:|:.:.:.:...|.| :.|.:|.:. |..
Rat 1561 TIEEEAAPEIH---RAISGDLTAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPPVM 1622
Fly 2565 SRRR--SFYNFFLRHQDA---VDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASST-------- 2616
:.:| .|....:...:: ::|...:|..| ..|..||.|..:|.|..:.:..::
Rat 1623 ANQRPLQFAEMEMEELESPVFLEDFPQNPGTH-PLARANTNNANANVAYGNSSHRNSPVFSSIRY 1686
Fly 2617 -------ATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQSALRVN 2674
|..|.|..||.:...|.| ...||..... |||.:|.:.
Rat 1687 ERELLEEAGRPVTREGPFSQPCSVS---------GVNSRSHVDK-------LERQMSQRR----- 1730
Fly 2675 KNAFVSEASAPEVIVTRPSP---EQQTHPHSLSLRPDNATLVHVLVHRE-------------SEE 2723
:.:...| ||| .|:.|| ||.| ||.
Rat 1731 ----MPKGQVP------PSPCQLSQEKHP----------------VHEEGKGPRSWSTETSDSES 1769
Fly 2724 YKEEDE-------SSPS---------VSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSMDTCAM 2772
::|... ::|: |.| |||.|:.. ....:.|| ::..|.|.|
Rat 1770 FEERVPRNSAHKCTAPATTMLIQEALVRG-------GLDSLAAD--ANFVMATG--QALADACQM 1823
Fly 2773 PTVQIMV--------DSPK 2783
...::.| :|||
Rat 1824 EPEEVEVAATELLKRESPK 1842
| 
