Protein Alignment NaCP60E and Scn7a

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_001375437.1
• Gene: Scn7a / 64155
• RGDID: 61922
• Length: 1680
• Species: Rattus norvegicus
• Alignment Length: 2455
• Identity: 593/2455 - (24%)
• Similarity: 968/2455 - (39%)
• Gaps: 894/2455 - (36%)

  Fly    51 VEDGDVLPRKFEPFPEHMYGKPLEEIDTFIY--EETFCVVSKRFRKNYIHRFTGTKSLFLFYPWS 113
            :|.|..||..:...|:....:|||::|.:.|  ..||.|::   |...|.||.....|....|.|
  Rat    44 LEAGKKLPFAYGTLPQGTVSEPLEDVDPYYYVKRNTFMVLN---RNRVIFRFNAVSILCTLSPLS 105

  Fly   114 PARRVCVYIATNQFFDYCVMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIAKGFLL 175
            ..||..:.:..:..|...::.::|.:.|.:.|:   |.:...|...|.||:.|:::|:||:|...
  Rat   106 SLRRAVIKVLVHPLFRLLILISVLTDSILMCMSNLPEWILAVENTLLGIYTFEILVKVIARGIWA 170

  Fly   176 NKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFR 240
            ..:::|.:.||||||.|......|....:.:|...:|.|.||.||.:.:..||::|:..|:...:
  Rat   171 GSFSFLGDLWNWLDFSVTLFELITRSSPLSSLPMFKTIRTLRILKIIPLNHGLQSIVVTLVQCLK 235

  Fly   241 QLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSH--TDWQIWVNDTDNWLYDED 303
            :|...:.|.:|.|.|.:||.:.::||.|::||||....|..:|.:  |..|..:.:.:|:.|.|.
  Rat   236 KLLGAIALALFFLTVSSLFGMGLFMGNLKHKCVRWPQEDGNDVMYNGTGSQYHILERENFYYMEG 300

  Fly   304 -ELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLAT 367
             ...:||||.|.|..||..|:|:..|.||::|:|:||||.|::|..|:|:|.||.|.:|:.:|..
  Rat   301 ARYALLCGNKTDAGLCPEGYMCVKEGSNPDNGFTSFDNFGWALLAMFRLMTQDYPELLYHQILYA 365

  Fly   368 CGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNV 432
            .|.:.:.||.::.|:.:||:.:|.|.::.::||:|.:..:|| .:|:
  Rat   366 SGKIYMIFFVLISFWFAFYMASLFLGILTMAYEQEKQRASEE-SRDM------------------ 411

  Fly   433 KKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSP 497
                                                              |:|.|
  Rat   412 --------------------------------------------------DSKCH---------- 416

  Fly   498 RHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYP 562
                         |..|::   |::|:.|:         |..|
  Rat   417 -------------QTVKEF---EEEHEGAE---------METT---------------------- 434

  Fly   563 SDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDD----HEEQDTTNDMGHVSTVELALSPREVR 623
                 |:......|:|.::.::         :::|    |:|:..|             |.:|..
  Rat   435 -----QIEMKKRSPTSINTTLD---------ILEDTALGHKEEPET-------------SRKECP 472

  Fly   624 LIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDP 688
            |  |               ..:|:....:      ..|..|         |::......:::..|
  Rat   473 L--C---------------WYKFTKTCFI------WKCSPC---------WIKLNEFADRIITHP 505

  Fly   689 LFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWN 752
            ||:|.:.:||:||..|||:||..|||...:.|.:||.||..|:|.|.|:|::|:.. .:|...|:
  Rat   506 LFDLFLVICIILNICFLALEHFPMSEELMSLLAIGNLVFIGIYTIEMILKIIAMHPYGYFQISWH 570

  Fly   753 IFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILV 817
            |||.::|...|.:::...::.::|...:.|: .:||.:.....|.|:.|:...:.||.:|.|::.
  Rat   571 IFDSILVVLGLTEMLLADIEEITVFILVPLI-FIKLGKYAPPFKNLMRILGRALVALKDLVLLVS 634

  Fly   818 IVIYIFAVIGMQLFSKDYTPEKFDPDPV---------PRWNFNDFFHSFMMIFRILCGEWIEPLW 873
            |.||..||.||:||.:.|      .|.|         .||:.:||.|:::.:||||||||||.||
  Rat   635 IFIYFSAVFGMKLFGRSY------KDCVCHVDQDCQRQRWHMSDFLHAYVTVFRILCGEWIETLW 693

  Fly   874 DCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIER 938
            :||   |..|.:.|...::..:::||.::|.||:| |::||.|.:..:   ||.:|:
  Rat   694 ECM---EVAGEAWCIPFYMMVILIGNLLILYLFVA-LVSSFASYDATT---EVSKEA-------- 743

  Fly   939 VRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLS 1003
                           |..:.|..:.::|::.                       ||.:.
  Rat   744 ---------------KNLQLAVAWIKMVINC-----------------------VLLKI------ 764

  Fly  1004 YQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAM 1068
                                                                             
  Rat   765 ----------------------------------------------------------------- 764

  Fly  1069 MATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTD 1133
                           .|:..|                |||:
  Rat   765 ---------------LCKEKT----------------VSTE------------------------ 774

  Fly  1134 TDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQ 1198
                |.||                                      |..||.::::
  Rat   775 ----ATDQ--------------------------------------TCDPSVKENI--------- 788

  Fly  1199 SQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGT 1263
                             ||.:|:.:|..|                       .||:.::: ..||
  Rat   789 -----------------SGHTLSELSNTQ-----------------------TFLRYKDQ-SSGT 812

  Fly  1264 KLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSP 1328
            :                      :|.|..||..::|
  Rat   813 E----------------------KTPVTESESQSLI----------------------------- 826

  Fly  1329 AADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRS 1393
                |:.::.|.:.|.:|.|               |..:|.:...||:|.:.:::.   |:|:.|
  Rat   827 ----ASPSVSETVPIASGES---------------DIENLDNKETRSKSANGSSKE---KMKQSS 869

  Fly  1394 LEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDR 1458
            ..:...:|
  Rat   870 SSECSTVD--------------------------------------------------------- 877

  Fly  1459 FKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLG 1523
               :::.|..|.|.|.||              ..||              .|.||.
  Rat   878 ---IAISEEEEMVYEHEK--------------SKLH--------------KNGYER--------- 902

  Fly  1524 MATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQ 1588
                           |||
  Rat   903 ---------------KSS----------------------------------------------- 905

  Fly  1589 AHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQ 1653
                  |||..|
  Rat   906 ------AGQVSR----------------------------------------------------- 911

  Fly  1654 KPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHF 1718
                                                                             
  Rat   912 ----------------------------------------------------------------- 911

  Fly  1719 YFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKR 1783
                       ::::.|.|..:|.....:|:...||.|:.::....:.||..|||.:|:.||:|.
  Rat   912 -----------ESRNGKIWRNIRKTCCKIVENSWFECFIGLVTLLCTGTLALEDIYIDQRKTIKI 965

  Fly  1784 VLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRT 1848
            .|.:.:..|..||::||:|||:|.||..||::.|..|||::|.|...||:.:..|:|..|.|::.
  Rat   966 FLEYGDMIFAYIFILEMLLKWVAYGFKAYFSNNWYKLDFMVVIVLCLSLIGKTREDLNPLASIKF 1030

  Fly  1849 LRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN-EMG 1912
            |||   ||.:|:::.|::|:.||:.......:|.||||:.||:||:|||..|.|||::|:: ..|
  Rat  1031 LRA---LRVLSQFERMKVVLRALIKTTLPAVSVFLVCLMIWLLFSVMGVFLFAGKFYECIDPTRG 1092

  Fly  1913 ELLPITEVNDKWDC----IEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVD 1973
            |...:.||.:|..|    ..::..|.|:|:.||:||.|:|:|.|||||.||:.:|..|:|:.||.
  Rat  1093 ERFSVFEVMNKSQCENLVFNESMPWENAKLNFDNVGNGFLSLFQVATFNGWISIMNSAIDSVGVY 1157

  Fly  1974 LQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAM 2038
            :||..|.:|:.|.||:||:|.|.|..|.:.|||||.|||  |:|.:.|...:|:|..||..|.|:
  Rat  1158 MQPSFEHSLHMYTYFIIFVVFGLFLPLCMLIGVIIRNFN--KQKIKQGGSNIFITVKQKKQYRAL 1220

  Fly  2039 KKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQ-PH---AVFFI 2099
            |||.....||...||.|.|.....|:...|.|.:.|.:||.....|:.|::.:| |.   |||::
  Rat  1221 KKLLYADSQKPAARPRNKFQGFICDVVTHRVFNVIIILLICFQATTIMIQNDEQSPQIETAVFWM 1285

  Fly  2100 LEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPIS------ 2158
                |:.||.:|.||.|:|:...|.||||..|||.||::|:.||.|:|       ||:|
  Rat  1286 ----NSLFTMLFTLECILKLTAFRCHYFTSAWNVHDFMVVVFSITGLL-------LPLSIGQYFV 1339

  Fly  2159 -PTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNV 2222
             |:|::::.:.||..:||..|..|....|:..|::|||||.||..|:.|:.|||||.||..|..|
  Rat  1340 PPSLVQLLLLSRIIHVLRPGKGPKVFHDLMLPLMLSLPALLNIALLIFLVMFIYAIFGMYNFAYV 1404

  Fly  2223 KLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLM-IQPPDCDP-FIHGHT--NGNCGHPL 2283
            |.:..::|:.||:|||.||..||::.|.:||:.:|:::. .|..|||| .|:..|  .|:||.|.
  Rat  1405 KKEAGINDVSNFETFGSSMLCLFQVTTFSGWDGMLDAIFNSQWSDCDPDKINPGTQVRGDCGSPS 1469

  Fly  2284 LAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHF 2348
            :.|.||.|:|:||::|::|||:.:|:|..:...:.:...:.|||...|:..|:::||..||:|..
  Rat  1470 VGIFYFVSYILISWLIIVNMYVVLIMEFLSIPSKRKNRTLSEDDFRRFFKVWNRFDPDRTQYIDS 1534

  Fly  2349 SQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQE 2413
            ::||||.|:|||||.::|||...||:.:||::.|::|||||||.|..|.|:|..|..:   ::..
  Rat  1535 TKLSDFAAALDPPLFMAKPNKGQLVAMDLPMAAGDRIHCLDILLAFTKRVMGKDERVE---KILS 1596

  Fly  2414 QMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKE 2463
            :::..|....|.:...|.:::|...|::..:|..||..:|.|..|:.:|:
  Rat  1597 EIESGFMLANPFKITYEPITTTLKRKQEAVSATIIQRAYKSYRLRQSDKK 1646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	85/251 (34%)
		Ion_trans	687..902	CDD:459842	81/224 (36%)
		Ion_trans	1751..2019	CDD:459842	116/272 (43%)
		Na_channel_gate	2009..2063	CDD:240441	21/53 (40%)
		Ion_trans	2067..2320	CDD:459842	105/267 (39%)
		GPHH	2332..2378	CDD:465306	21/45 (47%)
Scn7a	NP_001375437.1	I. /evidence=ECO:0000250|UniProtKB:Q01118	100..401		98/300 (33%)
		Ion_trans	117..405	CDD:459842	95/287 (33%)
		II. /evidence=ECO:0000250|UniProtKB:Q01118	487..756		97/314 (31%)
		Ion_trans	504..738	CDD:459842	89/247 (36%)
		Na_trans_assoc	742..926	CDD:461936	66/814 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	807..874		20/140 (14%)
		III. /evidence=ECO:0000250|UniProtKB:Q01118	915..1223		128/312 (41%)
		Ion_trans	932..1203	CDD:459842	116/275 (42%)
		Na_channel_gate	1194..1245	CDD:240441	21/52 (40%)
		IV. /evidence=ECO:0000250|UniProtKB:Q01118	1232..1530		117/308 (38%)
		Ion_trans	1249..1496	CDD:459842	104/257 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1646..1680		0/1 (0%)