Protein Alignment NaCP60E and SCN9A

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_001352465.1
• Gene: SCN9A / 6335
• HGNCID: 10597
• Length: 1988
• Species: Homo sapiens
• Alignment Length: 2610
• Identity: 819/2610 - (31%)
• Similarity: 1169/2610 - (44%)
• Gaps: 868/2610 - (33%)

  Fly    45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDTFIYE-ETFCVVSKRFRKNYIHRFTGTKSLFL 108
            |:..:.:|.|..||..:...|..|..:|||::|.:..: :||.|::|   ...|.||..|.:|::
Human    47 PKPSSDLEAGKQLPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNK---GKTIFRFNATPALYM 108

  Fly   109 FYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIA 170
            ..|:||.||:.:.|..:..|...:|.|||.||||:.|.   :..:..||.|..||:.|.::||:|
Human   109 LSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILA 173

  Fly   171 KGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINAL 235
            :||.:.::|:||:||||||||||...|.|..:.:||::.||||||||||||:|::||||||:.||
Human   174 RGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 238

  Fly   236 LHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDT----D 296
            :.|.::|::||.||:|||.||||..||::||.|::||.|.             .:..|:|    .
Human   239 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRN-------------SLENNETLESIM 290

  Fly   297 NWLYDEDEL------------PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTF 349
            |.|..|::.            .:|||..|.:..||..|.|:.:|.||::|||:||.|.|:.|..|
Human   291 NTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALF 355

  Fly   350 QLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDL 414
            :|:|.|||||:|...|...|...:.||.||:|.||||||||:|||||::|||:.:...||.|:
Human   356 RLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQ-- 418

  Fly   415 LDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGS 479
                         ..|..:::....||:.:..:.:..|:......||.:..|..|         |
Human   419 -------------KELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSE---------S 461

  Fly   480 NGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQ---HKLAKSGSGGSNNPMAPTP 541
            :.:.:|..|          .||.||.:....:.||:....|::   .||:||.|..|..
Human   462 SSETSKLSS----------KSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIR------ 510

  Fly   542 KGRISFQDSGMGVK-----------NPNMLYPSDYKGQLIANSGQPSSNSS-----------GVN 584
              |.||.   :||:           .||. .|...:|.|.  |.:.||.:|           |..
Human   511 --RKSFH---LGVEGHRRAHEKRLSTPNQ-SPLSIRGSLF--SARRSSRTSLFSFKGRGRDIGSE 567

  Fly   585 RESSQDDSGVVDDHE-------------EQDTTN-DMGHVSTVELALSPREVRLIKCNGNIARIK 635
            .|.:.|:..:..|:|             |:.::| .....|...|.::.:....:.|||.::.:.
Human   568 TEFADDEHSIFGDNESRRGSLFVPHRPQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVD 632

  Fly   636 NHNVYAL-------------------------HQE--FSSEVVVIDDLPDRNC------------ 661
            ..:...|                         |::  .||.::..|.|.|.|.
Human   633 GRSALMLPNGQLLPEVIIDKATSDDSGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRASILT 697

  Fly   662 ----------DRCVHW------------CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAF 704
                      .:|..|            |:.|  |::|:.|:|.:|.||..:||||:||||||.|
Human   698 NTVEELEESRQKCPPWWYRFAHKFLIWNCSPY--WIKFKKCIYFIVMDPFVDLAITICIVLNTLF 760

  Fly   705 LAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIF 768
            :|||||.|:|.|:|.|.:||.|||.||..|.::||:|:.. ::|..||||||.||||.||:::..
Human   761 MAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFL 825

  Fly   769 ELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSK 833
            ..|:||||||..|||||.|||:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|
Human   826 ADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 890

  Fly   834 DYTP--EKFDPD-PVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTL 895
            .|..  .|.:.| .:|||:.|||||||:::||:|||||||.:||||   |..|.:.|..:::..:
Human   891 SYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQAMCLIVYMMVM 952

  Fly   896 VMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAE 960
            |:||.:||||||||||:||:|:.|.:.:|
Human   953 VIGNLVVLNLFLALLLSSFSSDNLTAIEE------------------------------------ 981

  Fly   961 KFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHD 1025
                                                                             
Human   982 ----------------------------------------------------------------- 981

  Fly  1026 GLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTP 1090
                                                                             
Human   982 ----------------------------------------------------------------- 981

  Fly  1091 FVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQ 1155
                                                        ||.||:.:.......:|
Human   982 --------------------------------------------DPDANNLQIAVTRIKKG---- 998

  Fly  1156 DNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSL 1220
                            :.|.|.
Human   999 ----------------INYVKQ------------------------------------------- 1004

  Fly  1221 NSMSIEQDELLSQQGNLREELLNCDQK--ELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQ 1283
                           .|||.:|....|  ::.:.:::.|:|          |..:....|
Human  1005 ---------------TLREFILKAFSKKPKISREIRQAEDL----------NTKKENYIS----- 1039

  Fly  1284 PENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGAS 1348
              |.|:.|.|:..|    |.||.::|....:|::                 |.:||
Human  1040 --NHTLAEMSKGHN----FLKEKDKISGFGSSVD-----------------KHLME--------- 1072

  Fly  1349 ERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKI 1413
                                                                |.|
Human  1073 ----------------------------------------------------DSD---------- 1075

  Fly  1414 CDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPI 1478
                                      .||
Human  1076 --------------------------GQS------------------------------------ 1078

  Fly  1479 STLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIE 1543
                         |:|.|      ||::                   |.|..|.      :|.:|
Human  1079 -------------FIHNP------SLTV-------------------TVPIAPG------ESDLE 1099

  Fly  1544 PPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTL 1608
            .....::||
Human  1100 NMNAEELSS-------------------------------------------------------- 1108

  Fly  1609 DKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYV 1673
            |..:.:...|....||.                                         .|  |.|
Human  1109 DSDSEYSKVRLNRSSSS-----------------------------------------EC--STV 1130

  Fly  1674 DDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSC----MDTQSA 1734
            |:...|   ..:.|..:||.         :..|:.||...|.        |..||    :::...
Human  1131 DNPLPG---EGEEAEAEPMN---------SDEPEACFTDGCV--------WRFSCCQVNIESGKG 1175

  Fly  1735 KHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVE 1799
            |.|..:|.....:|:...||.|::::|..||..|.||||.:::.||:|.:|.:.:..|..||::|
Human  1176 KIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILE 1240

  Fly  1800 MILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQ 1862
            |:|||:|.|:..|||:.|..|||:||.||:.:|:...  ..:|..::|||||||||||||:||::
Human  1241 MLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFE 1305

  Fly  1863 GMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEM-GELLPITEVNDKWDC 1926
            |||:|||||:.|||||.|||||||:||||||||||..|.|||::|:|.. |...|.::|.::.:|
Human  1306 GMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSEC 1370

  Fly  1927 -----IEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYI 1986
                 :.||..|.|.|:.||:||:|||:|||||||:||..:|..|||:..||.||:.|.:||.||
Human  1371 FALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYI 1435

  Fly  1987 YFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIK 2051
            |||:||:.||||||||||||||||||..|||..|  .::|:||.||.||.||||||.|||||.|.
Human  1436 YFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIP 1498

  Fly  2052 RPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAI 2116
            ||.|......:||..::.|:|:|.|||.|||:||.:|...|...:..:|...|..|..:|..|.:
Human  1499 RPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECV 1563

  Fly  2117 VKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAK 2181
            :|::.||::||||.||:|||::|:.||.|:.:.|::....:||||.||:|:.||||||||:|.||
Human  1564 LKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAK 1628

  Fly  2182 GIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFR 2246
            |||.|||||::|||||||||.||.|:.|||||.|||.|..||.:..::||.||:|||.||..||:
Human  1629 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICLFQ 1693

  Fly  2247 LMTSAGWNDVLESLM-IQPPDCDP-FIH--GHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAI 2307
            :.|||||:.:|..:: .:|||||| .:|  ....|:||:|.:.|.||.|:||||:::|:|||||:
Human  1694 ITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAV 1758

  Fly  2308 ILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVAL 2372
            |||||:.|.:|....:.|||.||||..|.|:||.|||||.||:||||.|:|||||.|:|||.|.|
Human  1759 ILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQL 1823

  Fly  2373 VSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRI 2437
            ::.:||:..|::|||||||.|..|.|||...|.|:   |:.||:.:|....|::...|.:::|..
Human  1824 IAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDS---LRSQMEERFMSANPSKVSYEPITTTLK 1885

  Fly  2438 WKRQEKAAKTIQTGWKEYLRRKREKERS--------------------------NSG----DSAT 2472
            .|:::.:|..||..::.|..|:..|..|                          ||.    |:.:
Human  1886 RKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLLNKKDMAFDNVNENSSPEKTDATS 1950

  Fly  2473 QTSSPGGWQS 2482
            .|:||..:.|
Human  1951 STTSPPSYDS 1960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	115/264 (44%)
		Ion_trans	687..902	CDD:459842	120/218 (55%)
		Ion_trans	1751..2019	CDD:459842	153/275 (56%)
		Na_channel_gate	2009..2063	CDD:240441	30/53 (57%)
		Ion_trans	2067..2320	CDD:459842	133/256 (52%)
		GPHH	2332..2378	CDD:465306	28/45 (62%)
SCN9A	NP_001352465.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	26..55		1/7 (14%)
		I. /evidence=ECO:0000305	112..410		141/310 (45%)
		Ion_trans	125..410	CDD:459842	136/297 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	461..543		25/103 (24%)
		Na_trans_cytopl	535..694	CDD:463401	27/160 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	565..611		8/45 (18%)
		II. /evidence=ECO:0000305	726..989		146/477 (31%)
		Ion_trans	743..956	CDD:459842	118/215 (55%)
		Na_trans_assoc	982..1187	CDD:461936	67/616 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1102..1148		14/156 (9%)
		III. /evidence=ECO:0000305	1180..1488		166/309 (54%)
		Ion_trans	1191..1466	CDD:459842	151/274 (55%)
		Na_channel_gate	1458..1510	CDD:240441	30/53 (57%)
		IV. /evidence=ECO:0000305	1497..1795		151/297 (51%)
		Ion_trans	1514..1770	CDD:459842	132/255 (52%)
		GPHH	1782..1829	CDD:465306	29/46 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1934..1988		7/27 (26%)