Protein Alignment NaCP60E and SCN8A

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_055006.1
• Gene: SCN8A / 6334
• HGNCID: 10596
• Length: 1980
• Species: Homo sapiens
• Alignment Length: 2658
• Identity: 823/2658 - (30%)
• Similarity: 1176/2658 - (44%)
• Gaps: 871/2658 - (32%)

  Fly    45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFL 108
            |:..:.:|.|..||..:...|:.:...|||:.|. ::.::||.|::   |...:.||:.|.:|::
Human    53 PKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLN---RGKTLFRFSATPALYI 114

  Fly   109 FYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIA 170
            ..|::..||:.:.|..:..|...:|.|||.||:|:..:   :..:..||.|..||:.|.::||||
Human   115 LSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIA 179

  Fly   171 KGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINAL 235
            :||.::.:|:||:|||||||.||...|.|..:.:||::.||||||||||||:|::||||||:.||
Human   180 RGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 244

  Fly   236 LHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWT---NVSHT-------DWQI 290
            :.|.::|::||.||:|||.||||..||::||.||||||     .|.   |.|:.       ||:.
Human   245 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCV-----VWPINFNESYLENGTKGFDWEE 304

  Fly   291 WVNDTDNWLYDEDEL-PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITL 354
            ::|:..|:......| |:||||.:.|..||..|.|:..|.|||:|||:||.|.|:.|..|:|:|.
Human   305 YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQ 369

  Fly   355 DYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRD 419
            |||||:|.:.|...|...:.||.:|:|.|||||:||:|||||::|||:.:.|.||.:      :.
Human   370 DYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAE------QK 428

  Fly   420 DSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDN 484
            ::.|         |.:.:..||:.:..:...:|:.:...:.....:.|:|||.:..   |:.:.:
Human   429 EAEF---------KAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPR---SSSEIS 481

  Fly   485 KSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQ---HKLAKSGS-GGSNNPMAPTPKGRI 545
            |..|          .||.||.:....:.||:..:.|::   .|:.||.| .|........|..||
Human   482 KLSS----------KSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRI 536

  Fly   546 S-----FQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTN 605
            .     ...|.:.:.....|...:.|..:.:..|.......|...|.:.|:...|::.|
Human   537 GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESE------ 595

  Fly   606 DMGHVSTVELALSPREVR------------------------------LIKCNGNIARI---KNH 637
              |...::.:.:..||.|                              .:.|||.::.|   .:|
Human   596 --GRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSH 658

  Fly   638 NVYALHQEFSSEV-----------------------------------VVIDDLPD--RNCDRCV 665
            ....|..|.::||                                   .::::|.:  |.|..|.
Human   659 IGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCW 723

  Fly   666 H--------W-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALD 721
            :        | |..|  |::.:..:..:|.||..:||||:||||||.|:|||||.|:..|.:.|.
Human   724 YKFANTFLIWECHPY--WIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLA 786

  Fly   722 VGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRV 785
            |||.|||.|||.|..:||:|:.. .:|..||||||..||:.||:::....|:||||||..|||||
Human   787 VGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRV 851

  Fly   786 LKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPR 847
            .|||:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|..  .|.:.| .:||
Human   852 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPR 916

  Fly   848 WNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLN 912
            |:.:||||||:::||:|||||||.:||||   |..|.:.|..:|:..:|:||.:||||||||||:
Human   917 WHMHDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLS 978

  Fly   913 SFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTL 977
            ||:::.|.:..:: ||.:.|..|:.|:     ||.......|...|           .|||.:.
Human   979 SFSADNLAATDDD-GEMNNLQISVIRI-----KKGVAWTKLKVHAF-----------MQAHFKQ- 1025

  Fly   978 SHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDL 1042
                    ...|:...|.|.      |::..|...:              ||   |.:....||.
Human  1026 --------READEVKPLDEL------YEKKANCIAN--------------HT---GADIHRNGDF 1059

  Fly  1043 PEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVS 1107
            .:                                   |||||
Human  1060 QK-----------------------------------NGNGT----------------------- 1066

  Fly  1108 TQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFL 1172
                                              .||.||          |..:|..:|...:|:
Human  1067 ----------------------------------TSGIGS----------SVEKYIIDEDHMSFI 1087

  Fly  1173 KYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNL 1237
            . ..:|..|.|
Human  1088 N-NPNLTVRVP------------------------------------------------------ 1097

  Fly  1238 REELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSF 1302
                                                              ..|..|:|:|:
Human  1098 --------------------------------------------------IAVGESDFENL---- 1108

  Fly  1303 EKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYD 1367
              ..|::           |:.|:|..:.|
Human  1109 --NTEDV-----------SSESDPEGSKD------------------------------------ 1124

  Fly  1368 LSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAAT 1432
                                           |:|:                             |
Human  1125 -------------------------------KLDD-----------------------------T 1129

  Fly  1433 SASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPD 1497
            |:|:.                      ..:.:...|||||
Human  1130 SSSEG----------------------STIDIKPEVEEVP------------------------- 1147

  Fly  1498 QLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAAL 1562
                                                                             
Human  1148 ----------------------------------------------------------------- 1147

  Fly  1563 TEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAA 1627
                                                  :|.|:..||
Human  1148 --------------------------------------VEQPEEYLD------------------ 1156

  Fly  1628 DASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPM 1692
                                                                             
Human  1157 ----------------------------------------------------------------- 1156

  Fly  1693 TFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSC---MDTQSAKHWTRVRTAVLTVVDTPAFE 1754
                         ||.||.:.|...  |:|     |   ::....|.|..:|.....:|:...||
Human  1157 -------------PDACFTEGCVQR--FKC-----CQVNIEEGLGKSWWILRKTCFLIVEHNWFE 1201

  Fly  1755 WFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTI 1819
            .|::.:|..||..|.||||.:::.||::.:|.:.:..|..||::||:|||.|.||.|:||:.|..
Human  1202 TFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCW 1266

  Fly  1820 LDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVL 1882
            |||:||.||:.||:...  ...|..::|||||||||||||:||::|||:|||||:.|||||.|||
Human  1267 LDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1331

  Fly  1883 LVCLVFWLIFSIMGVQFFGGKFFKCVNEMGEL-LPITEVNDKWDC---IEQNYT---WINSKITF 1940
            ||||:||||||||||..|.||:..|.||..|: ..|.:||:|.:|   :|.|.|   |.|.||.|
Human  1332 LVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINF 1396

  Fly  1941 DHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIG 2005
            |:||.|||||||||||:|||::|..|||:|..|.||:.|.|:|.||||||||:.|||||||||||
Human  1397 DNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIG 1461

  Fly  2006 VIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRF 2070
            |||||||..|||:.|  .::|:||.||.||.||||||.|||||.|.||:|....:.:|....:.|
Human  1462 VIIDNFNQQKKKFGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAF 1524

  Fly  2071 EIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFD 2135
            :|.|.:||.|||:||.:|...|...:..||...|..|...|..|.::|:..||::|||:.||:||
Human  1525 DIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFD 1589

  Fly  2136 FLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNI 2200
            |::|:.||.|:.:.||:....:||||.||:|:.||||||||||.|||||.|||||::||||||||
Human  1590 FVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1654

  Fly  2201 GALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPP 2265
            |.||.|:.||::|.|||.|..||.:..:|||.||:|||.||..||::.|||||:.:|..::.:||
Human  1655 GLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPP 1719

  Fly  2266 DC--DPFIHGH-TNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDD 2327
            ||  |....|. ..|:||:|.:.|.:|.|:||||::||:|||||||||||:.|.:|....:.|||
Human  1720 DCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDD 1784

  Fly  2328 LEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILH 2392
            .|.||..|.|:||.|||||.:.:|:||..:|:.||.:.|||.:.|::.:||:..|::|||||||.
Human  1785 FETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILF 1849

  Fly  2393 ALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLR 2457
            |..|.|||...|.|   .|::||:.:|....|::...|.:::|...|::|.:|..:|..::.:|
Human  1850 AFTKRVLGDSGELD---ILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHL- 1910

  Fly  2458 RKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASS----------RKSSR 2512
                                                 :|||..|....|:          :|.|.
Human  1911 -------------------------------------ARRGFICKKTTSNKLENGGTHREKKEST 1938

  Fly  2513 ASDASDLSELAGPWLNLPLMLVSGADEVVK--DIKQQNDELGKRGSIFVEAPRASRRR 2568
            .|.||           ||     ..|.|.|  ..|||..|.|:|       .||.|::
Human  1939 PSTAS-----------LP-----SYDSVTKPEKEKQQRAEEGRR-------ERAKRQK 1973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	121/259 (47%)
		Ion_trans	687..902	CDD:459842	118/218 (54%)
		Ion_trans	1751..2019	CDD:459842	161/276 (58%)
		Na_channel_gate	2009..2063	CDD:240441	30/53 (57%)
		Ion_trans	2067..2320	CDD:459842	133/255 (52%)
		GPHH	2332..2378	CDD:465306	20/45 (44%)
SCN8A	NP_055006.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..62		2/8 (25%)
		I. /evidence=ECO:0000305	114..442		150/347 (43%)
		Ion_trans	131..421	CDD:459842	140/294 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..530		20/96 (21%)
		Na_trans_cytopl	546..702	CDD:463401	22/163 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	568..602		7/41 (17%)
		II. /evidence=ECO:0000305	735..1007		141/282 (50%)
		Ion_trans	752..965	CDD:459842	116/215 (54%)
		Na_trans_assoc	991..1192	CDD:461936	72/822 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1107..1148		16/303 (5%)
		III. /evidence=ECO:0000305	1180..1495		176/316 (56%)
		Ion_trans	1197..1473	CDD:459842	159/275 (58%)
		Na_channel_gate	1465..1517	CDD:240441	30/53 (57%)
		IV. /evidence=ECO:0000305	1504..1801		149/296 (50%)
		Ion_trans	1522..1776	CDD:459842	132/253 (52%)
		IQ	1894..1915	CDD:197470	6/58 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1922..1980		20/75 (27%)