|
Fly 10 DEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLE 74
:::||.:...:...::.:::...| :.::.:|.|..||..:...|..:.|.|||
Human 29 EQRAVEEEARLQRNKQMEIEEPER------------KPRSDLEAGKNLPMIYGDPPPEVIGIPLE 81
Fly 75 EIDTFI-YEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILF 138
::|.:. .::||.|::| ...|.||:.|.:|:|..|:|..||..:.:..:..|...:|.|||.
Human 82 DLDPYYSNKKTFIVLNK---GKAIFRFSATPALYLLSPFSVVRRGAIKVLIHALFSMFIMITILT 143
Fly 139 NCIFLAMTET---VEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATI 200
||:|:.|::. .:..||.|..||:.|.:|||:|:||.::.:|:||:|||||||.||...|.|.
Human 144 NCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTE 208
Fly 201 GMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYM 265
.:::||::.||||||||||||::::||||||:.||:.|.::|::||.||:|||.||||..||::|
Human 209 FVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFM 273
Fly 266 GELRNKCVRQVP------TDW----------------------------TNVSHTDWQIWVNDTD 296
|.||.||||..| |.| |..||..|. .|||.
Human 274 GNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWNSHASWA--TNDTF 336
Fly 297 NW-LYDEDE----------LPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQ 350
:| .|..|| ..:||||.:.|.|||..|.|:..|.|||:|||::|.|.|:.|..|:
Human 337 DWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFR 401
Fly 351 LITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLL 415
|:|.|||||::.:.|...|...:.||.|::|.||||||||:|||||::|.|:.|.|..|
Human 402 LMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAE------ 460
Fly 416 DHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGK--EGGTNGNGNG 478
|...:..|. .:|..:.|.:...:|.|..: |||.
Human 461 DKEKEEEFQ------------------------QMLEKFKKHQEELEKAKAAQALEGGE------ 495
Fly 479 SNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKG 543
::|| |.|.
Human 496 ADGD--------------PAHG------------------------------------------- 503
Fly 544 RISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMG 608
.|..|.|..:.|: .|..|:||..|||:.|..||.:..
Human 504 -------------------KDCNGSLDTSQGE-----KGAPRQSSSGDSGISDAMEELEEA---- 540
Fly 609 HVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCD----RCVH--- 666
||: |. :|.|
Human 541 ----------------------------------HQK---------------CPPWWYKCAHKVL 556
Fly 667 -W--CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFT 728
| |. .||:|:|.::.:|.||..:|.||:||||||.|:||||:.|:|.|.|.|.|||.|||
Human 557 IWNCCA---PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFT 618
Fly 729 SIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSW 792
.|||.|.::||:|:.. ::|..||||||.:|||.||:::....|.||||||..|||||.|||:||
Human 619 GIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSW 683
Fly 793 TTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPRWNFNDFF 854
.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|.. .|...| .:|||:.:|||
Human 684 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFF 748
Fly 855 HSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEEL 919
|||:::||||||||||.:|||| |..|.:.|..:||..:|:||.:||||||||||:||:::.|
Human 749 HSFLIVFRILCGEWIETMWDCM---EVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSL 810
Fly 920 KSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVG 984
.:..|: ||.:.|..:|.|::..| .||:.|...:| |.:.||
Human 811 AASDED-GEMNNLQIAIGRIKLGI-------------GFAKAFLLGLL-----HGKILS------ 850
Fly 985 LERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQ 1049
|:.|.|
Human 851 ----------------------------------------------------------PKDIML- 856
Fly 1050 AHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSR 1114
|....:|.|
Human 857 -------------------------SLGEADGAG------------------------------- 865
Fly 1115 EEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLL 1179
Human 866 ----------------------------------------------------------------- 865
Fly 1180 TRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNC 1244
.:|::..:..:.|:.|
Human 866 ---------------EAGEAGETAPEDEKKE---------------------------------- 881
Fly 1245 DQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEI 1309
..||:|:| ||
Human 882 ---------PPEEDLKK----------------------------------DN------------ 891
Fly 1310 KRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRR 1374
.|:.|:.:..| |..|.:|.
Human 892 --------------------------HILNHMGLADG---------------PPSSLELD----- 910
Fly 1375 SQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQP 1439
|..|:
Human 911 -------------------------------------------HLNFI----------------- 915
Fly 1440 NQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSL 1504
.:|:|..:|...:.:.|. |:|.||:..:....|..|.| |..|...:.
Human 916 -NNPYLTIQVPIASEESDL-----------EMPTEEETDTFSEPEDSKKP------PQPLYDGNS 962
Fly 1505 SLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHF 1569
|:.||..| :||.
Human 963 SVCSTADY------------------------------KPPE----------------------- 974
Fly 1570 HATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALA 1634
|.|:
Human 975 --------------------------------EDPE----------------------------- 978
Fly 1635 LAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGA 1699
||::.. |:..|....||....:.|.|| ||| .|||
Human 979 -------EQAEEN-PEGEQPEECFTEACVQRWPCL--YVD--------ISQG------------- 1012
Fly 1700 TKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFAS 1764
..|.|..:|.|...:|:...||.|::.:|..|
Human 1013 ---------------------------------RGKKWWTLRRACFKIVEHNWFETFIVFMILLS 1044
Fly 1765 SITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSV 1829
|..|.||||.:::.:.::.:|.:.:..|..||::||:|||:|.||..|||:.|..|||:||.||:
Human 1045 SGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSI 1109
Fly 1830 FSLLIE--ENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIF 1892
.||:.. ....|..::|||||||||||||:||::|||:|||||:.|||||.|||||||:|||||
Human 1110 ISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIF 1174
Fly 1893 SIMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDCIEQNYT----WINSKITFDHVGMGYLALLQ 1952
|||||..|.|||:.|:| ...|...|:|||:|.:|....:| |:|.|:.:|:||:|||:|||
Human 1175 SIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQ 1239
Fly 1953 VATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKK 2017
||||:|||::|..|||:|..:.|||.|.|||.|:||||||:.||||||||||||||||||..|||
Human 1240 VATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1304
Fly 2018 YEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNM 2082
..| .::|:||.||.||.||||||.|||||.|.||.|....|.|||...:.|:|.|.:||.|||
Human 1305 LGG--KDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNM 1367
Fly 2083 LTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGIL 2147
:||.:|..:|......||...|..|..:|..|.::|::.||.:||||.||:|||::|:.||.|:.
Human 1368 VTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLA 1432
Fly 2148 MEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYA 2212
:.|::....:||||.||:|:.||||:||||:.|||||.|||||::|||||||||.||.|:.|||:
Human 1433 LSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYS 1497
Fly 2213 ILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQ-PPDCDPFIHG--- 2273
|.|||.|..||.:..:|||.||:|||.|:..||.:.|||||:.:|..::.. ||||||.:..
Human 1498 IFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGT 1562
Fly 2274 HTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKY 2338
...|:||:|.:.|.:|.|:||||::||:||||||||||||.|.:|....:.|||.||||..|.|:
Human 1563 SVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKF 1627
Fly 2339 DPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVE 2403
||.|||||.:|:||||:.:|..||.|:|||.:.|::.:||:..|:||||||||.||.|.|||...
Human 1628 DPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSG 1692
Fly 2404 ETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERS--- 2465
|.|..||..|: ||....|::...|.:::|...|.:|..|..||..::.:|.::..|:.|
Human 1693 EMDALKQTMEE---KFMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMY 1754
Fly 2466 -----NSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAGP 2525
.|||.|.: :..|.|.....:.....|. ||..|..:...|.| |||
Human 1755 RHSHDGSGDDAPE-------KEGLLANTMSKMYGHENGN--SSSPSPEEKGEAGD-------AGP 1803
Fly 2526 WLNLPLMLVSGAD 2538
.:.||.:|.:|
Human 1804 --TMGLMPISPSD 1814
| 
