Protein Alignment NaCP60E and SCN3A

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_008853.3
• Gene: SCN3A / 6328
• HGNCID: 10590
• Length: 2000
• Species: Homo sapiens
• Alignment Length: 2638
• Identity: 829/2638 - (31%)
• Similarity: 1183/2638 - (44%)
• Gaps: 857/2638 - (32%)

  Fly    11 EKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLEE 75
            ||..|:.:.....:......||:           |:..:.:|.|..||..:...|..|..:|||:
Human    26 EKRAAEEKAKKPKKEQDNDDENK-----------PKPNSDLEAGKNLPFIYGDIPPEMVSEPLED 79

  Fly    76 IDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFN 139
            :|. :|.::||.|::|   ...|.||:.|.:|::..|.:|.|::.:.|..:..|...:|.|||.|
Human    80 LDPYYINKKTFIVMNK---GKAIFRFSATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTN 141

  Fly   140 CIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIG 201
            |:|:.::   :..:..||.|..||:.|.:|||:|:||.|..:|:||:|||||||.||...|.|..
Human   142 CVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEF 206

  Fly   202 MEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMG 266
            :::||::.||||||||||||:|::||||||:.||:.|.::|::||.||:|||.||||..||::||
Human   207 VDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271

  Fly   267 ELRNKCVRQVPTD--------------------WTNV--SHTDWQIWVNDTDN-WLYDEDELPVL 308
            .|||||::..|:|                    :.||  |..:|:.::.|..: ::.|..:.|:|
Human   272 NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLL 336

  Fly   309 CGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSV 373
            |||.:.|..||..|:|:..|.|||:|||:||.|.|:.|:.|:|:|.|||||:|.:.|...|...:
Human   337 CGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYM 401

  Fly   374 SFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKN 438
            .||.:|:|.|||||:||:|||||::|||:.:.|.||        .:.....|...:..:||..:.
Human   402 IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEE--------AEQKEAEFQQMLEQLKKQQEE 458

  Fly   439 NKKKI--------------------DSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDD 483
            .:...                    .|.:...|:|.|.|:.|.::.|..:.....||..|.....
Human   459 AQAVAAASAASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSF 523

  Fly   484 NKSHSATPSPGPSPRHSATERPSAL------TMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPK 542
            .||.|          ..:.:|.|.|      .:.:.|::.   ..|:...|..|...:|...:..
Human   524 PKSES----------EDSVKRSSFLFSMDGNRLTSDKKFC---SPHQSLLSIRGSLFSPRRNSKT 575

  Fly   543 GRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDM 607
            ...||:.....|.:.|     |:         ....:|:..:.||.:|...|...|.|:..:|
Human   576 SIFSFRGRAKDVGSEN-----DF---------ADDEHSTFEDSESRRDSLFVPHRHGERRNSN-- 624

  Fly   608 GHVSTVELALSPREV----------RLIKCNGNIA--------------------------RIKN 636
              ||  :.::|.|.|          ..:.|||.::                          |.:.
Human   625 --VS--QASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGPSALTSPTGQLPPEGTTTETEVRKRR 685

  Fly   637 HNVYALHQEFSSE--------------VVVIDDLPD--RNCDRCVH--------W-CTDYESWLQ 676
            .:.|.:..|...:              ...:::|.:  :.|..|.:        | |.|  :||:
Human   686 LSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCD--AWLK 748

  Fly   677 FQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMA 741
            .::.:..:|.||..:||||:||||||.|:||||:.|:|.|.:.|.|||.|||.|||.|.::|::|
Human   749 VKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA 813

  Fly   742 LSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIIST 805
            :.. .:|..||||||.:||:.||:::....|:||||||..|||||.|||:||.|:.:|:.||.::
Human   814 MDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNS 878

  Fly   806 IGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPRWNFNDFFHSFMMIFRILCGE 867
            :||||||||:|.|:::||||:|||||.|.|..  .|.:.| .:|||:.|||||||:::||:||||
Human   879 VGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE 943

  Fly   868 WIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKL 932
            |||.:||||   |..|.:.|..:|:..:|:||.:||||||||||:||:|:.|.:..:: .|.:.|
Human   944 WIETMWDCM---EVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDD-NEMNNL 1004

  Fly   933 ARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAET 997
            ..::.|:        |:..|..:.|..|.||:...                     .||.|
Human  1005 QIAVGRM--------QKGIDYVKNKMRECFQKAFF---------------------RKPKV---- 1036

  Fly   998 KFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPP 1062
                                   |.:|:|                                   .
Human  1037 -----------------------IEIHEG-----------------------------------N 1043

  Fly  1063 TYESAMMATTGGSFSSV-----NGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTES 1122
            ..:|.|...||...|..     :||||                  :|||.|
Human  1044 KIDSCMSNNTGIEISKELNYLRDGNGT------------------TSGVGT-------------- 1076

  Fly  1123 IELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRK 1187
                                                                             
Human  1077 ----------------------------------------------------------------- 1076

  Fly  1188 SLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQF 1252
                                         |.|:....|::::.:|...|
Human  1077 -----------------------------GSSVEKYVIDENDYMSFINN---------------- 1096

  Fly  1253 LQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQ---SFEKELEEIKRSTT 1314
                                    ||..:..|   ..|..|:|:|:..   |.|.||||.|....
Human  1097 ------------------------PSLTVTVP---IAVGESDFENLNTEEFSSESELEESKEKLN 1134

  Fly  1315 SLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVS 1379
            :                             |.:||.|..| ||||
Human  1135 A-----------------------------TSSSEGSTVD-VVLP-------------------- 1149

  Fly  1380 AAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPF 1444
                |:.
Human  1150 ----REG---------------------------------------------------------- 1152

  Fly  1445 LRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKST 1509
                                 |:.|..|||:
Human  1153 ---------------------EQAETEPEED---------------------------------- 1162

  Fly  1510 NSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSI 1574
                                                       ||
Human  1163 -------------------------------------------LK-------------------- 1164

  Fly  1575 QAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQ 1639
                                                                             
Human  1165 ----------------------------------------------------------------- 1164

  Fly  1640 KTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAK 1704
                                                                             
Human  1165 ----------------------------------------------------------------- 1164

  Fly  1705 VPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLC 1769
             |:.||.:.|...|    |:.....:....|.|..:|....::|:...||.|::.:|..||..|.
Human  1165 -PEACFTEGCIKKF----PFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALA 1224

  Fly  1770 FEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLI 1834
            ||||.:::.||:|.:|.:.:..|..||::||:|||:|.||..|||:.|..|||:||.||:.||:.
Human  1225 FEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVA 1289

  Fly  1835 EE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGV 1897
            ..  ...|..::|||||||||||||:||::|||:|||||:.|||||.|||||||:||||||||||
Human  1290 NALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGV 1354

  Fly  1898 QFFGGKFFKCVN-EMGELLPITEVNDKWDC--IEQNYTWINSKITFDHVGMGYLALLQVATFEGW 1959
            ..|.|||:.||| ..|.:..|::||:..||  :.:...|.|.|:.||:||.|||||||||||:||
Human  1355 NLFAGKFYHCVNMTTGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGW 1419

  Fly  1960 MEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLE 2024
            |::|..|||:|.|.|||..|.|||.|:||||||:.||||||||||||||||||..|||:.|  .:
Human  1420 MDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG--QD 1482

  Fly  2025 MFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEH 2089
            :|:||.||.||.||||||.|||||.|.||.|.|..|.:|....:.|:|:|.:||.|||:||.:|.
Human  1483 IFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVET 1547

  Fly  2090 YDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMID 2154
            .||...:..:|...|..|..:|..|.::|:|.||::|||:.||:|||::|:.||.|:.:.:::..
Human  1548 DDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEK 1612

  Fly  2155 LPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLF 2219
            ..:||||.||:|:.||||||||||.|||||.|||||::|||||||||.||.|:.|||||.|||.|
Human  1613 YFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF 1677

  Fly  2220 GNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLM-IQPPDCDP-FIH--GHTNGNCG 2280
            ..||.:..:|||.||:|||.||..||::.|||||:.:|..:: ..|||||| .||  ....|:||
Human  1678 AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCG 1742

  Fly  2281 HPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQF 2345
            :|.:.|.:|.|:||||:::|:|||||:|||||:.|.:|....:.|||.||||..|.|:||.||||
Human  1743 NPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQF 1807

  Fly  2346 IHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQ 2410
            |.||:||||.|:|||||.|:|||.|.|::.:||:..|::|||||||.|..|.|||...|.|   .
Human  1808 IEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMD---A 1869

  Fly  2411 LQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNS-------- 2467
            |:.||:.:|....|::...|.:::|...|::|.:|..||..::.||.::|.|..|::
Human  1870 LRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKG 1934

  Fly  2468 -----------------------GDSATQTSSPGGWQS 2482
                                   .|.::.|:||..:.|
Human  1935 RIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDS 1972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	121/271 (45%)
		Ion_trans	687..902	CDD:459842	118/218 (54%)
		Ion_trans	1751..2019	CDD:459842	160/272 (59%)
		Na_channel_gate	2009..2063	CDD:240441	32/53 (60%)
		Ion_trans	2067..2320	CDD:459842	134/256 (52%)
		GPHH	2332..2378	CDD:465306	28/45 (62%)
SCN3A	NP_008853.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..60		6/42 (14%)
		I. /evidence=ECO:0000305	110..455		149/352 (42%)
		Ion_trans	127..434	CDD:459842	140/306 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	493..528		10/34 (29%)
		Na_trans_cytopl	558..710	CDD:463401	27/171 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	587..631		13/63 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	662..681		0/18 (0%)
		II. /evidence=ECO:0000305	742..1014		141/285 (49%)
		Ion_trans	759..972	CDD:459842	116/215 (54%)
		Na_trans_assoc	998..1200	CDD:461936	73/827 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1118..1162		21/176 (12%)
		III. /evidence=ECO:0000305	1188..1499		175/312 (56%)
		Ion_trans	1205..1477	CDD:459842	158/271 (58%)
		Na_channel_gate	1469..1521	CDD:240441	32/53 (60%)
		IV. /evidence=ECO:0000305	1508..1806		153/297 (52%)
		Ion_trans	1525..1781	CDD:459842	133/255 (52%)
		GPHH	1793..1840	CDD:465306	29/46 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1949..2000		5/24 (21%)