|
Fly 45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFL 108
|:..:.:|.|..||..:...|..|..:|||::|. :|.::||.|::| ...|.||:.|.:|::
Human 49 PKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNK---GKAIFRFSATSALYI 110
Fly 109 FYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIA 170
..|::|.|::.:.|..:..|...:|.|||.||:|:.|: :..:..||.|..||:.|.:|||||
Human 111 LTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIA 175
Fly 171 KGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINAL 235
:||.|..:|:||:|||||||.|||..|.|..:::||::.||||||||||||:|::||||||:.||
Human 176 RGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240
Fly 236 LHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHT-------------- 286
:.|.::|::||.||:|||.||||..||::||.|||||::..||:.:...|:
Human 241 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLI 305
Fly 287 -------DWQIWVNDTDNWLYDEDEL-PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMW 343
||:.::.|:....:.|..| .:||||.:.|..||..|:|:..|.|||:|||:||.|.|
Human 306 NETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSW 370
Fly 344 SMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNE 408
:.|:.|:|:|.|:|||:|.:.|...|...:.||.:|:|.||||||||:|||||::|||:.:.|.|
Human 371 AFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLE 435
Fly 409 ERKK---------DLLDHRDD----------STFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASY 454
|.:: :.|..:.: |..|.:||.......:.:...|:.|: |.
Human 436 EAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSSEASKLSSK------SA 494
Fly 455 SKKKTRRKKTKGGKEGGTNGNGNGSNGDD-NKSHSAT----------------------PSPGP- 495
.:::.||||.|..::.| |...:.|: .||.|.. .||..
Human 495 KERRNRRKKRKQKEQSG----GEEKDEDEFQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQS 555
Fly 496 ---------SPRHSATERPSALTMQAQ-----KQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRIS 546
|||.:: |.|..:.:.: .:....:.:|...:......::...|...|...
Human 556 LLSIRGSLFSPRRNS--RTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERR 618
Fly 547 FQDSGMGVKNPNML--YPSDYK-------GQLIANSGQPSSNSSGVNR--------ESSQDDSGV 594
..:.....::..|| :|::.| ..:::..|.||..:|.|.: :.:.||:|.
Human 619 NSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNGT 683
Fly 595 VDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDR 659
..:.|.:...:...|||...|....:..|.: :||.|..:.|..|.:. .:
Human 684 TTETEMRKRRSSSFHVSMDFLEDPSQRQRAM----SIASILTNTVEELEES------------RQ 732
Fly 660 NCDRCVH--------W-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSES 715
.|..|.: | |:.| ||:.::.:..||.||..:||||:||||||.|:||||:.|::.
Human 733 KCPPCWYKFSNIFLIWDCSPY--WLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDH 795
Fly 716 FRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRG 779
|.|.|.|||.|||.|||.|..:|::|:.. .:|..||||||..|||.||:::....|:||||||.
Human 796 FNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRS 860
Fly 780 LRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDP 842
.|||||.|||:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|.. .|...
Human 861 FRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIAS 925
Fly 843 D-PVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLF 906
| .:|||:.|||||||:::||:|||||||.:|||| |..|.:.|..:|:..:|:||.:|||||
Human 926 DCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQAMCLTVFMMVMVIGNLVVLNLF 987
Fly 907 LALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQ 971
|||||:||:::.|.:..:: .|.:.|..:::|:...:...: ||..|..||..:..|:
Human 988 LALLLSSFSADNLAATDDD-NEMNNLQIAVDRMHKGVAYVK--------RKIYEFIQQSFIRKQK 1043
Fly 972 AHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEY 1036
:|.|.| ||.|
Human 1044 ---------------------ILDEIK-----------------------PLDD----------- 1053
Fly 1037 DDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQ 1101
:|
Human 1054 ------------------------------------------LN--------------------- 1055
Fly 1102 ISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEE 1166
|:.||...|.:...|
Human 1056 -----------------------------------------------NKKDSCMSNHTAEIG--- 1070
Fly 1167 HDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELL 1231
|.||.|...:|.:... .:|.|:....|::.:.:
Human 1071 --------------------KDLDYLKDVNGTTSGI------------GTGSSVEKYIIDESDYM 1103
Fly 1232 SQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFD 1296
|...| ||..:..| ..|..|:|:
Human 1104 SFINN----------------------------------------PSLTVTVP---IAVGESDFE 1125
Fly 1297 NI-IQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPL 1360
|: .:.|..| :.||.....|:|.|.:::.:|..| ||
Human 1126 NLNTEDFSSE--------SDLEESKEKLNESSSSSEGSTVDI--------GA------------- 1161
Fly 1361 NPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAME 1425
Human 1162 ----------------------------------------------------------------- 1161
Fly 1426 AMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPR 1490
|.||:|:
Human 1162 ----------------------------------------------PVEEQPV------------ 1168
Fly 1491 KFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKT 1555
:|
Human 1169 ---------------------------------------------------VE------------ 1170
Fly 1556 TPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTE 1620
|:.||:
Human 1171 ------------------------------------------------PEETLE----------- 1176
Fly 1621 SHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQ 1685
Human 1177 ----------------------------------------------------------------- 1176
Fly 1686 GAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSC---MDTQSAKHWTRVRTAVLTV 1747
|:.||.:.|... |:| | ::....|.|..:|.....:
Human 1177 --------------------PEACFTEGCVQR--FKC-----CQINVEEGRGKQWWNLRRTCFRI 1214
Fly 1748 VDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKY 1812
|:...||.|::.:|..||..|.||||.:|:.||:|.:|.:.:..|..||::||:|||:|.|:..|
Human 1215 VEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTY 1279
Fly 1813 FTSFWTILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAI 1875
||:.|..|||:||.||:.||.... ...|..::|||||||||||||:||::|||:|||||:.||
Human 1280 FTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAI 1344
Fly 1876 PSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDC---IEQNYT--WI 1934
|||.|||||||:||||||||||..|.|||:.|:| ..|:...|.:||:..|| ||:|.| |.
Human 1345 PSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWK 1409
Fly 1935 NSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFT 1999
|.|:.||:||.|||:|||||||:|||::|..|||:|.|:|||:.|.:||.|:||||||:.|||||
Human 1410 NVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFT 1474
Fly 2000 LNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDL 2064
|||||||||||||..|||:.| .::|:||.||.||.||||||.|||||.|.||.|.|..|.:|.
Human 1475 LNLFIGVIIDNFNQQKKKFGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDF 1537
Fly 2065 SNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTV 2129
...:.|:|:|.:||.|||:||.:|..||...|..||...|..|..:|..|.::|::.||::|||:
Human 1538 VTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTI 1602
Fly 2130 PWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSL 2194
.||:|||::|:.||.|:.:.:::....:||||.||:|:.||||||||||.|||||.|||||::||
Human 1603 GWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSL 1667
Fly 2195 PALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLES 2259
|||||||.||.|:.|||||.|||.|..||.:..:|||.||:|||.||..||::.|||||:.:|..
Human 1668 PALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1732
Fly 2260 LM-IQPPDCDPFIHGHTN------GNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQ 2317
:: .:|||||| ...| |:||:|.:.|.:|.|:||||:::|:|||||:|||||:.|.:
Human 1733 ILNSKPPDCDP---NKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATE 1794
Fly 2318 EEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKG 2382
|....:.|||.||||..|.|:||.||||:.|.:||.|.|:|:|||.:.:||.:.|::.:||:..|
Human 1795 ESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSG 1859
Fly 2383 NKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKT 2447
::|||||||.|..|.|||...|.| .|:.||:.:|....|::...:.:::|...|::|.:|..
Human 1860 DRIHCLDILFAFTKRVLGESGEMD---ALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVI 1921
Fly 2448 IQTGWKEYLRRKREKERS 2465
||..::.:|.::..|:.|
Human 1922 IQRAYRRHLLKRTVKQAS 1939
| 
