Protein Alignment NaCP60E and scn5lab

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_001038588.1
• Gene: scn5lab / 566868
• ZFINID: ZDB-GENE-060908-3
• Length: 1954
• Species: Danio rerio
• Alignment Length: 2608
• Identity: 850/2608 - (32%)
• Similarity: 1191/2608 - (45%)
• Gaps: 836/2608 - (32%)

  Fly    45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDTFIYE--ETFCVVSKRFRKNYIHRFTGTKSLF 107
            |:.:|.:|.|..|||.|...|..:.|.|||:||.|.::  .||.|::|   ...|.||:.|.:|:
Zfish    49 PKPRADLEAGKQLPRIFGDIPSALVGVPLEDIDPFYFQNRRTFIVLNK---GKAIFRFSATSALY 110

  Fly   108 LFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMTETVEEA---EYIFLAIYSIEMVIKII 169
            :|.|:.|.||..:.|..:..|...:|.|||.||.|:||:|..:.|   ||.|..||:.|.:|||:
Zfish   111 IFSPFHPIRRASIRILVHSLFSLFIMCTILTNCCFMAMSEPAQWAKYVEYTFTGIYTFESLIKIL 175

  Fly   170 AKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINA 234
            |:||.:..:|:||:|||||||.||...|.|..:::||::.||||||||||||:|::||||||:.|
Zfish   176 ARGFCIGPFTFLRDPWNWLDFSVILMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240

  Fly   235 LLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQ--------VPT-----------DW 280
            |:.|.::||:||.||:|||.||||..||::||.||.||||.        :||           .|
Zfish   241 LIQSVKKLADVMILTVFCLSVFALIGLQLFMGNLRQKCVRSASQCLNTTLPTYNNSTFICNNRSW 305

  Fly   281 TNVSHTDWQIWVNDTDNWLYDE---DELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFM 342
            .::..     :.|:.||:...|   |.|  :|||.:.|..||..:.||..|.|||:|||:||.|.
Zfish   306 ASLEE-----FFNNEDNFFKVEGAKDAL--ICGNASDAGKCPDGFECLKTGRNPNYGYTSFDTFG 363

  Fly   343 WSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITN 407
            |:.|:.|:|:|.|||||:|:..|.:.|...:.||.||:|.|||||:||:|||||::|||:.:.|.
Zfish   364 WAFLSLFRLMTQDYWENLYHHTLRSAGKAYMVFFVVVIFLGSFYLVNLILAVVAMAYEEQNQATI 428

  Fly   408 EERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNK--KKIDSRKGVLLASYS------KKKTRRKKT 464
            .|..      :.:..|.     |.:::|.|..:  :|....:.:|.|..|      |.|..|:|:
Zfish   429 AEAL------QKEQEFQ-----LAMEQLKKEQQAAQKAQETESILTADVSPFSTQDKAKLERRKS 482

  Fly   465 KGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQ-------YQQMEQQ 522
            ......||        |:| |.....|..|....||...|  .|:::|:::       ::.:.:.
Zfish   483 SRPLSEGT--------GED-KPAKLDPIEGIKQTHSLLVR--TLSLRARRESAVSIFNFRPVNKD 536

  Fly   523 HKLAKSGSGGSNNP---------MAPTPKGRISFQDSGMGVKNPNMLYPS-DYKGQLIANSGQPS 577
            .:|..:....||:.         ..|..:.|.|.|.|..  .:....:|| :..|:|:....|..
Zfish   537 SELDFADDEFSNHGDSDSRGGALALPWSRRRTSAQSSCS--HSSQFFFPSFNINGKLMVAVEQNG 599

  Fly   578 SNSSG-------------VNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNG 629
            .:|.|             ...|..:::||       |:::|::   |::.|...|.|.|
Zfish   600 ISSQGPLTPMTPLTPLPACTMEKLKEESG-------QNSSNEL---SSMLLPQLPPEGR------ 648

  Fly   630 NIARIKNHNVYALHQEFSSEVVVIDDLPD-----RNCDRCVH--------WCTDYESWLQFQNCL 681
                         .:..|:...:.|.:.:     :.|..|.:        | |....||:.:..:
Zfish   649 -------------DRALSATSYITDAMEELEEAQQKCHPCWYVFAHKYLVW-TCSPRWLKVKEWV 699

  Fly   682 YKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-D 745
            ..:|.||..:||||:||||||.|:|:||:.|::.|...|.|||.|||.|||.|.::|::||.. .
Zfish   700 KIMVMDPFLDLAITICIVLNTLFMALEHYPMTDEFNRMLSVGNLVFTGIFTAEMVLKIIALDPYY 764

  Fly   746 FFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALG 810
            :|..||||||.|||:.||:::....|:||||||..|||||.|||:||.|:..|:.||.:::||||
Zfish   765 YFQQGWNIFDSLIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 829

  Fly   811 NLTLILVIVIYIFAVIGMQLFSKDY--TPEKFDPD-PVPRWNFNDFFHSFMMIFRILCGEWIEPL 872
            ||||:|.|:::||||:|||||.|:|  ...|...| .:|||:..||||||:::||:|||||||.:
Zfish   830 NLTLVLAIIVFIFAVVGMQLFGKNYDLCVCKISKDCTLPRWHMKDFFHSFLIVFRVLCGEWIETM 894

  Fly   873 WDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIE 937
            ||||   |..|...|..:|:..:|:||.:||||||||||:||:::.| |..:|.||.:.|..:|.
Zfish   895 WDCM---EVAGQPLCILVFMLVMVIGNLVVLNLFLALLLSSFSADNL-SAPDEDGEMNNLQIAIA 955

  Fly   938 RVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRL 1002
            |::..:...||...|.....|..:.|:    |::|.|.                     .|..||
Zfish   956 RIQRGMLWLRQALCDFFNGNFKRRRQK----AKEAKAM---------------------LKLKRL 995

  Fly  1003 SYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESA 1067
            :.                                            |||
Zfish   996 TQ--------------------------------------------QAH---------------- 1000

  Fly  1068 MMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNST 1132
                      ...||||                   :||.
Zfish  1001 ----------WAEGNGT-------------------AGVI------------------------- 1011

  Fly  1133 DTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSG 1197
                   ::.||.|| ...||...|.:                   ||.|         :..:.|
Zfish  1012 -------ERSSGAGS-GEDDSYMTNPN-------------------LTIS---------VPIAPG 1040

  Fly  1198 QSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKG 1262
            :|.                                                 .:|.:||:|
Zfish  1041 ESD-------------------------------------------------VEFPEEEDE---- 1052

  Fly  1263 TKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPS 1327
                                                    |::.||                |.|
Zfish  1053 ----------------------------------------EEDEEE----------------EAS 1061

  Fly  1328 PAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRR 1392
            .::||..:                       |..|.|...||
Zfish  1062 ASSDEEPE-----------------------PCKPRDDTSLS----------------------- 1080

  Fly  1393 SLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFD 1457
                     |..:|  ::||
Zfish  1081 ---------EGSTI--DLRK--------------------------------------------- 1089

  Fly  1458 RFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKL 1522
                          |.||:
Zfish  1090 --------------PGEEE---------------------------------------------- 1094

  Fly  1523 GMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHS 1587
                                                                             
Zfish  1095 ----------------------------------------------------------------- 1094

  Fly  1588 QAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDAT 1652
                                            :.:|..|.:|..
Zfish  1095 --------------------------------DEYSEMAEEAMD--------------------- 1106

  Fly  1653 QKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDH 1717
                                                                 |::|||..|..|
Zfish  1107 -----------------------------------------------------PENCFPDVCVRH 1118

  Fly  1718 FYFRCPWFMSCMDTQSA----KHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKN 1778
            |        .|.|..::    :.|.|:|.....:|:...||.|::.:|..||..|.||||.:|:.
Zfish  1119 F--------KCCDINTSEGLGRAWWRLRKTCYQIVEHSWFETFIIFMILLSSGALAFEDIYIDQR 1175

  Fly  1779 KTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEE--NENLK 1841
            |.:|.:|.:.:..|..||::||.|||:|.||.||||::|..|||:||.||:.||:...  ..:..
Zfish  1176 KVVKVILEYADKIFTYIFILEMSLKWIAYGFRKYFTNYWCWLDFLIVDVSLVSLVANTLGYSDFA 1240

  Fly  1842 VLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFK 1906
            .::|||||||||||||:||::|||:|||||:.|||||.|||||||:||||||||||..|.|||.:
Zfish  1241 AIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1305

  Fly  1907 CVNEMGELLPITEVNDKWDCIEQN---YTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVD 1968
            |||..|.:...:::|::.:|:|.|   |.|...|:.||:||.|||||||||||:||||:|..|||
Zfish  1306 CVNRTGFIYNSSDINNRSECLEMNSTQYYWTKVKVNFDNVGAGYLALLQVATFKGWMEIMYAAVD 1370

  Fly  1969 ARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKH 2033
            :|.|:.||.:|.:||.|:||||||:.||||||||||||||||||..|:|..|  .::|:||.||.
Zfish  1371 SRAVEEQPIKENSLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKRKLGG--QDIFMTEEQKK 1433

  Fly  2034 YYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFF 2098
            ||.||||||.|||||.|.||.|.....|:||.:.:.|:|.|.:||.|||:||.:|..:|..::..
Zfish  1434 YYNAMKKLGSKKPQKPIPRPPNPVQGFFFDLVSKQAFDILIMLLIILNMVTMMVETDEQSPSIKH 1498

  Fly  2099 ILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLR 2163
            ||:..|..|..:|..|.|:||:.||.::|||.||:|||::|:.||.||::.||:....:||||.|
Zfish  1499 ILDCINLVFIVIFTSECILKIIALRCYFFTVSWNIFDFVVVILSIVGIVLADIIEKYFVSPTLFR 1563

  Fly  2164 VVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGAL 2228
            |:|:.|||||||||:.|||||.|||||::|||||||||.||.|:.|||||.||:.|..||.||.:
Zfish  1564 VIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMANFAYVKKQGGI 1628

  Fly  2229 DDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPP-DCDPFI-HGHTN--GNCGHPLLAITYF 2289
            |||.||:|||.||..||::.|||||:::|..::..|| :|||.| |..||  ||||.|.:.||:|
Zfish  1629 DDMFNFETFGNSMICLFQITTSAGWDNLLSPILNTPPEECDPEIPHTGTNARGNCGKPSVGITFF 1693

  Fly  2290 TSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDF 2354
            .::||||::||:|||||||||||:.|.:|....:.|||.||||..|.|:||.|||||.:.:||||
Zfish  1694 VTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFEMFYEVWEKFDPEATQFIEYLKLSDF 1758

  Fly  2355 IASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKF 2419
            ..:|..||.|.|||.:.|:|.:||:..|:||||||||.|..|.|||...|.|..||   ||:.||
Zfish  1759 ADTLSEPLRIGKPNKIKLISMDLPMVSGDKIHCLDILFAFTKRVLGESGEMDALKQ---QMEEKF 1820

  Fly  2420 KKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERS------------NSGDSAT 2472
            ....|::...|.:::|...|::|.:|..||..::.:|.|::.|:.|            .:|||:.
Zfish  1821 MMANPSKISYEPITTTLRRKQEEVSAIMIQRSYRRHLIRRQLKQASLLYRQMTMPDADKAGDSSP 1885

  Fly  2473 Q-----------------------TSSPGGWQSKLSALN-FFHLQVSRRGTACSSRASSRKSSRA 2513
            :                       ||||..:.|...|.: .||..:       ....:...|...
Zfish  1886 ESQGLIVSMIMENYATEAEITISATSSPPSYDSVTRATSEIFHALI-------PEETNEILSEHL 1943

  Fly  2514 SDASDLSE 2521
            :||...||
Zfish  1944 ADAEKESE 1951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	125/270 (46%)
		Ion_trans	687..902	CDD:459842	117/218 (54%)
		Ion_trans	1751..2019	CDD:459842	157/272 (58%)
		Na_channel_gate	2009..2063	CDD:240441	30/53 (57%)
		Ion_trans	2067..2320	CDD:459842	142/256 (55%)
		GPHH	2332..2378	CDD:465306	23/45 (51%)
scn5lab	NP_001038588.1	Ion_trans	128..427	CDD:459842	145/305 (48%)
		Na_trans_cytopl	515..656	CDD:463401	28/171 (16%)
		Ion_trans	705..918	CDD:459842	115/215 (53%)
		Na_trans_assoc	944..1143	CDD:461936	75/823 (9%)
		Ion_trans	1147..1419	CDD:459842	156/271 (58%)
		Na_channel_gate	1411..1463	CDD:240441	30/53 (57%)
		Ion_trans	1481..1723	CDD:459842	135/241 (56%)
		IQ	1841..1863	CDD:197470	6/21 (29%)