DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and cacna1aa

DIOPT Version :10

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_001429978.1 Gene:cacna1aa / 562059 ZFINID:ZDB-GENE-040724-26 Length:2483 Species:Danio rerio


Alignment Length:3095 Identity:662/3095 - (21%)
Similarity:1098/3095 - (35%) Gaps:1024/3095 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 RHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKP---------LEEIDTFIYEETFCVV 88
            ||:|:           .....||.:|.::...|.|..|.|         .......:|:::   :
Zfish   118 RHVQI-----------GMARFGDEVPSRYGGGPGHAQGGPGRGGSRQGGPPGAQQRMYKQS---M 168

  Fly    89 SKRFRKNYIHR--------FTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLA- 144
            ::|.|...::.        ||..:|||:|...:..|:....|.....|:|.::|||:.|||.|| 
Zfish   169 AQRARTMALYNPIPVRQNCFTVNRSLFIFSEDNFVRKYAKKITEWPPFEYMILATIIANCIVLAL 233

  Fly   145 -----------MTETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSG-Y 197
                       |:|.:|:.|..|:.|:..|..|||:|.||..:|.:||||.||.:||||:.:| .
Zfish   234 EQHLPDGDKTPMSERLEDTEPYFIGIFCFESGIKILALGFAFHKGSYLRNGWNVMDFVVVLTGIL 298

  Fly   198 ATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQ 262
            :|:|.:. :|..||..||||.||.||.:|.|:.::.:::.:...|.::..|..|.:::||:..|:
Zfish   299 STVGSDF-DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILMFAIIGLE 362

  Fly   263 VYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCV 327
            .|||:....|..::                  ||.   ..:|.|  ||....||.||...||...
Zfish   363 FYMGKFHTTCFDKI------------------TDE---IREEFP--CGEEVPARICPNGTVCKKY 404

  Fly   328 GENPNHGYTNFDNFMWSMLTTFQLITLDYWEN-VYNMVLATCGPMSVSFFTVVVFFGSFYLINLM 391
            ...||:|.|.|||.::::||.||.||::.|.: :|....|.....:..:|..::..|||:::||:
Zfish   405 WLGPNYGITQFDNILFAVLTVFQCITMEGWTDLLYYSNDAAGSAWNWMYFIPLIIIGSFFMLNLV 469

  Fly   392 LAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSK 456
            |.|::..:.:|.|  ..|.:.:.|..:......        ::|| ...:.|...:.|:||.   
Zfish   470 LGVLSGEFAKERE--RVENRSEFLKLKRQQQIE--------RELN-GYLEWICKAEEVILAD--- 520

  Fly   457 KKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPG----PSPRHSATERPSALTMQAQKQYQ 517
                                     :||......|..|    |:.:.|.|:...           
Zfish   521 -------------------------EDNDPDDRMPFDGSRRRPTIKKSKTDLLD----------- 549

  Fly   518 QMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSG 582
                    |:.|.|...:|.|                           :|.|.::..:.||    
Zfish   550 --------AEDGDGDIGSPFA---------------------------RGSLKSSKLEGSS---- 575

  Fly   583 VNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFS 647
                          .|:::                  |.:|..     |.||.....:       
Zfish   576 --------------FHKKE------------------RRLRFF-----IRRIVKTQAF------- 596

  Fly   648 SEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIV-LNTAFLAMEHHG 711
                              :|                          ..||:| |||..:|:.|:.
Zfish   597 ------------------YW--------------------------TVLCLVGLNTLCVAVVHYD 617

  Fly   712 MSESFRNALDVGNKVFTSIFTFECIVKLMAL-SKDFFLCGWNIFDLLIVTASLLDIIFELVD--- 772
            ..|:..:.|.....:|..||..|..:|:..| ::.:|...:|.||.:::..|:.::::.::.   
Zfish   618 QPETLSDFLYFAEFIFLGIFMSEMCIKMYGLGTRPYFHSSFNCFDCIVICGSIFEVLWAMIQPGT 682

  Fly   773 --GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDY 835
              |:||||.|||||:.|:.:.|.:::.|:..:::::.::.:|..:|.:.|.:||::|||||...:
Zfish   683 SFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF 747

  Fly   836 TPEKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVM-G 898
            ..|.    ..|..||:.|..:.|.:|:||.|| |...::|.:.::........|::|...|.: |
Zfish   748 NFEA----GTPPTNFDTFPAAIMTVFQILTGEDWNMVMYDGIESQGGVKKGMVFSVFFIVLTLFG 808

  Fly   899 NFMVLNLFLALLL-NSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKF 962
            |:.:||:|||:.: |..|::||                        .|..||.:....:|.|.:.
Zfish   809 NYTLLNVFLAIAVDNLANAQEL------------------------TKDEQEEEQAANKKMALQT 849

  Fly   963 QQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGL 1027
            .:.|.:.....|..||              :.|..:.|.                      |.|.
Zfish   850 AKEVAEVSPLSAANLS--------------IAASCQPHN----------------------HKGQ 878

  Fly  1028 HTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFV 1092
            :..|:.          |::....|.|                              .|:      
Zfish   879 NVTVNS----------ERLDATEHFL------------------------------DCK------ 897

  Fly  1093 QAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTD------------------------ 1133
              |::..|:....|..|:.......|...|.|.|  ||..|                        
Zfish   898 --EQQKNHKGCKSVWEQRTSELRRQTLVNSREAL--YNELDPEDRWKVSYSRHIRPDMKTHLDRP 958

  Fly  1134 --TDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRK--------- 1187
              .||..| :.:.......||          |..:|..       .||.:.|::.:         
Zfish   959 LVVDPQEN-RNNNTNKTRPGD----------GQPQHSH-------QLLHKQPNFNEAETGGGGGS 1005

  Fly  1188 ----SLDRLSQSSGQSQRSLLKSEEAE-----MRRHSSGQSLNSMSIEQDELLSQQGNLREELLN 1243
                :|:| ..|:| |:||||.||..|     .|||...|                        :
Zfish  1006 ESWPALER-GDSTG-SRRSLLGSEHYEEGRESHRRHQHSQ------------------------H 1044

  Fly  1244 CDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEE 1308
            |.|                        ..:.|:.:...|:|..                      
Zfish  1045 CSQ------------------------ARQHRKAAEGGGEPGG---------------------- 1063

  Fly  1309 IKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPR 1373
                    .|..|...|..|..:.:.....:|                                |
Zfish  1064 --------RRHRSKAKERGPECEHSDGGERKH--------------------------------R 1088

  Fly  1374 RSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQ 1438
            |.:......:.:.|:.:.|.                      ..||          :..:.|..:
Zfish  1089 RHRHEGEGRKERGVRHRNRR----------------------DGHA----------SGPTLSTTR 1121

  Fly  1439 PNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDS 1503
            |.|                  |.||                                    |.||
Zfish  1122 PIQ------------------KTLS------------------------------------RQDS 1132

  Fly  1504 LSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQH 1568
               :.:...:|.:..|    :||.|                                        
Zfish  1133 ---QYSEDLDNAMNNK----LATQP---------------------------------------- 1150

  Fly  1569 FHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSAL 1633
             |.:.:..|.|     |||...||:.......:.:|.||:....|.      .|           
Zfish  1151 -HDSLLNLANT-----AHSAGLAHTGTESSLILTNPSSTIANVTSI------GH----------- 1192

  Fly  1634 ALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYG 1698
               :..|.|.:....|......:|..::                      ::.|..:|:  |...
Zfish  1193 ---LGMKPEYTAVDIPPMFPSSNAILQV----------------------NKNANTEPL--PKKE 1230

  Fly  1699 ATKA---AKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVL 1760
            .||.   ....||..|:.        .|.:.|.....:...:.|:...::|:   ..||..:|::
Zfish  1231 DTKGDDDDDEKDDGGPKP--------MPPYTSMFILTTTNPFRRLCHYIVTL---RYFEMCILLV 1284

  Fly  1761 IFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILD 1821
            |..|||.|..|| .:........||.:.::.|..:|..||::|.:.||.    ..||...|.|||
Zfish  1285 IAMSSIALAAED-PVWPESPRNNVLRYFDYVFTGVFTFEMLIKMVDLGLVLHQGSYFRDLWNILD 1348

  Fly  1822 FIIVFVSVFSLLIEEN---ENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLL 1883
            ||:|..::.:.....|   :::..::|||.||.||||:.|.|...::.|.:.::.::.::.|:|:
Zfish  1349 FIVVSGALVAFAFTGNSKGKDISTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILI 1413

  Fly  1884 VCLVFWLIFSIMGVQFFGGKFFKCVNE--------MGELLPITEVNDKWDCIEQNYTWINSKITF 1940
            |.::|..||:::.||.|.|:||.|.:|        .||.|.....|   :...|...|......:
Zfish  1414 VYMLFMFIFAVVAVQLFKGRFFYCTDESKEFERDCRGEYLVYERDN---EVRSQKREWKKYDFHY 1475

  Fly  1941 DHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQP----QREANLYAYIYFVIFIVCGSFFTLN 2001
            |:|....|.|..|:|.|||.:|:..:|||...:..|    :.|.:::..:|||:|    .||.:|
Zfish  1476 DNVLWALLTLFTVSTGEGWPQVLKHSVDATYENQGPSPGYRMEMSIFYVVYFVVF----PFFFVN 1536

  Fly  2002 LFIGVIIDNFNMLKKKYEGGVLEMFLTESQKH----YYTAMKKLGRKKPQKVIKRPINHFLAMFY 2062
            :|:.:||..|.....|    ::|.:..|..:.    :....|.|.|..||..     ..|....:
Zfish  1537 IFVALIIITFQEQGDK----MMEDYSLEKNERACIDFAINAKPLTRHMPQNK-----QTFQYRMW 1592

  Fly  2063 DLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVF-FILEVSNAFFTTVFGLEAIVKIVGL-RYH 2125
            :...|..||..|..||.||.:.:.:: ||.....: .:|:..|..||::|.:|.|:||:.. ..:
Zfish  1593 EFVVSPPFEYTIMALIALNTIVLMMK-YDGASLTYEDVLKYLNIVFTSLFSMECILKIIAFGALN 1656

  Fly  2126 YFTVPWNVFDFLLVLASIFGILMEDI---MIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLL 2187
            ||...||:||.:.||.||..||:.::   .|:|..       :|:||..|:::|::..:.||.||
Zfish  1657 YFKDAWNIFDCVTVLGSITDILVTELGNNFINLSF-------LRLFRAARLIKLLRQGETIRILL 1714

  Fly  2188 FALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMV----NFQTFGRSMQLLFRLM 2248
            :..|.|..||..:..|:.::.|||||:||.||||:|::...|..:    ||:||.:::.||||..
Zfish  1715 WTFVQSFKALPYVCLLIAMLFFIYAIIGMQLFGNIKIEENSDSAITQHNNFRTFFQALMLLFRSA 1779

  Fly  2249 TSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFN 2313
            |...|:|::.|.:.:.| || .:..:....||.. .|..||.|||.:...:::|:::|:|::||.
Zfish  1780 TGEAWHDIMLSCLGKKP-CD-ILSDNLKPECGSE-FAYLYFVSFIFLCSFLMLNLFVAVIMDNFE 1841

  Fly  2314 QAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LV 2373
            ...::..| :....|:.:...|::|||.|...||:..:...:..:|||||:.|  |:.||   |:
Zfish  1842 YLTRDSSI-LGPHHLDEYVRIWAEYDPAACGRIHYKDMYSLLRVIDPPLGLGKKCPHRVACKRLL 1905

  Fly  2374 SFNLPISKGNKIHCLDILHALVKHVL------GHVEETDNFKQLQEQMDVKFKKQ----FP--TR 2426
            ..:||::..|.:|....|.||::..|      |.|:        :.|||.:.:|:    :|  ::
Zfish  1906 RMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGVD--------KHQMDAELRKEMMAIWPNLSQ 1962

  Fly  2427 KELEIV-----SSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNSGD---------------SA 2471
            |.|:::     |:|.:...:..||..|.    ||.|:.:.|......|               |.
Zfish  1963 KNLDLLVTPHKSATDLTVGKIYAAMMIM----EYYRQSKAKRTQALHDEQNRTPLMFQRLEPPSP 2023

  Fly  2472 TQTSSPG--GW-QSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLML 2533
            :|...||  |. .:::...|  ||.|..|.....|..::|       |.::|:.||.|      .
Zfish  2024 SQDVGPGLTGLPDTQMHPAN--HLPVDERIPESQSWVTAR-------AQEISQKAGNW------S 2073

  Fly  2534 VSG--ADEVVKDIKQQND----ELGKRGSIFVE--APRASRRRSFYNFFLRHQDAVDDSLTSPSV 2590
            ..|  .|:...:.:|...    |:|:.|....|  .|.....|                  :.|:
Zfish  2074 PEGQHPDDTTDNRRQSQTVEMREMGRDGYSDTEQYLPMEGHGR------------------AASM 2120

  Fly  2591 HRKTAMNNTTNTTSNSASTSGTASSTATAPATGCGPAATSASDSD------------RHQAVGGG 2643
            .|..|.|....|.::....|        |.:.|.|.|..|....|            ||      
Zfish  2121 PRLPADNQQPITDNSPMKRS--------ASSLGHGRAGRSMRGEDYAMERVIPEEGHRH------ 2171

  Fly  2644 SAPSRKRASSFIRKKPPLERGLSAQSALRVNKNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPD 2708
              ..|.|..|....:..|.|...|.:.|..:.:........|.....|...:.:.|.|.......
Zfish  2172 --GHRHRDRSHRASERSLSRYTDADTGLGTDLSTTTQSGDLPSKERDRGRAKDRKHHHHHHHHHG 2234

  Fly  2709 NATLVHVLVHRESEEY-----KEED-----------------ESSPSVSGNGNGFGVGLDM---- 2747
            :....|....|:..||     :|.|                 :.|.||||:......|...    
Zfish  2235 SLDKEHYGHERDRGEYGHRQSRERDRRWSRSPSEGRECLTHRQGSSSVSGSPVPSTSGTSTPRRG 2299

  Fly  2748 ------------------------LSKQPPP--QIRITTGSVESSMDTCAMPTVQIMVDSPKDPP 2786
                                    :|..|||  |.|:.|            ||.:....:..:||
Zfish  2300 RRQLPQTPATPRPHVTYSPVVRKPISSTPPPGQQSRLPT------------PTSRRFSPTGPEPP 2352

  Fly  2787 RGDFSSAPIDDVGAPIDVNVQGDTSQVFYDYNPEKATDDQGNG----QD------ETAQFESLP- 2840
            ............|:|        .|.....:.||.|...:|:|    ||      |...:|..| 
Zfish  2353 LPPHHHPSPPHHGSP--------RSGRHAHWGPEPAESVEGDGFYDDQDYEFNHHEPPSYEQSPV 2409

  Fly  2841 -----------DRQRXPPVNTPLRDSEKRSSRGSRSSSSS 2869
                       .|...||..   :...:|...|.||||.|
Zfish  2410 QGNPHPHSPRTSRHNTPPQG---QAHPRRMPNGYRSSSPS 2446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 125..371 CDD:459842 88/259 (34%)
Ion_trans 687..902 CDD:459842 62/223 (28%)
Ion_trans 1751..2019 CDD:459842 88/286 (31%)
Na_channel_gate 2009..2063 CDD:240441 10/57 (18%)
Ion_trans 2067..2320 CDD:459842 88/261 (34%)
GPHH 2332..2378 CDD:465306 17/50 (34%)
cacna1aaNP_001429978.1 None

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