Protein Alignment NaCP60E and tpcn3

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_001170916.1
• Gene: tpcn3 / 557460
• ZFINID: ZDB-GENE-141215-16
• Length: 773
• Species: Danio rerio
• Alignment Length: 894
• Identity: 172/894 - (19%)
• Similarity: 314/894 - (35%)
• Gaps: 347/894 - (38%)

  Fly  1640 KTEQSQSTAPDATQKPSAFT------------RLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPM 1692
            |||::..|    ..|...||            ::||| :.....||.|          ..||..:
Zfish     5 KTEKTSHT----LTKDEGFTNGGNHVPSNVTDQMTEK-FDLATVYVSD----------AKYNRNI 54

  Fly  1693 TFPSYGATKAAKVPDDCFPQK-----CYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPA 1752
            .|             |..||.     .|:|      |||     |:..:...:....|.:.:.||
Zfish    55 FF-------------DTSPQAVKLYLLYNH------WFM-----QTLVYVFIIINLALALFEDPA 95

  Fly  1753 FEWFVLVLIFASSI--TLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTS 1815
               .|.:.|:|:|.  |:|..                 .|:..:|...::|.|          ..
Zfish    96 ---VVPLPIWATSTIETICLS-----------------AFTVRIIHYAKVIPK----------DK 130

  Fly  1816 FW----TILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQG--MRIVVNALMYA 1874
            ||    .|...|||.:|...::|...........:|..|.||||..::..:|  :|....::..|
Zfish   131 FWKDPKNICIIIIVTLSFIDMVIYGALKATGHYGIRWSRVLRPLLLVNVTEGRQLRRAFRSIRNA 195

  Fly  1875 IPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQNYTWINSKIT 1939
            :|.|..|..:.:...|:||:|.::.||.:....:|
Zfish   196 LPQISYVFFLFMFSVLVFSLMALKLFGKRGLLTIN------------------------------ 230

  Fly  1940 FDHVGMGYLALLQVATFEGWMEVMAD----AVDARGVD-LQPQREANLYAYIYFVIFIVCGSFFT 1999
                |..|        |..:|:::.|    ...|...| :.|...:::|..|:|:::||..::..
Zfish   231 ----GSPY--------FTDYMDIVFDLYVLVTTANSPDVMMPAYNSSVYFTIFFILYIVINTYTF 283

  Fly  2000 LNLFIGVIIDNFNMLKKKY----------------------------EGG--------------- 2021
            ::.|:.|:.:|:    |||                            |||
Zfish   284 MSFFLAVVYNNY----KKYLKEEVRQLVKAKRIKMCRAFSLLQENRGEGGEPVVTQANWNHLVKL 344

  Fly  2022 -------------------------------------VLEMFLTESQKH-YYTAMKKLGRKKPQK 2048
                                                 .:::...:||.| .......|....|.:
Zfish   345 VKPKISTAHRELLWSVLDDQNKGHIGKFAFVQLADLLSIQVITVKSQAHPIQICFPSLYNSLPSR 409

  Fly  2049 VIKRPINHFLAMF-YDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNA--FFTTV 2110
            .|::.::|.:.:: |||            :|.:|.:.:|:   |:.:.|     ||||  .|..:
Zfish   410 FIRQMVHHRVFVYAYDL------------IILVNAVFIGL---DEENPV-----VSNAEWGFLAL 454

  Fly  2111 FGLEAIVKIVGLRYHYFTVP---------WNVFDFLLVLASIFGILMEDIMIDLP--ISPTLLRV 2164
            :.||.::|:      |.|.|         ||.||.::|::::||.::...:....  .|..:|.:
Zfish   455 YMLEILLKL------YATEPRAFFARHQFWNWFDTIIVVSALFGTIINSALKHSGGYTSRQVLDI 513

  Fly  2165 VRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLF---------- 2219
            |.:.|:.|::|::.:.|..|.::..|:...|.:...|.|:.::.:|:|::||.||
Zfish   514 VFILRVLRLIRVVDSIKRFRAIINTLIKIGPTILTFGQLILVVYYIFAMVGMELFKGKIQFFEPN 578

  Fly  2220 ---------GNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLES--LMIQPPDCDPFIHG 2273
                     ||..|:......:|:              ....:|||:.|  |:::....:.: |.
Zfish   579 STSPDREYCGNPLLKSTSFAKLNY--------------CKNNFNDVISSFILLLELTVVNQW-HV 628

  Fly  2274 HTNGNCGHPLLAIT------YFTSFIIISYMIVINMYIAIILENF---------------NQAHQ 2317
            .|:|     ..|:|      :|..|.|:..:|:||:::|.|||.|               .:..:
Zfish   629 LTSG-----FTAVTHVSARLFFVIFHIVVVIIIINIFVAFILEAFLVEYTVDKSELQTSLEKKIE 688

  Fly  2318 EEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK 2366
            |.|:.:.:|.::                   :.|.|.:.:.|..||.|:
Zfish   689 ELELNVQQDGVD-------------------TGLVDAMETNDSDLGSSE 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842
		Ion_trans	687..902	CDD:459842
		Ion_trans	1751..2019	CDD:459842	58/308 (19%)
		Na_channel_gate	2009..2063	CDD:240441	14/135 (10%)
		Ion_trans	2067..2320	CDD:459842	67/307 (22%)
		GPHH	2332..2378	CDD:465306	6/35 (17%)
tpcn3	NP_001170916.1	Ion_trans	73..295	CDD:459842	58/298 (19%)
		Ion_trans	417..>571	CDD:459842	45/179 (25%)