Protein Alignment NaCP60E and para

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Alignment Length: 2856
• Identity: 852/2856 - (29%)
• Similarity: 1239/2856 - (43%)
• Gaps: 910/2856 - (31%)

  Fly     1 MSDDQATFNDE-----KAVAKHQVVAYTQRSQVKHENRHIQLVR--------EYGFH-------- 44
            |::|..:.::|     :...:..:|...||...:||.:. :|.|        :||..
  Fly     1 MTEDSDSISEEERSLFRPFTRESLVQIEQRIAAEHEKQK-ELERKRAEGEVPQYGRKKKQKEIRY 64

  Fly    45 --------PRTKASVEDGDVLPRKFE-PFPEHMYGKPLEEIDTFIYEE--TFCVVSKRFRKNYIH 98
                    |:...::|.|..:|.:.: .||..:...|||:||.: |..  ||.||||   ...|.
  Fly    65 DDEDEDEGPQPDPTLEQGVPIPVRLQGSFPPELASTPLEDIDPY-YSNVLTFVVVSK---GKDIF 125

  Fly    99 RFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAM--TETVEEAEYIFLAIYS 161
            ||:.:|::::..|::|.|||.:||..:..|...::.|||.|||.:.|  |.|||..|.||..||:
  Fly   126 RFSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTEVIFTGIYT 190

  Fly   162 IEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMP 226
            .|..:|::|:||:|..:||||:.|||||||||...|.|:|:::||||.|||||||||||||:|:|
  Fly   191 FESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVP 255

  Fly   227 GLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTD--WTNVSHTDWQ 289
            |||||:.|::.|.:.|.:|:.||:|.|.||||..||:|||.|..||:::.|.|  |.|::..:|.
  Fly   256 GLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWD 320

  Fly   290 IWVNDTDNWLYDEDE---LPVLCGNLTGARHCPFEYVCL-CVGENPNHGYTNFDNFMWSMLTTFQ 350
            ....::.|| |.|||   .| ||||::||..|..:|||| ..|.|||:|||:||:|.|:.|:.|:
  Fly   321 YHNRNSSNW-YSEDEGISFP-LCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFR 383

  Fly   351 LITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYE------EEAEITNEE 409
            |:|.|:||::|.:||...||..:.||.|::|.|||||:||:||:||:||:      ||.|...||
  Fly   384 LMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEE 448

  Fly   410 ----------RKKDLLDHRDD---------------------------STFSFDPSVLNVKKLNK 437
                      .|...|:.|.:                           |..|::..|...|..:.
  Fly   449 AIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDD 513

  Fly   438 NNKKK-------IDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGS----NGDDNKSHSATP 491
            |||:|       ::|....::.......|..:.||..|...|:.:..||    ......||..|.
  Fly   514 NNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTI 578

  Fly   492 SPGPS----PRHSATERPSALTMQAQKQYQQMEQQHKLAKS--------------------GSGG 532
            ..|..    |  .:..:|..|:     .||..:|....|..                    |:.|
  Fly   579 RNGRGRFGIP--GSDRKPLVLS-----TYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLG 636

  Fly   533 SNNPMAPTPKGRISFQDSG--MGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVV 595
            |.:....:.:.|||:...|  :|             |..:......:..|...||.:.....|..
  Fly   637 SRHSSYTSHQSRISYTSHGDLLG-------------GMAVMGVSTMTKESKLRNRNTRNQSVGAT 688

  Fly   596 DDHEE-QDTTNDMGHVSTVELALSPREVRL-IKCNGNIARIKNHN------VYALHQEFSSEVVV 652
            :.... .||.:.:.|          |:..: ::|.....:||:|:      |.........:|:|
  Fly   689 NGGTTCLDTNHKLDH----------RDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMV 743

  Fly   653 IDDLPD-------RNCDR----------------------------------CVHWCTDYESWLQ 676
            ::|:.:       |..||                                  ||..|.  ..||:
  Fly   744 LNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCC--WVWLK 806

  Fly   677 FQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMA 741
            ||..:..:|.||..||.||||||:||.|:||:||.|::.....|..||..||:.|..|..:||||
  Fly   807 FQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMA 871

  Fly   742 LS-KDFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIIST 805
            :| |.:|..||||||.:||..|||::..|.|.||||||..|||||.|||:||.|:.:|:||:..|
  Fly   872 MSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRT 936

  Fly   806 IGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEK--FDPDPVPRWNFNDFFHSFMMIFRILCGEW 868
            :|||||||.:|.|:|:||||:|||||.|:|...|  |....:|||||.||.||||::||:|||||
  Fly   937 MGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEW 1001

  Fly   869 IEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLA 933
            ||.:||||..    |..:|...||.|:|:||.:||||||||||::|.|..|.:...: .:.:|:|
  Fly  1002 IESMWDCMYV----GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTAD-NDTNKIA 1061

  Fly   934 RSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETK 998
            .:..|:...        |...:|..|:.|:.|        ...|::|.:      |:|
  Fly  1062 EAFNRIGRF--------KSWVKRNIADCFKLI--------RNKLTNQIS------DQP------- 1097

  Fly   999 FHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPT 1063
                                                    :|:...||
  Fly  1098 ----------------------------------------SGERTNQI----------------- 1105

  Fly  1064 YESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQ 1128
                       |:....|.|.|:
  Fly  1106 -----------SWIWSEGKGVCR------------------------------------------ 1117

  Fly  1129 YNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLS 1193
                            |.|...||
  Fly  1118 ----------------CISAEHGD----------------------------------------- 1125

  Fly  1194 QSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEE 1258
                                       |.:.:..||:|:
  Fly  1126 ---------------------------NELELGHDEILA-------------------------- 1137

  Fly  1259 LQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNL 1323
                                                 |.:|:...||       .|.||
  Fly  1138 -------------------------------------DGLIKKGIKE-------QTQLE------ 1152

  Fly  1324 SEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVK 1388
                             :||..|.
  Fly  1153 -----------------VAIGDGM----------------------------------------- 1159

  Fly  1389 LKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFT 1453
                          :|:|..:::                        ..:|.:|.:|....|.
  Fly  1160 --------------EFTIHGDMK------------------------NNKPKKSKYLNNATDD-- 1184

  Fly  1454 VQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQ 1518
                                                            |:.|:.|..|::|
  Fly  1185 ------------------------------------------------DTASINSYGSHKN---- 1197

  Fly  1519 KQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHT 1583
                                                                        .|...
  Fly  1198 ------------------------------------------------------------RPFKD 1202

  Fly  1584 HAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTA 1648
            .:| :..|.:|.|:.:|
  Fly  1203 ESH-KGSAETMEGEEKR------------------------------------------------ 1218

  Fly  1649 PDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQK 1713
             ||:::........::...|               .:|..:..:...::......:.|.||
  Fly  1219 -DASKEDLGLDEELDEEGEC---------------EEGPLDGDIIIHAHDEDILDEYPADC---- 1263

  Fly  1714 CYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKN 1778
            |.|.:|.:.|......|:...:.|..:|.....:::...||..|:.:|..||:.|..||::|.:.
  Fly  1264 CPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQR 1328

  Fly  1779 KTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLL--IEENENLK 1841
            ..|:.:||:::..|.:||.:||::|||||||..|||:.|..|||:||.||:.:.:  :.....::
  Fly  1329 PILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQ 1393

  Fly  1842 VLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFK 1906
            ..:::|||||||||||:||.||||:|||||:.|||||||||||||:|||||:|||||.|.||:||
  Fly  1394 AFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1458

  Fly  1907 CVNEMGELLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARG 1971
            |.:..|..|....:.::..|..:||||:||.:.|||||..||.|.|||||:||:::|.||:|:|.
  Fly  1459 CEDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSRE 1523

  Fly  1972 VDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYT 2036
            ||.||.||.|:|.|:|||.||:.||||||||||||||||||..||| .||.||||:||.||.||.
  Fly  1524 VDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKK-AGGSLEMFMTEDQKKYYN 1587

  Fly  2037 AMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILE 2101
            ||||:|.|||.|.|.||.....|:.:::...::|:|.|.:.|.|||.||.::.||.......:|:
  Fly  1588 AMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLD 1652

  Fly  2102 VSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVR 2166
            ..||.|..:|..|.::||..||||||..|||:||.::|:.||.|:::.||:....:|||||||||
  Fly  1653 YLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVR 1717

  Fly  2167 VFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDM 2231
            |.::||:|||:|.|||||.|||||.:||||||||..||.|:.||:||.|||.|.:||.:..::|:
  Fly  1718 VAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDV 1782

  Fly  2232 VNFQTFGRSMQLLFRLMTSAGWNDVLESLM----IQPPDCDPFIHGHTNGNCGHPLLAITYFTSF 2292
            .||:|||:||.|||::.|||||:.||::::    ..|||.|   .|:. ||||...:.||:..|:
  Fly  1783 YNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDND---KGYP-GNCGSATVGITFLLSY 1843

  Fly  2293 IIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIAS 2357
            ::||::||||||||:||||::||.::.:.|:.:||.:|:|..|.::||..||:|.:.|||:|:..
  Fly  1844 LVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDV 1908

  Fly  2358 LDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGH----VEETDNFKQLQEQMDVK 2418
            |:|||.|.|||...::|.::||.:|:.::|:|||.||.|.....    :|||....::..:
  Fly  1909 LEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEETGEIGEIAAR---- 1969

  Fly  2419 FKKQFPTRKELEIVSSTRIWK-RQEKAAKTIQTGWKEYLRRKREKERSNSGDSATQTSSPGGWQS 2482
                 |..:..|.|||| :|: |:|..|:.||..|:::      |.|...|.|....:..|
  Fly  1970 -----PDTEGYEPVSST-LWRQREEYCARLIQHAWRKH------KARGEGGGSFEPDTDHG---- 2018

  Fly  2483 KLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQ 2547
                                            |..|               ....|....:....
  Fly  2019 --------------------------------DGGD---------------PDAGDPAPDEATDG 2036

  Fly  2548 NDELGKRGSIFVEAPRASRRRSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGT 2612
            :...|..||:...|..|:             ||.:.::.||......|.         :|:.:..
  Fly  2037 DAPAGGDGSVNGTAEGAA-------------DADESNVNSPGEDAAAAA---------AAAAAAA 2079

  Fly  2613 ASSTATAPATGCGPAATSAS---DSD------RHQAVGGGSAPS--RKRASSFIRKKPPLE 2662
            |:.|.||.:.|.|.|....:   :||      .|:.|....:||  .:.|....|.:|||:
  Fly  2080 AAGTTTAGSPGAGSAGRQTAVLVESDGFVTKNGHKVVIHSRSPSITSRTADVXARPRPPLQ 2140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	128/253 (51%)
		Ion_trans	687..902	CDD:459842	121/217 (56%)
		Ion_trans	1751..2019	CDD:459842	151/269 (56%)
		Na_channel_gate	2009..2063	CDD:240441	32/53 (60%)
		Ion_trans	2067..2320	CDD:459842	129/256 (50%)
		GPHH	2332..2378	CDD:465306	20/45 (44%)
para	NP_001259619.1	Ion_trans	152..436	CDD:459842	146/285 (51%)
		Na_trans_cytopl	555..740	CDD:463401	36/214 (17%)
		Ion_trans	817..1028	CDD:459842	119/214 (56%)
		Na_trans_assoc	1054..1296	CDD:461936	68/820 (8%)
		Ion_trans	1300..1571	CDD:459842	151/271 (56%)
		Na_channel_gate	1561..1613	CDD:240441	32/52 (62%)
		Ion_trans	1621..1871	CDD:459842	129/253 (51%)
		GPHH	1882..1929	CDD:465306	20/46 (43%)