Protein Alignment NaCP60E and Tpcn2

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: XP_038935131.1
• Gene: Tpcn2 / 309139
• RGDID: 1311779
• Length: 867
• Species: Rattus norvegicus
• Alignment Length: 789
• Identity: 142/789 - (17%)
• Similarity: 272/789 - (34%)
• Gaps: 321/789 - (40%)

  Fly  1794 LIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAI 1858
            |:|:.::.:|...:|.::...:.|.:..|:::.|||...::..:.|.:  .|||..|.|||...:
  Rat   116 LVFLADLSVKGYLVGQAQLQQNLWLLAYFVVLVVSVVDWIVSLSLNCE--ESLRVRRLLRPFFLL 178

  Fly  1859 SRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDK 1923
            .....|:..:..:.:::|.:.:|.|:..:...:|:::|:..|               .|.|.::
  Rat   179 QNSSMMKKTLKCIRWSLPEMASVGLLLTIHLCLFTVIGMLLF---------------TIAEKDE- 227

  Fly  1924 WDCIEQNYTWINSKIT-FDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIY 1987
                .||    ..::| |.::.....:||.:.|.....:||..|        ..|..|  || ::
  Rat   228 ----AQN----KERLTYFRNLPEALTSLLVLLTTSNNPDVMIPA--------YTQNRA--YA-LF 273

  Fly  1988 FVIFIVCGSFFTLNLFIGVIIDNF----------NMLKKK------YE----------------G 2020
            |:||.:.||.|.:||...:|.:.|          ::.:::      ||                |
  Rat   274 FIIFTLIGSLFLMNLLTAIIYNQFRGYLMKSLQTSLFRRRLGARAAYEVLTLQAGPNGTTSELVG 338

  Fly  2021 GVLEMFLTESQKHYYTAMKKLGRKKPQKVIK-------RPI--NHFLAMFYDLS----------- 2065
            ...|.||...||   |.:.|:.:   |.:|:       |||  :.|..:|.::.
  Rat   339 VNPENFLRVLQK---TQLNKIHK---QAIIQKVHSYEGRPILADEFQKLFDEVDKGIVKERPPKP 397

  Fly  2066 --NSRRFEIAIFV-----------LIFL-NMLTMGI----------------------------- 2087
              .|...:.|.|:           ||.| |:|::.:
  Rat   398 QYQSPFLQTAQFIFSHRYFDYLGNLIALGNLLSICVPGAGLKPAAWGTERLCPGDSQLHFHLVLP 462

  Fly  2088 ---------------------------EHYDQPHAVFFI---------LEVSNAFFTTVFGLEAI 2116
                                       :|:......|:.         :|:|:|.....:.|..|
  Rat   463 AGAAVQGVRAGPTGLPVLPQQRVRWPPDHHPAGFGDFYSGRVPIAAPRMELSSAGLPRSWALTTI 527

  Fly  2117 --VKIVGL----------------RYHYFTVPWNVFDFLLVLASIF------------GILMEDI 2151
              .|:.|.                ||     .|.: ..|.||.|:.            |:::..:
  Rat   528 SAFKLWGCSERCGPGCGRCGCDCGRY-----DWQL-GALAVLGSVAMTVLSVAVAVLGGMMVAVV 586

  Fly  2152 M-----------------------------------------IDLPISPTLL------------- 2162
            |                                         :....||.|:
  Rat   587 MAAWALGMSRVWLGSVSHLLGAFSAWCPYSDYCCLVTPAASSLSPSASPNLVTRLRYLLRKPEQY 651

  Fly  2163 ---------RVVRVFRIGRILRLIKAAKG---IRKLLFALVVSLPALFNIGALLGLITFIYAILG 2215
                     |:|.:..:.|.||:|.:.|.   :...:..|:.:|.|   .|.:|.::.:::|::|
  Rat   652 GPLSLWDMTRLVNILIVIRFLRIIPSIKPTAVVASTILGLIQNLRA---FGGILVVVYYVFAMIG 713

  Fly  2216 MSLF-------GNVKLQ--------GALDDM----VNFQTFGRSMQLLFRLMTSAGWNDVLESLM 2261
            ::||       ||..|.        |:.:.:    .||..|..::..|:.:|....|..:||:
  Rat   714 INLFRGVIVPPGNSSLVPDNSSAPCGSFEQLGYWPNNFDDFAAALITLWDVMVVNNWQVILEA-- 776

  Fly  2262 IQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENF-----NQAHQEEEI 2321
                      :.|.:|.     .::.||..:.::|.:|.||:::|::||||     .|.|::..:
  Rat   777 ----------YKHYSGP-----WSMVYFVLWWLVSSVIWINLFLALLLENFLHRWDPQGHKQLLV 826

  Fly  2322 GIVEDDLEM 2330
            |..:...||
  Rat   827 GTKQITYEM 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842
		Ion_trans	687..902	CDD:459842
		Ion_trans	1751..2019	CDD:459842	50/241 (21%)
		Na_channel_gate	2009..2063	CDD:240441	18/94 (19%)
		Ion_trans	2067..2320	CDD:459842	72/449 (16%)
		GPHH	2332..2378	CDD:465306
Tpcn2	XP_038935131.1	Ion_trans	66..297	CDD:459842	49/217 (23%)
		Ion_trans	<661..812	CDD:459842	39/170 (23%)