Protein Alignment NaCP60E and Cacna1d

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: XP_017455544.1
• Gene: Cacna1d / 29716
• RGDID: 70973
• Length: 2207
• Species: Rattus norvegicus
• Alignment Length: 3121
• Identity: 589/3121 - (18%)
• Similarity: 975/3121 - (31%)
• Gaps: 1368/3121 - (43%)

  Fly    88 VSKRFRKNYI-HRFTGTKS-------LFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLA 144
            :|:|.|:.|. .:..|..|       ||.....:|.||.|:.|...:.||..::..|..||:.||
  Rat    80 LSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVDWKPFDIFILLAIFANCVALA 144

  Fly   145 M------------TETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGY 197
            :            ...:|:.||.||.|:::|..:||||.|.||:...|:||.||.||||::..|.
  Rat   145 IYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGL 209

  Fly   198 ATIGMEV-------GN----------LAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEV 245
            .::.:|.       ||          :..||.|||||.|:.||.:|.|:.::|:::.:...|..:
  Rat   210 FSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHI 274

  Fly   246 MTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCG 310
            ..|.:|.::::|:..|::::|::...|                  :..|:| .:.:||..|  |.
  Rat   275 ALLVLFVIIIYAIIGLELFIGKMHKTC------------------FFADSD-IVAEEDPAP--CA 318

  Fly   311 NLTGARHCPFEYV-CLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCG---PM 371
            .....|.|..... |......||.|.||||||.::|||.||.||::.|.:|...|....|   |.
  Rat   319 FSGNGRQCAANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPW 383

  Fly   372 SVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLN 436
              .:|..::..|||:::||:|
  Rat   384 --VYFVSLIILGSFFVLNLVL-------------------------------------------- 402

  Fly   437 KNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSA 501
                       |||...:||::.:.|                :.||
  Rat   403 -----------GVLSGEFSKEREKAK----------------ARGD------------------- 421

  Fly   502 TERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYK 566
                    .|..::.||:|:.                  .||.:.:......: :|........:
  Rat   422 --------FQKLREKQQLEED------------------LKGYLDWITQAEDI-DPENEEEGGEE 459

  Fly   567 GQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDM-------GHVSTVELALSPREVRL 624
            |:  .|:..|:|.:..||.|:      |..:.|.|.....:       |...|     .|...|
  Rat   460 GK--RNTSMPTSETESVNTEN------VSGEGETQGCCGSLWCWWKRRGAAKT-----GPSGCR- 510

  Fly   625 IKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPL 689
             :....|::.|....:.....|:.          |.|...|...|.|  ||
  Rat   511 -RWGQAISKSKLSRRWRRWNRFNR----------RRCRAAVKSVTFY--WL-------------- 548

  Fly   690 FELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNI 753
                :.:.:.|||..::.||:...:......|:.|||..::||.|.:||:.:|. :.:|:..:|.
  Rat   549 ----VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNR 609

  Fly   754 FDLLIVTASLLDII---FELVD--GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLT 813
            ||..:|...:.:.|   .||:.  |:||.|.:||||:.|:.:.||::..|::.:::::.::.:|.
  Rat   610 FDCFVVCGGITETILVELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLL 674

  Fly   814 LILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMR 877
            |:|.:.|.||:::|||||...:   .||.....|..|::|..:.:.:|:||.|| |...::|.:.
  Rat   675 LLLFLFIIIFSLLGMQLFGGKF---NFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIM 736

  Fly   878 A---EEEQGASTCFAIFLPTLVMGNFMVLNLFLALLL-NSFNSEELKSKKEEVGEESKLARSIER 938
            |   ....|...|. .|:...:.||:::||:|||:.: |..::|.|.:.::|..||.:
  Rat   737 AYGGPSSSGMIVCI-YFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKE------- 793

  Fly   939 VRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLS 1003
                  :|:..||:..|.|                             :.:||.|
  Rat   794 ------RKKIARKESLENK-----------------------------KNNKPEV---------- 813

  Fly  1004 YQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAM 1068
                           .||...|...||.|
  Rat   814 ---------------NQIANSDNKVTIDD------------------------------------ 827

  Fly  1069 MATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTD 1133
                                                              |.|..|        |
  Rat   828 --------------------------------------------------YQEEAE--------D 834

  Fly  1134 TDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQ 1198
            .|||.
  Rat   835 KDPYP------------------------------------------------------------ 839

  Fly  1199 SQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGT 1263
                                                        .||..     :.||||
  Rat   840 --------------------------------------------PCDVP-----VGEEEE----- 850

  Fly  1264 KLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSP 1328
                                                     |.||
  Rat   851 -----------------------------------------EEEE-------------------- 854

  Fly  1329 AADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRS 1393
                                     ||..:|..|
  Rat   855 -------------------------DEPEVPAGP------------------------------- 863

  Fly  1394 LEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDR 1458
              :.|:|.|
  Rat   864 --RPRRISE-------------------------------------------------------- 870

  Fly  1459 FKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLG 1523
               |::.|::..:||..
  Rat   871 ---LNMKEKIAPIPEGS------------------------------------------------ 884

  Fly  1524 MATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQ 1588
                                                           |..|.:...|.....|..
  Rat   885 -----------------------------------------------AFFILSKTNPIRVGCHKL 902

  Fly  1589 AHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQ 1653
            .:.|
  Rat   903 INHH------------------------------------------------------------- 906

  Fly  1654 KPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHF 1718
               .||.|
  Rat   907 ---IFTNL--------------------------------------------------------- 911

  Fly  1719 YFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKR 1783
                                                  :||.|..||..|..|| .:..:.....
  Rat   912 --------------------------------------ILVFIMLSSAALAAED-PIRSHSFRNT 937

  Fly  1784 VLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLR 1844
            :|.:.:::|..||.||::||....|.    ..:..:::.:||.::|.||:.|..|:.:. :.|::
  Rat   938 ILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA-ISVVK 1001

  Fly  1845 SLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN 1909
            .||.||.|||||||:|.:|::.||..:..||.:|.|:::|..:...:|:.:|||.|.|||::|.:
  Rat  1002 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTD 1066

  Fly  1910 EMGE-------LLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAV 1967
            |...       |..:.:..|....:.:...|.||...||:|....:||..|:|||||..::..|:
  Rat  1067 EAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAI 1131

  Fly  1968 DARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQK 2032
            |:.|.::.|.....:...|:|:|:|:..:||.:|:|:|.:|..|.      |.|..|....|..|
  Rat  1132 DSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQ------EQGEKEYKNCELDK 1190

  Fly  2033 HYYTAMKKLGRKKPQKVIKR--PINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHA 2095
            :....::...:.:|   ::|  |.|.:...|:.:.||..||..:||||.||.|.:.::||:|...
  Rat  1191 NQRQCVEYALKARP---LRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKM 1252

  Fly  2096 VFFILEVSNAFFTTVFGLEAIVKIVGLR---Y--------------------------HYFTVPW 2131
            ....:::.|..||.||.:|.::|::..:   |                          ||||..|
  Rat  1253 FNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADHYFTDAW 1317

  Fly  2132 NVFDFLLVLASIFGILMEDI------MIDLP------------ISPTLLRVVRVFRIGRILRLIK 2178
            |.||.|:|:.|:..|.:.::      .|.||            ||.|..   |:||:.|:::|:.
  Rat  1318 NTFDALIVVGSVVDIAITEVNPSDSENIPLPTATPGNSEESNRISITFF---RLFRVMRLVKLLS 1379

  Fly  2179 AAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQ--GALDDMVNFQTFGRSM 2241
            ..:|||.||:..:.|..||..:..|:.::.||||::||.:||.|.::  ..::...|||||.:::
  Rat  1380 RGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAV 1444

  Fly  2242 QLLFRLMTSAGWNDVLESLM---IQPPDCDPFIHGHTNG---NCGHPLLAITYFTSFIIISYMIV 2300
            .||||..|...|.:::.:.:   :..||.|     :..|   .||.. .||.||.||.::...::
  Rat  1445 LLLFRCATGEAWQEIMLACLPGKLCDPDSD-----YNPGEEYTCGSN-FAIVYFISFYMLCAFLI 1503

  Fly  2301 INMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGIS 2365
            ||:::|:|::||:...::..| :....|:.|...||:|||.|...|....:...:..:.||||..
  Rat  1504 INLFVAVIMDNFDYLTRDWSI-LGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFG 1567

  Fly  2366 K--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPT 2425
            |  |:.||   ||:.|:|::....:.....|.|||:..| .::...|.:|..|::....||
  Rat  1568 KLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTAL-KIKTEGNLEQANEELRAVIKK---- 1627

  Fly  2426 RKELEIVSSTRIWKRQEK---------------------AAKTIQTGWKEYLRR-KREKERSNSG 2468
                       |||:...                     |...||    :|.|: |:.||:...|
  Rat  1628 -----------IWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQ----DYFRKFKKRKEQGLVG 1677

  Fly  2469 ----------------------------------DSATQTSSP-------------GGW------ 2480
                                              |...:.|.|             |.:
  Rat  1678 KYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEDSKPEEEDVFKRNGALLGNYVNHVNS 1742

  Fly  2481 --QSKLSALNFFH--LQVSR------------------------------------------RGT 2499
              :..|...|..|  |.|.|                                          ...
  Rat  1743 DRRESLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNN 1807

  Fly  2500 ACSSRASSRKSSRASDASDLSE------------------LAGPWLNLPLMLVSGADEVVKDIKQ 2546
            |..|:|:..|.....|...:||                  ....:....:...|| ||.:..|.:
  Rat  1808 ANMSKAAHGKRPSIGDLEHVSENGHYSYKHDRELQRRSSIKRTRYYETYIRSESG-DEQLPTICR 1871

  Fly  2547 QNDEL----------GKR------------------------------GSIFVEAPRA------- 2564
            ::.|:          |::                              .|:..|.||.
  Rat  1872 EDPEIHGYFRDPRCFGEQEYFSSEECCEDDSSPTWSRQNYSYYNRYPGSSMDFERPRGYHHPQGF 1936

  Fly  2565 --------------------------SRRRSFYNF-FLRHQDAVDDSLTSPSVHRKTAM------ 2596
                                      |.|||.:|| .||.|::.||.|.||::..:.|:
  Rat  1937 LEDDDSPIGYDSRRSPRRRLLPPTPPSHRRSSFNFECLRRQNSQDDVLPSPALPHRAALPLHLMQ 2001

  Fly  2597 ----------NNTTNTTSNSASTSGTASSTATAPATGCGPAATSASDSDRHQAVG--GGSAPSRK 2649
                      ::.....|.|.||...|:..||.|.....|..|.....||.:::.  .||.||..
  Rat  2002 QQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVDRSESMDQVNGSLPSLH 2066

  Fly  2650 RASSFIRKKPPLERGLSAQSALRVNKNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPDNATLVH 2714
            |:|.:                           ...|::.....:|...|.|.|..
  Rat  2067 RSSWY---------------------------TDEPDISYRTFTPASLTVPSSFR---------- 2094

  Fly  2715 VLVHRESEEYKEEDESSPSVSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSMDTCAMPTVQIMV 2779
               ::.|::.:..|....:|.     ...||...::.|    :..:.:.....|.|.: |:..|.
  Rat  2095 ---NKNSDKQRSADSLVEAVL-----ISEGLGRYARDP----KFVSATKHEIADACDL-TIDEME 2146

  Fly  2780 DSPKDPPRGDFSSAPIDDVGAPI----DVNVQGDTSQVFYDYNPEKATDDQGNGQDETAQFESLP 2840
            .:......|........|:| ||    |..:|        |:.|..:.::...|::|    |.|.
  Rat  2147 SAASTLLNGSVCPRANGDMG-PISHRQDYELQ--------DFGPGYSDEEPDPGREE----EDLA 2198

  Fly  2841 D 2841
            |
  Rat  2199 D 2199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	83/278 (30%)
		Ion_trans	687..902	CDD:459842	64/224 (29%)
		Ion_trans	1751..2019	CDD:459842	86/278 (31%)
		Na_channel_gate	2009..2063	CDD:240441	11/55 (20%)
		Ion_trans	2067..2320	CDD:459842	91/307 (30%)
		GPHH	2332..2378	CDD:465306	18/50 (36%)
Cacna1d	XP_017455544.1	Ion_trans	125..417	CDD:459842	96/369 (26%)
		Ion_trans	545..780	CDD:459842	73/258 (28%)
		Ion_trans	905..1182	CDD:459842	92/443 (21%)
		Ion_trans	1224..1523	CDD:459842	91/307 (30%)
		GPHH	1532..1585	CDD:465306	19/52 (37%)
		Ca_chan_IQ	1595..1669	CDD:462591	18/93 (19%)
		CAC1F_C	1690..2206	CDD:465298	90/574 (16%)