Protein Alignment NaCP60E and NALCN

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: XP_024305104.1
• Gene: NALCN / 259232
• HGNCID: 19082
• Length: 1786
• Species: Homo sapiens
• Alignment Length: 2615
• Identity: 472/2615 - (18%)
• Similarity: 804/2615 - (30%)
• Gaps: 1089/2615 - (41%)

  Fly   106 LFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT-ETVEEAEYI-------FLAIYSI 162
            |::..||           .:.....|.:.:::..|:...|| |.....:|:       .:.:|:.
Human    50 LWINKPW-----------VHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTA 103

  Fly   163 EMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAG----------LRTFRVLR 217
            ||:.|:..:|.:....:|:::.|...|..::...:.::.::|..:|.          ||..|.|.
Human   104 EMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLI 168

  Fly   218 ALKTVSI-----MPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVP 277
            .::...|     :|..: |.|.|..|..|:..|....:|.|:::.:..:|:: |.....||
Human   169 MIRAFRIYFRFELPRTR-ITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCV---- 227

  Fly   278 TDWTNVSHTDWQIWVNDT--DNWLYDEDELP-VLCG-NLTGARHCPFEYVCLCVGE----NPNHG 334
                          ||||  .|..::...:| ..|. .|.....||..:.|:.:.:    ....|
Human   228 --------------VNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELG 278

  Fly   335 YTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCG-P--MSVSFFTVVVFFGSFYLINLMLAVVA 396
            |:.|:....|:.|.::..:.:.|  |:.|..|... |  .|..:|..::||.::.:.|:.:||:
Human   279 YSGFNEIGTSIFTVYEAASQEGW--VFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVI- 340

  Fly   397 LSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRR 461
              .|..|||
Human   341 --IETFAEI-------------------------------------------------------- 347

  Fly   462 KKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLA 526
                                                               :.|:|||
Human   348 ---------------------------------------------------RVQFQQM------- 354

  Fly   527 KSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDD 591
                .||.:....|...::..:|:..|             .||:|
Human   355 ----WGSRSSTTSTATTQMFHEDAAGG-------------WQLVA-------------------- 382

  Fly   592 SGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDL 656
               ||.::.|              ..:|.
Human   383 ---VDVNKPQ--------------GRAPA------------------------------------ 394

  Fly   657 PDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALD 721
                                   ||.|::|..:|.:.| |.:|.....:|..::...|:||...|
Human   395 -----------------------CLQKMMRSSVFHMFI-LSMVTVDVIVAASNYYKGENFRRQYD 435

  Fly   722 ---VGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVDG-LSVLRGLR 781
               :....||.:|..|.::|:..|. ..:.....:.|:||:|..:.|.:..:|... .:..:.||
Human   436 EFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVLR 500

  Fly   782 LLRVLKLAQSWTTMKVLLSIIISTIG---ALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPD 843
            ::|::|::.:      |...:....|   .||:|.:....::.:.:.|.:|:|.   ..|:.|
Human   501 VVRLIKISPA------LEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFC---FVEELD-- 554

  Fly   844 PVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFL 907
                 .|..|..:||.:|:||..| |::.:...:.|.....|......|:...:....::|:||:
Human   555 -----RFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFV 614

  Fly   908 ALLLNSFN-SEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKER-----KFAEKFQQIV 966
            |::|::.. .|:||..|:                   .|:.:...|.||:     :..|||.
Human   615 AVILDNLELDEDLKKLKQ-------------------LKQSEANADTKEKLPLRLRIFEKFP--- 657

  Fly   967 LDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIV 1031
                                                      ||
Human   658 ------------------------------------------NR--------------------- 659

  Fly  1032 DGLEYDDTGDLPEQIQLQAHPLPPTSD-SMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAE 1095
                       |:.:::...|    || ::|...||.|
Human   660 -----------PQMVKISKLP----SDFTVPKIRESFM--------------------------- 682

  Fly  1096 RRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSR 1160
                         :|:..|::   .::..||....:|.:....:.:||         :::||
Human   683 -------------KQFIDRQQ---QDTCCLLRSLPTTSSSSCDHSKRS---------AIEDN--- 719

  Fly  1161 RYGSEE-HDEAFLKYQKSLLTRSPSYRKSLDR--LSQSSGQSQRSLLKSEEAEMRRHSSG----- 1217
            :|..:: ....|....::||.:..:..|.|.:  |..||..|.|..|....:..  ||||
Human   720 KYIDQKLRKSVFSIRARNLLEKETAVTKILSKRPLPTSSPISIRCCLYLGRSHC--HSSGVRACT 782

  Fly  1218 -QSLNSMSIE-----QDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRR 1276
             |.:.|.|.|     :..:||.|.::|               ||...|:.|:..:|||.
Human   783 RQRMLSGSFEGQPAKERSILSVQHHIR---------------QERRSLRHGSNSQRISR------ 826

  Fly  1277 PSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHI 1341
                                      .|.||.:.:..::..|..:...|     |...|.|.|
Human   827 --------------------------GKSLETLTQDHSNTVRYRNAQRE-----DSEIKMIQE-- 858

  Fly  1342 AIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSI 1406
                                                            |:...|.:||:.|:
Human   859 ------------------------------------------------KKEQAEMKRKVQEE--- 872

  Fly  1407 SNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEV 1471
              |:|                                                         |..
Human   873 --ELR---------------------------------------------------------ENH 878

  Fly  1472 PEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPT 1536
            |..:||:             |:.|
Human   879 PYFDKPL-------------FIVG----------------------------------------- 889

  Fly  1537 SLKSSIEPPTLAQISSLKTTPPLAALTEHQ-QHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRR 1600
                                      .||: ::|....::
Human   890 --------------------------REHRFRNFCRVVVR------------------------- 903

  Fly  1601 MEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKP 1665
                       |.|.:::|
Human   904 -----------ARFNASKT---------------------------------------------- 911

  Fly  1666 WHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMD 1730
                                    ||:|    ||.|..|.      .:.||
Human   912 ------------------------DPVT----GAVKNTKY------HQLYD-------------- 928

  Fly  1731 TQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLY-----WINF 1790
                      ...::|.:|     |.::::...|.|::.||       ...:||::     ...:
Human   929 ----------LLGLVTYLD-----WVMIIVTICSCISMMFE-------SPFRRVMHAPTLQIAEY 971

  Fly  1791 SFCLIFVVEMILKWLALGFSKYFTSFWTILDF---IIVFVSVFSLLI----------EENENLKV 1842
            .|.:...:|:.||.:|.|.  :||....|.||   :.:|:.:.||:.          |....|
Human   972 VFVIFMSIELNLKIMADGL--FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-- 1032

  Fly  1843 LRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKC 1907
               |..||.|||||.......||.||..|......||.|.::.|...|:|:..|||.|.||..||
Human  1033 ---LMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKC 1094

  Fly  1908 VNEMGELLPITEVND-----KWDC---------IEQNY-----------------TWINSK-ITF 1940
                         ||     :.||         :.:|.                 .|.|.: ..|
Human  1095 -------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNF 1146

  Fly  1941 DHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIG 2005
            |:||...|||.:|.:.:||:||.         |:...|...::. ||..:|:..|....|.||:|
Human  1147 DNVGNAMLALFEVLSLKGWVEVR---------DVIIHRVGPIHG-IYIHVFVFLGCMIGLTLFVG 1201

  Fly  2006 VIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINH-FLAMFYDLSNSRR 2069
            |:|.|||    :.:|..|   ||..|:.:.....:|...:|..:..||.|. |.|..||::....
Human  1202 VVIANFN----ENKGTAL---LTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYDITQHPF 1259

  Fly  2070 FEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGL-----------R 2123
            |:..|.:|:....:.:.:: :|....|...|...:..||.:|.||..:||:.:           |
Human  1260 FKRTIALLVLAQSVLLSVK-WDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNR 1323

  Fly  2124 YHYFT----VPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRI-GRILRLIKAAKGI 2183
            |....    |.|.|..|.|:.|  :..:|...:|          |.|.|.| |:.:.|
Human  1324 YDLLVTSLGVVWVVLHFALLNA--YTYMMGACVI----------VFRFFSICGKHVTL------- 1369

  Fly  2184 RKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLM 2248
            :.||..:|||:...|.|...:.|:...||..|:.|||.||....::...||.:.|:::.:|||::
Human  1370 KMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITVLFRIV 1434

  Fly  2249 TSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFN 2313
            |...||.::...|:|||.|.|....:...:||:...|:.||.||.:|...|::|:.:|||:|||:
Human  1435 TGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFS 1499

  Fly  2314 QAHQEEEIGIVE-DDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNL 2377
            ..:..||..::. :||..|.|.|:..|                   |...|:..   ...|.|.|
Human  1500 LFYSTEEDQLLSYNDLRHFQIIWNMVD-------------------DKREGVIP---TFRVKFLL 1542

  Fly  2378 PISKGNKIHCLDILHALVKHVLGHVEETDN-----FKQL-----QEQMDVKFKKQFP---TRKEL 2429
            .:.:|.....||....|.||:...:|...|     |..:     ...:|::...|..   .|::|
Human  1543 RLLRGRLEVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQL 1607

  Fly  2430 EIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNS------------------GDSATQTSS 2476
            |...      .:|.|.:||:...|:.|:|.|.|::.:.                  ...:.:|:.
Human  1608 EYTI------EEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIHSLRESQQQELSRFLNPPSIETTQ 1666

  Fly  2477 PGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSR--ASDASDLSELAGPWLNLPLMLVSGADE 2539
            |....:..|..|....:.|.:....|...|.|..||  |:||.......|.| .||    |....
Human  1667 PSEDTNANSQDNSMQPETSSQQQLLSPTLSDRGGSRQDAADAGKPQRKFGQW-RLP----SAPKP 1726

  Fly  2540 VVKDIKQQNDELGKR 2554
            :...:...|...|.|
Human  1727 ISHSVSSVNLRFGGR 1741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	55/279 (20%)
		Ion_trans	687..902	CDD:459842	47/223 (21%)
		Ion_trans	1751..2019	CDD:459842	84/317 (26%)
		Na_channel_gate	2009..2063	CDD:240441	15/54 (28%)
		Ion_trans	2067..2320	CDD:459842	76/268 (28%)
		GPHH	2332..2378	CDD:465306	7/45 (16%)
NALCN	XP_024305104.1	Ion_trans	55..350	CDD:459842	68/437 (16%)
		Ion_trans	402..622	CDD:459842	52/236 (22%)
		Ion_trans	935..1209	CDD:459842	85/319 (27%)
		Ion_trans	1257..1506	CDD:459842	76/268 (28%)