|
Fly 10 DEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLE 74
:::||.:...:...::.:::...| :.::.:|.|..||..:...|..:.|.|||
Rat 29 EQRAVEEEARLQRNKQMEIEEPER------------KPRSDLEAGKNLPLIYGDPPPEVIGIPLE 81
Fly 75 EIDTFIYE-ETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILF 138
::|.:..: :||.|::| ...|.||:.|.:|:|..|:|..|||.:.:..:..|...:|.|||.
Rat 82 DLDPYYSDKKTFIVLNK---GKAIFRFSATPALYLLSPFSIVRRVAIKVLIHALFSMFIMITILT 143
Fly 139 NCIFLAMTET---VEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATI 200
||:|:.|:.. .:..||.|..||:.|.:||::|:||.::.:|:||:|||||||.|||..|.|.
Rat 144 NCVFMTMSNPPSWSKHVEYTFTGIYTFESLIKMLARGFCIDDFTFLRDPWNWLDFSVITMAYVTE 208
Fly 201 GMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYM 265
.:::||::.||||||||||||::::||||||:.||:.|.::|::||.||:|||.||||..||::|
Rat 209 FVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFM 273
Fly 266 GELRNKCVRQVP------------------------------------TDWTNVSHTDWQIWVND 294
|.||.||||..| ..|...|..||:.::||
Rat 274 GNLRQKCVRWPPPMNDTNTTWYGNDTWYSNDTWYGNDTWYINDTWNSQESWAGNSTFDWEAYIND 338
Fly 295 TDNWLYDE---DELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDY 356
..|:.:.| |.| ||||.:.|.|||..|.|:..|.|||:|||::|.|.|:.|..|:|:|.||
Rat 339 EGNFYFLEGSNDAL--LCGNSSDAGHCPEGYECIKAGRNPNYGYTSYDTFSWAFLALFRLMTQDY 401
Fly 357 WENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDS 421
|||::.:.|...|...:.||.|::|.||||||||:|||||::|.|:.|.|..| |...:.
Rat 402 WENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAE------DQEKEE 460
Fly 422 TFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGK--EGGTNGNGNGSNGDDN 484
.|. .:|..|.|.:...:|.|..: |.|...:|:
Rat 461 EFQ------------------------QMLEKYKKHQEEVEKAKAAQALESGEEADGD------- 494
Fly 485 KSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQD 549
|.|:
Rat 495 ------------PTHN------------------------------------------------- 498
Fly 550 SGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVE 614
.|..|.|.| |...|..|.|...||.:.|..||.:..
Rat 499 -------------KDCNGSLDA------SGEKGPPRPSCSADSAISDAMEELEEA---------- 534
Fly 615 LALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCD----RCVH----W--CT 669
||: |. :|.| | |.
Rat 535 ----------------------------HQK---------------CPPWWYKCAHKVLIWNCCA 556
Fly 670 DYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFE 734
.|::|::.:|.:|.||..:|.||:||||||.|:||||:.|:|.|.|.|.|||.|||.|||.|
Rat 557 ---PWVKFKHIIYLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLSVGNLVFTGIFTAE 618
Fly 735 CIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVL 798
.::||:|:.. ::|..||||||..|||.||:::....|.||||||..|||||.|||:||.|:.:|
Rat 619 MVLKLIAMDPYEYFQQGWNIFDSFIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNML 683
Fly 799 LSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPRWNFNDFFHSFMMI 860
:.||.:::||||||||:|.|:::||||:|||||.|.|.. .|...| .:|||:.|||||||:::
Rat 684 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIASDCNLPRWHMNDFFHSFLIV 748
Fly 861 FRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEE 925
||||||||||.:|||| |..|.:.|..:||..:|:||.:||||||||||:||:::.|.:..|:
Rat 749 FRILCGEWIETMWDCM---EVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDED 810
Fly 926 VGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDK 990
||.:.|..:|.|::..| .||:.| .:||.||.
Rat 811 -GEMNNLQIAIGRIKWGI-------------GFAKTF-------------------LLGLLRGK- 841
Fly 991 PGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPP 1055
:|: |::|.|
Rat 842 --ILS-----------------------------------------------PKEIIL------- 850
Fly 1056 TSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYT 1120
|.....|.| ::.||:|
Rat 851 -------------------SLGEPGGAG----------------------------ENAEEST-- 866
Fly 1121 ESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSY 1185
Rat 867 ----------------------------------------------------------------- 866
Fly 1186 RKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELF 1250
Rat 867 ----------------------------------------------------------------- 866
Fly 1251 QFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTS 1315
|..:..:|..| :|||::
Rat 867 --------------------------PEDEKKEPPPE---------------DKELKD------- 883
Fly 1316 LERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSA 1380
..|:.|:.:..|.......|.:....|||.:
Rat 884 -------------------NHILNHVGLTDGPRSSIELDHLNFINNPYLT--------------- 914
Fly 1381 AAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFL 1445
||.|..:.|:..
Rat 915 ------------------------------------IHVPIASEESDL----------------- 926
Fly 1446 RRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTN 1510
|:|.||:..:....|..|.|.:.|:..:. |:.||.
Rat 927 ------------------------EMPTEEETDAFSEPEDIKKPLQPLYDGNS------SVCSTA 961
Fly 1511 SYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQ 1575
.| :||.
Rat 962 DY------------------------------KPPE----------------------------- 967
Fly 1576 AAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQK 1640
|.|:
Rat 968 --------------------------EDPE----------------------------------- 971
Fly 1641 TEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKV 1705
||::.. |:..|
Rat 972 -EQAEEN-PEGEQ---------------------------------------------------- 982
Fly 1706 PDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCF 1770
|::||.:.|.. |||.....:.....|.|..:|.|...:|:...||.|::.:|..||..|.|
Rat 983 PEECFTEACVK----RCPCLYVDISQGRGKMWWTLRRACFKIVEHNWFETFIVFMILLSSGALAF 1043
Fly 1771 EDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIE 1835
|||.:::.:.::.:|.:.:..|..||::||:|||:|.||..|||:.|..|||:||.||:.||:..
Rat 1044 EDIYIEQRRVIRTILEYADKVFTYIFILEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVAN 1108
Fly 1836 --ENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQ 1898
....|..::|||||||||||||:||::|||:|||||:.|||||.|||||||:||||||||||.
Rat 1109 WLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1173
Fly 1899 FFGGKFFKCVN-EMGELLPITEVNDKWDCIEQNYT----WINSKITFDHVGMGYLALLQVATFEG 1958
.|.|||:.||| ...|...|:.||:|.:|....|| |:|.|:.:|:||:|||:|||||||:|
Rat 1174 LFAGKFYYCVNTTTSERFDISVVNNKSECESLMYTGQVRWMNVKVNYDNVGLGYLSLLQVATFKG 1238
Fly 1959 WMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVL 2023
||::|..|||:|..:.||..|.|||.|:||||||:.||||||||||||||||||..|||:.| .
Rat 1239 WMDIMYAAVDSREKEEQPDYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG--K 1301
Fly 2024 EMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIE 2088
::|:||.||.||.||||||.|||||.|.||.|....|.||....:.|:|:|.:||.|||:||.:|
Rat 1302 DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDFVTKQVFDISIMILICLNMVTMMVE 1366
Fly 2089 HYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMI 2153
..||......||...|..|..:|..|.::|:..||::|||:.||:|||::|:.||.|:.:.|::.
Rat 1367 TDDQSQLKVDILYNINMVFIIIFTGECVLKMFALRHYYFTIGWNIFDFVVVILSIVGLALSDLIQ 1431
Fly 2154 DLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSL 2218
...:||||.||:|:.||||:||||:.|||||.|||||::|||||||||.||.|:.|||:|.|||.
Rat 1432 KYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSN 1496
Fly 2219 FGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQ-PPDCDPFIHG---HTNGNC 2279
|..||.:..:|||.||:|||.|:..||.:.|||||:.:|..::.. ||||||.:.. :..|:|
Rat 1497 FAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPTLENPGTNVRGDC 1561
Fly 2280 GHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQ 2344
|:|.:.|.:|.|:||||::||:||||||||||||.|.:|....:.|||.||||..|.|:||.|||
Rat 1562 GNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLSEDDFEMFYETWEKFDPDATQ 1626
Fly 2345 FIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFK 2409
||.:|:||||:.:|..||.|:|||.:.|::.:||:..|:||||||||.||.|.|||...|.|..|
Rat 1627 FIDYSRLSDFVDTLQEPLKIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALK 1691
Fly 2410 QLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERS--------N 2466
|..|: ||....|::...|.:::|...|::|..|..||..::.:|.::..|:.| .
Rat 1692 QTMEE---KFMAANPSKVSYEPITTTLKRKQEEVCAIKIQRAYRRHLLQRSVKQASYMYRHSQDG 1753
Fly 2467 SGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAGP 2525
:||.|.:.. |..:......:.| .:.|....|:....|:| :|.|||
Rat 1754 NGDGAPEKE---GLLANTMNKMYGH---EKEGDGVQSQGEEEKAS--------TEDAGP 1798
| 
