Protein Alignment NaCP60E and Cacna1c

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: XP_063141552.1
• Gene: Cacna1c / 24239
• RGDID: 2245
• Length: 2215
• Species: Rattus norvegicus
• Alignment Length: 3045
• Identity: 626/3045 - (20%)
• Similarity: 997/3045 - (32%)
• Gaps: 1293/3045 - (42%)

  Fly    69 YGKPLEEIDTFIYEETFCVVSKRFRKNYIHRFTGT---KSLFLFYPWSPARRVCVYIATNQFFDY 130
            ||||.::..|                      |.|   ::|......:|.||.|:.|...:.|:.
  Rat   116 YGKPKKQGGT----------------------TATRPPRALLCLTLKNPIRRACISIVEWKPFEI 158

  Fly   131 CVMATILFNCIFLAM------------TETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRN 183
            .::.||..||:.||:            ...:|..||:||.|:::|..:|:||.|.|.:...||||
  Rat   159 IILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 223

  Fly   184 PWNWLDFVVITSGYATIGMEV-----------GNLAG-----LRTFRVLRALKTVSIMPGLKTII 232
            .||.|||:::..|..:..:|.           |..||     ||.|||||.|:.||.:|.|:.::
  Rat   224 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 288

  Fly   233 NALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQ-----VPTDWTNVSHTDWQIWV 292
            |:::.:...|..:..|.:|.::::|:..|:::||::...|..|     ||.
  Rat   289 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIIDVPA-------------- 339

  Fly   293 NDTDNWLYDEDELPVLCGNLTG-ARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDY 356
                    :||..|  |...|| .|.|....||....:.|.||.||||||.::|||.||.||::.
  Rat   340 --------EEDPSP--CALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 394

  Fly   357 WENV-YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDD 420
            |.:| |.|..|....:...:|..:|.||||:::||:|
  Rat   395 WTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVL---------------------------- 431

  Fly   421 STFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNK 485
                                       |||...:||::.:.|                :.||
  Rat   432 ---------------------------GVLSGEFSKEREKAK----------------ARGD--- 450

  Fly   486 SHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDS 550
                                    .|..::.||:|:
  Rat   451 ------------------------FQKLREKQQLEE----------------------------- 462

  Fly   551 GMGVKNPNMLYPSDYKGQL----IANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTND-MGHV 610
                         |.||.|    .|....|.:...|::.:..::.......|:::..... ..|.
  Rat   463 -------------DLKGYLDWITQAEDIDPENEDEGMDEDKPRNRGAPAGLHDQKKGKFAWFSHS 514

  Fly   611 STVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCD-RCVH------WC 668
            :...:::...|.                     :..::|.|...|:...||. |..|      :.
  Rat   515 TETHVSMPTSET---------------------ESVNTENVAGGDIEGENCGARLAHRISKSKFS 558

  Fly   669 TDYESWLQFQNCLYK---VVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSI 730
            ..:..|.:|  |..|   .|:..:|...:...:.|||..:|.||:..........|..||...::
  Rat   559 RYWRRWNRF--CRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLAL 621

  Fly   731 FTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-------GLSVLRGLRLLRVLK 787
            ||.|.::|:.:|. :.:|:..:|.||..||...:|:.|  ||:       |:||||.:||||:.|
  Rat   622 FTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETI--LVETKIMSPLGISVLRCVRLLRIFK 684

  Fly   788 LAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNFND 852
            :.:.|.::..|::.:::::.::.:|.|:|.:.|.||:::|||||...:   .||.....|..|::
  Rat   685 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF---NFDEMQTRRSTFDN 746

  Fly   853 FFHSFMMIFRILCGE-WIEPLWDCMRA---EEEQGASTCFAIFLPTLVMGNFMVLNLFLALLL-N 912
            |..|.:.:|:||.|| |...::|.:.|   ....|...|. .|:...:.||:::||:|||:.: |
  Rat   747 FPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDN 810

  Fly   913 SFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTL 977
            ..::|.|.|.::|..||                  :|||........||.|:::
  Rat   811 LADAESLTSAQKEEEEE------------------KERKKLARTASPEKKQEVM----------- 846

  Fly   978 SHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDL 1042
                       :||.|           :||..
  Rat   847 -----------EKPAV-----------EESKE--------------------------------- 856

  Fly  1043 PEQIQLQAHPLPPTSD-SMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGV 1106
             |:|:|::    .|:| ..|||.:..|                 .:|.|
  Rat   857 -EKIELKS----ITADGESPPTTKINM-----------------DDLQP---------------- 883

  Fly  1107 STQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAF 1171
                  |..|                |..|::|...:|
  Rat   884 ------SENE----------------DKSPHSNPDTAG--------------------------- 899

  Fly  1172 LKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGN 1236
                                                                  |:||
  Rat   900 ------------------------------------------------------EEDE------- 903

  Fly  1237 LREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQS 1301
                              ||.|:..|.:.|.:|
  Rat   904 ------------------EEPEMPVGPRPRPLS-------------------------------- 918

  Fly  1302 FEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSY 1366
                           |..|...:.|.|   ||:...:
  Rat   919 ---------------ELHLKEKAVPMP---EASAFFI---------------------------- 937

  Fly  1367 DLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAA 1431
                                                 ||.:|..|..|.:|
  Rat   938 -------------------------------------FSPNNRFRLQCHRI-------------- 951

  Fly  1432 TSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGP 1496
                                  |....|..|.|.
  Rat   952 ----------------------VNDTIFTNLILF------------------------------- 963

  Fly  1497 DQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAA 1561
             .:.|.|:||
  Rat   964 -FILLSSISL------------------------------------------------------- 972

  Fly  1562 LTEHQQHFHATSIQAAPTPA-HTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSG 1625
                          ||..|. ||                             ||::
  Rat   973 --------------AAEDPVQHT-----------------------------SFRN--------- 985

  Fly  1626 AADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYND 1690
                                                     |.|
  Rat   986 -----------------------------------------HIL--------------------- 988

  Fly  1691 PMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEW 1755
                                       |||.
  Rat   989 ---------------------------FYFD---------------------------------- 992

  Fly  1756 FVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKYFTSF 1816
            .|...||...|.|              ::|...::.|..||.:|:|||..|.|.    ..:..::
  Rat   993 IVFTTIFTIEIAL--------------KILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNY 1043

  Fly  1817 WTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNV 1881
            :.|||.::|.||:.|..|:.:. :.|::.||.||.|||||||:|.:|::.||..:..||.:|.|:
  Rat  1044 FNILDLLVVSVSLISFGIQSSA-INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNI 1107

  Fly  1882 LLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIE-----------QNYTWIN 1935
            ::|..:...:|:.:|||.|.||.:.|.:...:    ||...|.:.|.           |..:|.|
  Rat  1108 VIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQ----TEAECKGNYITYKDGEVDHPIIQPRSWEN 1168

  Fly  1936 SKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAY-----IYFVIFIVCG 1995
            ||..||:|....:||..|:|||||.|::..::|:...|..|     :|.|     |:|:|:|:..
  Rat  1169 SKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGP-----IYNYRVEISIFFIIYIIII 1228

  Fly  1996 SFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPI---NHF 2057
            :||.:|:|:|.:|..|.      |.|..|....|..|:....::...:.:|   ::|.|   .|.
  Rat  1229 AFFMMNIFVGFVIVTFQ------EQGEQEYKNCELDKNQRQCVEYALKARP---LRRYIPKNQHQ 1284

  Fly  2058 LAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGL 2122
            ..::| :.||..||..:||||.||.:.:.::||.|.......:.:.|..||.:|.:|.|:|::..
  Rat  1285 YKVWY-VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF 1348

  Fly  2123 R-YHYFTVPWNVFDFLLVLASIFGILMEDI--MIDLPISPTL---------LRVVRVFRIGRILR 2175
            : .|||...||.||.|:|:.||..|.:.::  ......||::         :...|:||:.|:::
  Rat  1349 KPKHYFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVK 1413

  Fly  2176 LIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMV------NF 2234
            |:...:|||.||:..:.|..||..:..|:.::.||||::||.:||.:    ||:|..      ||
  Rat  1414 LLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKI----ALNDTTEINRNNNF 1474

  Fly  2235 QTFGRSMQLLFRLMTSAGWNDVLESLMIQP-----PDCDPFIHGHTNGN--CGHPLLAITYFTSF 2292
            |||.:::.||||..|...|.|::  |...|     |:.:|  ...|.|.  ||.. .|:.||.||
  Rat  1475 QTFPQAVLLLFRCATGEAWQDIM--LACMPGKKCAPESEP--SNSTEGETPCGSS-FAVFYFISF 1534

  Fly  2293 IIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIAS 2357
            .::...::||:::|:|::||:...::..| :....|:.|...|::|||.|...|....:...:..
  Rat  1535 YMLCAFLIINLFVAVIMDNFDYLTRDWSI-LGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRR 1598

  Fly  2358 LDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDV 2417
            :.||||..|  |:.||   |||.|:|::....:.....|.|||:..| .::...|.:|..|::..
  Rat  1599 IQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTAL-RIKTEGNLEQANEELRA 1662

  Fly  2418 KFKKQFPTRKELEIVSSTRIWKRQEK---------------------AAKTIQTGWKEYLRR-KR 2460
            ..||               ||||...                     |...||    ||.|: |:
  Rat  1663 IIKK---------------IWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQ----EYFRKFKK 1708

  Fly  2461 EKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAGP 2525
            .||:              |...|.|..|...||...|                    .|.:: ||
  Rat  1709 RKEQ--------------GLVGKPSQRNALSLQAGLR--------------------TLHDI-GP 1738

  Fly  2526 WLNLPLMLVSG----ADEVVKDIKQ------QNDELGKRGSIF---VEAPRASRRRSFYNFFL-- 2575
            .:.   ..:||    .:|:.|.:|:      ::|...:.|.:|   |...::..|.:|...|.
  Rat  1739 EIR---RAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDSRSNFPQTFATQ 1800

  Fly  2576 ------------------RHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSA-----STSGTASSTA 2617
                              .|:..||.:.| ||.:..|..|...|..:|:|     ..:|.:|:.:
  Rat  1801 RPLHINKTGNNQADTESPSHEKLVDSTFT-PSSYSSTGSNANINNANNTALGRFPHPAGYSSTVS 1864

  Fly  2618 TAPATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQSALRVNKNAFVSEA 2682
            |....|                                   |||      ..|:||.:.|:...:
  Rat  1865 TVEGHG-----------------------------------PPL------SPAVRVQEAAWKLSS 1888

  Fly  2683 SAPEVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRESEEYKEEDE--SSPSVSGNGNGFGVGL 2745
            ....      |.|.|....|..:.||..        |.|....||.|  |.||:        :..
  Rat  1889 KRCH------SRESQGATVSQDMFPDET--------RSSVRLSEEVEYCSEPSL--------LST 1931

  Fly  2746 DMLSKQPPPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPPRGDFSSAPIDDVGAPIDVNVQGDT 2810
            |:||.|..          |:...||.....:.:..|||   |....||.:.
  Rat  1932 DILSYQDD----------ENRQLTCLEEDKREIQPSPK---RSFLRSASLG-------------- 1969

  Fly  2811 SQVFYDYNPEKATDDQGNGQDETAQFESLP---------------------------DRQR-XPP 2847
            .:..:.....|...|||.   :.:|..:||                           .|.| .||
  Rat  1970 RRASFHLECLKRQKDQGG---DISQKTALPLHLVHHQALAVAGLSPLLQRSHSPSTFPRPRPTPP 2031

  Fly  2848 V-----NTPLRDSEKRSSRGSRSSSSSTSSIRS--CSS-SSSSSAASAAAPSARR 2894
            |     ..||:........|:.||....||..|  ||| |..::|.|..:..|||
  Rat  2032 VTPGSRGRPLQPIPTLRLEGAESSEKLNSSFPSIHCSSWSEETTACSGGSSMARR 2086

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	88/280 (31%)
		Ion_trans	687..902	CDD:459842	67/226 (30%)
		Ion_trans	1751..2019	CDD:459842	89/287 (31%)
		Na_channel_gate	2009..2063	CDD:240441	10/56 (18%)
		Ion_trans	2067..2320	CDD:459842	89/277 (32%)
		GPHH	2332..2378	CDD:465306	18/50 (36%)
Cacna1c	XP_063141552.1	None