Protein Alignment NaCP60E and Scn10a

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_001192250.1
• Gene: Scn10a / 20264
• MGIID: 108029
• Length: 1958
• Species: Mus musculus
• Alignment Length: 2646
• Identity: 824/2646 - (31%)
• Similarity: 1182/2646 - (44%)
• Gaps: 850/2646 - (32%)

  Fly    11 EKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLEE 75
            ||.:|.|:.   .::.:.|...:     ::....||.:..::..:.|||.:...|..:.|:|||:
Mouse    25 EKQIAAHRA---AKKGRPKQRGQ-----KDKSEKPRPQLDLKACNQLPRFYGELPAELVGEPLED 81

  Fly    76 IDTFI-YEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFN 139
            :|.|. ...||.|:.|   ...|.||:.|.:|:||.|::..||..:.::.:.:|...:..|||.|
Mouse    82 LDPFYSTHRTFIVLDK---SRTISRFSATWALWLFSPFNLIRRTAIKVSVHSWFSIFITVTILVN 143

  Fly   140 CIFLAMTETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEV 204
            |:.:..|:..|:.||.|..:|:.|.:|||:|:||.||::||||:|||||||.|||..|....:::
Mouse   144 CVCMTRTDLPEKLEYAFTVVYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGAAIDL 208

  Fly   205 GNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELR 269
            ..::|||||||||||||||::||||.|:.||:||.|:||:|..||:|||.||||..||::.|.|:
Mouse   209 RGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFALVGLQLFKGNLK 273

  Fly   270 NKCVRQ--VPTDWTNVSHT---DWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGE 329
            |||::.  .|....|:|..   |..|....||         |:||||.:.|.|||.:|||....:
Mouse   274 NKCIKNGTDPHKADNLSSEMAGDIFIKPGTTD---------PLLCGNGSDAGHCPNDYVCRKTSD 329

  Fly   330 NPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAV 394
            ||:..||:||:|.|:.|:.|:|:|.|.||.:|...|...|.|.:.||.:|:|.|||||:||:|||
Mouse   330 NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMVFFVLVIFLGSFYLVNLILAV 394

  Fly   395 VALSYEEE-----AEITNEERK-KDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLAS 453
            |.::|||:     |||..:|:| |:.|:     ....:..||....::..:   :.|..|..||.
Mouse   395 VTMAYEEQSQATIAEIEAKEKKFKEALE-----VLQKEQEVLAALGIDTTS---LYSHNGSPLAP 451

  Fly   454 YSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQ 518
            .:..:.|.:......||.|         |||:|..:.|                        |.|
Mouse   452 KNANERRPRVKSRMSEGST---------DDNRSLQSDP------------------------YNQ 483

  Fly   519 MEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGV 583
            .                        |:||    :|:                 :||:..::.|.|
Mouse   484 R------------------------RMSF----LGL-----------------SSGRRRASHSSV 503

  Fly   584 --NRESSQDDS---GVVDD---HEEQDTTND---MGH---------------------------- 609
              .|..|||.|   |::||   |.:|::...   :|.
Mouse   504 FHFRAPSQDVSFPDGILDDGVFHGDQESRRSSILLGRGAGQAGPLPRSPLPQSPNPGPRRGEEGQ 568

  Fly   610 --VSTVELALSPREVRLIKCNGNIARIKNH-NVYALHQEFSSE----VV-----VIDDLPDR--N 660
              |.|.|||....|...:...|.    ||. :...|::.|.::    ||     ||::|.:.  .
Mouse   569 RGVPTGELATGAPEGPALDAAGQ----KNFLSADYLNEPFRAQRAMSVVSIMTSVIEELEESKLK 629

  Fly   661 CDRC--------VHW-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESF 716
            |..|        :.| |.  ..|.:|:..|:::|.||..||.||||||:||.|:||||:.|:::|
Mouse   630 CPPCLISLAQKYLIWECC--PKWKKFKMVLFELVTDPFAELTITLCIVVNTVFMAMEHYPMTDAF 692

  Fly   717 RNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGL 780
            ...|..||.|||..||.|...|::|... .:|...|||||.:|||.|||::.......|||||..
Mouse   693 DAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSLLELSTSKKGSLSVLRTF 757

  Fly   781 RLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPV 845
            |||||.|||:||.|:.:|:.||.:::|||||||.||.|:::|||::|.||.|::|...:   |.:
Mouse   758 RLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTFILAIIVFIFALVGKQLLSENYGCRR---DGI 819

  Fly   846 P-------RWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVL 903
            .       ||:..||||||:::||||||||||.:|.||...::.   .|..:||..:|:||.:||
Mouse   820 SVWNGERLRWHMCDFFHSFLVVFRILCGEWIENMWVCMEVSQDY---ICLTLFLTVMVLGNLVVL 881

  Fly   904 NLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLD 968
            |||:|||||||:::.|.:.::: ||.:.|..::.|:
Mouse   882 NLFIALLLNSFSADNLTAPEDD-GEVNNLQVALARI----------------------------- 916

  Fly   969 AQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDG 1033
                  |...|:|:
Mouse   917 ------QVFGHRAS--------------------------------------------------- 924

  Fly  1034 LEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRL 1098
                                                                :.:|.::::..||
Mouse   925 ----------------------------------------------------RAITSYIRSHCRL 937

  Fly  1099 QHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYG 1163
            :
Mouse   938 R---------------------------------------------------------------- 938

  Fly  1164 SEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQD 1228
                   :.|.:..|..:.|                    |.|.:||  .|          |..|
Mouse   939 -------WPKVETQLGMKPP--------------------LTSCKAE--NH----------IATD 964

  Fly  1229 ELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHS 1293
            .:.:..|||.:..|.                                      |..||     |.
Mouse   965 AVNAAVGNLAKPALG--------------------------------------GPKEN-----HG 986

  Fly  1294 EFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVL 1358
            :|                           :::|:         :...:.|..|.|:....:|
Mouse   987 DF---------------------------ITDPN---------VWVSVPIAEGESDLDELEE--- 1012

  Fly  1359 PLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVA 1423
                       .|...|||   :.|.:|.|.::..|::.:|.::.
Mouse  1013 -----------DVEHASQS---SWQEESPKGQQELLQQVQKCEDH-------------------- 1043

  Fly  1424 MEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKM 1488
               .|..:..:..:..:.:|:|.          :|::|                        |:.
Mouse  1044 ---QAARSPPSGMSSEDLAPYLG----------ERWQR------------------------EES 1071

  Fly  1489 PRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSL 1553
            ||                                       |||
Mouse  1072 PR---------------------------------------VPA--------------------- 1076

  Fly  1554 KTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSAR 1618
                                                                             
Mouse  1077 ----------------------------------------------------------------- 1076

  Fly  1619 TESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRN 1683
                 .|..|.||         :|.|....||..:.......|.|:        :|:
Mouse  1077 -----EGVDDTSS---------SEGSTVDCPDPEEILRKIPELAEE--------LDE-------- 1111

  Fly  1684 SQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKH-WT---RVRTAV 1744
                                  ||||||:.|..    |||    |....::|. |.   :||...
Mouse  1112 ----------------------PDDCFPEGCTR----RCP----CCKVNTSKFPWATGWQVRKTC 1146

  Fly  1745 LTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF 1809
            ..:|:...||.|::.:|..||..|.|||..|::...:|.||.:.:..|..|||.||:|||:|.||
Mouse  1147 YRIVEHSWFESFIIFMILLSSGALAFEDNYLEEKPRVKSVLEYTDRVFTFIFVFEMLLKWVAYGF 1211

  Fly  1810 SKYFTSFWTILDFIIVFVSVFSLL--IEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALM 1872
            .||||:.|..|||:||.:|:.||:  |.|..::..:::||||||||||||:||::|||:||:||:
Mouse  1212 KKYFTNAWCWLDFLIVNISLTSLIAKILEYSDVASIKALRTLRALRPLRALSRFEGMRVVVDALV 1276

  Fly  1873 YAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPI---TEVNDKWDCIEQNYT-- 1932
            .|||||.|||||||:||||||||||..|.|||.:||:.......:   |.|.:|.||..||.|
Mouse  1277 GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFSRCVDTRSNPFSVVNSTFVTNKSDCYNQNNTGH 1341

  Fly  1933 --WINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCG 1995
              |:|.|:.||:|.||||||||||||:|||::|..|||:|.::.||..|.:||.|:|||:||:.|
Mouse  1342 FFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSRDINSQPNWEESLYMYLYFVVFIIFG 1406

  Fly  1996 SFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAM 2060
            .|||||||:||||||||..|||..|  .::|:||.||.||.||||||.|||||.|.||:|.:...
Mouse  1407 GFFTLNLFVGVIIDNFNQQKKKIRG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGF 1469

  Fly  2061 FYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYH 2125
            .:|:...:.|:|.|..||.|||:||.:|..:|......:|...|.||..||..|.::|:..||.:
Mouse  1470 VFDIVTRQAFDIIIMALICLNMITMMVETDNQSEEKTKVLGRINQFFVAVFTGECVMKMFALRQY 1534

  Fly  2126 YFTVPWNVFDFLLVLASIFGILMEDIMIDLP--ISPTLLRVVRVFRIGRILRLIKAAKGIRKLLF 2188
            |||..||||||::|:.||..:|...|:..|.  .|||||||:|:.|||||||||:||||||.|||
Mouse  1535 YFTNGWNVFDFIVVILSISSLLFSAILSSLESYFSPTLLRVIRLARIGRILRLIRAAKGIRTLLF 1599

  Fly  2189 ALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGW 2253
            ||::|||||||||.||.|:.|||:|.||:.|.||..:..:|||.||:|||.||..||::.|||||
Mouse  1600 ALMMSLPALFNIGLLLFLVMFIYSIFGMASFANVIDEAGIDDMFNFKTFGNSMLCLFQITTSAGW 1664

  Fly  2254 NDVLESLM-IQPPDCD---PFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQ 2314
            :.:|..:: ..||.||   |..:| :.||||.|.:.|.:||::||||::||:|||||:||||||.
Mouse  1665 DGLLSPILNTGPPYCDPNRPNSNG-SKGNCGSPAVGILFFTTYIIISFLIVVNMYIAVILENFNV 1728

  Fly  2315 AHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPI 2379
            |.:|....:.|||.:|||..|.|:||.|||||.||.||||..:|..||.|.|||...|:..:||:
Mouse  1729 ATEESTEPLSEDDFDMFYETWEKFDPEATQFIAFSALSDFADTLSGPLRIPKPNQNILIQMDLPL 1793

  Fly  2380 SKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKA 2444
            ..|:||||||||.|..|:|||...|.|:   |:..|:.||.....::...|.:::|...|:::.:
Mouse  1794 VPGDKIHCLDILFAFTKNVLGESGELDS---LKTNMEEKFMATNLSKASYEPIATTLRCKQEDIS 1855

  Fly  2445 AKTIQTGWKEYLRRK-----------REKE---------------RSNSG-----DSATQTSSPG 2478
            |..||..::.|:.::           |.:|               ..|.|     ::|:.||.|.
Mouse  1856 ATIIQKAYRNYMLQRSLMLSNPLHVPRAEEDGVSLPREGYVTFMANDNGGLPDKSETASATSFPP 1920

  Fly  2479 GWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAG 2524
            .:.|....|              |.||:...||...:..:::...|
Mouse  1921 SYDSVTRGL--------------SDRANISTSSSMQNEDEVTAKEG 1952

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	117/250 (47%)
		Ion_trans	687..902	CDD:459842	107/222 (48%)
		Ion_trans	1751..2019	CDD:459842	154/276 (56%)
		Na_channel_gate	2009..2063	CDD:240441	30/53 (57%)
		Ion_trans	2067..2320	CDD:459842	137/258 (53%)
		GPHH	2332..2378	CDD:465306	24/45 (53%)
Scn10a	NP_001192250.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..54		5/34 (15%)
		I. /evidence=ECO:0000305	116..404		138/296 (47%)
		Ion_trans	129..406	CDD:459842	136/285 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..483		13/71 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	539..583		6/43 (14%)
		II. /evidence=ECO:0000305	646..910		127/272 (47%)
		Ion_trans	663..893	CDD:459842	118/235 (50%)
		Na_trans_assoc	903..1148	CDD:461936	80/824 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1006..1094		27/300 (9%)
		III. /evidence=ECO:0000305	1141..1450		168/310 (54%)
		Ion_trans	1152..1428	CDD:459842	152/275 (55%)
		Na_channel_gate	1420..1472	CDD:240441	30/53 (57%)
		IV. /evidence=ECO:0000305	1459..1758		153/299 (51%)
		Ion_trans	1476..1733	CDD:459842	136/257 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1901..1958		14/66 (21%)