Protein Alignment NaCP60E and Cacna1e

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: XP_011246211.1
• Gene: Cacna1e / 12290
• MGIID: 106217
• Length: 2466
• Species: Mus musculus
• Alignment Length: 2898
• Identity: 636/2898 - (21%)
• Similarity: 1081/2898 - (37%)
• Gaps: 942/2898 - (32%)

  Fly   100 FTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLA------------MTETVEEA 152
            ||..:|||:|...:..|:....:.....|:|.::|||:.|||.||            |:..:|:.
Mouse   210 FTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 274

  Fly   153 EYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSG-YATIGMEVG---NLAGLRTF 213
            |..|:.|:..|..|||:|.||:.:|.:||||.||.:||:|:.|| .||.|....   :|..||..
Mouse   275 EPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAV 339

  Fly   214 RVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPT 278
            ||||.||.||.:|.|:.::.:::.:...|.::..|..|.:::||:..|:.|.|:|...|
Mouse   340 RVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRAC------ 398

  Fly   279 DWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCL-CVGENPNHGYTNFDNFM 342
                        ::|::.  :.:..:.|..|    |.:.||..|.|. .:|  ||.|.|.|||.:
Mouse   399 ------------FMNNSG--ILEGFDPPHPC----GVQGCPAGYECKDWIG--PNDGITQFDNIL 443

  Fly   343 WSMLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEIT 406
            :::||.||.||::.|..| ||...|.....:..:|..::..|||:::||:|.|::..:.:|.|
Mouse   444 FAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERE-- 506

  Fly   407 NEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGG 471
            ..|.::..:..|......        ::|| ..:..||..:.|:||
Mouse   507 RVENRRAFMKLRRQQQIE--------RELN-GYRAWIDKAEEVMLA------------------- 543

  Fly   472 TNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNP 536
                      ::||             :|.|   |||
Mouse   544 ----------EENK-------------NSGT---SAL---------------------------- 554

  Fly   537 MAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQ 601
                                           :::..:....|.:..:.|:||  |...||
Mouse   555 -------------------------------EVLRRATIKRSRTEAMTRDSS--DEHCVD----- 581

  Fly   602 DTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVH 666
                    :|:|...|:...::..|.:|        ..|..|:|....:
Mouse   582 --------ISSVGTPLARASIKSTKVDG--------ASYFRHKERLLRI---------------- 614

  Fly   667 WCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIF 731
                         .:..:|:..:|...:...:.||||.:|:.||...:...:.|.....:|..:|
Mouse   615 -------------SIRHMVKSQVFYWIVLSVVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLF 666

  Fly   732 TFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-----GLSVLRGLRLLRVLKLAQ 790
            ..|..:|:..:. :.:|...:|.||..:...|:.::::.:..     |:||||.|||||:.|:.:
Mouse   667 LLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITK 731

  Fly   791 SWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFH 855
            .|.:::.|:..::|::.::.:|..:|.:.|.:||::|||||...:   .|: |..|..||:.|..
Mouse   732 YWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF---NFN-DGTPSANFDTFPA 792

  Fly   856 SFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVM-GNFMVLNLFLALLL-NSFNSE 917
            :.|.:|:||.|| |.|.:::.:|::....:....||:...|.: ||:.:||:|||:.: |..|::
Mouse   793 AIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQ 857

  Fly   918 ELKSKKEEVGEESKLARSIERVRDL----------IRKKRQER-------------KDRKERKFA 959
            ||...::|..|......::::.:::          |.:.|:.|             ::|:.|...
Mouse   858 ELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRRRHHM 922

  Fly   960 EKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMN---------RPVSGS 1015
            ..::|.....:: |.|..|.:|   |.:.:.|.:......:.||....:|         ||:.|.
Mouse   923 SVWEQRTSQLRR-HMQMSSQEA---LNKEEAPPMNPLNPLNPLSPLNPLNAHPSLYRRPRPIEGL 983

  Fly  1016 DFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPL------PPTSDSMPPTYESAMMATTGG 1074
            ..|..:...:.......|....|.|.|...:..|..||      ||.   :|
Mouse   984 ALGLGLEKCEEERISRGGSLKGDIGGLTSALDNQRSPLSLGKREPPW---LP------------- 1032

  Fly  1075 SFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYAN 1139
              .|.:||  |.          .:|.:...|.:...::.|  |.:.:|
Mouse  1033 --RSCHGN--CD----------PIQQEAGGGETVVTFEDR--ARHRQS----------------- 1064

  Fly  1140 DQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLL 1204
             ||.             :..||..:|..|.|     .:..:||.|..:|||......|
Mouse  1065 -QRR-------------SRHRRVRTEGKDSA-----SASRSRSASQERSLDEGVSVEG------- 1103

  Fly  1205 KSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRIS 1269
               |.|...|||.:|                           ||  ..:.|||..|   .|||.:
Mouse  1104 ---EKEHEPHSSHRS---------------------------KE--PTIHEEERTQ---DLRRTN 1133

  Fly  1270 NVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEA- 1333
            ::| ..|.|..:|                                :|:...:.|.:|.|..:..
Mouse  1134 SLM-VPRGSGLVG--------------------------------ALDEAETPLVQPQPELEVGK 1165

  Fly  1334 TKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQR 1398
            ..|:.|..|  .|:||::...:|.|.:              .:.:|                 |.
Mouse  1166 DAALTEQEA--EGSSEQALLGDVQLDV--------------GRGIS-----------------QS 1197

  Fly  1399 KIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLS 1463
            :.|.....:|               |:.....:||.:.|.|:..|.:...|...:.:.|  ...|
Mouse  1198 EPDLSCMTAN---------------MDKATTESTSVTVAIPDVDPLVDSTVVNISNKTD--GEAS 1245

  Fly  1464 LIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPP 1528
            .::..|...|||:      :|.:|..:|                          :|::.|.|..|
Mouse  1246 PLKEAETKEEEEE------VEKKKKQKK--------------------------EKRETGKAMVP 1278

  Fly  1529 AVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHS 1593
                                                                             
Mouse  1279 ----------------------------------------------------------------- 1278

  Fly  1594 MAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAF 1658
                                        ||                                |.|
Mouse  1279 ----------------------------HS--------------------------------SMF 1283

  Fly  1659 TRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCP 1723
            ...|..|
Mouse  1284 IFSTTNP---------------------------------------------------------- 1290

  Fly  1724 WFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFED---INLDKNKTLKRVL 1785
                            :|.|...:|:...||..:|::|.||||.|..||   .|.::||    ||
Mouse  1291 ----------------IRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNK----VL 1335

  Fly  1786 YWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIV------FVSVFSLLIEENENL 1840
            .:.::.|..:|..||::|.:..|.    ..||...|.||||::|      |....:|...:..::
Mouse  1336 RYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDI 1400

  Fly  1841 KVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFF 1905
            |.::|||.||.||||:.|.|...::.|.:.::.::.::||:|:|..:|..||:::.||.|.||||
Mouse  1401 KTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF 1465

  Fly  1906 KCVNEMGELLPITEVNDKWDCIEQNYT-------------WINSKITFDHVGMGYLALLQVATFE 1957
            .|.:...:    ||.    :|| .||.             |...:..:|::....|.|..|:|.|
Mouse  1466 YCTDSSKD----TEK----ECI-GNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGE 1521

  Fly  1958 GWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGV 2022
            ||.:|:..:||....|..|.|...:...|::|::.|...||.:|:|:.:||..|   :::.:..:
Mouse  1522 GWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITF---QEQGDKMM 1583

  Fly  2023 LEMFLTESQK---HYYTAMKKLGRKKPQK--VIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNM 2082
            .|..|.::::   .:..:.|.|.|..||.  ..:..:.||:.       |..||..|..:|.||.
Mouse  1584 EECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVV-------SPSFEYTIMAMIALNT 1641

  Fly  2083 LTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRY-HYFTVPWNVFDFLLVLASIFGI 2146
            :.:.:::|..|......|:..|..||.||.||.::|::...: :||...||:|||:.|:.||..|
Mouse  1642 VVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEI 1706

  Fly  2147 LMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIY 2211
            ::.|..: :..|...:..:::||..|:::|::....||.||:..|.|..||..:..|:.::.|||
Mouse  1707 ILTDSKL-VNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIY 1770

  Fly  2212 AILGMSLFGNVKL--QGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGH 2274
            ||:||.:|||:||  :..::...||::|..|:.||||..|...|.:::.|.:.: ..|:|.....
Mouse  1771 AIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGE-KGCEPDTTAP 1834

  Fly  2275 TNGN----CGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRW 2335
            :..|    ||.. ||..||.|||.....:::|:::|:|::||....::..| :....|:.|...|
Mouse  1835 SGQNESERCGTD-LAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSI-LGPHHLDEFVRVW 1897

  Fly  2336 SKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALV 2395
            ::||..|...||::::.:.:..:.||||:.|  |:.||   ||..|:|:::...:|....|.||:
Mouse  1898 AEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALI 1962

  Fly  2396 KHVL------GHVEETDNFKQLQEQ------------------------------------MDV- 2417
            :..|      |..:......:||::                                    ||.
Mouse  1963 RTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYY 2027

  Fly  2418 ---KFKKQFPTRKELEIVSSTRIWKRQEKAA--KTIQTGWKEYLRRKREKERSNSGDSATQTSSP 2477
               |.|||   |::||...:..:::|.|.::  :.|....|.....:::.....||.|...:.||
Mouse  2028 KQSKVKKQ---RQQLEEQKNAPMFQRMEPSSLPQEIIANAKALPYLQQDPVSGLSGRSGYPSMSP 2089

  Fly  2478 -----------------GGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASD-----ASDLS 2520
                             |.:|.:.|.:|           |.....|..||.::|:     ..|..
Mouse  2090 LSPQEIFQLACMDPADDGQFQEQQSLVN-----------AQEPEVSELKSVQSSNHGIYLPPDTQ 2143

  Fly  2521 ELAG-------PWLNLPLMLVSGADEV------VKDIKQQN----DELG-KRGSIFVEAPRASRR 2567
            |.||       |.|.:...:|:....:      ::| |:.|    :|.. :|.|   |....|||
Mouse  2144 EHAGSGRASSMPRLTMDPQVVTDPSSMRRSFSTIRD-KRSNSSWLEEFSMERSS---ENTYKSRR 2204

  Fly  2568 RSFYNFFLR-----------HQDAVDDS-------------LTSPSVHRKTAMNNTTNT------ 2602
            || |:..||           |:.....|             |.||.|.|..:....|..
Mouse  2205 RS-YHSSLRLSAHRLNSDSGHKSDTHRSGGRERGRSKERKHLLSPDVSRCNSEERGTQADWESPE 2268

  Fly  2603 TSNSASTSGTASSTATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSA 2667
            ...|.|.|...|.|.....||....::..|.||.       |.|.|.|..  :...||..|.|.:
Mouse  2269 RRQSRSPSEGRSQTPNRQGTGSLSESSIPSISDT-------STPRRSRRQ--LPPVPPKPRPLLS 2324

  Fly  2668 QSALRVNKNAFV-----SEASAP---------EVIVTRPS----PEQQTHP---HSLSLRPDNAT 2711
            .|:|..:.....     ||..:|         ...:|..|    |:|..||   |.:| .|
Mouse  2325 YSSLMRHTGGISPPPDGSEGGSPLASQALESNSACLTESSNSLHPQQGQHPSPQHYIS-EP---- 2384

  Fly  2712 LVHVLVHRES--EEYKEED----ESSPSVS-GNGNGFG 2742
              ::.:|.:|  .:..||:    |::.:.| |..|..|
Mouse  2385 --YLALHEDSHASDCGEEETLTFEAAVATSLGRSNTIG 2420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	87/263 (33%)
		Ion_trans	687..902	CDD:459842	62/222 (28%)
		Ion_trans	1751..2019	CDD:459842	91/293 (31%)
		Na_channel_gate	2009..2063	CDD:240441	10/58 (17%)
		Ion_trans	2067..2320	CDD:459842	84/259 (32%)
		GPHH	2332..2378	CDD:465306	17/50 (34%)
Cacna1e	XP_011246211.1	Ion_trans	235..509	CDD:459842	97/301 (32%)
		Ion_trans	622..861	CDD:459842	71/242 (29%)
		Ion_trans	1302..1536	CDD:459842	78/246 (32%)
		Ion_trans	1626..1883	CDD:459842	84/259 (32%)
		GPHH	1892..1945	CDD:465306	18/52 (35%)
		Ca_chan_IQ	1955..2031	CDD:462591	9/75 (12%)