Protein Alignment NaCP60E and Cacna1h

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_722521.1
• Gene: Cacna1h / 114862
• RGDID: 68943
• Length: 2359
• Species: Rattus norvegicus
• Alignment Length: 2965
• Identity: 636/2965 - (21%)
• Similarity: 1044/2965 - (35%)
• Gaps: 1043/2965 - (35%)

  Fly   116 RRVCVYIATNQFFDYCVMATILFNCIFLAMTETVEEAE--------------YIFLAIYSIEMVI 166
            |..|:.:..|.:|::..|..|:.||:.|.|....|:.|              :|| |.:::||||
  Rat    90 RSWCLRLVCNPWFEHISMLVIMLNCVTLGMFRPCEDVECRSERCSILEAFDDFIF-AFFAVEMVI 153

  Fly   167 KIIAKGFLLNKYTYLRNPWNWLDFVVITSG---YATIGMEVGNLAGLRTFRVLRALKTVSIMPGL 228
            |::|.| |..:..||.:.||.|||.::.:|   |:..|..| :|:.:||.||||.|:.::.:|.:
  Rat   154 KMVALG-LFGQKCYLGDTWNRLDFFIVMAGMMEYSLDGHNV-SLSAIRTVRVLRPLRAINRVPSM 216

  Fly   229 KTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKC------VRQ------VPTDWT 281
            :.::..||.:...|..|:.|..|...:|.:..:|::.|.|||:|      ||.      .|...|
  Rat   217 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQT 281

  Fly   282 NVSHTDWQIWVNDTDNWLY------DEDELPVLC--------------GNLTGARHC----PFEY 322
            .....:..|..:..||.:.      ...||.|.|              |. .|...|    .:..
  Rat   282 EEGEENPFICSSRRDNGMQKCSHIPSRRELRVQCTLGWEAYGQPQAEDGG-AGRNACINWNQYYN 345

  Fly   323 VCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYL 387
            ||.....||::|..||||..::.:..||:|||:.|.::...|:......:..:|.:::..|||::
  Rat   346 VCRSGEFNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIMGSFFM 410

  Fly   388 INLMLAVVALSYEE----EAEITNEERKKDLLDHRDDSTFSFDPSVLN---------VKKLNKNN 439
            |||.|.|:|..:.|    |.::..|:|.:.|.:....::||...|...         .:|:.:.:
  Rat   411 INLCLVVIATQFSETKQRENQLMREQRARYLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRS 475

  Fly   440 -----------KKKIDSRKGVLLASYSKKKTRRKKTKGGK----------------------EGG 471
                       :||:|....|    :.:...||.:..|.:                      .||
  Rat   476 LRLYARWQSRWRKKVDPSSTV----HGQGPGRRPRRAGRRTASVHHLVYHHHHHHHHHYHFSHGG 536

  Fly   472 TNGNGNGSNGDDNK--SHSATPSPGPSPRHSATERPSALTM-----QAQKQYQQMEQQHKLA--- 526
            ...........||:  ...|.||| |||.|...:..|..::     ..:...::....|.:|
  Rat   537 PRRPSPEPGAGDNRLVRACAPPSP-PSPGHGPPDSESVHSIYHADCHVEGPQERARVAHSIATAA 600

  Fly   527 ----KSGSGGSNNP-MAPT------------PKGRISFQDSGMGVKNPNML-YPSDY-KGQLIAN 572
                .||.|..|.| :.|:            |||.......|..|.:|..| .|..| |.|.:..
  Rat   601 SLKLASGLGTMNYPTILPSGTVNSKGGTSSRPKGLRGAGAPGAAVHSPLSLGSPRPYEKIQDVVG 665

  Fly   573 S---GQPSSNSSGVN-------------------------------RESSQDDSGVVDDHEEQDT 603
            .   |:.||:.||::                               .|.|..:||..|.|...:.
  Rat   666 EQGLGRASSHLSGLSVPCPLPSPQAGTLTCELKSCPYCASALEDPEFEFSGSESGDSDAHGVYEF 730

  Fly   604 TNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWC 668
            |.|:.|....:....|.||      |............|.:  :|:...|..|
  Rat   731 TQDVRHGDCRDPVQQPHEV------GTPGHSNERRRTPLRK--ASQPGGIGHL------------ 775

  Fly   669 TDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTF 733
                 |..|...|.::|....|...|...|::||..:.:|:|...|...|||::.|.||||:|..
  Rat   776 -----WASFSGKLRRIVDSKYFNRGIMAAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 835

  Fly   734 ECIVKLMALSKDFFLCG--------WNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQ 790
            |.::||:|       ||        :||||.::|..|:.:|:.:...||||||..||||||||.:
  Rat   836 EMLLKLLA-------CGPLGYIRNPYNIFDGIVVVISVWEIVGQANGGLSVLRTFRLLRVLKLVR 893

  Fly   791 SWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVP-RWNFNDFF 854
            ....::..|.:::.|:..:....::|::.|:||:::||.||...::.:....|.|| |.||:...
  Rat   894 FLPALRRQLVVLMRTMDNVATFCMLLMLFIFIFSILGMHLFGCKFSLKTDSGDTVPDRKNFDSLL 958

  Fly   855 HSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSE- 917
            .:.:.:|:||..| |...|::.|.:.....|    ..|:..:..||:::.||.:|:|:..|.:|
  Rat   959 WAIVTVFQILTQEDWNVVLYNGMASTSSWAA----LYFVALMTFGNYVLFNLLVAILVEGFQAEG 1019

  Fly   918 -ELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQA 981
             ..:|..:|....::|....:::|||
  Rat  1020 DATRSDTDEDKTSTQLEGDFDKLRDL--------------------------------------- 1045

  Fly   982 AVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQI 1046
                       ...|.|.:.|:                          :......:..|.||..:
  Rat  1046 -----------RATEMKMYSLA--------------------------VTPNGHLEGRGSLPPPL 1073

  Fly  1047 QLQAHPLP-PTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQ 1110
            .......| ||..|.|                         ||                .|:...
  Rat  1074 ITHTAATPMPTPKSSP-------------------------NL----------------DVAHAL 1097

  Fly  1111 YDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQ 1175
            .|||..             :|...||...||:|..       ||:.:....:|
  Rat  1098 LDSRRS-------------SSGSVDPQLGDQKSLA-------SLRSSPCTPWG------------ 1130

  Fly  1176 KSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREE 1240
                             ..|:|.|:||                |.||:
  Rat  1131 -----------------PNSAGSSRRS----------------SWNSL----------------- 1145

  Fly  1241 LLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKE 1305
                                             .|.||
  Rat  1146 ---------------------------------GRAPS--------------------------- 1150

  Fly  1306 LEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSS 1370
               :||.....||:                      ::::|..:.|..||.
  Rat  1151 ---LKRRNQCGERE----------------------SLLSGEGKGSTDDEA-------------- 1176

  Fly  1371 VPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSAS 1435
                                           ||                           :..::
  Rat  1177 -------------------------------ED---------------------------SRPST 1183

  Fly  1436 QAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLR 1500
            ...|..||..|                               .:.||                 |
  Rat  1184 GTHPGASPGPR-------------------------------ATPLR-----------------R 1200

  Fly  1501 LDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEH 1565
            .:||..:||            |.:. ||...|..||.
  Rat  1201 AESLDHRST------------LDLC-PPRPAALLPTK---------------------------- 1224

  Fly  1566 QQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADAS 1630
               ||..:.|....|:...                                .|.:||...||:
  Rat  1225 ---FHDCNGQMVALPSEFF--------------------------------LRIDSHKEDAAE-- 1252

  Fly  1631 SALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFP 1695
                                                     :.||:            .|...|
  Rat  1253 -----------------------------------------FDDDI------------EDSCCF- 1263

  Fly  1696 SYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVL 1760
                 :..||.:...||.|..    |..|.:.....|:     |:|.:...|:....|:..|||.
  Rat  1264 -----RLHKVLEPYAPQWCRS----RESWALYLFPPQN-----RLRVSCQKVIAHKMFDHVVLVF 1314

  Fly  1761 IFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILD 1821
            ||.:.||:..|..::|...|.:..|...|:.|..||||||::|.:|||.    ..|..|.|.:||
  Rat  1315 IFLNCITIALERPDIDPGSTERAFLSVSNYIFTAIFVVEMMVKVVALGLLWGEHAYLQSSWNVLD 1379

  Fly  1822 FIIVFVSVFSLLIE-----ENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNV 1881
            .::|.||:..:::.     ..:.|.|||.||.||.|||||.|||..|:::||..|:.::..|.|:
  Rat  1380 GLLVLVSLVDIIVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNI 1444

  Fly  1882 LLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQNYTWINSKITFDHVGMG 1946
            :|:|..|::||.|:|||.|.|||:.|     |......:..|.:|...:|.|:..|..||::|..
  Rat  1445 VLICCAFFIIFGILGVQLFKGKFYYC-----EGTDTRNITTKAECHAAHYRWVRRKYNFDNLGQA 1504

  Fly  1947 YLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNF 2011
            .::|..:::.:||:.:|.|.:||.|:|.||.:..|.:..:||:.|::..|||.||:|:||:::||
  Rat  1505 LMSLFVLSSKDGWVNIMYDGLDAVGIDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1569

  Fly  2012 NMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRP----INHFLAMFYDLSNSRRFEI 2072
            :..::..|.       .|:::.....:::|.|:: :|..:||    .:|.....:.|..|...::
  Rat  1570 HKCRQHQEA-------EEARRREEKRLRRLERRR-RKAQRRPYYADYSHTRRSIHSLCTSHYLDL 1626

  Fly  2073 AIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRY-HYFTVPWNVFDF 2136
            .|..:|.||::||.:|||:||.::...|:..|..||.||..||.:|:|...: .:|...||..|.
  Rat  1627 FITFIICLNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDL 1691

  Fly  2137 LLVLASIFGILMEDIMID--LPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFN 2199
            .:||.||.||.:|:|.::  |||:||::|::||.||.|:|:|:|.|.|:|.||..:|.:||.:.|
  Rat  1692 AIVLLSIMGIALEEIEMNAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGN 1756

  Fly  2200 IGALLGLITFIYAILGMSLFGNVKLQ-----GALDDMVNFQTFGRSMQLLFRLMTSAGWN----D 2255
            :|.|..|:.||||.||:.|||.::..     ..|.....|..||.:...|||:.|...||    |
  Rat  1757 LGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFTNFGMAFLTLFRVSTGDNWNGIMKD 1821

  Fly  2256 VLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEE 2320
            .|.....:...|..::          |.|:..||.:|::::..:::|:.:|:::::..::::|
  Rat  1822 TLRECTREDKHCLSYL----------PALSPVYFVTFMLVAQFVLVNVVVAVLMKHLEESNKE-- 1874

  Fly  2321 IGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKI 2385
               ..:|.||          .|...:..:|.|    :..||                |.::.::
  Rat  1875 ---AREDAEM----------DAEIELEMAQGS----TAQPP----------------PTAQESQ- 1905

  Fly  2386 HCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQT 2450
                          |...:|.|...:         ::....:.|.:.:.:.:::....||
  Rat  1906 --------------GTQPDTPNLLVV---------RKVSVSRMLSLPNDSYMFRPVAPAA----- 1942

  Fly  2451 GWKEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASD 2515
              ..:....:|.|........|...||                      ....|||.:..|.||.
  Rat  1943 --APHSHPLQEVEMETYTGPVTSAHSP----------------------PLEPRASFQVPSAASS 1983

  Fly  2516 ASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKRGSIFVEAPRASRRRSFYNFFLRHQDA 2580
            .:.:|:        ||..:|                          ||.:.|....:..|..|:|
  Rat  1984 PARVSD--------PLCALS--------------------------PRGTPRSLSLSRILCRQEA 2014

  Fly  2581 VDDSLTSPSVHRK---TAMNNTTNTTSNSASTSGTASSTATAPATGCGPAATSASDSDRHQAVGG 2642
                :.|.|:..|   ...::..:.|..:.:.|.:.:||....:..|.|...|.
  Rat  2015 ----MHSESLEGKVDDVGGDSIPDYTEPAENMSTSQASTGAPRSPPCSPRPASV----------- 2064

  Fly  2643 GSAPSRKRASSF----IRKKPPLERGLSAQSALRVNKNAFVSEASAPEVIVTRPSPEQQTHPHSL 2703
                 |.|..:|    |..:||...|..|::|                    .|:.|:.:|..|
  Rat  2065 -----RTRKHTFGQRCISSRPPTLGGDEAEAA--------------------DPADEEVSHITS- 2103

  Fly  2704 SLRPDNATLVHVLVHRESEEYKEEDESSPSVSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSMD 2768
            |..|..||..|            ..|:||:.|                   .::.|.||......
  Rat  2104 SAHPWPATEPH------------SPEASPTAS-------------------PVKGTMGSGRDPRR 2137

  Fly  2769 TCAMPTVQIMVDSPKDPPRGDFSSAPIDDVGAPIDV-NVQGDTSQVFYDYNP------------- 2819
            .|:: ..|..:|.|..|....:||..:|:..:.::. .|:|..|::    .|
  Rat  2138 FCSV-DAQSFLDKPGRPDAQRWSSVELDNGESHLESGEVRGRASEL----EPALGSRRKKKMSPP 2197

  Fly  2820 ----EKATDDQGNGQDETAQFESLPDRQRXPPVNTPL-RD 2854
                |..|.|:|:.:...|:..:...|:| |.....| ||
  Rat  2198 CISIEPPTKDEGSSRPPAAEGGNTTLRRRTPSCEAALHRD 2237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	84/298 (28%)
		Ion_trans	687..902	CDD:459842	71/224 (32%)
		Ion_trans	1751..2019	CDD:459842	102/276 (37%)
		Na_channel_gate	2009..2063	CDD:240441	10/57 (18%)
		Ion_trans	2067..2320	CDD:459842	90/264 (34%)
		GPHH	2332..2378	CDD:465306	5/45 (11%)
Cacna1h	NP_722521.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63
		I	87..422		96/335 (29%)
		Ion_trans	99..430	CDD:459842	95/334 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	490..573		17/87 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	620..656		8/35 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	737..769		6/39 (15%)
		II	776..1015		79/249 (32%)
		Ion_trans	789..1023	CDD:459842	77/244 (32%)
		PHA03307	1058..>1219	CDD:223039	58/501 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1061..1197		48/446 (11%)
		III	1292..1569		103/286 (36%)
		Ion_trans	1304..1576	CDD:459842	102/276 (37%)
		IV	1607..1868		91/270 (34%)
		Ion_trans	1621..1852	CDD:459842	87/240 (36%)
		PHA03307	1878..>2259	CDD:223039	94/554 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1891..1913		7/56 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1974..2003		11/62 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2016..2258		58/295 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2335..2359