|
Fly 10 DEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLE 74
:::|:.:...:...::.:::...| :.::.:|.|..||..:...|..:.|.|||
Mouse 29 EQRAMEEEARLQRNKQMEIEEPER------------KPRSDLEAGKNLPLIYGDPPPEVIGVPLE 81
Fly 75 EIDTFIYE-ETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILF 138
::|.:..: :||.|::| ...|.||:.|.:|::..|:|..|||.:.:..:..|...:|.|||.
Mouse 82 DLDPYYSDKKTFIVLNK---GKAIFRFSATPALYMLSPFSIVRRVAIKVLIHALFSMFIMITILT 143
Fly 139 NCIFLAMTET---VEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATI 200
||:|:.|:.. .::.||.|..||:.|.:||::|:||.::.:|:||:|||||||.|||..|.|.
Mouse 144 NCVFMTMSNPPSWSKDVEYTFTGIYTFESLIKMLARGFCIDDFTFLRDPWNWLDFSVITMAYVTE 208
Fly 201 GMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYM 265
.:::||::.||||||||||||::::||||||:.||:.|.::|::||.||:|||.||||..||::|
Mouse 209 FVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFM 273
Fly 266 GELRNKCVRQVP------------------------------------TDWTNVSHTDWQIWVND 294
|.||.||||..| ..|.:.|..||:.::||
Mouse 274 GNLRQKCVRWPPPMNDTNTTWYGNDTWYGNDTWYGNDTWYGNDTWNSQESWVSNSTFDWEAYIND 338
Fly 295 TDNWLYDE---DELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDY 356
..|:.:.| |.| ||||.:.|.|||..|.|:..|.|||:|||::|.|.|:.|..|:|:|.||
Mouse 339 EGNFYFLEGSNDAL--LCGNSSDAGHCPEGYECMKAGRNPNYGYTSYDTFSWAFLALFRLMTQDY 401
Fly 357 WENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDS 421
|||::.:.|...|...:.||.|::|.||||||||:|||||::|.|:.|.|..| |...:.
Mouse 402 WENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAE------DQEKEE 460
Fly 422 TFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGK--EGGTNGNGNGSNGDDN 484
.|. .:|..:.|.:...:|.|..: |||...:|:
Mouse 461 EFQ------------------------QMLEKFKKHQEELEKAKAAQALEGGEEADGD------- 494
Fly 485 KSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQD 549
|.||
Mouse 495 ------------PTHS------------------------------------------------- 498
Fly 550 SGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVE 614
.|..|.| .:|...|..|.|...:|.:.|..||.:..
Mouse 499 -------------KDCNGSL------DTSGEKGPPRPSCSAESAISDAMEELEEA---------- 534
Fly 615 LALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCD----RCVH----W--CT 669
||: |. :|.| | |.
Mouse 535 ----------------------------HQK---------------CPPWWYKCAHKVLIWNCCA 556
Fly 670 DYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFE 734
.|::|::.:..:|.||..:|.||:||||||.|:||||:.|:|.|.|.|.|||.|||.|||.|
Mouse 557 ---PWVKFKHIILLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLSVGNLVFTGIFTAE 618
Fly 735 CIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVL 798
.::||:|:.. ::|..||||||..|||.||:::....|.||||||..|||||.|||:||.|:.:|
Mouse 619 MVLKLIAMDPYEYFQQGWNIFDSFIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNML 683
Fly 799 LSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPRWNFNDFFHSFMMI 860
:.||.:::||||||||:|.|:::||||:|||||.|.|.. .|...| .:|||:.:||||||:::
Mouse 684 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIASDCSLPRWHMHDFFHSFLIV 748
Fly 861 FRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEE 925
||||||||||.:|||| |..|.:.|..:||..:|:||.:||||||||||:||:::.|.:..|:
Mouse 749 FRILCGEWIETMWDCM---EVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDED 810
Fly 926 VGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDK 990
||.:.|..:|.|::..| .||:.| .:||
Mouse 811 -GEMNNLQIAIGRIKWGI-------------AFAKTF-------------------LLGL----- 837
Fly 991 PGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPP 1055
||..:.::.|
Mouse 838 --------------------------------LHGKILSLKD----------------------- 847
Fly 1056 TSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYT 1120
:|.:.|
Mouse 848 ------------IMLSLG----------------------------------------------- 853
Fly 1121 ESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSY 1185
:..|.|.
Mouse 854 --------------------EPGGAGE-------------------------------------- 860
Fly 1186 RKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELF 1250
|..|..:||
Mouse 861 -----------------------------------NGESPPEDE--------------------- 869
Fly 1251 QFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTS 1315
.:.|..:.| .|||::
Mouse 870 -----------------------KKEPPPEDG--------------------NKELKD------- 884
Fly 1316 LERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSA 1380
..|:.|:.:..|.......|.:....|||.:
Mouse 885 -------------------NHILNHVGLTDGPRSSIEMDHLNFINNPYLT--------------- 915
Fly 1381 AAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFL 1445
||.|..:.|:..
Mouse 916 ------------------------------------IHVPIASEESDL----------------- 927
Fly 1446 RRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTN 1510
|:|.||:..:....|..|.|.:.|:..:. |:.||.
Mouse 928 ------------------------EMPTEEETDTFSEPEDIKKPLQPLYDGNS------SVCSTA 962
Fly 1511 SYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQ 1575
.| :||.
Mouse 963 DY------------------------------KPPE----------------------------- 968
Fly 1576 AAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQK 1640
|.|:
Mouse 969 --------------------------EDPE----------------------------------- 972
Fly 1641 TEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKV 1705
||:: .|.:| ::
Mouse 973 -EQAE------------------------------------ENPEG-----------------EL 983
Fly 1706 PDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCF 1770
|::||.:.|.. |||.....:.....|.|..:|.|...:|:...||.|::.:|..||..|.|
Mouse 984 PEECFTEACVK----RCPCLYVDISQGRGKMWWTLRRACFKIVEHNWFETFIVFMILLSSGALAF 1044
Fly 1771 EDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIE 1835
|||.:::.:.::.:|.:.:..|..||::||:|||:|.||..|||:.|..|||:||.||:.||:..
Mouse 1045 EDIYIEQRRVIQTILEYADKVFTYIFILEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVAN 1109
Fly 1836 --ENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQ 1898
....|..::|||||||||||||:||::|||:|||||:.|||||.|||||||:||||||||||.
Mouse 1110 WLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1174
Fly 1899 FFGGKFFKCVN-EMGELLPITEVNDKWDCIEQNYT----WINSKITFDHVGMGYLALLQVATFEG 1958
.|.|||:.|:| ...|...|:.||:|.:|....|| |:|.|:.:|:||:|||:|||||||:|
Mouse 1175 LFAGKFYYCINTTTSERFDISVVNNKSECESLMYTGQVRWMNVKVNYDNVGLGYLSLLQVATFKG 1239
Fly 1959 WMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVL 2023
||::|..|||:|..:.||..|.|||.|:||||||:.||||||||||||||||||..|||:.| .
Mouse 1240 WMDIMYAAVDSREKEEQPDYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG--K 1302
Fly 2024 EMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIE 2088
::|:||.||.||.||||||.|||||.|.||.|....|.||....:.|:|:|.:||.|||:||.:|
Mouse 1303 DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDFVTKQVFDISIMILICLNMVTMMVE 1367
Fly 2089 HYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMI 2153
..||......||...|..|..||..|.::|:..||::|||:.||:|||::|:.||.|:.:.|::.
Mouse 1368 TDDQSQLKVDILYNINMVFIIVFTGECVLKMFALRHYYFTIGWNIFDFVVVILSIVGLALSDLIQ 1432
Fly 2154 DLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSL 2218
...:||||.||:|:.||||:||||:.|||||.|||||::|||||||||.||.|:.|||:|.|||.
Mouse 1433 KYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSN 1497
Fly 2219 FGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQ-PPDCDPFIHG---HTNGNC 2279
|..||.:..:|||.||:|||.|:..||.:.|||||:.:|..::.. ||||||.:.. :..|:|
Mouse 1498 FAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPTLENPGTNIKGDC 1562
Fly 2280 GHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQ 2344
|:|.:.|.:|.|:||||::||:||||||||||||.|.:|....:.|||.||||..|.|:||.|||
Mouse 1563 GNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLCEDDFEMFYETWEKFDPDATQ 1627
Fly 2345 FIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFK 2409
||.:|:||||:.:|..||.|:|||.:.|::.:||:..|:||||||||.||.|.|||...|.|..|
Mouse 1628 FIDYSRLSDFVDTLQEPLKIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALK 1692
Fly 2410 QLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERS--------N 2466
|..|: ||....|::...|.:::|...|::|..|..||..::.:|.::..|:.| .
Mouse 1693 QTMEE---KFMAANPSKVSYEPITTTLKRKQEEVCAIKIQRAYRRHLLQRSVKQASYMYRHSQEG 1754
Fly 2467 SGDSATQTSSPGGWQSKLSALNFFHLQVS-RRGTACSSRASSRKSSRASDASDLSELAGP 2525
:||.|.: :..|.|.....:..| :......|:....|.| ..||...:|:..|
Mouse 1755 NGDGAPE-------KEGLLANTMNKMYGSEKEDNGVQSQGEKEKDS-TEDAGPTTEVTAP 1806
| 
