Protein Alignment NaCP60E and cacna1h

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: XP_031748783.1
• Gene: cacna1h / 100494894
• XenbaseID: XB-GENE-6042121
• Length: 2460
• Species: Xenopus tropicalis
• Alignment Length: 3065
• Identity: 663/3065 - (21%)
• Similarity: 1104/3065 - (36%)
• Gaps: 1062/3065 - (34%)

  Fly   116 RRVCVYIATNQFFDYCVMATILFNCIFLAMTETVEEAE--------------YIFLAIYSIEMVI 166
            |..|:.:..|.:|::..|..||.||:.|.|.:..|:..              :|| |.:::||||
 Frog    90 RNWCLRLVCNPWFEHVSMLVILLNCVTLGMFQPCEDTNCMSERCNILEAFDGFIF-AFFAVEMVI 153

  Fly   167 KIIAKGFLLNKYTYLRNPWNWLDFVVITSG---YATIGMEVGNLAGLRTFRVLRALKTVSIMPGL 228
            |::|.| :..:..||.:.||||||.::.:|   |:..|..| :|:.:||.||||.|:.::.:|.:
 Frog   154 KMVALG-IFGQKCYLGDTWNWLDFFIVMAGMLEYSLDGHNV-SLSAIRTVRVLRPLRAINRVPSM 216

  Fly   229 KTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVN 293
            :.::..||.:...|..|:.|..|...:|.:..:|::.|.|||:|...          |::.:..|
 Frog   217 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFMD----------TNFVMSYN 271

  Fly   294 DTDNWLY----DEDELPVLCGNL--TGARHC-----------------PFEYVCLCVGE------ 329
            .|....|    |.::.|.:|.:.  .|...|                 |....|:.:.:
 Frog   272 FTPLRPYYQVDDAEDNPYICSSNRDNGMLKCQDIPPKMDCSHVYYSDFPSRNSCVNINQYYNVCK 336

  Fly   330 ----NPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINL 390
                ||:.|..||||..::.:..||:|||:.|.::...|:......:..:|.:::..|||::|||
 Frog   337 PGEFNPHKGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINL 401

  Fly   391 MLAVVALSYEE----EAEITNEERKKDLLDHRDDSTF-SFDPSVLNVKKLNK---NNKKKIDSRK 447
            .|.|:|..:.|    |.::..|:|.:.|   .:|||. ||.......::|.|   :..:|:..|.
 Frog   402 CLVVIATQFSETKQRENQLMQEQRARYL---SNDSTIASFSEPGSCYEELLKYICHIFRKVKRRT 463

  Fly   448 GVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKS----------------------HSAT 490
            ..|..::..|  ||||.:      .|.|.| |.|...|.                      |.:.
 Frog   464 LRLYNNWQNK--RRKKVQ------PNSNTN-SQGRHRKCKRRITSIHHLIHHHHHHHHHHYHISN 519

  Fly   491 PSP-GP--------------SPRHSATERPSALTMQAQKQYQQM------------EQQHKLAKS 528
            .|| ||              .|::.....|::.::|:.....:.            ..|.|.:||
 Frog   520 GSPRGPRSSPEICDVEMKIMKPKNQLRLPPASPSLQSMSPNSEAVHSIYHADCHLEAPQRKSSKS 584

  Fly   529 GSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSG 593
            .:..||..:             ..|:.:.||.||:....|  ||...|::...|....|
 Frog   585 SNASSNIKL-------------NAGLNHSNMNYPTIMPSQ--ANKTSPATLPKGKRNGS------ 628

  Fly   594 VVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPD 658
                             :.|.|..||..::..........:..|.:.....:.|. :.|...||.
 Frog   629 -----------------NAVSLLSSPVSMKADSFGKTNHLVGEHGLCRSSSKLSG-LSVPCSLPS 675

  Fly   659 ----------RNCDRCVHW-------CTDYES--------------------------------- 673
                      :||..|.:.       .:|.||
 Frog   676 PQPSPLLCEIQNCPYCANLLENPDLELSDSESCESDSNGVYEFTQDLRRGDQRDQVQKGRKLKTK 740

  Fly   674 ----------WLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFT 728
                      |.:|...|.::|....|...|.:.|::||..:.:|:|...|...|||::.|.|||
 Frog   741 PKEANKVYLLWEEFTVRLKRIVDSKYFNRGIMIAILINTLSMGIEYHEQPEELTNALEISNIVFT 805

  Fly   729 SIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSW 792
            |:|..|.::||:|.. ..:....:||||.:||..|:.:||.:...||||||..||||||||.:..
 Frog   806 SMFALEMLLKLLAFGIFQYIKNPYNIFDGIIVVISVWEIIGQSDGGLSVLRTFRLLRVLKLVRFM 870

  Fly   793 TTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPV-PRWNFNDFFHS 856
            ..::..|.:::.|:..:....::|::.|:||:::||.||...:|......:.| .|.||:....:
 Frog   871 PALRRQLVVLVKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFTWTADTGETVKDRKNFDSLLWA 935

  Fly   857 FMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELK 920
            .:.:|:||..| |...|::.|.:.....|    ..|:..:..||:::.||.:|:|:..|.:|
 Frog   936 IVTVFQILTQEDWNMVLYNGMASTSSWAA----LYFVALMTFGNYVLFNLLVAILVEGFQAE--- 993

  Fly   921 SKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGL 985
                  |:.:                   |.|.:|.|.:..|.:.:...::..|
 Frog   994 ------GDAT-------------------RSDTEEDKASGNFDEDLEKLKELRA----------- 1022

  Fly   986 ERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQA 1050
                     ||.|.:.|:                          :......|....:|..|.::.
 Frog  1023 ---------AELKMYSLA--------------------------VTPNGHLDPRSSMPPPIIMRT 1052

  Fly  1051 HPLP-PTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLT-PFVQAERRLQHQISSGVSTQQYDS 1113
            ...| ||..|.|                       |.:.: ||                   .||
 Frog  1053 AATPMPTPKSSP-----------------------CMDSSHPF-------------------GDS 1075

  Fly  1114 REEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSL 1178
            |.|             :|...||...||:|..       ||:......:|
 Frog  1076 RRE-------------SSVSIDPSIVDQKSLA-------SLRSTPCTPWG--------------- 1105

  Fly  1179 LTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLN 1243
                          :.|:..|:||                |.||:
 Frog  1106 --------------TYSNWGSRRS----------------SWNSL-------------------- 1120

  Fly  1244 CDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEE 1308
                                          .|.||
 Frog  1121 ------------------------------GRAPS------------------------------ 1125

  Fly  1309 IKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPR 1373
            ||:.:.|.||:                      ::::|..:.|..|         ||.|..|.|
 Frog  1126 IKKKSQSGERE----------------------SLLSGEGKGSTDD---------DSDDCKSSP- 1158

  Fly  1374 RSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQ 1438
                    |.|.|:..:..||:.:..:|           |.|.:..|
 Frog  1159 --------AARVSLHRRAGSLDTRGSLD-----------IPDFLQVP------------------ 1186

  Fly  1439 PNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDS 1503
                                                     |||                   .|
 Frog  1187 -----------------------------------------TLR-------------------HS 1191

  Fly  1504 LSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQH 1568
            ||:.                                                  |||.:....|.
 Frog  1192 LSVS--------------------------------------------------PLAMVPSDYQD 1206

  Fly  1569 FHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSAL 1633
            .:.                            :|.|..|.|       ..|.|.|
 Frog  1207 CNG----------------------------KMMHVPSDL-------FVRVEKH----------- 1225

  Fly  1634 ALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYG 1698
                                        .|.|    :.|.||:            .|...|
 Frog  1226 ----------------------------REDP----LEYEDDI------------EDSYCF---- 1242

  Fly  1699 ATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFA 1763
              :..|:.:...|..|..|.    .|.:.....|:     :.|.....|:....|:..|||.||.
 Frog  1243 --RIRKMLEPYKPTWCKTHE----DWSLYMFSPQN-----QFRMMCQKVIAHKMFDHVVLVFIFL 1296

  Fly  1764 SSITLCFEDINLDKNKTLKRVLYWI-NFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFI 1823
            :.||:..|..::|.| :|:|:...: |:.|..|||:||.:|.:||||    :.|..|.|.:||.|
 Frog  1297 NCITIALERPDIDPN-SLERIFLSVSNYIFTAIFVLEMAIKVVALGFVSGENTYLQSSWNVLDGI 1360

  Fly  1824 IVFVSVFSLLIE-----ENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLL 1883
            :||||:..:::.     ..:.|.|||.||.||.|||||.|||..|:::||..|:.::..|.|::|
 Frog  1361 LVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVL 1425

  Fly  1884 VCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYL 1948
            :|..|::||.|:|||.|.|||:.|     |.|....:.::.:|....|.|:..|..||::|...:
 Frog  1426 ICCAFFIIFGILGVQLFKGKFYYC-----EGLETRNITNRSECTRARYKWVRRKYNFDNLGQALM 1485

  Fly  1949 ALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNM 2013
            :|..:::.:||:.:|.|.:||...|:||.:..|.:..:||:.|::..|||.||:|:||:::||:.
 Frog  1486 SLFVLSSKDGWVNIMYDGLDAVATDVQPVKNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHK 1550

  Fly  2014 LKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVI------KRPINHFLAMF-------YDLS 2065
            .::..|.       .|:::.....:::|.:|:..|.:      :||   :.|.:       :.:.
 Frog  1551 CRQHQEA-------EEARRREEKRLRRLEKKRRSKALYMSEAQRRP---YYAEYSPARLYIHTMC 1605

  Fly  2066 NSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRY-HYFTV 2129
            .|...::.|..:|.:|::||.:|||:||.::...|:..|..||.||..||:.|:|...: .:|..
 Frog  1606 TSHYLDLFITCIICINVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEALFKLVAFGFRRFFKD 1670

  Fly  2130 PWNVFDFLLVLASIFGILMEDIMID--LPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVV 2192
            .||..|..:||.||.||.:|:|.|:  |||:||::|::||.||.|:|:|:|.|.|:|.||..:|.
 Frog  1671 RWNQLDLAIVLLSIMGITLEEIEINASLPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQ 1735

  Fly  2193 SLPALFNIGALLGLITFIYAILGMSLFGNV------KLQGALDDMVNFQTFGRSMQLLFRLMTSA 2251
            :||.:.|:|.|..|:.||||.||:.|||.:      ..:| |.....|:.||.:...|||:.|..
 Frog  1736 ALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNEENPCEG-LSRHATFENFGMAFLTLFRVSTGD 1799

  Fly  2252 GWNDVLESLMIQPPDCDPFIHGHTNGNC--GHPLLAITYFTSFIIISYMIVINMYIAIILENFNQ 2314
            .||.:::..:   .:|:     ..:.||  ..|:::..||.:|::|:..:::|:.:|:::::..:
 Frog  1800 NWNGIMKDTL---RECN-----SDDKNCLTYLPVISPVYFVTFVLIAQFVLVNVVVAVLMKHLEE 1856

  Fly  2315 AHQE-EEIGIVEDDLEMFYIR------------------WSKYDPHATQFIHFSQLSDFIASLDP 2360
            :::| :|...::.::||...|                  ....||...:.:  .|:...:...:.
 Frog  1857 SNKEAKEDAEMDAEIEMEMSRALTPISGGCTPASDGKGTEGGQDPLKGELL--KQVGGAVCQENV 1919

  Fly  2361 PLGISKP-NNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFP 2424
            .|.|.:. ...||::..:|.....:...|.:  .|...||||.:.....:......::...|:..
 Frog  1920 TLVIPESMEGAALLNDAVPACSIYQQQALPL--PLQPCVLGHEDGDFQRRDGSGSRNLLAVKKIS 1982

  Fly  2425 TRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNS--GDSATQTSSPGGWQSKLSAL 2487
            ..:.|.:.:.:.:: |....||:      .|..::.|....||  |.:|:..|.||...|.|:.
 Frog  1983 VSRMLSLPNDSYMF-RPVLPAKS------SYPLQEVETTEDNSPHGSTASLHSQPGDNNSLLNI- 2039

  Fly  2488 NFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELG 2552
                      ...|..:||   .|...|::||.:
 Frog  2040 ----------PVECQPQAS---VSNHQDSADLPK------------------------------- 2060

  Fly  2553 KRGSIFVEAPRASRRRSFYNFFLRHQDAVD-DSLTSPSVHRKTAMNNTTNTTSNSASTSGTASST 2616
                  :..|..|.|....|..||.|:|:. ||:.      :...:...|..|..:...|..|.|
 Frog  2061 ------IPPPHTSSRSPSLNRSLRRQEAIRMDSVD------QGGDSKDLNVESTESLHLGAPSVT 2113

  Fly  2617 ATAPATGC-------GPAATS--ASDSDRHQAV-------GGGSAPSRKRASSFIRKKPPLERGL 2665
            ...|...|       |...:|  .|...||.:|       ...|.|||..:.|.....|  |..:
 Frog  2114 TLVPNLLCTLNVSLQGTPQSSPRLSPQPRHSSVLTHNHVYSQHSIPSRPSSVSSGNSNP--EESM 2176

  Fly  2666 SAQSAL------RVNKNA----------------FVSEASAPEVIVTRPSPEQQTHPHSLSLRPD 2708
            ...|.|      .:|.:|                |:|::|:|.             |.|.||:..
 Frog  2177 FESSDLADEEVSHINSSAKDWRGSSNNRSHSVSPFISQSSSPP-------------PLSPSLKNC 2228

  Fly  2709 NATLVHVLVHRESEEYKEEDESSPSVSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSMDTCAMP 2773
            |:|:                    |::|:.     |.|...|:            ..|:||
 Frog  2229 NSTV--------------------SLAGSS-----GKDKDLKK------------FYSVDT---- 2252

  Fly  2774 TVQIMVDSP---KDPPRGDFSSAP-IDDVGAPIDVNVQG-DTSQVFYDYNPEKATDDQGNGQDET 2833
              |..:..|   .|..|......| |||..:..|::::. ..|.|....:||..     ||...
 Frog  2253 --QGFLAKPCWGDDQRRHSIEICPSIDDGDSCFDLSMEDKHCSSVLIRSDPEYI-----NGVRR- 2309

  Fly  2834 AQFESLPDRQRXPP---VNTPLRDSEKRSSRGSRSSSSSTSSIR--SCSSS--------SSSSAA 2885
                   .::..||   ::.|:.|....:||...|.:|.....|  ||.|:        |.:...
 Frog  2310 -------KKKMSPPCISIDPPMEDEGGTASRTKASENSMMLRRRTPSCESTAYRDSLDLSDNQLG 2367

  Fly  2886 SAAAPSARRT 2895
            ...:.:.|||
 Frog  2368 DQISKTDRRT 2377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	79/295 (27%)
		Ion_trans	687..902	CDD:459842	70/217 (32%)
		Ion_trans	1751..2019	CDD:459842	104/277 (38%)
		Na_channel_gate	2009..2063	CDD:240441	10/66 (15%)
		Ion_trans	2067..2320	CDD:459842	91/264 (34%)
		GPHH	2332..2378	CDD:465306	8/64 (13%)
cacna1h	XP_031748783.1	Ion_trans	99..418	CDD:459842	90/331 (27%)
		Ion_trans	764..998	CDD:459842	77/265 (29%)
		Ion_trans	1283..1555	CDD:459842	104/277 (38%)
		Ion_trans	1607..1838	CDD:459842	87/239 (36%)