DRSC/TRiP Functional Genomics Resources

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Protein Alignment Atf-2 and FOS

DIOPT Version :10

Sequence 1:NP_001033973.1 Gene:Atf-2 / 37978 FlyBaseID:FBgn0265193 Length:381 Species:Drosophila melanogaster
Sequence 2:NP_005243.1 Gene:FOS / 2353 HGNCID:3796 Length:380 Species:Homo sapiens


Alignment Length:313 Identity:76/313 - (24%)
Similarity:112/313 - (35%) Gaps:107/313 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 FDIGFQQAAERNVSGTPSRPEARPNDGESL---HTP------QVYPVEAP---TVVSVPSENQVP 136
            |:..::.::.|..|.:|:        |:||   |:|      ...||.|.   |.::|.|.|.:|
Human     6 FNADYEASSSRCSSASPA--------GDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANFIP 62

  Fly   137 QSVSCGDMDVDQLLATTVTSPSKASQDGPPPLQ-LIQPQVLTWVLPAQSVPISIATVDCNRNRVK 200
                            |||:.|.:     |.|| |:||.:::.|.|:|                 
Human    63 ----------------TVTAISTS-----PDLQWLVQPALVSSVAPSQ----------------- 89

  Fly   201 PTGAIHPFILPKPTAKELNKTSKRPEPILVSCNPPNNEPSSASLTPTSQLPIKERLKAIIHSNNN 265
             |.|.|||.:|.|:|...::..      :|.........|........||..:|..|..|     
Human    90 -TRAPHPFGVPAPSAGAYSRAG------VVKTMTGGRAQSIGRRGKVEQLSPEEEEKRRI----- 142

  Fly   266 RRSFSTPPKAAKAKDRSRDEDCMERRRAAASRYRNKMRNEHKDLIKQNAQLQQENQELHERISRL 330
            ||                     ||.:.||::.||:.|.....|..:..||:.|...|...|:.|
Human   143 RR---------------------ERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANL 186

  Fly   331 EKE-------LQQHRSHSSLAGVVADQLRIPP----SSIHLLINVPNVLVPSS 372
            .||       |..||.    |..:.|.|..|.    :|:.|...:|.|..|.|
Human   187 LKEKEKLEFILAAHRP----ACKIPDDLGFPEEMSVASLDLTGGLPEVATPES 235

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Atf-2NP_001033973.1 Jnk-SapK_ap_N <302..343 CDD:462875 13/47 (28%)
FOSNP_005243.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 119..138 4/18 (22%)
Basic motif, required for the activation of phospholipid synthesis, but not for CDS1-binding 139..159 10/45 (22%)
bZIP_Fos 147..200 CDD:269869 15/52 (29%)
coiled coil 147..199 CDD:269869 15/51 (29%)
Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 165..193 9/27 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..380
Blue background indicates that the domain is not in the aligned region.

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