DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atf-2 and FOS

DIOPT Version :9

Sequence 1:	NP_001033973.1	Gene:	Atf-2 / 37978	FlyBaseID:	FBgn0265193	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_005243.1	Gene:	FOS / 2353	HGNCID:	3796	Length:	380	Species:	Homo sapiens

Alignment Length:	313	Identity:	76/313 - (24%)
Similarity:	112/313 - (35%)	Gaps:	107/313 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 FDIGFQQAAERNVSGTPSRPEARPNDGESL---HTP------QVYPVEAP---TVVSVPSENQVP 136
            |:..::.::.|..|.:|:        |:||   |:|      ...||.|.   |.::|.|.|.:|
Human     6 FNADYEASSSRCSSASPA--------GDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANFIP 62

  Fly   137 QSVSCGDMDVDQLLATTVTSPSKASQDGPPPLQ-LIQPQVLTWVLPAQSVPISIATVDCNRNRVK 200
                            |||:.|.:     |.|| |:||.:::.|.|:|
Human    63 ----------------TVTAISTS-----PDLQWLVQPALVSSVAPSQ----------------- 89

  Fly   201 PTGAIHPFILPKPTAKELNKTSKRPEPILVSCNPPNNEPSSASLTPTSQLPIKERLKAIIHSNNN 265
             |.|.|||.:|.|:|...::..      :|.........|........||..:|..|..|
Human    90 -TRAPHPFGVPAPSAGAYSRAG------VVKTMTGGRAQSIGRRGKVEQLSPEEEEKRRI----- 142

  Fly   266 RRSFSTPPKAAKAKDRSRDEDCMERRRAAASRYRNKMRNEHKDLIKQNAQLQQENQELHERISRL 330
            ||                     ||.:.||::.||:.|.....|..:..||:.|...|...|:.|
Human   143 RR---------------------ERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANL 186

  Fly   331 EKE-------LQQHRSHSSLAGVVADQLRIPP----SSIHLLINVPNVLVPSS 372
            .||       |..||.    |..:.|.|..|.    :|:.|...:|.|..|.|
Human   187 LKEKEKLEFILAAHRP----ACKIPDDLGFPEEMSVASLDLTGGLPEVATPES 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atf-2	NP_001033973.1	Cnn_1N	<300..336	CDD:285263	12/42 (29%)
FOS	NP_005243.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..138		4/18 (22%)
		Basic motif, required for the activation of phospholipid synthesis, but not for CDS1-binding	139..159		10/45 (22%)
		bZIP_Fos	147..200	CDD:269869	15/52 (29%)
		coiled coil	147..199	CDD:269869	15/51 (29%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	165..193		9/27 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R103
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030