DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16896 and TBC1D31

DIOPT Version :9

Sequence 1:	NP_611973.2	Gene:	CG16896 / 37977	FlyBaseID:	FBgn0035073	Length:	988	Species:	Drosophila melanogaster
Sequence 2:	NP_663622.2	Gene:	TBC1D31 / 93594	HGNCID:	30888	Length:	1066	Species:	Homo sapiens

Alignment Length:	976	Identity:	256/976 - (26%)
Similarity:	407/976 - (41%)	Gaps:	237/976 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 VHHTIKEAGQALRIQIAACCFNELSNKLVVIDKRGNVFVFDFVRKRYWRLGFRMPKAKLIRPSPL 163
            :|:|.....:.||....|  |:...:.|:..|.:||::|||                       |
Human    32 IHNTSDYHPKVLRFLNVA--FDGTGDCLIAGDHQGNIYVFD-----------------------L 71

  Fly   164 HGSDYIVGNKTGHIFT--------------IDVDNSILGVDGEVGSAALEELSWSNSLQNARSSI 214
            ||:.:.:..:|....|              ...|.||...|    :...|.:||....:::..||
Human    72 HGNRFNLVQRTAQACTALAFNLRRKSEFLVALADYSIKCFD----TVTKELVSWMRGHESSVFSI 132

  Fly   215 ALMRFGSDAL--------LVNLHTLEVSHQLDFDQSRYTLKFAAFLPHSDQFFIGFSNDSLHVWS 271
            ::...|..|:        |.:|.|.:...:|:..|| ..::...|||.|:.....|.::|:..|.
Human   133 SVHASGKYAITTSSDTAQLWDLDTFQRKRKLNIRQS-VGIQKVFFLPLSNTILSCFKDNSIFAWE 196

  Fly   272 SHSL-STLRMGQP---------IKARNRKLRLLPA-------------AESIPEIV-----LRS- 307
            ..:| ...::..|         :.|..|..|:|.|             |..:..|:     :|:
Human   197 CDTLFCKYQLPAPPESSSILYKVFAVTRDGRILAAGGKSNHLHLWCLEARQLFRIIQMPTKVRAI 261

  Fly   308 ------PDDSD---------LEED------------LTFDCQHYDFADGMLLSYCFTPDGNKMCL 345
                  ||..|         |.:|            |.|:....|  :| :.|...:|.|..:..
Human   262 RHLEFLPDSFDAGSNQVLGVLSQDGIMRFINMQTCKLLFEIGSLD--EG-ISSSAISPHGRYIAS 323

  Fly   346 STLDGYLLLLSVASFDLEKMYRLTDFTLHQMAFLSQPKERIVFGI--TTRNQAVMLDLANTDHKL 408
            ...:|.|.:.||.:...|               :::|...:|..|  ..:|:     |:::|.|:
Human   324 IMENGSLNIYSVQALTQE---------------INKPPPPLVKVIEDLPKNK-----LSSSDLKM 368

  Fly   409 IVQRSNARSLSLSRDGKLLSVTSRCGEVNVWSTCRIFNALQAQIRCLSQ-VKSTFKQPNPLPPCS 472
            .|.....:..:.||:.|:                        |.|.|.| :...|:..
Human   369 KVTSGRVQQPAKSRESKM------------------------QTRILKQDLTGDFESK------- 402

  Fly   473 VGGGVSKELRDLLNPQRLKTMLKEYGCYPEKYRYLIWTSLLDLPCNGPQFQELIKLGAPLLVRNR 537
                 ..||.|.||.:||:.:||.||.||.|||..||.|||.||.|...|..||..|..:...|.
Human   403 -----KNELPDGLNKKRLQILLKGYGEYPTKYRMFIWRSLLQLPENHTAFSTLIDKGTHVAFLNL 462

  Fly   538 AKKLKIRNDHQRRVVIKIWSCLAQWCKVLAHADFMPHLIFPFVKRMPKNSLVCFELIATLVLNHF 602
            .||..|::....||:.:..|.||.|..:.:...::|.|.|||||....|.|:|||:||||::|..
Human   463 QKKYPIKSRKLLRVLQRTLSALAHWSVIFSDTPYLPLLAFPFVKLFQNNQLICFEVIATLIINWC 527

  Fly   603 QLCFEFHPLPPSNYLAMCENILQHCDEQLCKFYKSQEMLPKDFAWPLLSTAFSEVLEEEQWLSLW 667
            |..||:.|.||.|.|:|.||:|...|::|.:.:...::..:.:|||||.|.|||||..|:||.|:
Human   528 QHWFEYFPNPPINILSMIENVLAFHDKELLQHFIDHDITSQLYAWPLLETVFSEVLTREEWLKLF 592

  Fly   668 DNIFSEPPWFPVFLVVAYNLINREIILRLPDKRSVLFFFHDQNPVDISKLLSKARKLMSKCALAL 732
            |||||..|.|.:..|||||:.:|..:|....|....||||.:|.:||:.::.:...||......:
Human   593 DNIFSNHPSFLLMTVVAYNICSRTPLLSCNLKDDFEFFFHHRNNLDINVVIRQVYHLMETTPTDI 657

  Fly   733 HPQRFMTHFSPIPKGVYPKFLKYPSEWIDEQEYQAVSLIKHNQEIDARIRHLELEEVKIMERLET 797
            ||...:..|..:.||.||.|.:||...:|.|..:...:  .|.|:|      .|.|.:.:|.::.
Human   658 HPDSMLNVFVALTKGQYPVFNQYPKFIVDYQTQERERI--RNDELD------YLRERQTVEDMQA 714

  Fly   798 GLKQEEHARRLKEMERVYQDTIHREEERITCQRKMLLTYQMEVRRRKSEVITKLQESE----QRR 858
            .:.|:                  |.|:....|::.||....|.||   |::  |||.|    ||:
Human   715 KVDQQ------------------RVEDEAWYQKQELLRKAEETRR---EML--LQEEEKMIQQRQ 756

  Fly   859 KILEMEKDMDLL-MHSIERERRRHNQEMQLAEDEIRNQEMELLAQRYYSDTEGAPLAQKYYDKIQ 922
            ::..:::::.:. ||..:..|||.   ::|.:|:   |||||               ::..|:|.
Human   757 RLAAVKRELKVKEMHLQDAARRRF---LKLQQDQ---QEMEL---------------RRLDDEIG 800

  Fly   923 KLCYQRD-QLQKNLRDMTMEQLRTPATSSVQFSPQLVDIENSIFEIQREFTEIITTDKTLEYRRN 986
            :..|.|| ::....||:.|.||...:...:        .|.::.|.|....:.:..|.. .|||.
Human   801 RKVYMRDREIAATARDLEMRQLELESQKRL--------YEKNLTENQEALAKEMRADAD-AYRRK 856

  Fly   987 L 987
            :
Human   857 V 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16896	NP_611973.2	WD40	228..>467	CDD:225201	55/297 (19%)
		BAR	766..>952	CDD:299863	44/191 (23%)
		SPFH_like	<817..909	CDD:302763	27/96 (28%)
TBC1D31	NP_663622.2	WD 1	33..74		15/65 (23%)
		WD40	<34..346	CDD:225201	68/359 (19%)
		WD40	39..334	CDD:295369	64/327 (20%)
		WD40 repeat	46..81	CDD:293791	12/59 (20%)
		WD 2	75..116		6/44 (14%)
		WD40 repeat	86..123	CDD:293791	8/40 (20%)
		WD 3	117..157		9/39 (23%)
		WD40 repeat	130..164	CDD:293791	7/33 (21%)
		WD 4	158..200		10/42 (24%)
		WD40 repeat	171..207	CDD:293791	8/35 (23%)
		WD 5	201..248		7/46 (15%)
		WD40 repeat	215..253	CDD:293791	7/37 (19%)
		WD 6	249..296		7/46 (15%)
		WD40 repeat	261..291	CDD:293791	5/29 (17%)
		WD 7	297..334		9/39 (23%)
		WD40 repeat	309..335	CDD:293791	5/25 (20%)
		RabGAP-TBC	469..609	CDD:295329	60/139 (43%)
		TPH	684..960	CDD:290579	53/235 (23%)
		vATP-synt_E	713..>838	CDD:304907	39/176 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159686
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1093
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2936
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368524at33208
OrthoFinder	1	1.000	-	-		FOG0007441
OrthoInspector	1	1.000	-	-		oto90152
orthoMCL	1	0.900	-	-		OOG6_104990
Panther	1	1.100	-	-	LDO	PTHR19853
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5782
SonicParanoid	1	1.000	-	-		X5573
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790