DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16896 and DIP2

DIOPT Version :9

Sequence 1:	NP_611973.2	Gene:	CG16896 / 37977	FlyBaseID:	FBgn0035073	Length:	988	Species:	Drosophila melanogaster
Sequence 2:	NP_013230.1	Gene:	DIP2 / 850820	SGDID:	S000004119	Length:	943	Species:	Saccharomyces cerevisiae

Alignment Length:	968	Identity:	167/968 - (17%)
Similarity:	302/968 - (31%)	Gaps:	356/968 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 FNELSNKLVVIDKRGNVFVFDFVRK--------------RYWRLGFRMPKAKLIRPSPLHGSDYI 169
            |:....:|:...|..|:.|:|.|.:              .:|                ..|.|::
Yeast   129 FDGTGTRLISGSKDSNIIVWDLVGEVGLYKLRSHKDSITGFW----------------CQGEDWL 177

  Fly   170 VGNK----------------------TGHIFTIDVDNSIL---GVDGEVGSAALEELSWSNSLQN 209
            :...                      ||..:.:.|.:.:|   |.|.:|       ..|...::|
Yeast   178 ISTSKDGMIKLWDLKTHQCIETHIAHTGECWGLAVKDDLLITTGTDSQV-------KIWKLDIEN 235

  Fly   210 ARSSIALMRFGSDALLVNLHTLEVSHQLDFDQSRYTLKFAAFLPHSDQ---FFIGFSNDSLHVWS 271
            .:....|...|.               .:....:..||.......||:   |:|..::.::..:.
Yeast   236 DKMGGKLTEMGI---------------FEKQSKQRGLKIEFITNSSDKTSFFYIQNADKTIETFR 285

  Fly   272 SHSLSTLRMGQPIKARNRKLRLLPAAESIPEIVLRSPDDSDLEEDLTFDCQHYDFADGMLLSYCF 336
            ......:..|  :|.|.::|:.....|   |.:.:|..:|            |.       |:..
Yeast   286 IRKEEEIARG--LKKREKRLKEKGLTE---EEIAKSIKES------------YS-------SFIL 326

  Fly   337 TPDGNKMCLSTLDGYLLLLS-----VASFDLEKMYRLTDFTLHQMAFLSQPKERIVFGITTRNQA 396
            .|      ..|:.....:.|     |:|..||.:...:..|:.   :.|.|.|:       |:..
Yeast   327 HP------FQTIRSLYKIKSASWTTVSSSKLELVLTTSSNTIE---YYSIPYEK-------RDPT 375

  Fly   397 VMLDLANTDHKLIVQRSNARSLSLSRDGKLLSVTSRCGEVNVWSTCRIFNALQAQIRCLSQVKST 461
            ....|.....:|..||::.||:.:|.|.|||:..|. |.:.:|:.        ...:|:    .|
Yeast   376 SPAPLKTHTIELQGQRTDVRSIDISDDNKLLATASN-GSLKIWNI--------KTHKCI----RT 427

  Fly   462 FKQPNPLPPCSVGGGV---------SKELRDLLNPQRLKTMLKEYGCYPEKYRYLIWTSLLDLPC 517
            |:....|....:.||:         ..:|.||.:...|.|:       .:.:...||:  |||..
Yeast   428 FECGYALTCKFLPGGLLVILGTRNGELQLFDLASSSLLDTI-------EDAHDAAIWS--LDLTS 483

  Fly   518 NGPQFQELIKLGAPLLVRNRAKKLKIRNDHQRRVVIKIWSCLAQWCKVLAHADF-MPHLIFPFVK 581
            :|.:           ||...|.|           .:|.|             || :.:.:.|..|
Yeast   484 DGKR-----------LVTGSADK-----------TVKFW-------------DFKVENSLVPGTK 513

  Fly   582 RMPKNSLVCFELIATLVLNHFQLCFEFHPLPPSNYLAMCENILQHCDEQLCKFYKSQEMLPKD-- 644
            .         :.:..|.|:|                   :..|:..|:.||     ..:.|.|
Yeast   514 N---------KFLPVLKLHH-------------------DTTLELTDDILC-----VRVSPDDRY 545

  Fly   645 FAWPLLSTAFSEVLEEEQ--WLSLWDNIFSEPPWFPVFLVVAYNLINREIILRLPDKRSVLF--- 704
            .|..||.........:..  :|||:.:      ..|| |.:..:..::.||....||...::
Yeast   546 LAISLLDNTVKVFFLDSMKFYLSLYGH------KLPV-LSIDISFDSKMIITSSADKNIKIWGLD 603

  Fly   705 --------FFHDQNPVDISKLLSKARKLMSKCALALHPQRFMTHFSPIPKGVYPKFLKYPSEWID 761
                    |.|..:.::: |.|.::....| |:                |....|:      | |
Yeast   604 FGDCHKSLFAHQDSIMNV-KFLPQSHNFFS-CS----------------KDAVVKY------W-D 643

  Fly   762 EQEYQAV-SLIKHNQEIDAR---------IRHLELEEVKIMERLETGLKQEEHARRLKEMERVYQ 816
            .::::.: .|..|..|:.|.         :.......::|.|..|..:..||  .:.||:|..|:
Yeast   644 GEKFECIQKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWEETEDQVFLEE--EKEKELEEQYE 706

  Fly   817 DTIHREEERITCQRKMLLTYQMEVRRRKSEVITKLQE--------------------SEQRRKIL 861
            ||:                            :|.|:|                    |...::.|
Yeast   707 DTL----------------------------LTSLEEGNGDDAFKADASGEGVEDEASGVHKQTL 743

  Fly   862 EMEKDMDLLMHSIERERRRHNQEMQLAED---EIRNQEMELLAQRYYSDTEGAPLAQKYYDKIQK 923
            |..|..:.||.::         ::.:||.   |..|::|:|..::...:....|........:.|
Yeast   744 ESLKAGERLMEAL---------DLGIAEIEGLEAYNRDMKLWQRKKLGEAPIKPQGNAVLIAVNK 799

  Fly   924 LCYQRDQLQKNLRDMTMEQLRTPATSSVQFSPQLVDIENSIFEIQREFTEIITTDKTL 981
            ...|  .:...|..:.|.||. .|...:.||..|..:         :|.:.:..:|||
Yeast   800 TPEQ--YIMDTLLRIRMSQLE-DALMVMPFSYVLKFL---------KFIDTVMQNKTL 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16896	NP_611973.2	WD40	228..>467	CDD:225201	45/246 (18%)
		BAR	766..>952	CDD:299863	38/218 (17%)
		SPFH_like	<817..909	CDD:302763	17/114 (15%)
DIP2	NP_013230.1	WD40	<16..150	CDD:225201	5/20 (25%)
		WD40 repeat	83..118	CDD:293791
		WD40	88..501	CDD:421866	86/506 (17%)
		WD40 repeat	124..160	CDD:293791	7/30 (23%)
		WD40 repeat	168..201	CDD:293791	3/48 (6%)
		WD40 repeat	207..229	CDD:293791	5/28 (18%)
		WD40 repeat	256..284	CDD:293791	6/27 (22%)
		WD40 repeat	332..382	CDD:293791	11/59 (19%)
		WD40	383..685	CDD:238121	77/423 (18%)
		WD40 repeat	396..430	CDD:293791	12/46 (26%)
		WD40 repeat	434..470	CDD:293791	8/42 (19%)
		WD40 repeat	476..521	CDD:293791	16/90 (18%)
		WD40 repeat	535..570	CDD:293791	9/39 (23%)
		WD40 repeat	577..613	CDD:293791	5/35 (14%)
		WD40 repeat	618..654	CDD:293791	8/60 (13%)
		WD40 repeat	660..684	CDD:293791	1/23 (4%)
		Utp12	801..910	CDD:397900	13/57 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346496
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930