DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16896 and tbc1d31

DIOPT Version :9

Sequence 1:	NP_611973.2	Gene:	CG16896 / 37977	FlyBaseID:	FBgn0035073	Length:	988	Species:	Drosophila melanogaster
Sequence 2:	XP_695006.1	Gene:	tbc1d31 / 563134	ZFINID:	ZDB-GENE-061218-4	Length:	1070	Species:	Danio rerio

Alignment Length:	914	Identity:	238/914 - (26%)
Similarity:	402/914 - (43%)	Gaps:	160/914 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 SESGNVLTVHHTIKEAGQALRIQIAACCFNELSNKLVVIDKRGNVFVFDFVRKRY---------- 145
            |::|.:.||... ..|.|...::.....|:......:..|..||::|||..|.|:
Zfish    21 SKNGVLATVIRN-SSARQTKTVRFLQVAFDTTGESFLAGDHHGNIYVFDICRNRFKLVQKTGQAC 84

  Fly   146 WRLGFRMPKAKLIRPSPLHGSDYIVGNKTGHIFTIDVDNSILGVDGEVGSAALEELSWSNSLQNA 210
            ..|.|.:.:.          ::::|......|...|.|...|             :||....:.|
Zfish    85 TALAFNLRRT----------TEFLVALADYSIKCFDKDTRQL-------------VSWMRGHEGA 126

  Fly   211 RSSIALMRFGSDAL--------LVNLHTLEVSHQLDFDQSRYTLKFAAFLPHSDQFFIGFSNDSL 267
            .||:::...||.|:        |.:|.|.:...:|:..|| ..::...|||||:.....||::|:
Zfish   127 VSSLSIHSSGSFAISTSSDTAQLWSLDTFQRKRKLNVRQS-VGIQKVFFLPHSNTILSCFSDNSI 190

  Fly   268 HVWSSHSL--------------------STLRMGQPIKARNRK----LRLLPAAESIPEIVLRSP 308
            ..|.:.:|                    :..:.|:.:.|..|.    |..|.:.:.|.  |::.|
Zfish   191 FAWETDTLFCKYQLPVPQNGPRIHYRTFAVTQNGKTLAAAGRSNLVHLWCLDSQQLIR--VIQMP 253

  Fly   309 DDSDLEEDLTFDCQHYDFADGMLLSYCFTPDGNKMCLSTL--DGYLLLLSVASFDLEKMYRLTDF 371
            .:......|.|....:|             ||:...|..|  ||.:..:::.|  .::::.:..
Zfish   254 SNVKTVRYLDFLPDSFD-------------DGSNQTLGVLSQDGIMRFVNIQS--CKQLFLIGS- 302

  Fly   372 TLHQMAFLSQ---PKERIVFGITTRNQAVMLDLANTDHKL------IVQRSNARSLSLSRDGKLL 427
              |:.|..|.   ||...:..:.......:.|:.:...::      :::|....::|   ||..|
Zfish   303 --HEDAISSATVCPKGHHIVAVMDSGAIKIYDVRSLTTEISKPPQPLLKRVTKVNIS---DGSCL 362

  Fly   428 --SVTSRCGEVNVWSTCRIFNALQAQIRCLSQVKSTF-KQPNPLPPCSVGGGVSKELRDLLNPQR 489
              .|.:..|:..|.::.|     :.|.:.|....||. .:.|.||     .|:||        :|
Zfish   363 KMKVNTGAGQRAVKTSGR-----RIQSKLLPPSVSTLDDKENDLP-----NGLSK--------KR 409

  Fly   490 LKTMLKEYGCYPEKYRYLIWTSLLDLPCNGPQFQELIKLGAPLLVRNRAKKLKIRNDHQRRVVIK 554
            |:.:|:|:|.||.|||..||.|||.||.|...|..|...|.........::..|::...:|.:.:
Zfish   410 LQALLREFGEYPAKYRMFIWRSLLRLPENHAAFSSLTDKGLHSAFLCLQEQYPIKSHKLQRGLQR 474

  Fly   555 IWSCLAQWCKVLAHADFMPHLIFPFVKRMPKNSLVCFELIATLVLNHFQLCFEFHPLPPSNYLAM 619
            :.|.||.|..|....|::|.|.|||||....|.|:|||.:||:::|..|..||:.|.||.|.|::
Zfish   475 VLSALAHWAAVFGETDYVPLLAFPFVKLFQNNPLICFEAVATVIVNWCQHWFEYFPNPPLNVLSL 539

  Fly   620 CENILQHCDEQLCKFYKSQEMLPKDFAWPLLSTAFSEVLEEEQWLSLWDNIFSEPPWFPVFLVVA 684
            .||:|.|.|::|.:.:.:..:..:.:|||||.|.|||||..|:||.|:||:||..|.|.:..|||
Zfish   540 AENVLAHHDKELLQHFVACGVTSQLYAWPLLETLFSEVLMREEWLKLFDNVFSNHPSFLLMAVVA 604

  Fly   685 YNLINREIILRLPDKRSVLFFFHDQNPVDISKLLSKARKLMSKCALALHPQRFMTHFSPIPKGVY 749
            |....|..:|...|||...:|||.:|.:||..:|.:..:||.:....:||...:..|.|:.:|.|
Zfish   605 YVTCCRAPLLLCTDKRDFEYFFHHRNSLDIGAMLKETYRLMDRTPADIHPSSALNDFEPLTQGQY 669

  Fly   750 PKFLKYPSEWIDEQ-------EYQAVSLIKHNQEIDARIRHLELEEVKIMERLETGLKQEEHARR 807
            |.|.|||:..::.|       ..|.|..::..||    ::.|..|.|:.....|...||:|...:
Zfish   670 PVFNKYPTFIVEYQSQERERIRQQEVEYLRERQE----VQKLHAEAVRQQAEFEAWYKQQELLLQ 730

  Fly   808 LKEMERVYQDTIHREEERITCQRKMLLTYQMEVRRRKSEVITKLQESEQRRKILEMEKD-----M 867
            .:|..|:   .:..||.::..||..|...:.|::.::..:|     ...||:.|:.::|     :
Zfish   731 GEEQRRL---ILQEEESKLAQQRARLAAMKRELKVKELSLI-----DSSRRRFLKHQQDQRRVHL 787

  Fly   868 DLLMHSIERERRRHNQEMQLAEDEIRNQEMELLAQRYYSDTEGAPLAQKYYDKIQKLCYQRDQLQ 932
            ..|...|:|:....:||...|..|:..::|||.|||...:              |:|..:::::.
Zfish   788 KRLDDEIQRKMALRDQETAAAVQEVEVRQMELDAQRQLFE--------------QQLAREQERVS 838

  Fly   933 KNLR 936
            :.:|
Zfish   839 QEVR 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16896	NP_611973.2	WD40	228..>467	CDD:225201	52/276 (19%)
		BAR	766..>952	CDD:299863	40/176 (23%)
		SPFH_like	<817..909	CDD:302763	24/96 (25%)
tbc1d31	XP_695006.1	WD40	<7..344	CDD:225201	70/367 (19%)
		WD40	44..332	CDD:295369	63/331 (19%)
		WD40 repeat	44..79	CDD:293791	9/34 (26%)
		WD40 repeat	84..121	CDD:293791	9/59 (15%)
		WD40 repeat	128..162	CDD:293791	8/33 (24%)
		WD40 repeat	169..205	CDD:293791	10/35 (29%)
		WD40 repeat	215..251	CDD:293791	7/37 (19%)
		WD40 repeat	259..288	CDD:293791	9/41 (22%)
		RabGAP-TBC	423..614	CDD:295329	77/190 (41%)
		GBP_C	<685..761	CDD:303769	19/82 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595902
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1093
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	251	1.000	Inparanoid score	I3214
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368524at33208
OrthoFinder	1	1.000	-	-		FOG0007441
OrthoInspector	1	1.000	-	-		oto41189
orthoMCL	1	0.900	-	-		OOG6_104990
Panther	1	1.100	-	-	LDO	PTHR19853
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5782
SonicParanoid	1	1.000	-	-		X5573
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.790