DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16896 and Tbc1d31

DIOPT Version :9

Sequence 1:	NP_611973.2	Gene:	CG16896 / 37977	FlyBaseID:	FBgn0035073	Length:	988	Species:	Drosophila melanogaster
Sequence 2:	NP_001128314.1	Gene:	Tbc1d31 / 299949	RGDID:	1587370	Length:	1061	Species:	Rattus norvegicus

Alignment Length:	946	Identity:	242/946 - (25%)
Similarity:	398/946 - (42%)	Gaps:	190/946 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 VLTVHHTIKEAGQALRIQIAACCFNELSNKLVVIDKRGNVFVFDFVRKRYWRLGFRMPKAKLIRP 160
            |..||.|.:...:.||....|  |:...:..:..|.:||::|||
  Rat    29 VNVVHSTSEYHPKVLRFLNVA--FDGSGDSFIAGDHQGNIYVFD--------------------- 70

  Fly   161 SPLHGSDYIVGNKTGHIFT--------------IDVDNSILGVDGEVGSAALEELSWSNSLQNAR 211
              |||:.:.:..:|....|              ...|.||...|    :...|.:||....:::.
  Rat    71 --LHGNRFNLVQRTAQACTALAFNLRRKSEFLVALADYSIKCFD----TVTKELVSWMRGHESSV 129

  Fly   212 SSIALMRFG-------SD-ALLVNLHTLEVSHQLDFDQSRYTLKFAAFLPHSDQFFIGFSNDSLH 268
            .||::...|       || |.|.:|.|.:...:|:..|| ..::...|||.|:.....|.::|:.
  Rat   130 RSISVHTSGRYAITTSSDTAQLWDLDTFQRKRKLNVRQS-VGIQKVFFLPLSNTILSCFKDNSIF 193

  Fly   269 VWSSHSLSTLRM--GQP--------IKARNRKLRLLPAAESIPEIVLRSPDDSDLEEDLTFD--- 320
            .|...:|.....  |.|        :.|..|..|:|.|......:.|...:.:.|...:...
  Rat   194 AWECDTLFCKYQLPGPPEGCNILYKVFAVTRDGRILAAGGKSNHVHLWCLEATQLFRIIQMPTKV 258

  Fly   321 --CQHYDFADGMLLSYCFTPD----GNKMCLSTL--DGYLLLLSVASFDLEKMYRLTDFTLHQMA 377
              .:|.:          |.||    |:...|..|  ||.                        |.
  Rat   259 RAVRHLE----------FLPDSFDAGSNQVLGVLSQDGI------------------------MR 289

  Fly   378 FLSQPKERIVFGITTRNQAVMLDLANTDHKLIVQRSNARSLSLSRDGKLLSVTSRCGEVNVWSTC 442
            |::....:::|.|.|..:.|                  .|..:|..|:.::.....|.:||:|.
  Rat   290 FVNIQTCKLLFQIGTVEEGV------------------SSSVISPHGRYITAIMENGSLNVYSV- 335

  Fly   443 RIFNALQAQI--------RCLSQVKSTFKQPNPLPPCSVGGGVSK-------------------- 479
               .||..:|        :.:..:.:.....|.|....:.|.|.:
  Rat   336 ---QALTQEINKPPPPLVKVIEDLPNNTVSSNNLKVKVMSGRVQRPARCKERKNQTRVLKQDLTG 397

  Fly   480 -------ELRDLLNPQRLKTMLKEYGCYPEKYRYLIWTSLLDLPCNGPQFQELIKLGAPLLVRNR 537
                   ||.:.||.:||:.:||.||.||.|||..||.|||.||.|...|..|:..|......:.
  Rat   398 NLENKENELSEGLNKKRLQVLLKGYGEYPTKYRMFIWRSLLQLPENHTAFSSLMDKGTHAAYLDL 462

  Fly   538 AKKLKIRNDHQRRVVIKIWSCLAQWCKVLAHADFMPHLIFPFVKRMPKNSLVCFELIATLVLNHF 602
            .||..|::....||:.:..|.||.|..:.:...::|.|.|||||....|.|:|||::|||::|..
  Rat   463 QKKYPIKSRRLLRVLQRTLSALAHWSAIFSDMPYLPLLAFPFVKLFQNNQLICFEVVATLIINWC 527

  Fly   603 QLCFEFHPLPPSNYLAMCENILQHCDEQLCKFYKSQEMLPKDFAWPLLSTAFSEVLEEEQWLSLW 667
            |..||:.|.||.|.|.|.||:|...|::|.:.:..:::..:.:|||||.|.|||||..|:||.|:
  Rat   528 QHWFEYFPNPPINILTMIENVLAFHDKELLQHFIDRDITSQVYAWPLLETLFSEVLTREEWLRLF 592

  Fly   668 DNIFSEPPWFPVFLVVAYNLINREIILRLPDKRSVLFFFHDQNPVDISKLLSKARKLMSKCALAL 732
            |||||..|.|.:..|||||..:|..:|....|....:|||.:|.:|::.::.:...||......:
  Rat   593 DNIFSSHPSFLLMTVVAYNTCSRAPLLNCTLKDDFEYFFHHRNNLDLNVVIREVYHLMETTPADI 657

  Fly   733 HPQRFMTHFSPIPKGVYPKFLKYPSEWIDEQEYQAVSLIKHNQEID-----ARIRHLELEEVKIM 792
            ||...:..|..:.||.||.|.:||...:|.|..:...:  .|.|:|     ..:.:::.|..:..
  Rat   658 HPNSMLDAFVALTKGQYPIFNQYPKFIVDYQTKERERI--RNDELDFLRERQTVENMQAEVDEQR 720

  Fly   793 ERLETGLKQEEHARRLKEMERVYQDTIHREEERITCQRKMLLTYQMEVRRRKSEVITKLQESEQR 857
            .:.|...:::|..||.:|..|   :.:.:|||::..||..|...:.|:..::    ..||::.:|
  Rat   721 AKDEAWYQKQEMLRRAEETRR---EMLLQEEEKMAQQRHRLAAVKRELEIKE----IHLQDAARR 778

  Fly   858 R--KILEMEKDMDL--LMHSIERERRRHNQEMQLAEDEIRNQEMELLAQR--YYSDTEGA--PLA 914
            |  |:.:.:::|:|  |...|||:.:..:||:.....::..:::||.|::  |..|...:  .:|
  Rat   779 RLLKLQQDQREMELRRLEDEIERKVQMRDQEIAATAKDLEMRQLELEARKRLYEKDLTASQEAIA 843

  Fly   915 QKYYDKI----QKLCYQRDQLQKNLRDMTMEQLRTP 946
            :...:..    :|:..:....||.|.:..|...|||
  Rat   844 KGIREDTDAHRRKMVLEEHVFQKLLENSQMGSRRTP 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16896	NP_611973.2	WD40	228..>467	CDD:225201	47/267 (18%)
		BAR	766..>952	CDD:299863	44/198 (22%)
		SPFH_like	<817..909	CDD:302763	25/97 (26%)
Tbc1d31	NP_001128314.1	WD40	<34..346	CDD:225201	77/397 (19%)
		WD40	39..334	CDD:295369	72/376 (19%)
		WD40 repeat	43..81	CDD:293791	13/62 (21%)
		WD40 repeat	86..123	CDD:293791	8/40 (20%)
		WD40 repeat	130..164	CDD:293791	9/33 (27%)
		WD40 repeat	171..207	CDD:293791	8/35 (23%)
		WD40 repeat	215..253	CDD:293791	7/37 (19%)
		WD40 repeat	261..290	CDD:293791	10/62 (16%)
		RabGAP-TBC	460..609	CDD:295329	62/148 (42%)
		ARGLU	693..842	CDD:291991	35/157 (22%)
		vATP-synt_E	713..>834	CDD:304907	31/127 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353753
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1093
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2862
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368524at33208
OrthoFinder	1	1.000	-	-		FOG0007441
OrthoInspector	1	1.000	-	-		oto97270
orthoMCL	1	0.900	-	-		OOG6_104990
Panther	1	1.100	-	-	LDO	PTHR19853
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5573
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.760