Protein Alignment CG16896 and Tbc1d31

DIOPT Version :10

• Sequence 1: NP_611973.2
• Gene: CG16896 / 37977
• FlyBaseID: FBgn0035073
• Length: 988
• Species: Drosophila melanogaster
• Sequence 2: NP_001128314.1
• Gene: Tbc1d31 / 299949
• RGDID: 1587370
• Length: 1061
• Species: Rattus norvegicus
• Alignment Length: 946
• Identity: 242/946 - (25%)
• Similarity: 398/946 - (42%)
• Gaps: 190/946 - (20%)

  Fly    96 VLTVHHTIKEAGQALRIQIAACCFNELSNKLVVIDKRGNVFVFDFVRKRYWRLGFRMPKAKLIRP 160
            |..||.|.:...:.||....|  |:...:..:..|.:||::|||
  Rat    29 VNVVHSTSEYHPKVLRFLNVA--FDGSGDSFIAGDHQGNIYVFD--------------------- 70

  Fly   161 SPLHGSDYIVGNKTGHIFT--------------IDVDNSILGVDGEVGSAALEELSWSNSLQNAR 211
              |||:.:.:..:|....|              ...|.||...|    :...|.:||....:::.
  Rat    71 --LHGNRFNLVQRTAQACTALAFNLRRKSEFLVALADYSIKCFD----TVTKELVSWMRGHESSV 129

  Fly   212 SSIALMRFG-------SD-ALLVNLHTLEVSHQLDFDQSRYTLKFAAFLPHSDQFFIGFSNDSLH 268
            .||::...|       || |.|.:|.|.:...:|:..|| ..::...|||.|:.....|.::|:.
  Rat   130 RSISVHTSGRYAITTSSDTAQLWDLDTFQRKRKLNVRQS-VGIQKVFFLPLSNTILSCFKDNSIF 193

  Fly   269 VWSSHSLSTLRM--GQP--------IKARNRKLRLLPAAESIPEIVLRSPDDSDLEEDLTFD--- 320
            .|...:|.....  |.|        :.|..|..|:|.|......:.|...:.:.|...:...
  Rat   194 AWECDTLFCKYQLPGPPEGCNILYKVFAVTRDGRILAAGGKSNHVHLWCLEATQLFRIIQMPTKV 258

  Fly   321 --CQHYDFADGMLLSYCFTPD----GNKMCLSTL--DGYLLLLSVASFDLEKMYRLTDFTLHQMA 377
              .:|.:          |.||    |:...|..|  ||.                        |.
  Rat   259 RAVRHLE----------FLPDSFDAGSNQVLGVLSQDGI------------------------MR 289

  Fly   378 FLSQPKERIVFGITTRNQAVMLDLANTDHKLIVQRSNARSLSLSRDGKLLSVTSRCGEVNVWSTC 442
            |::....:::|.|.|..:.|                  .|..:|..|:.::.....|.:||:|.
  Rat   290 FVNIQTCKLLFQIGTVEEGV------------------SSSVISPHGRYITAIMENGSLNVYSV- 335

  Fly   443 RIFNALQAQI--------RCLSQVKSTFKQPNPLPPCSVGGGVSK-------------------- 479
               .||..:|        :.:..:.:.....|.|....:.|.|.:
  Rat   336 ---QALTQEINKPPPPLVKVIEDLPNNTVSSNNLKVKVMSGRVQRPARCKERKNQTRVLKQDLTG 397

  Fly   480 -------ELRDLLNPQRLKTMLKEYGCYPEKYRYLIWTSLLDLPCNGPQFQELIKLGAPLLVRNR 537
                   ||.:.||.:||:.:||.||.||.|||..||.|||.||.|...|..|:..|......:.
  Rat   398 NLENKENELSEGLNKKRLQVLLKGYGEYPTKYRMFIWRSLLQLPENHTAFSSLMDKGTHAAYLDL 462

  Fly   538 AKKLKIRNDHQRRVVIKIWSCLAQWCKVLAHADFMPHLIFPFVKRMPKNSLVCFELIATLVLNHF 602
            .||..|::....||:.:..|.||.|..:.:...::|.|.|||||....|.|:|||::|||::|..
  Rat   463 QKKYPIKSRRLLRVLQRTLSALAHWSAIFSDMPYLPLLAFPFVKLFQNNQLICFEVVATLIINWC 527

  Fly   603 QLCFEFHPLPPSNYLAMCENILQHCDEQLCKFYKSQEMLPKDFAWPLLSTAFSEVLEEEQWLSLW 667
            |..||:.|.||.|.|.|.||:|...|::|.:.:..:::..:.:|||||.|.|||||..|:||.|:
  Rat   528 QHWFEYFPNPPINILTMIENVLAFHDKELLQHFIDRDITSQVYAWPLLETLFSEVLTREEWLRLF 592

  Fly   668 DNIFSEPPWFPVFLVVAYNLINREIILRLPDKRSVLFFFHDQNPVDISKLLSKARKLMSKCALAL 732
            |||||..|.|.:..|||||..:|..:|....|....:|||.:|.:|::.::.:...||......:
  Rat   593 DNIFSSHPSFLLMTVVAYNTCSRAPLLNCTLKDDFEYFFHHRNNLDLNVVIREVYHLMETTPADI 657

  Fly   733 HPQRFMTHFSPIPKGVYPKFLKYPSEWIDEQEYQAVSLIKHNQEID-----ARIRHLELEEVKIM 792
            ||...:..|..:.||.||.|.:||...:|.|..:...:  .|.|:|     ..:.:::.|..:..
  Rat   658 HPNSMLDAFVALTKGQYPIFNQYPKFIVDYQTKERERI--RNDELDFLRERQTVENMQAEVDEQR 720

  Fly   793 ERLETGLKQEEHARRLKEMERVYQDTIHREEERITCQRKMLLTYQMEVRRRKSEVITKLQESEQR 857
            .:.|...:::|..||.:|..|   :.:.:|||::..||..|...:.|:..::    ..||::.:|
  Rat   721 AKDEAWYQKQEMLRRAEETRR---EMLLQEEEKMAQQRHRLAAVKRELEIKE----IHLQDAARR 778

  Fly   858 R--KILEMEKDMDL--LMHSIERERRRHNQEMQLAEDEIRNQEMELLAQR--YYSDTEGA--PLA 914
            |  |:.:.:::|:|  |...|||:.:..:||:.....::..:::||.|::  |..|...:  .:|
  Rat   779 RLLKLQQDQREMELRRLEDEIERKVQMRDQEIAATAKDLEMRQLELEARKRLYEKDLTASQEAIA 843

  Fly   915 QKYYDKI----QKLCYQRDQLQKNLRDMTMEQLRTP 946
            :...:..    :|:..:....||.|.:..|...|||
  Rat   844 KGIREDTDAHRRKMVLEEHVFQKLLENSQMGSRRTP 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16896	NP_611973.2	DUF5401	<754..>987	CDD:375164	48/210 (23%)
Tbc1d31	NP_001128314.1	WD40 repeat	43..81	CDD:293791	13/62 (21%)
		WD40	44..321	CDD:441893	68/358 (19%)
		WD40 repeat	86..123	CDD:293791	8/40 (20%)
		WD40 repeat	130..164	CDD:293791	9/33 (27%)
		WD40 repeat	171..207	CDD:293791	8/35 (23%)
		WD40 repeat	215..253	CDD:293791	7/37 (19%)
		WD40 repeat	261..290	CDD:293791	10/62 (16%)
		RabGAP-TBC	462..605	CDD:480642	61/142 (43%)
		DUF5401	<684..>998	CDD:375164	46/205 (22%)