DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16896 and Tbck

DIOPT Version :9

Sequence 1:	NP_611973.2	Gene:	CG16896 / 37977	FlyBaseID:	FBgn0035073	Length:	988	Species:	Drosophila melanogaster
Sequence 2:	XP_008759718.1	Gene:	Tbck / 295446	RGDID:	1307816	Length:	894	Species:	Rattus norvegicus

Alignment Length:	909	Identity:	171/909 - (18%)
Similarity:	291/909 - (32%)	Gaps:	306/909 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 FKLKQSESG----------------NVLTV-HHTIKEAGQALRIQI-------AACCFNELS--- 123
            |.||.:|.|                |.|.: .::||..|   |.|:       ..|.:.::|
  Rat     2 FPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILG---RFQVLKTITHPRLCQYVDISRGK 63

  Fly   124 -NKLVVIDKRGNVFVFDFVRKRYWRLGFRMPKAKLIRPSP-----------LHGSDYIVGNKTGH 176
             .:|||:.:.....:.|.:|:|              ||:.           |.|..|:  ||.|.
  Rat    64 HERLVVVAEHCERSLEDLLRER--------------RPASHSAVLCIAYEVLEGLQYL--NKHGI 112

  Fly   177 IFTIDVDNSILGVDGEVGSAALEELSWSNSLQNARSSIALMRFGSDALLVNLHTLEVSHQLDFDQ 241
            :.                    ..||..|.|.:.:..|.|.:||       |:.: .:|..|.|
  Rat   113 VH--------------------RALSPHNILLDRKGHIKLAKFG-------LYHM-TAHGDDVD- 148

  Fly   242 SRYTLKFAAFL-------------------------PHSDQFFIGFSNDSLHV----WSSHSLS- 276
              :.:.:.::|                         |.||.:.:|.....|.|    :.|..:|
  Rat   149 --FPIGYPSYLAPEVIAQGIFKSTDHVPSEKPLPSGPKSDVWSLGIILFELCVGRKLFQSLDISE 211

  Fly   277 TLRMGQPIKARNRKLRLLPAAESIPEIVLRSPDD--SDLEEDLTFDCQHYDFADGML-------L 332
            .|:....:...:..|.:|.......:|:...|::  |.|::.|||........|.::       :
  Rat   212 RLKFLLTLGCVDDTLIVLAEEHGCLDIIKELPENALSILKKCLTFHPPKRPTPDELMKDQVFSEV 276

  Fly   333 SYCFTP---------------------DGNKMCLSTLDGYL---------LLLSVASFDLEKMYR 367
            |..:||                     |.:.:|....|.||         .|..:|..||||.
  Rat   277 SPLYTPFIKPASLFSSSLRCADLTLPEDISDVCKDIDDDYLAERSIEEVYYLWCLAGGDLEKE-- 339

  Fly   368 LTDFTLHQMAFLSQPKERIVFGITTRNQAVMLDLANTDHKLIVQRSNARSLSLSRD-GKLLSVTS 431
                .:::....|:|.      |.|....:..|              ..|....|| ..||..|:
  Rat   340 ----LINKEIIRSKPP------ICTLPNFLFED--------------GESFGQGRDRSSLLDDTT 380

  Fly   432 RCGEVNVWSTCRIFNAL-----QAQIRCLSQVKSTFKQPNPLPPCSVGGGVSKELRDLLNPQRLK 491
                |.: |.|::.|.|     :|....|...:|:....|.....|....:...:|:.....:|.
  Rat   381 ----VTL-SLCQLRNRLKDVGGEAFYPLLEDDQSSLPHSNSNNELSAAASLPLIIRERDTEYQLN 440

  Fly   492 ------TMLKEYGC------------YPEKYRYLIWTSLL------------------------- 513
                  .:||.|..            .|...|.|.|.:||
  Rat   441 RIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQI 505

  Fly   514 --DLP-CNGPQFQELIKLGAPLLVRNRAKKLKIRNDHQR-RVVIKIWSCLAQWCKVLAHADF--- 571
              |:| |:  |:.||  |.:|             ..|.: |.|:|.|        |::|.|.
  Rat   506 EVDIPRCH--QYDEL--LSSP-------------EGHAKFRRVLKAW--------VVSHPDLVYW 545

  Fly   572 --MPHLIFPFVKRMPKNSLVCFELIATLV---LNHFQLCFEFHPLPPSNYLAMCENILQHCDEQL 631
              :..|..||:.....|..:.:..::..:   |.:|.|....|.:  ..||.:...::...|.:|
  Rat   546 QGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVI--QEYLTVFSQMISFHDPEL 608

  Fly   632 CKFYKSQEMLPKDFAWPLLSTAFSEVLEEEQWLSLWDNIFSEPPWFPVFLVVAYNLINREIILRL 696
            .........:|..:|.|...|.|:.|....:...|||.:......||..:.||       |:.:|
  Rat   609 SNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVA-------ILQQL 666

  Fly   697 PDK------RSVLFFFHDQNPVDISKLLSKARKLM----SKCALALH--PQRFMTHFSPIPKGVY 749
            .|:      ...:..|.|...:||.:.:.::..|.    .......|  |.|..:..|.:.....
  Rat   667 RDRLLANGFNECILLFSDLPEIDIERCVRESVNLFCWTPKSATYRQHAQPPRPASESSAVRSSSA 731

  Fly   750 PKFLKYPSEWID----EQEYQAVSLIKHNQEIDARIRH---LELEEVKIMERLETGLKQEEHAR 806
            |.|   .:|..|    :...:::.|.....|:..||..   ::|.|:.:....:|..|:.:.::
  Rat   732 PYF---SAECTDPPKTDLSRESIPLSDLKSEVSPRISAEDLIDLCELTVTGHFKTPTKKTKSSK 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16896	NP_611973.2	WD40	228..>467	CDD:225201	57/313 (18%)
		BAR	766..>952	CDD:299863	8/44 (18%)
		SPFH_like	<817..909	CDD:302763
Tbck	XP_008759718.1	S_TKc	43..273	CDD:214567	49/276 (18%)
		PKc_like	43..269	CDD:304357	49/272 (18%)
		TBC	467..671	CDD:214540	50/237 (21%)
		RHOD	772..883	CDD:294087	4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1093
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900