DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16896 and Tbc1d31

DIOPT Version :9

Sequence 1:	NP_611973.2	Gene:	CG16896 / 37977	FlyBaseID:	FBgn0035073	Length:	988	Species:	Drosophila melanogaster
Sequence 2:	XP_006520761.1	Gene:	Tbc1d31 / 210544	MGIID:	2684931	Length:	1061	Species:	Mus musculus

Alignment Length:	963	Identity:	248/963 - (25%)
Similarity:	402/963 - (41%)	Gaps:	221/963 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 VHHTIKEAGQALRIQIAACCFNELSNKLVVIDKRGNVFVFDFVRKRYWRLGFRMPKAKLIRPSPL 163
            ||.|.:...:.||....|  |:...:..:..|.:||::|||                       |
Mouse    32 VHSTSEYHPKVLRFLNVA--FDGSGDSFIAGDHQGNIYVFD-----------------------L 71

  Fly   164 HGSDYIVGNKTGHIFT--------------IDVDNSILGVDGEVGSAALEELSWSNSLQNARSSI 214
            ||:.:.:..:|....|              ...|.||...|    :...|.:||....:::..||
Mouse    72 HGNRFNLVQRTAQACTALAFNLRRKSEFLVALADYSIKCFD----TVTKELVSWMRGHESSVCSI 132

  Fly   215 ALMRFG-------SD-ALLVNLHTLEVSHQLDFDQSRYTLKFAAFLPHSDQFFIGFSNDSLHVWS 271
            ::...|       || |.|.:|.|.:...:|:..|| ..::...|||.|:.....|.::|:..|.
Mouse   133 SVHASGRYAITTSSDTAQLWDLDTFQRKRKLNIRQS-VGIQKVFFLPLSNTILSCFKDNSIFAWE 196

  Fly   272 SHSLSTLRM--GQP--------IKARNRKLRLLPAAESIPEIVLRSPDDSDLEEDLTFDC----- 321
            ..:|.....  |.|        :.|..|..|:|.|......:.|...:.:.|...:....
Mouse   197 CDTLFCKYQLPGPPEGSNILYKVFAVTRDGRILAAGGKSNHLHLWCLEATGLFRIIQMPAKVRAV 261

  Fly   322 QHYDFADGMLLSYCFTPD----GNKMCLSTL--DGYLLLLSVASFDLEKMYRLTDFTLHQMAFLS 380
            :|.:          |.||    |:...|..|  ||.                        |.|::
Mouse   262 RHLE----------FLPDSFDAGSNQVLGVLSQDGI------------------------MRFVN 292

  Fly   381 QPKERIVFGITTRNQAVMLDLANTDHKLIVQRSNARSLSLSRDGKLLSVTSRCGEVNVWSTCRIF 445
            ....:::|.|.|..:.:                  .|..:|..|:.::.....|.:||:|.
Mouse   293 IQTCKLLFEIGTVEEGI------------------SSSVISPHGRYIASIMENGSLNVYSV---- 335

  Fly   446 NALQAQIRCLSQVKSTFKQPNP-------LPPCSVG----------GGVSK-------------- 479
            .||..:|.         |.|.|       ||..:|.          |.|.:
Mouse   336 QALTQEIN---------KPPPPLVKVIEDLPSNTVSSSNLKMKIMPGRVQRPARCKESKIPTRVL 391

  Fly   480 -------------ELRDLLNPQRLKTMLKEYGCYPEKYRYLIWTSLLDLPCNGPQFQELIKLGAP 531
                         ||.:.||.:||:.:||.||.||.|||..||.|||.||.|...|..|:..|..
Mouse   392 KQDLTGDLENKENELSEGLNKKRLQILLKGYGEYPTKYRMFIWRSLLQLPENHTAFSSLVDKGTH 456

  Fly   532 LLVRNRAKKLKIRNDHQRRVVIKIWSCLAQWCKVLAHADFMPHLIFPFVKRMPKNSLVCFELIAT 596
            ....:..||..|::....||:.:..|.||.|..:.:...::|.|.|||||....|.|:|||::||
Mouse   457 AAYLSLQKKYPIKSRKLLRVLQRTLSALAHWSAIFSDTPYLPLLAFPFVKLFQNNQLICFEVVAT 521

  Fly   597 LVLNHFQLCFEFHPLPPSNYLAMCENILQHCDEQLCKFYKSQEMLPKDFAWPLLSTAFSEVLEEE 661
            |::|..|..||:.|.||.|.|:|.||:|...|::|.:.:..:::..:.:|||||.|.|||||..|
Mouse   522 LIINWCQHWFEYFPNPPINILSMIENVLAFHDKELLQHFIDRDITSQVYAWPLLETLFSEVLTRE 586

  Fly   662 QWLSLWDNIFSEPPWFPVFLVVAYNLINREIILRLPDKRSVLFFFHDQNPVDISKLLSKARKLMS 726
            :||.|:|||||..|.|.:..||||:..:|..:|....|....:|||.:|.:||:.::.:...||.
Mouse   587 EWLRLFDNIFSNHPSFLLMTVVAYSTCSRAPLLNCTLKNDFEYFFHHRNNLDINVVIREVYHLME 651

  Fly   727 KCALALHPQRFMTHFSPIPKGVYPKFLKYPSEWIDEQ--EYQAVSLIKHNQEID-----ARIRHL 784
            .....:||...:..|..:.||.||.|.:||...:|.|  |::.:    .|.|:|     ..:.::
Mouse   652 TTPADIHPNSMLDAFVALTKGQYPIFNQYPKFIVDYQTREWERI----RNDELDFLRERQTVENM 712

  Fly   785 ELEEVKIMERLETGLKQEEHARRLKEMERVYQDTIHREEERITCQRKMLLTYQMEVRRRKSEVIT 849
            :.|..:...:.|...:::|..||.:|..|   :.:.:|||::..||:.|...:.|:..::    .
Mouse   713 QAEVDEQRAKDEAWYQKQELLRRAEETRR---EILLQEEEKMAQQRQRLAAVKRELEIKE----I 770

  Fly   850 KLQESEQRR--KILEMEKDMDL--LMHSIERERRRHNQEMQLAEDEIRNQEMELLAQRYYSDTEG 910
            .||::.:||  |:.:.:::|:|  |...|||:.:..:||:.....::..:::||.||:
Mouse   771 HLQDAARRRLLKLQQDQREMELRRLEDEIERKVQMRDQEIAATAKDLEIRQLELEAQK------- 828

  Fly   911 APLAQKYYDKIQKLCYQRDQLQKNLRDMTMEQLRTPATSSVQFSPQLVDIENS 963
                 :.|:|  .|...::.:.|.:|:.|....|..|.....|...|   |||
Mouse   829 -----RLYEK--DLTTSQEAVAKEIREDTDAHRRKAALEEHMFQKLL---ENS 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16896	NP_611973.2	WD40	228..>467	CDD:225201	48/259 (19%)
		BAR	766..>952	CDD:299863	42/194 (22%)
		SPFH_like	<817..909	CDD:302763	24/95 (25%)
Tbc1d31	XP_006520761.1	WD40	39..334	CDD:392136	71/376 (19%)
		WD40 repeat	43..81	CDD:293791	13/62 (21%)
		WD40 repeat	86..123	CDD:293791	8/40 (20%)
		WD40 repeat	131..164	CDD:293791	9/32 (28%)
		WD40 repeat	171..211	CDD:293791	9/39 (23%)
		WD40 repeat	219..255	CDD:293791	7/35 (20%)
		WD40 repeat	261..290	CDD:293791	10/62 (16%)
		RabGAP-TBC	428..619	CDD:382990	80/190 (42%)
		DUF5401	<684..>1006	CDD:375164	50/216 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850057
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1093
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2909
Isobase	1	0.950	-	0	Normalized mean entropy	S6031
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007441
OrthoInspector	1	1.000	-	-		oto93728
orthoMCL	1	0.900	-	-		OOG6_104990
Panther	1	1.100	-	-	LDO	PTHR19853
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5782
SonicParanoid	1	1.000	-	-		X5573
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.730