DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16896 and F13H8.2

DIOPT Version :9

Sequence 1:	NP_611973.2	Gene:	CG16896 / 37977	FlyBaseID:	FBgn0035073	Length:	988	Species:	Drosophila melanogaster
Sequence 2:	NP_001370512.1	Gene:	F13H8.2 / 174038	WormBaseID:	WBGene00017435	Length:	929	Species:	Caenorhabditis elegans

Alignment Length:	870	Identity:	166/870 - (19%)
Similarity:	305/870 - (35%)	Gaps:	246/870 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 YIVGNKTGHIFTIDV--DNSILGVDGEVGSAALE----ELSWSNSL---QNARSSIALMRFGS-- 221
            |.|.:....|:::.:  |.::|    ...:|.||    ||:|.|..   |..:|.....:..:
Worm   181 YTVMDSRNEIYSMSLHRDETVL----VAATAELELLVFELNWKNGAIFEQEVKSEEPSAKKATND 241

  Fly   222 ----DALLVNLHTLEVSHQLD---FDQSR-YTLKFAAFLPHSDQFFIGFSNDSL----HVWSSHS 274
                |.:|.|:....::.:|.   ..||: ..|:..|  .|.|:|.:....|.:    .|: |.:
Worm   242 DEKEDDVLANMANRYITTKLRGRVIRQSKGRALQLVA--THDDRFLVCVGADKVADVYRVF-SET 303

  Fly   275 LSTLRMGQPIKARNRKLRLLPAAESIPEIVLRSPDDSDLEEDLTFDCQHYDFADGMLLSYCFTPD 339
            .|..|:.:.:|:..||      |.|....|    ::.|:.:|:|.               ..|..
Worm   304 ESAKRLTKKLKSAKRK------ATSDTTTV----NEDDVAKDVTI---------------LVTRI 343

  Fly   340 GNKMCLSTLDGYLLLLSVASFDLEKMYR----LTDFTLHQMAFLSQPKERIVFGITTRNQAVMLD 400
            |..:....:....::.||.:.:...:|:    |||.|:|.          :...|.|.:.:|..|
Worm   344 GEMVLPHKIKWIDVVRSVKTNENTLIYKWYALLTDNTVHW----------VKMSIETTSNSVECD 398

  Fly   401 -LANTDHKLIVQRSNARSLSLSRDGKLLSVTSRCGEVNVWSTCRIFNALQAQIRCLSQVKSTFKQ 464
             :.|.|.  :..|.:.|:|.:|....||: :....||.||||..:.::|......:..:.:.
Worm   399 SVGNLDK--LGHREDVRALCVSSSSSLLA-SGGGNEVIVWSTHSLRSSLTLTDNDIKDIVAV--- 457

  Fly   465 PNPLPPCS--VGGGVSKELR--DLLNPQRLKTMLKEYGCYPEKYRYLIWTSLLDLPCNGPQFQEL 525
             |.:|..:  :.||.:.|:.  :|.:.:.::|.....|.        |||..     |.|..:..
Worm   458 -NFVPGDNYILTGGKNGEIGVFELSSAELVETRKAHTGA--------IWTIQ-----NSPDNEGF 508

  Fly   526 IKLGAPLLVRNRAKKLKIRNDHQRRVVIKIWSCLAQWCKVLAHADFMPHLIFPFVKRMPKNSLVC 590
            |...|...||..:..| :....::|:.||....|....:.|| |.|.....|..|..:.....|.
Worm   509 ITASADKTVRFWSFVL-VTEGSRKRISIKEQKVLELPDEALA-ASFSADGKFLVVALLNNTCSVY 571

  Fly   591 FELIATLVLNHFQLCFEFHPLPPSNYLAMCENILQHCDEQLC---KFYKSQEMLPKDF-----AW 647
            |  :.||   .|.:....|.||     ..|.:|..  ..:||   ...||.::...||     ::
Worm   572 F--VNTL---KFFVSLYGHSLP-----VTCVDIAP--SSKLCVTGSVDKSVKVWGLDFGDCHKSF 624

  Fly   648 PLLSTAFSEVL---EEEQ--W-------LSLWDNIFSEPPWFPVFLVVAYNLINREIILRLPDKR 700
            .....|.:.||   .|||  |       :..||.:        .|::|
Worm   625 HAHDDAVTSVLFCPGEEQLFWSAGKDGKIKQWDAV--------KFIMV----------------- 664

  Fly   701 SVLFFFHDQNPVDISKLLSKARKLMSKCALALHPQRFMTHFSPIPKGVYPKFLKYPSEWIDEQEY 765
            .||    |::.:||..|..                  .|:.|.:....:.|.::.   |   ::.
Worm   665 QVL----DRHTLDIRCLAQ------------------FTNGSVMFSASHDKSIRC---W---EKT 701

  Fly   766 QAVSLIKHNQEIDARIRH----LELEEVKIMERL--ETGLKQEEHARRLKEMERVYQ-------D 817
            ..:.:::..:|::....:    :|.|:|...|..  |.|:...:.:..:...|.:.|       :
Worm   702 DEILIVEEREEVEREEEYEKKLIEEEDVVAGENADNEAGVASSKTSSSVVSAENIIQAVDIARNE 766

  Fly   818 TIHREEERITCQRKMLLTYQMEVRRRKS------EVITKLQESEQRRKIL--------------- 861
            .:.|:|:.......::..|     ..||      :|:.|.:.|:..|.:|
Worm   767 KVQRQEDPGHEPHPLIGAY-----NSKSLDHFIVDVVAKCRASDLDRTLLLVPLSYVADILLAIS 826

  Fly   862 ---EMEKDMDLLMHSIERERRRHNQEMQLAEDEIRNQEMELLAQRYYSDTEGAPLAQKYYDKIQK 923
               :.:...:|..|......|.|...:..:.|.:...|.               :..|..:.::|
Worm   827 SCTQQQYKAELCTHVAVYLTRIHLSHITASSDYVPIFEQ---------------MKSKMSEGVEK 876

  Fly   924 LCYQRDQLQKNLRDMTMEQLRTPAT 948
            |        :|:..:.:..||..||
Worm   877 L--------RNVTGINLAALRLLAT 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16896	NP_611973.2	WD40	228..>467	CDD:225201	51/251 (20%)
		BAR	766..>952	CDD:299863	33/220 (15%)
		SPFH_like	<817..909	CDD:302763	16/115 (14%)
F13H8.2	NP_001370512.1	WD40	60..>217	CDD:421866	9/39 (23%)
		WD40 repeat	63..101	CDD:293791
		WD40 repeat	107..143	CDD:293791
		WD40 repeat	148..185	CDD:293791	2/3 (67%)
		WD40	430..699	CDD:238121	72/352 (20%)
		WD40 repeat	454..491	CDD:293791	7/40 (18%)
		WD40 repeat	497..535	CDD:293791	10/43 (23%)
		WD40 repeat	540..583	CDD:293791	12/48 (25%)
		WD40 repeat	590..625	CDD:293791	8/36 (22%)
		WD40 repeat	631..666	CDD:293791	10/59 (17%)
		Utp12	791..891	CDD:397900	17/122 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167227
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930