Protein Alignment Eps-15 and PAN1

DIOPT Version :10

• Sequence 1: NP_611965.2
• Gene: Eps-15 / 37961
• FlyBaseID: FBgn0035060
• Length: 1253
• Species: Drosophila melanogaster
• Sequence 2: NP_012271.3
• Gene: PAN1 / 854822
• SGDID: S000001445
• Length: 1480
• Species: Saccharomyces cerevisiae
• Alignment Length: 1439
• Identity: 278/1439 - (19%)
• Similarity: 433/1439 - (30%)
• Gaps: 580/1439 - (40%)

  Fly    23 IDPKGTGAIEAMTAAKF-----LKKSGLSDVVLSRIWDLSDPS--------------GKGF---- 64
            |.|:|||..:|...|..     |:..|..       :.:|.|:              |.|:
Yeast   143 IQPQGTGYYQAANTANVHSVQPLQSQGTG-------YYVSTPNLISSNQTQQPLQAQGTGYYQSQ 200

  Fly    65 ---LDKPGFFVALKLVSLSQAGQVASMANIYLDIANPPKLGELPKTMPSRIQTVPVASGGVANGD 126
               :..|....:|:.:...|.|       .||...|...|..|..|....:.:  .|:.|: |.|
Yeast   201 PQQVPPPQQAQSLQPLKPQQTG-------FYLQPQNQAPLEPLKPTATGFVNS--FANNGL-NND 255

  Fly   127 WSIGVI--------DRLKYEQLFESLHPSNGMLPGNKVKG-----VLMDSKLPMSILGTIWDLAD 178
            ..|..|        |:.|:|.||.|: .:||   .|.|.|     :||.|.||.|.|..||.|.|
Yeast   256 IKIPAIRLSFITAQDQAKFETLFRSI-VTNG---SNTVSGANCRKILMRSGLPPSQLARIWTLCD 316

  Fly   179 QDKDGNLDMHEFVVAMHLVYQTLQKRTIP------------------------------------ 207
            ..|.|.|...||.:||||:...||..|||
Yeast   317 TSKAGELLFPEFALAMHLINDVLQGDTIPYELDSKTKNEVSSFIDAINLSIANQDSSANDAPKTP 381

  Fly   208 ---------------------------------------SVLPPE---------------LRKPG 218
                                                   |.|.|:               ...||
Yeast   382 FDEFITAGVQNLQPQPTGYMPQTSFGIPLQSQITGGGVASALNPQSTGFMAPTTFNMSMNTGTPG 446

  Fly   219 ------GAGP-------------PPKPAMPP------PPAGAAMPRAPSGEGFG----------- 247
                  |..|             |....|.|      |.....||:...|...|
Yeast   447 LNPQITGGAPASMQPNITGNALQPQTTGMMPQTTGMMPQTTGMMPQTSFGVNLGPQLTGGALQSQ 511

  Fly   248 -DGGFVANFPKDIAPPAAIPPLP------------VAVPPMTRIPPVGAVSSQPL---------- 289
             .||:.:..|:. :.||::|.|.            :...|...:||....::.||
Yeast   512 YTGGYGSVMPQQ-SGPASMPNLSFNQQGLQSQLTGLQPQPTGFLPPSNFSATMPLTAQKTGFGNN 575

  Fly   290 -IQTDPLIPIGAPVMANADWVVTPADLKRFEEIFRQSDLDKDGLVSGLEVKDIFIKSGIPQRSLA 353
             |.|...........::.|.:.| .:...|.:||...|....||:......:||.|||:.:..|.
Yeast   576 EIYTKSNFNNNLIDNSSQDKIST-EEKSLFYKIFETFDTQNKGLLDSPTAVEIFRKSGLNRADLE 639

  Fly   354 DIWALCDTNQSGKLTVEQFALAMWFVERKQRGVDPPHVLNANMVPPSM----------------- 401
            .||.|||.|.:|:|..::|||.|..|..|..|...|:||.::::|.|.
Yeast   640 QIWNLCDINNTGQLNKQEFALGMHLVYGKLNGKPIPNVLPSSLIPSSTKLLDNLKNQLKTEPTTT 704

  Fly   402 --RATVAGVDL-----QPQEVKPTY-----------------SNPELEMISKEIEELARERRVLE 442
              :.:...:|.     ...:|.|.|                 |:|..:.::.....|..:...::
Yeast   705 KEKPSFGKIDALSYKNNDDDVLPNYRNRRKVYSAKNEEQSSFSSPSAKSVNHSSSTLQTDDISVD 769

  Fly   443 TEIAQKEA---------DVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQKRL-DDLQAQVSHN 497
            ..:.:|.|         ::.:||  :.||::|       :|.:.|........: .||.::....
Yeast   770 KTVEKKTAKPKYAGFSREINLKN--IASLENE-------IKNISNPENCYDSSIPSDLTSRFDAI 825

  Fly   498 TAVLANVSLDISRTNEQVTKIRDQCHMQ-------------EVTINEQE-----GELNAKRSELQ 544
            .|.|.|:..:||..:.::|..:.|.:.:             |:|.|:::     ..|.|:.|.|.
Yeast   826 IAKLPNLFNEISTIDNEITNAKIQLYRKKNPSSIIGSGPNGEITENDRKKAKSRALLRARMSALT 890

  Fly   545 -KLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISSVRSMVTQLLETQRQ-MTDALLICRAAME 607
             |..:.|.||..|.:..:.|:.::.......|..|..:||.::.:..:.:. ||.:.:|.....|
Yeast   891 GKSTESEDSLSMEDEQQSAEIKRIQQENGKNQEIIKDIRSSISDISASLKSTMTGSNMISNQEFE 955

  Fly   608 NQNAELVSEYQLKIEPDFDEARKTLTKEVQLPKDDPFEENNSGAANQATNGFGSDPFSGQPVNKP 672
            ..      |:.:.:|   |..|:.|         |..:.|::.:..:      |.||  .|.:.|
Yeast   956 RW------EFGIGLE---DGVREFL---------DDLKSNSNKSVTE------SSPF--VPSSTP 994

  Fly   673 AISTGFDDSFNMSS---------------------------GFDSGFDAFGQSGAGSAFGQTQRD 710
               |..||..:..|                           .||.......||....:...::..
Yeast   995 ---TPVDDRSSSPSYSQFKTAEERAAYLKEQAKKRMKEKLAKFDKNRRNVTQSSRSISSENSREQ 1056

  Fly   711 PFGSDAFAANKSNAITPEPGKDDFGSDPFAALHAPTGQGQVLSPNAQKSGP--------PPRPES 767
            |    ...|..||.:  ||....|..:.:..:..||...|...| .|.:.|        |.:|..
Yeast  1057 P----QQIAGSSNLV--EPRATPFQEEKYVEVAQPTQPVQSTQP-VQPTQPVQPTQPVQPTQPVQ 1114

  Fly   768 PSPALPP------------------------------------KKS------------------- 777
            |:..:.|                                    ||:
Yeast  1115 PTQPVQPTQPVQNVYNAKQESDDEDEDDEEKRLQEELKRLKLKKKADKEKRLAALRKQIEDAQNE 1179

  Fly   778 ----------------KVPPPRPAPPRAA----------------QPTGGFGSGG---------- 800
                            .||...|..|.||                .|..|..|.|
Yeast  1180 SDEEETNGKDNFGGHVNVPQAAPVAPSAAFSQNSTNAPRSVHAAVTPAAGKNSTGLPSTTMGHNP 1244

  Fly   801 --------------------------------GGGFADFDDFDN-----------KLHH------ 816
                                            ..|::|.|:.:|           |:.|
Yeast  1245 YFKDASASSTSTFDARAAEMQRRIQRGLDEDEDDGWSDEDESNNRVAVDNKVEEAKIGHPDHARA 1309

  Fly   817 --IPSAPSPSATALSPLPPTLP-----------APIPVVSGSSLLDSFTLFDDPGQIHKQAASTP 868
              :.:||.||.|   |:||.:|           :|||:   :.:..|.|  .:|          |
Yeast  1310 PPVTAAPLPSVT---PVPPAVPVPQANTSNEKSSPIPI---APIPPSVT--QEP----------P 1356

  Fly   869 NPTPITVPTVHTLLQTSLSTPAAPSPALASLSTSGSGSVAGAGADLPSSVTITTAPSLNNQHLSR 933
            .|....:|.|....:..:  |:||:.|.| :..|||.:.|.||..||      ..|.|..|..|.
Yeast  1357 VPLAPPLPAVDGFQEPPI--PSAPAIATA-VQKSGSSTPALAGGVLP------PPPPLPTQQAST 1412

  Fly   934 SNTPLQNQRTADVKLETKAVVSVFDAFGEIGTRKAPTPSLITGPTDFKDDPFKDYRYEDPFSIKD 998
            |                :.:::..|.:.  |..|.      ||......|       :|..||.:
Yeast  1413 S----------------EPIIAHVDNYN--GAEKG------TGAYGSDSD-------DDVLSIPE 1446

  Fly   999 PFAEEGEEE 1007
            ....:.|||
Yeast  1447 SVGTDEEEE 1455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eps-15	NP_611965.2	EH	16..82	CDD:238009	15/84 (18%)
		EH	126..215	CDD:197477	42/191 (22%)
		EH	307..402	CDD:197477	34/113 (30%)
		SMC_prok_B	<423..>632	CDD:274008	44/238 (18%)
PAN1	NP_012271.3	DUF1720	144..243	CDD:369766	22/112 (20%)
		EH	265..356	CDD:197477	36/94 (38%)
		DUF1720	<391..453	CDD:369766	5/61 (8%)
		DUF1720	459..553	CDD:369766	16/94 (17%)
		EH	595..688	CDD:197477	33/93 (35%)
		MAT1	<833..>934	CDD:461894	21/100 (21%)
		PAT1	982..>1127	CDD:401645	30/162 (19%)
		Amelogenin	<1064..1125	CDD:197891	15/63 (24%)